Rimantadin - Instructions For The Use Of Tablets, Reviews, Price, Analogues

Table of contents:

Rimantadin - Instructions For The Use Of Tablets, Reviews, Price, Analogues
Rimantadin - Instructions For The Use Of Tablets, Reviews, Price, Analogues

Video: Rimantadin - Instructions For The Use Of Tablets, Reviews, Price, Analogues

Video: Rimantadin - Instructions For The Use Of Tablets, Reviews, Price, Analogues
Video: Tablet dosage form 2023, March


Rimantadin: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  1. 11. In case of impaired renal function
  2. 12. For violations of liver function
  3. 13. Use in the elderly
  4. 14. Drug interactions
  5. 15. Analogs
  6. 16. Terms and conditions of storage
  7. 17. Terms of dispensing from pharmacies
  8. 18. Reviews
  9. 19. Price in pharmacies

Latin name: Rimantadine

ATX code: J05AC02

Active ingredient: rimantadine (rimantadine)

Producer: Irbitsky Chemical-Pharmaceutical Plant, JSC (Russia), Biosynthesis (Russia), Usolye-Sibirskiy KhFZ, JSC (Russia), PharmVILAR NPO (Russia), Moskhimpharmpreparaty them. N. A. Semashko (Russia), Ozon, LLC (Russia), Eurofarm, CJSC (Russia), Tatkhimpharmpreparaty, OJSC (Russia), Marbiopharm (Russia)

Description and photo updated: 2018-23-11

Prices in pharmacies: from 42 rubles.


Rimantadin tablets
Rimantadin tablets

Rimantadine is an antiviral agent.

Release form and composition

Dosage form - tablets: round, white or almost white, with a chamfer, there may be risks (10, 20 or 30 pcs. In blisters, in a cardboard box 1, 2, 3, 4, 5, 6, 8 or 10 packs; 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 pcs. In polymer cans, in a cardboard box 1 can; packing for hospitals - in a cardboard box 200, 400, 500, 600, 800, 1000 blister packs).

Composition of 1 tablet:

  • active substance: rimantadine hydrochloride - 50 mg;
  • auxiliary substances (may differ slightly for different manufacturers): calcium stearate, lactose monohydrate, talc, potato starch.

Pharmacological properties


Rimantadine is an adamantane derivative antiviral. Effective against various strains of influenza A virus (especially A2).

Due to the polymer structure, long-term circulation of rimantadine in the body is ensured, therefore the drug is used not only for treatment, but also for the prevention of influenza.

Rimantadine suppresses the early stage of specific viral reproduction (after its penetration into the cell and before the initial transcription of RNA).

Rimantadine is a weak base. Its action is due to the ability to raise the pH of endosomes, which have a vacuole membrane and surround viral particles after they enter the cell. Thus, the drug substance prevents acidification in these vacuoles, thereby blocking the fusion of the viral envelope with the endosomal membrane and, as a consequence, interrupts the transcription of the viral genome, i.e., prevents the transfer of viral genetic material into the cytoplasm of the cell.

When rimantadine is taken in a daily dose of 200 mg for 2–3 days before and for 6–7 days after the development of clinical symptoms of influenza A, the incidence, severity of symptoms and the degree of serological reactions decrease. Some therapeutic effect of the drug is possible if it is taken within the next 18 hours after the first signs of influenza appear.


After oral administration, rimantadine is slowly but almost completely absorbed in the intestine. It binds to plasma proteins by about 40%. Its volume of distribution is 17-25 l / kg in adults, 289 l / kg in children.

In the nasal secretion, the concentration of the drug is 50% higher than in the blood plasma. Maximum plasma concentrations: 181 ng / ml - when taking a daily dose of 100 mg, 416 ng / ml - when taking a daily dose of 200 mg.

It is metabolized in the liver. It is excreted by the kidneys mainly in the form of metabolites (75-85%), partially - unchanged (15%). The half-life is 24–36 hours, but it doubles in patients with concomitant chronic renal failure.

