Traitor
Instructions for use:
- 1. Release form, composition and packaging
- 2. Pharmacological action
- 3. Indications for use
- 4. Contraindications to use
- 5. Method of administration and dosage regimen
- 6. Overdose
- 7. Application during pregnancy and lactation
- 8. Side effects
- 9. Conditions and expiration dates
- 10. Special instructions
Prices in online pharmacies:
from 1535 rub.
Buy
Trajenta is a hypoglycemic drug for oral administration.
Release form, composition and packaging
This drug is produced in the form of bright red round tablets. Each has beveled edges and two raised sides, one with the company's symbol and the other with a D5 engraving.
As stated in the instructions for Trazhenta, the main component of one tablet is 5 mg linagliptin. Additional elements include corn starch (18 mg), copovidone (5.4 mg), mannitol (130.9 mg), pregelatinized starch (18 mg), magnesium stearate (2.7 mg). The shell contains pink opadry (02F34337) 5 mg.
You can buy Trajenta in aluminum blisters (7 tablets in one). For ease of use, they are in cardboard boxes, where you can find 2, 4 or 8 blisters. 1 blister can also hold 10 tablets (in this case, there are 3 of them in the package).
Pharmacological action Traders
The main active ingredient of Trajenta is an inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), which rapidly destroys the incretin hormones (GLP-1 and GIP), which are necessary for the human body to maintain a normal amount of glucose in it. The concentrations of these two hormones increase immediately after a meal. If there is a normal or slightly increased glucose concentration in the blood, then GLP-1 and GIP accelerate the biosynthesis of insulin, as well as its secretion by the pancreas. Also GLP-1 helps to reduce the production of glucose in the liver.
Analogs of Trajents and the drug itself, by their action, increase the amount of incretins and, by influencing them, force them to maintain their active work for quite a long time. In the reviews to Trazhente, it was noted that this drug promotes an increase in glucose-dependent insulin secretion and reduces the secretion of glucagon, thus normalizing blood glucose levels.
Indications for use Trajents
In the reviews to Trazhenta it is said that this drug is prescribed for patients who have type II diabetes mellitus, as well as:
- Prescribed as one possible drug for patients with inadequate glycemic control, which occurs due to diet or exercise.
- If metformin is intolerant or if the patient suffers from renal failure and is strictly prohibited from taking metformin.
- It can be used together with metformin, sulfonylurea derivatives or thiazolidinedione when treatment with diet, monotherapy with these drugs, and sports did not give the desired result.
Contraindications to the use of Traders
The instructions for Trazhente clearly indicate that the drug is strictly prohibited to be taken in type I diabetes mellitus, during pregnancy, as well as during lactation.
It is forbidden to prescribe the remedy to children under the age of 18.
The drug should not be used by people with diabetic ketoacidosis, as well as by those who have hypersensitivity to certain components of the drug.
Route of administration Trajents and dosage regimen
The instructions for Trazhenta say that the drug should be taken orally, 1 tablet a day before meals, during or after meals. It is not recommended to consume more than one tablet per day.
Overdose
Numerous medical studies show that volunteer patients who took 600 mg of the drug (120 tablets) once did not harm their health. Nowadays, no cases have been recorded that would exceed the indicated dosage.
The responses to Trazhenta indicate that if the patient has taken too much of the drug, the still undissolved tablets should be immediately removed from the gastrointestinal tract, and also seek help from a doctor who can prescribe the appropriate treatment.
Application of Trajenta during pregnancy and lactation
It is strictly forbidden to take Trajenta and Trajenta analogues during pregnancy and lactation. Experiments conducted on animals indicate that the main active ingredient of the drug penetrates into breast milk and has a negative effect on the normal development and life of the newborn.
In cases of urgent need to take linagliptin, it is imperative to stop breastfeeding.
Side effects
As stated in the reviews to Trazhenta, the number of side effects after taking this drug is identical to the number of negative effects after taking a placebo.
After taking Trajenta, the following side reactions occur:
- Hypersensitivity to the individual components of the drug;
- Cough, pancreatitis;
- Sometimes an infectious disease such as nasopharyngitis occurs.
With the simultaneous use of Trazhenta or analogues Trazhenta with metformin, nasopharyngitis, cough, pancreatitis, as well as hypersensitivity to some components of the drug are observed.
Taking Trajenta and sulfonylurea derivatives at once often causes cough, nasopharyngitis, pancreatitis, hypertriglyceridemia, and some patients become more sensitive to the constituents of the analyzed drug.
The simultaneous administration of linagliptin and pioglitazone promotes weight gain, the occurrence of nasopharyngitis, pancreatitis, cough, hyperlipidemia, as well as hypersensitivity from the immune system in some patients.
When using Trajenta with sulfonylurea derivatives and metformin, cough, hypoglycemia, nasopharyngitis, pancreatitis occurs and sensitivity to the components of the drug increases.
Expiry terms and conditions Traders
The instructions for Trazhenta state that this drug must be stored at temperatures up to 25 degrees in a dark place. Keep out of reach of children. The shelf life of the drug is 2.5 years.
special instructions
Trajenta is not prescribed to people in whose body diabetic ketoacidosis, as well as type I diabetes mellitus, is recorded. The incidence of hypoglycemia with Trajenta as one possible drug has been equated to that due to placebo.
Medical studies show that the likelihood of developing hypoglycemia after concomitant use of Trajenta with other drugs that do not cause hypoglycemia at all was similar after taking placebo.
Sulfonylurea derivatives contribute to the development of hypoglycemia. That is why one should be careful when taking them with linagliptin. In some cases, the doctor may significantly reduce the dosage of sulfonylurea derivatives.
To date, no medical research has been recorded that would tell about the interaction of Trajenta with insulin. Patients with severe renal insufficiency are prescribed Trajenta together with other hypoglycemic drugs.
The concentration of glucose is best reduced if the analogs of Trajenta or the drug are taken before meals. Because of possible dizziness while using this drug, it is best not to drive.
Trajenta: prices in online pharmacies
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Drug name Price Pharmacy |
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Trajenta 5 mg film-coated tablets 30 pcs. 1535 RUB Buy |
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Trajenta tablets p.o. 5mg 30 pcs. 1830 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
