Reserpine
Reserpine: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Reserpine
ATX code: C02AA02
Active ingredient: reserpine (Reserpine)
Manufacturer: Grodzin pharmaceutical plant Polfa Sp. z o.o. (Grodzisk Pharmaceutical Works Polfa Co.) (Poland)
Description and photo update: 03.10.2019
Reserpine is a drug from the group of sympatholytics that has a hypotensive and sedative effect, enhancing the effects of analgesics and hypnotics.
Release form and composition
Dosage form - tablets (1000 pcs in a container; 50 pcs in a package and instructions for using Reserpine).
Active ingredient: reserpine - 0.1 or 0.25 mg in 1 tablet.
Pharmacological properties
Pharmacodynamics
Reserpine is a sympatholytic antihypertensive agent.
The main effects of the drug:
- weakening of the influence of sympathetic innervation on the cardiovascular system, which manifests itself in the form of a decrease in the heart rate, a decrease in the total peripheral vascular resistance, and a decrease in renin secretion;
- depressing effect on the central nervous system (when used in large doses, it acts like neuroleptics);
- increased secretion of exocrine glands;
- increased peristalsis of the gastrointestinal tract.
Reserpine is characterized by a long latency period and a long duration of action.
Pharmacokinetics
When taken orally, the absorption of reserpine is 40%, the bioavailability is from 50 to 60%, the volume of distribution is 9.1 l / kg, the level of binding to plasma proteins is 96%.
The maximum plasma concentration in the blood after oral administration is reached within 1-3 hours. The substance penetrates the placental barrier and is excreted in breast milk.
The elimination of both reserpine and its metabolites is carried out in two stages (α- and β-phase), the half-life is 4.5 and 271 hours, respectively. 8% of the dose within 96 hours after administration is excreted by the kidneys (mainly as metabolites), 62% through the intestines (mainly in the form of an unchanged substance).
In renal failure, delayed excretion by the kidneys is compensated by an increase in excretion in the bile, and therefore no accumulation of reserpine occurs.
Indications for use
- Arterial hypertension;
- Hyperkinetic syndrome;
- Psychoses against the background of high blood pressure;
- Mental diseases of vascular etiology.
Also, Reserpine is sometimes used in the following cases:
- Mild forms of heart failure with tachycardia (in combination with cardiac glycosides);
- Thyrotoxicosis (simultaneously with thyrostatic drugs, to reduce neurovegetative disorders and slow down the pulse);
- Hypersympathicotonia;
- Persistent insomnia;
- Schizophrenia (in combination with antipsychotics);
- Alcoholic psychoses.
Contraindications
- Congestive heart failure;
- Severe diseases of the cardiovascular system;
- Bradycardia;
- AV block;
- Depression;
- Ulcerative colitis in the acute phase;
- Exacerbation of gastric ulcer and 12 duodenal ulcer;
- Kidney disease with impaired function;
- Bronchial asthma;
- Nephrosclerosis;
- Atherosclerosis of cerebral vessels;
- The period before the electro-pulse therapy;
- Pregnancy and lactation period;
- Simultaneous use of monoamine oxidase inhibitors and 1 week after their cancellation;
- Hypersensitivity to the drug.
Reserpine, instructions for use: method and dosage
Reserpine should be taken orally after meals.
The specific doses and duration of treatment are determined individually.
In the early stages of arterial hypertension, 0.05-0.1 mg is prescribed 2-3 times a day. Further, if necessary (but provided that the drug is well tolerated), the dose is gradually increased. The maximum daily dose is 1 mg. If the hypotensive effect cannot be achieved within 10-14 days, the drug is canceled. After achieving the effect, the daily dose is gradually reduced: first to 0.5 mg, then to 0.2 mg, then to 0.1 mg. For maintenance therapy, the minimum effective dose is prescribed. Treatment is carried out in courses of 2-3 months up to 4 times a year.
With neuroses, Reserpine is prescribed in a dose of 0.25 mg 2-3 times a day to 0.5 mg 3-4 times a day.
In case of mental illness, 0.25-2 mg is prescribed on the first day, then, depending on the clinical situation, the daily dose is increased to 10-15 mg.
Maximum doses for adults: single - 2 mg, daily - 10 mg.
For children, depending on age and indications, the drug is indicated in a daily dose of 0.1-0.4 mg in 2-4 doses.
Side effects
- From the digestive system: abdominal pain, nausea, diarrhea, vomiting, ulceration of the gastrointestinal tract mucosa; with prolonged use in high doses - liver dysfunction;
- From the urinary system: increased frequency of urination or urinary retention;
- On the part of the cardiovascular system: bradycardia; when taken in high doses - increased symptoms of angina pectoris;
- From the central and peripheral nervous system: dryness and swelling of the mucous membranes, fatigue, weakness, anxiety, dizziness, insomnia or drowsiness, depressive conditions; when taken in high doses - nightmares, parkinsonism;
- Dermatological reactions: pruritus, herpes;
- Others: nasal congestion, hyperemia of the mucous membranes of the eyes, shortness of breath, weight gain, decreased potency and libido.
Overdose
The main symptoms: increased severity of adverse reactions.
Therapy: symptomatic.
special instructions
Due to their low effectiveness and numerous side effects, sympatholytics (including Reserpine) are referred to as second-line drugs for hypertension and psychosis.
Blood pressure should be monitored during treatment.
Influence on the ability to drive vehicles and complex mechanisms
Patients taking Reserpine constantly should avoid performing potentially hazardous types of work that require increased attention and high speed of psychomotor reactions.
Application during pregnancy and lactation
Reserpine is not prescribed during pregnancy / lactation.
Pediatric use
In pediatrics, Reserpine is used according to indications, according to the dosing regimen prescribed by a specialist.
With impaired renal function
In case of impaired renal function, taking Reserpine is contraindicated.
Drug interactions
- Beta-blockers: there is a mutual enhancement of pharmacological effects;
- Adreno- and sympathomimetics: there is a mutual decrease in activity;
- Antihypertensive drugs: the antihypertensive effect is potentiated;
- Bromocriptine: its effect on prolactin levels decreases (dose adjustment is necessary);
- Alcohol and drugs that depress the central nervous system: the depressive effect increases;
- Non-steroidal anti-inflammatory drugs (especially indomethacin): decreases the antihypertensive effect;
- Anticholinergics: the effect on gastric secretion decreases;
- Drugs that cause extrapyramidal disorders: disorders increase;
- Levodopa: its effect decreases (dose increase is required);
- Quinidine, cardiac glycosides: proarrhythmic effect develops;
- Furazolidone, procarbazine, as well as monoamine oxidase inhibitors, including selegiline: there is a risk of developing sudden hypertension and hyperpyrexia.
Analogs
Reserpine analogs are: Rausedil, Christoserpine, Alserin, Escaserp, Raupazil, Hypnoserpil, Paysed Serfin, Rausedan, Serpazil, Kvescin, Serpen, Reserpoid, Sedaraupin, Roxinoid, Serpat, Serpin, Serpiloid, Tenserpin.
Terms and conditions of storage
Store in a cool, dark place, out of reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Reserpine
Reviews about Reserpine are few, since the drug is not available in pharmacies. There are reports that the drug is highly addictive.
As an active ingredient, reserpine is currently included in combination preparations.
Price for Reserpine in pharmacies
The price of Reserpine is unknown, the drug is not available in pharmacies.
The approximate cost of analogues: Normatens (20 tablets) - 121-139 rubles, Raunatin (50 tablets, 2 mg each) - 100-117 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