In renal failure and in elderly patients, the accumulation of rimantadine in toxic concentrations is possible, if the dose is not adjusted in proportion to the decrease in creatinine clearance.

Indications for use

According to the instructions, Rimantadine is used for early treatment and prevention of influenza A in children aged 7 years and older.

Prophylactic reception is recommended after contact with a sick person (recommended reception for at least 10 days), in case of spread of infection in closed groups, as well as in the presence of a high risk of morbidity during an influenza epidemic.


  • acute and chronic kidney disease;
  • acute liver disease;
  • thyrotoxicosis;
  • glucose-galactose malabsorption, lactase deficiency, lactose intolerance;
  • children under 7 years of age;
  • the period of pregnancy and breastfeeding;
  • the presence of hypersensitivity to any component of the drug.

With caution, an antiviral agent must be used for diseases of the gastrointestinal tract, liver failure, arterial hypertension, atherosclerosis of the cerebral vessels, epilepsy (in history, including), as well as in old age.

Instructions for the use of Rimantadine: method and dosage

Rimantadine tablets are taken orally, after meals with water.

Recommended preventive dosing regimens:

  • adults: 50 mg once a day for up to 30 days;
  • children from 7 years old: 50 mg once a day for a course of up to 15 days.

The duration of admission is determined by the epidemiological situation.

With the flu, Rimantadine should be taken within the first 24–48 hours after the first symptoms of the disease appear.

Scheme of prescribing the drug for adults and adolescents from 14 years old by day:

  • 1st day - 100 mg 3 times a day or 300 mg once;
  • 2nd day - 100 mg 2 times a day;
  • 3rd day - 100 mg 2 times a day;
  • 4th day - 100 mg once a day;
  • 5th day - 100 mg once a day.

For children from 7 years of age for medicinal purposes, doses are determined depending on age:

  • 7-10 years old - 50 mg 2 times a day;
  • 10-14 years old - 50 mg 3 times a day.

The duration of treatment is also 5 days.

Elderly patients and patients with concomitant chronic renal / hepatic insufficiency, as well as those with epilepsy, are prescribed Rimantadin 100 mg once a day for the treatment of influenza.

Side effects

  • from the respiratory system: shortness of breath, cough, bronchospasm;
  • from the nervous system: movement disorders, fatigue, headache, insomnia, impaired concentration, confusion, depressed mood, irritability, hyperkinesia, drowsiness, hallucinations, dizziness, tremors, euphoria, convulsions;
  • from the gastrointestinal tract: dryness of the oral mucosa, loss of appetite, nausea, diarrhea, abdominal pain, vomiting, dyspepsia;
  • on the part of the cardiovascular system: loss of consciousness, impaired cerebral circulation, arterial hypertension, heart block (heart rhythm disturbance), tachycardia, palpitations, heart failure;
  • on the part of the senses: loss or change of smell, tinnitus;
  • others: fatigue, rash.


Symptoms: arrhythmia, hallucinations, agitation. Dry skin, eye pain, tearing eyes, inflammation of the oral mucosa, sweating, constipation, increased urination, fever are also possible.

The first measure in case of an overdose is gastric lavage. Further treatment is symptomatic, aimed, among other things, at maintaining the vital functions of the body. In the case of the development of negative symptoms from the nervous system, intravenous administration of physostigmine (1.2 mg for adults and 0.5 mg for children) is indicated, if necessary, the drug is administered repeatedly (no more than 2 mg / h). Rimantadine can be partially removed by hemodialysis.

special instructions

It is advisable to take the drug to prevent influenza after contact with a sick family member. However, it is less effective for prophylactic use in a family in which patients with influenza took rimantadine for prophylactic purposes, which is probably associated with the transmission of viruses resistant to its action.

In influenza caused by the B virus, Rimantadine has antitoxic activity.

During the period of antiviral treatment, an exacerbation of existing chronic diseases is possible. Older people with hypertension are more likely to develop hemorrhagic stroke. Patients with a history of epilepsy and anticonvulsant therapy are at increased risk of a seizure. In such cases, Rimantadine is prescribed in a daily dose of 100 mg simultaneously with anticonvulsant therapy.

