Miramistin
Miramistin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Miramistin
ATX code: D08AJ
Active ingredient: benzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrate {Benzyldimethyl [3- (myristoilamine) -propyl] ammonium chloride monohydrate}
Manufacturer: LLC INFAMED (Russia)
Description and photo update: 2020-01-06
Prices in pharmacies: from 179 rubles.
Buy
Miramistin is a new generation antiseptic drug for topical use with broad-spectrum antibacterial, antimycotic and antiviral activity.
Release form and composition
Dosage form - solution for topical use: clear, colorless liquid, foams when shaken (in polyethylene bottles: 50 ml each, sealed with a urological applicator with a screw cap, the kit includes a spray nozzle; 50 or 100 ml each, sealed with a urological applicator with a screw-on cap, the kit includes a gynecological nozzle; 100, 150 or 200 ml each, the kit includes a spray nozzle or a spray pump and a protective cap; 500 ml each, with a screw cap equipped with a first opening control system; 1 bottle is placed in a cardboard box and instructions for use of Miramistin For hospitals: 12 bottles of 500 ml volume without individual packaging and an equal number of instructions for use are placed in a box made of cardboard for consumer packaging).
Composition for 1 liter of solution:
- active substance: benzyldimethyl [3-myristoylamino) propyl] ammonium chloride monohydrate (miramistin, in terms of absolutely dry substance) - 0.1 g;
- auxiliary component: purified water - up to 1 liter.
Pharmacological properties
Pharmacodynamics
Miramistin is a new generation antiseptic with a wide spectrum of antimicrobial activity, including effective against hospital strains that are resistant to antibiotics.
The use of Miramistin provides a good result in the prevention of infection of burn surfaces and wounds. The solution activates the regeneration of damaged tissues; at the site of application stimulates protective reactions, enhancing the absorption and digestion functions of phagocytes; potentiates the function of the mononuclear phagocyte system; has a pronounced hyperosmolar effect, thereby stopping wound and perifocal inflammation, absorbing purulent exudate and promoting the formation of dry scab. Does not damage viable skin cells and granulation tissue, does not inhibit epithelialization of the edge sections of the wound.
Types of pharmacological activity of Miramistin:
- bactericidal (pronounced): against gram-positive bacteria, for example, Streptococcus pneumoniae, Streptococcus spp., Staphylococcus spp. and others, in relation to gram-negative bacteria, for example, Escherichia coli, Pseudomonas aeruginosa, Klebsiella spp. and others, in relation to aerobes and anaerobes isolated in the form of microbial associations and monocultures, including hospital strains, multi-resistant to antibiotics;
- antimycotic: against ascomycetes of the genus Penicillium and the genus Aspergillus; yeasts such as Rhodotorula rubra, Torulopsis glabrata, and yeasts such as Candida tropicalis, Candida albicans, Candida krusei, Malassezia furfur (Pityrosporum orbiculare); dermatophytes, for example, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton verrucosum, Trichophyton schoenleinii, Trichophyton violacent, Epidermophyton floccosum, Epidermophyton Kaufman-Wolf, Microsporum canis, Microsporum gypseum; in relation to other pathogenic fungi isolated in the form of microbial associations and monocultures, including fungal microflora resistant to chemotherapeutic agents;
- antiviral: against complex viruses such as HIV (human immunodeficiency virus), herpes viruses, etc.
Miramistin is also effective against sexually transmitted pathogens: Neisseria gonorrhoeae, Chlamydia spp., Trichomonas vaginalis, Treponema spp. and etc.
The solution does not have a local irritating effect and does not possess allergenic properties.
Pharmacokinetics
Provided that it is applied topically, Miramistin is not absorbed through the mucous membranes and skin, as a result of which it does not have a systemic effect on the human body.
