Naxojin
Naxogen: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Naxogin
ATX code: P01AB06
Active ingredient: nimorazole (nimorazole)
Manufacturer: PFIZER ITALIA, SrL (Italy)
Description and photo update: 2019-26-08
Naxogin is an antiprotozoal drug.
Release form and composition
Dosage form - tablets: convex, round, white or slightly yellowish in color, on one side there is a break line (6 pcs. In dark glass bottles, in a cardboard box 1 bottle and instructions for use of Naxogin).
Composition of 1 tablet:
- Active ingredient: nimorazole - 0.5 g;
- Auxiliary components: corn starch, microcrystalline cellulose, methylcellulose 400, stearic acid.
Pharmacological properties
Pharmacodynamics
The active ingredient of the drug is nimorazole, which belongs to the 2nd generation of 5-nitroimidazoles. Its mechanism of action is explained by the ability to accumulate in the cells of protozoa, the specific intracellular enzymes of which restore the nitro group. When activated, nimorazole disrupts the replication of bacterial DNA and protein synthesis in the microbial cell, inhibits the processes of tissue respiration.
Naxogin is an antiprotozoal agent that is effective against Lamblia intestinalis, Trichomonas vaginalis, Entamoeba histolytica and Giardia intestinalis strains. The drug is also active in diseases caused by strains of anaerobic bacteria, including Bacteroides and Gardnerella vaginalis.
For the death of Trichomonas, the minimum inhibitory concentration (MIC) of nimorazole is 0.3–3 μg / ml.
Pharmacokinetics
After oral administration, nimorazole is well absorbed from the gastrointestinal tract.
When the drug is prescribed at a dose of 1 g twice a day, the plasma concentration 3 hours after taking the first dose reaches a level of 16 μg / ml, 25 hours after taking the first dose - 28 μg / ml, 12 hours after taking the last dose - 7, 5 μg / ml.
In vaginal secretions and urine, nimorazole creates concentrations that significantly exceed the trichomonadocyte level. When three consecutive doses of 1 g are prescribed every 12 hours, the concentration of nimorazole in the vaginal secretion is: 24 hours after administration - 129 μg / g, after 48 hours - 95 μg / g, after 72 hours - 4 μg / g.
Nimorazole is excreted by the kidneys.
Indications for use
The drug is intended for the treatment of a number of infections caused by the following microorganisms sensitive to nimorazole:
- Trichomonas vaginalis - urogenital trichomoniasis;
- Giardia lamblia - giardiasis;
- Entamoeba histolytica - amebiasis;
- Gardnerella vaginalis - vaginitis;
- Candida albicans, Actinomyces israelii, Treponema pallidum - Vincent's gingivitis, or acute necrotizing ulcerative gingivitis.
Contraindications
- Severe blood diseases;
- Severe diseases of the central nervous system;
- Severe renal and / or hepatic impairment;
- Children under 5 years old;
- Pregnancy and lactation;
- Individual hypersensitivity to the components of Naxogin tablets and other drugs belonging to the 5-nitroimidazole group.
The antiprotozoal agent should be taken with caution in case of impaired renal or liver function, active neurological diseases.
Naxodzhin, instructions for use: method and dosage
Naxogin tablets are taken orally after meals.
Recommended dosage regimens depending on indications and age:
- Trichomoniasis: adults - 2 g once, or 1 g 3 times at intervals of 12 hours (for example, in the evening, morning and next evening), or 0.25 g 3 times a day; children - 15 mg / kg / day in 3 divided doses. The course of treatment is 5-7 days;
- Giardiasis: adults - 0.5 g 2 times a day; children - 15 mg / kg / day in 2 divided doses. The duration of treatment is 5-7 days;
- Amoebiasis: adults - 0.5 g 2 times a day; children - 20 mg / kg / day in 2 divided doses. The course of therapy is 5-10 days;
- Vincent's gingivitis (acute necrotizing ulcerative gingivitis): adults - 0.5 g 2 times a day in a 2-day course;
- Infections associated with Gardnerella vaginalis: adults - 2 g once or 0.5 g 2 times a day for 7 days.
Side effects
- Digestive system: heartburn, nausea, vomiting, liver dysfunction, gastralgia;
- Central and peripheral nervous system: drowsiness, dizziness, polyneuropathy, exacerbation of mental illness, paresthesia;
- Allergic reactions: skin rashes.
Overdose
Overdose symptoms are: dizziness, gastrointestinal discomfort (nausea, vomiting, heartburn, diarrhea), neurological symptoms (tingling, paresthesia, numbness and convulsions).
To improve the condition, gastric lavage should be performed and then symptomatic treatment should be carried out.
special instructions
In order to avoid re-infection during the treatment of trichomoniasis, both sexual partners should be treated at the same time, even if one of them has no symptoms of the disease.
Under strict medical supervision, it is required to treat patients with exacerbation of neurological diseases.
At the end of the course, clinical symptoms of inflammation may persist for several days with complete bacteriological cure.
Influence on the ability to drive vehicles and complex mechanisms
Naxogin can cause side effects from the central nervous system (for example, dizziness and drowsiness), therefore, during the period of therapy, it is recommended to stop driving and perform other work that requires attention and quick reactions.
Application during pregnancy and lactation
Nimrazole may have a mutagenic effect, therefore, during pregnancy (especially in the first trimester) and during lactation, Naxogin is contraindicated.
Pediatric use
For the treatment of children under 5 years old, the use of Naxojin is prohibited.
With impaired renal function
Naxogin tablets should be used with caution in the presence of concomitant renal dysfunction; in severe renal failure, the drug is contraindicated.
For violations of liver function
Naxogin should be used with caution to treat patients with impaired liver function; in severe hepatic impairment, the drug is contraindicated.
Drug interactions
The simultaneous use of Naxogin with alcohol can cause disulfiram-like reactions.
Nimorazole can enhance the anticoagulant effect of warfarin and reduce the clearance of lithium and phenytoin.
Cimetidine can increase and phenobarbital can decrease the plasma concentration of Naxogine.
Analogs
Naxogin's analogs are: Ornigil, Meradazol, Orgil.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Naxojin
In general, the reviews about Naxojin are positive. Patients note its effectiveness when used according to indications. Some negative reports describe side effects or complaints about the high cost of the drug.
Price for Naxogen in pharmacies
The approximate price of Naxojin is 252–303 rubles. for a pack of 6 tablets of 0.5 g.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
