Xymelin Extra - Instructions For Use, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Xymelin Extra

Xymelin Extra: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Xymelin Extra

ATX code: R01AB06

Active ingredient: ipratropium bromide (ipratropium bromide) + xylometazoline (xylometazoline)

Producer: Takeda GmbH (Germany), Nycomed Pharma (Norway)

Description and photo update: 2018-21-11

Prices in pharmacies: from 190 rubles.

Buy

Xymelin Extra is a local combined drug with a vasoconstrictor effect used in ENT practice.

Release form and composition

The dosage form of Xymelin Extra is a nasal spray: transparent, colorless or somewhat colored (in a cardboard box - 1 plastic bottle with a pump dispensing device of 10 ml).

Active substances in 1 spray dose:

• xylometazoline hydrochloride - 0.07 mg;
• ipratropium bromide monohydrate - 0.084 mg.

Auxiliary components: disodium edetate dihydrate - 0.07 mg; 85% glycerol - 3.91 mg; concentrated hydrochloric acid - up to pH 4.5; sodium hydroxide - to pH; purified water - up to 0.14 ml.

Pharmacological properties

Pharmacodynamics

Xymelin Extra is one of the topical combined preparations used in ENT practice.

The main properties of the components:

• xylometazoline: is an alpha-adrenergic agonist. It leads to narrowing of the blood vessels of the nasal mucosa, which helps to eliminate edema and hyperemia of the nasopharyngeal mucosa. With rhinitis, it facilitates nasal breathing;
• ipratropium bromide: has anticholinergic properties. When used intranasally, it helps to reduce the secretion of the glands of the nasal mucosa.

When using the drug in therapeutic doses, the mucous membrane is not irritated and hyperemia does not occur.

The action of Xymelin Extra develops in 5-10 minutes, its duration is 6-8 hours.

Pharmacokinetics

With intranasal administration, the active components of Xymelin Extra are absorbed little, their plasma concentration is negligible.

Indications for use

• swelling and hyperemia of the nasal cavity (symptomatic therapy);
• acute respiratory diseases with symptoms of rhinitis;
• sinusitis;
• hay fever;
• acute allergic rhinitis.

Contraindications

Absolute:

• atrophic rhinitis;
• arterial hypertension;
• burdened history of surgical interventions on the meninges;
• thyrotoxicosis;
• tachycardia;
• glaucoma;
• severe atherosclerosis;
• age up to 18 years;
• I trimester of pregnancy;
• individual intolerance to the components of the drug.

Relative (Xymelin Extra is prescribed under medical supervision):

• cystic fibrosis;
• hyperplasia of the prostate;
• diabetes;
• obstruction of the bladder neck;
• angina pectoris III – IV functional class;
• the presence of a predisposition to the development of the following diseases / conditions: nosebleeds, paralytic intestinal obstruction, dizziness, tremor of skeletal muscles, sleep disturbances, arrhythmias, increased blood pressure;
• II – III trimesters of pregnancy and lactation.

Instructions for use of Xymelin Extra: method and dosage

Xymelin Extra is used intranasally.

Recommended regimen of drug use: 3 times a day, 1 injection into each nasal passage for up to 10 days. Long-term use is decided by the doctor.

Side effects

Possible side reactions with frequent / prolonged use: dryness / irritation of the nasopharyngeal mucosa, nosebleeds, sneezing, burning and tingling in the throat and nose, headache, swelling of the nasal mucosa, hypersecretion of the glands of the nasal mucosa.

In rare cases, the development of the following disorders is noted: insomnia, headache, systemic allergic reactions, dizziness, visual impairment, tachycardia, palpitations, arrhythmias, increased blood pressure.

Overdose

The appearance of an acute overdose after intranasal use of Xymelin Extra is unlikely, since the absorption of its active substances is extremely insignificant.

The main symptoms are manifested in the form of xerostomia, accommodation disorders, tachycardia, headache, and arterial hypertension.

Therapy: symptomatic. Cancellation of the drug is shown.

special instructions

Before using Xymelin Extra, the nasal passages must be cleaned.

Long-term therapy, for example for chronic rhinitis, is not recommended.

The spray should not be sprayed into or around the eyes. If Xymelin Extra gets into your eyes, rinse them with cold water.

If after three days of drug therapy the condition has not improved or worsened, you should consult your doctor.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Xymelin Extra may affect the ability to drive vehicles in the event of an overdose or spray in the eyes.

Application during pregnancy and lactation

• I trimester of pregnancy: therapy is contraindicated;
• II – III trimesters of pregnancy and lactation period: Xymelin Extra can be used after the doctor assesses the ratio of the expected benefit to the possible risk. Do not exceed the therapeutic dose.

Pediatric use

Xymelin Extra is not prescribed for patients under 18 years of age.

Drug interactions

Possible interactions:

• monoamine oxidase inhibitors: blood pressure rises;
• tri- and tetracyclic antidepressants: the sympathomimetic effect of xylometazoline is enhanced;
• other anticholinergics: The anticholinergic effect of ipratropium bromide may be enhanced.

Analogs

The analogue of Xymelin Extra is Otrivin Complex.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Xymelin Extra

According to reviews, Xymelin Extra has a quick and long-term vasoconstrictor effect in rhinitis. Also note the convenient dosage form and compact packaging. Of the shortcomings, they indicate the development of burning and severe dryness of the nasal mucosa, as well as the high cost of the drug. In some cases, Xymelin Extra has insufficient therapeutic effect.

Price for Xymelin Extra in pharmacies

The approximate price for Xymelin Extra (1 bottle of 10 ml) is 188-219 rubles.

Xymelin Extra: prices in online pharmacies

Drug name Price Pharmacy

Xymelin Extra 84 mcg + 70 mcg / dose nasal spray 10 ml 1 pc. 190 RUB Buy

Xymelin Extra nasal spray. 0.6mg / ml + 0.5mg / ml 10ml 226 r Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!