Indications for use
Miramistin is used for infections of various etiology and localization in the following areas of medicine:
- otorhinolaryngology: as part of the complex therapy of acute / chronic otitis media, laryngitis, tonsillitis, sinusitis, pharyngitis. In children and adolescents aged 3-14 years, the antiseptic is used in the complex treatment of acute pharyngitis and exacerbation of chronic tonsillitis;
- dentistry: for the prevention and treatment of such infectious and inflammatory diseases of the oral cavity as stomatitis, gingivitis, periodontitis, periodontitis; for hygienic processing of removable dentures;
- traumatology, surgery: for the prevention of suppuration and treatment of purulent wounds, therapy of purulent-inflammatory processes of the musculoskeletal system;
- obstetrics and gynecology: for the prevention and treatment of perineal and vaginal wounds, suppuration of postpartum trauma, postpartum infections, inflammatory processes in the vulva and vagina (vulvovaginitis, endometritis);
- combustiology: in the treatment of superficial and deep burns (II – IIIA degree); in order to prepare burn wounds for dermatoplasty;
- dermatology, venereology: for the prevention and treatment of such infectious and inflammatory skin lesions as pyoderma, dermatomycosis, candidiasis of the skin and mucous membranes, mycoses of the feet; for individual prevention of sexually transmitted infections (gonorrhea, genital candidiasis, syphilis, trichomoniasis, chlamydia, genital herpes, etc.);
- urology: in the complex treatment of acute and chronic course of urethritis and urethroprostatitis of both specific (gonorrhea, chlamydia, trichomoniasis) and non-specific nature.
Contraindications
An antiseptic is contraindicated for use in case of individual intolerance to Miramistin.
Miramistin, instructions for use: method and dosage
Antiseptic solution Miramistin is ready for use and does not require additional dilution.
Otorhinolaryngology
For the treatment of purulent sinusitis during puncture, the maxillary sinus is washed with a sufficient amount of solution.
For tonsillitis, pharyngitis and laryngitis 3-4 times a day, the throat is rinsed with a solution and / or irrigated using a spray nozzle by pressing the head of the nozzle 3-4 times. One rinse requires 10-15 ml of solution.
Treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis in children is carried out by irrigating the pharynx using a spray nozzle:
- children 3–6 years old: press once on the head of the spray nozzle (3-5 ml for one irrigation), 3–4 times / day;
- children and adolescents 7-14 years old: double pressing (for one irrigation 5-7 ml), 3-4 times / day;
- adolescents over 14 years of age: 3-4 times pressing (for one irrigation 10-15 ml), 3-4 times / day.
The duration of the course is 4-10 days and depends on the timing of the onset of remission.
Dentistry
For the treatment and prevention of stomatitis, gingivitis, periodontitis, it is recommended to rinse the mouth 3 to 4 times / day. One rinse requires 10-15 ml of solution.
Combustiology, surgery, traumatology
For the purpose of therapy and prevention, wound and burn surfaces are irrigated with a solution, wounds and fistulous passages are loosely tamponed, gauze tampons moistened with Miramistin solution are fixed. The treatment procedure is repeated 2 to 3 times / day for 3-5 days.
The method of active drainage of wounds and cavities with an antiseptic solution has shown high efficiency. The daily consumption of the drug for the procedure is up to 1 liter.
Obstetrics, gynecology
For the prevention of postpartum infection, the solution is used in the form of vaginal irrigation: within 5-7 days before childbirth; during delivery after each vaginal examination; in the postpartum period in the form of a vaginal tampon with an exposure duration of 2 hours, 50 ml of solution for 5 days. In order to improve the convenience of vaginal irrigation, a special gynecological nozzle should be used, which is inserted into the vagina, after which irrigation is performed.
When delivering by cesarean section for the prevention of postpartum infection, the vagina is processed immediately before the operation, the uterine cavity and the incision on it - during the operation. In the postoperative period, the tampons moistened with Miramistin are inserted into the vagina, the exposure duration is 2 hours, the course is 7 days. Therapy of inflammatory diseases is carried out in a 2-week course by introducing tampons with the drug into the vagina, as well as carrying out drug electrophoresis.