Consideration should be given to the likelihood of the appearance of drug-resistant viruses.

Influence on the ability to drive vehicles and complex mechanisms

Due to the risk of side effects from the central nervous system, during the entire period of taking the drug, care must be taken when performing potentially hazardous types of work that require increased attention and speed of reactions (including driving vehicles).

Application during pregnancy and lactation

Rimantadine tablets are contraindicated for use throughout the entire period of pregnancy and lactation.

Pediatric use

This dosage form of the drug is not intended for the treatment of children under the age of 7 years.

With impaired renal function

The presence of acute and chronic kidney disease is a contraindication to the use of Rimantadine.

In renal failure, the dose is reduced in proportion to the level of creatinine clearance.

For violations of liver function

In acute liver diseases, the administration of the drug is prohibited. In case of liver failure, the agent should be used with caution.

Use in the elderly

Elderly patients during treatment should be under close medical supervision. Dose reduction required.

Drug interactions

Rimantadine reduces the effect of antiepileptic drugs.

The effect of other drugs on the action of rimantadine:

  • adsorbents, coatings and astringents reduce absorption;
  • cimetidine reduces clearance by 18%;
  • acetylsalicylic acid and paracetamol reduce the maximum concentration (by 10 and 11%, respectively);
  • agents that acidify urine (including ammonium chloride, sodium bicarbonate, diacarb, acetazolamide, ascorbic acid), enhance renal excretion and, as a result, reduce the effect.


Analogs of Rimantadine are: Orvirem, Remantadin, Rimantadin Avexima, Rimantadin Aktitab.

Terms and conditions of storage

Store in a dry, dark place, out of reach of children, at temperatures up to 25 ° C.

The shelf life is 3 or 5 years (depending on the manufacturer).

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Rimantadine

According to reviews, Rimantadine is an antiviral agent that is effective both in the treatment of influenza in the early stages, and for prophylaxis after contact with a patient or after staying in a closed team where there are flu patients.

Additional advantages include the low price of the drug and its good tolerance. Side effects, according to patients' reviews, are rare and usually in case of individual intolerance.

Price for Rimantadin in pharmacies

The approximate price for Rimantadine for a pack of 20 tablets is 29–54 rubles.

Rimantadin: prices in online pharmacies

Drug name



Rimantadine 50 mg tablets 20 pcs.

42 RUB


Rimantadine 50 mg tablets 20 pcs.

RUB 46


Rimantadine 50 mg tablets 20 pcs.

RUB 60


Rimantadine Avexima 50 mg tablets 20 pcs.

RUB 61


Rimantadine 50 mg tablets 20 pcs.

RUB 65


Rimantadine 50 mg tablets 20 pcs.

RUB 66


Rimantadine tablets 50mg 20 pcs.

RUB 69


Rimantadin Velpharm 50 mg tablets 20 pcs.

RUB 75


Rimantadine Avexima 50mg tablets 20 pcs.

RUB 76


Rimantadine 50 mg tablets 20 pcs.

77 RUB


Rimantadine tablets 50mg 20 pcs. Ozone

RUB 81


Rimantadine 50 mg tablets 20 pcs.

83 rbl.


Rimantadin Actitab 50 mg tablets 20 pcs.

83 rbl.


Rimantadine tablets 50mg 20 pcs.

RUB 85


Rimantadin Actitab tablets 50mg 20 pcs.

RUB 99


Rimantadine tablets 50mg 20 pcs.

130 RUB


Rimantadine Kids 2 mg / ml syrup 100 ml 1 pc.

RUB 150


Rimantadin Kids syrup for children 2mg / ml bottle 100ml

210 RUB


Rimantadine Kids 2 mg / ml syrup 200 ml 1 pc.

216 r


Rimantadine Kids syrup for children 2mg / ml 200ml bottle (with measuring spoon)

309 RUB


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Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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