Venereology
Miramistin is effective for the prevention of sexually transmitted infections when it is used no later than 2 hours after intercourse. The contents of the bottle are introduced into the urethra for 2-3 minutes using an urological applicator. For men the dose is 2–3 ml, for women - 1–2 ml into the urethra and 5–10 ml into the vagina. For convenience, women are advised to use a gynecological attachment. After that, the skin of the pubis, inner thighs and genitals should be treated. After the completion of the debridement, it is recommended to refrain from urinating for 2 hours.
Urology
Miramistin as part of the complex treatment of urethritis and urethroprostatitis should be injected into the urethra 1-2 times a day, 2-3 ml of solution; course - 10 days.
Side effects
Since Miramistin acts only on pathogenic microorganisms, without affecting human tissue, the drug is well tolerated.
In some cases, a slight burning sensation may appear at the site of application, which disappears on its own after 15–20 seconds, and does not require discontinuation of the drug.
With individual hypersensitivity to Miramistin, allergic reactions may develop.
Overdose
There is no data on Miramistin overdose.
special instructions
Using the spray nozzle packaging:
- Remove the cap from the bottle, additionally remove the urological applicator from the 50 ml bottle.
- Remove the supplied spray nozzle from the protective packaging.
- Attach a spray nozzle to the bottle.
- Press again to activate the spray nozzle.
Use of packaging with a gynecological attachment (bottles of 50 or 100 ml):
- Remove the cap from the bottle.
- Remove the included gynecological attachment from the protective packaging.
- Without removing the urological applicator, attach the gynecological attachment to the bottle.
Application during pregnancy and lactation
Antiseptic is used in the prevention and treatment of postpartum infections.
There are no restrictions on the use of Miramistin during pregnancy and during breastfeeding.
Pediatric use
In pediatrics, Miramistin is used to prevent diaper rash and pustular diseases; prevention and treatment of angina, acute respiratory viral infections, influenza; disinfection of wounds, treatment and treatment of abrasions, insect bites.
Age restrictions for the use of the drug are not indicated.
Drug interactions
The use of Miramistin simultaneously with antibiotics enhances their antibacterial and antifungal effectiveness.
Analogs
Miramistin's analogues are Virotek Clinic, Virotek intim, Miramistin-Darnitsa, Miramidez, Decaxidin, Gorosten, Celista, etc.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Miramistin
According to reviews, Miramistin is a universal antiseptic of a very wide spectrum. Patients confirm the effectiveness of the drug in the treatment and prevention of infection of burns, wounds, acute respiratory viral diseases, tonsillitis, infections of the genital tract, thrush, urethritis, acne, herpes, streptoderma, etc. Use a solution for disinfection of dental and sports protective caps, menstrual caps.
Many recommend including Miramistin in the home and children's first-aid kits, as well as in the traveler's first-aid kit.
Price for Miramistin in pharmacies
In a network of pharmacies, the price of Miramistin, a 0.01% solution for local use, is:
- spray bottle: 150 ml - 399 rubles; 50 ml - 253 rubles;
- bottle with a gynecological nozzle: 50 ml - 295 rubles;
- bottle without attachments: 50 ml - 224 rubles.
Miramistin: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Miramistin 0.01% solution for topical application 50 ml 1 pc. 179 r Buy |
|
Miramistin 0.01% solution for topical use with urological applicator and gynecological attachment 50 ml 1 pc. 215 RUB Buy |
|
Miramistin 0.01% solution for local application with a spray nozzle 50 ml 1 pc. 216 r Buy |
|
Miramistin solution for places. approx. 0.01% 50ml bottle with urological applicator (complete with gynecological attachment) 225 RUB Buy |
|
Miramistin 0.01% solution for local application with a spray nozzle 150 ml 1 pc. 351 r Buy |
|
Miramistin solution of places. approx. 0.01% 150ml 405 RUB Buy |
|
Miramistin 0.01% solution for topical application 500 ml 1 pc. 696 r Buy |
|
Miramistin solution of places. approx. 500ml 756 r Buy |
| See all offers from pharmacies |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
