Metformin - Instructions, Reviews, Application

Table of contents:

Metformin - Instructions, Reviews, Application
Metformin - Instructions, Reviews, Application

Video: Metformin - Instructions, Reviews, Application

Video: Metformin - Instructions, Reviews, Application
Video: Таблетка каждый день: метформин. Жить здорово! 21.11.2018 2024, March
Anonim

Metformin

Instructions for use:

  1. 1. Pharmacological action
  2. 2. Release form
  3. 3. Analogs
  4. 4. Indications for use
  5. 5. Instructions for use
  6. 6. Side effects
  7. 7. Contraindications to use
  8. 8. Special instructions
  9. 9. Storage rules

Prices in online pharmacies:

from 85 rubles.

Buy

Enteric-coated tablets, Metformin
Enteric-coated tablets, Metformin

Metformin is an antidiabetic drug that promotes better glucose absorption. The World Health Organization has included this drug in the list of essential medicines.

pharmachologic effect

The drug belongs to the biguanide group, the active ingredient is dimethyl biguanide. It is obtained from the plant Galega officinalis. Metformin interferes with the synthesis of glucose by the liver (the process of gluconeogenesis), thereby lowering blood sugar levels. In parallel with this, the drug increases the sensitivity of insulin receptors, improving its absorption, promotes better oxidation of fatty acids, increases the peripheral utilization of glucose, and reduces its absorption from the digestive tract.

The agent helps to reduce thyroid-stimulating hormone in the blood serum, lowering the level of cholesterol and low-density lipoproteins, thereby preventing pathological changes in blood vessels. Normalizes blood clotting, improving its rheological properties, thereby helping to reduce the risk of thrombus formation.

Reviews of Metformin from endocrinologists confirm the information that it contributes to weight loss in obesity.

Release form

Available in the form of coated tablets for oral administration, 30, 60 and 120 tablets in a blister. The tablets contain 500 or 850 mg of dimethyl biguanide. In addition to the main active ingredient, the tablet contains starch, magnesium stearate, talc.

Metformin's analogs

Metformin analogs include the following drugs: Glucophage, Metformin-BMS, Metformin hydrochloride, Metformin-vero, Metformin-Richter, Formetin, Formin Pliv, Glyformin, Glucophagus, Vero-Metformin Novoformin, Metospanin, Metfogamma, Siofor, Glycomet, Orabetan Bagomet, Glyminfor, Glykon.

From the point of view of pharmacological action, the analogue of Metformin is insulin.

Indications for use

The use of Metformin is indicated in the treatment of type 2 diabetes with preserved renal function, as well as in a pre-diabetic state. A direct indication for use is type 2 diabetes, accompanied by obesity.

It is also used as part of complex therapy in the treatment of abdominal-visceral obesity.

During its use in clinical practice, reviews of Metformin were so positive that after conducting clinical studies that confirmed them, in 2007 the drug was recommended for use in pediatric practice for the treatment of type 1 diabetes, as an adjunct to insulin therapy.

Instructions for the use of Metformin

Metformin tablets are taken strictly after meals with plenty of water. The first and initial doses are 1000 mg per day, within 1-2 weeks the dose is gradually increased, its value is adjusted under the control of laboratory data on the level of glucose in the blood. The maximum allowable dose is 3000 mg per day. The daily dose can be used in one dose, but at the beginning of therapy, during the adaptation period, it is recommended to divide it into 2-3 doses, which helps to reduce the side effect of the drug on the gastrointestinal tract.

The highest concentration of the drug in the blood plasma is observed 2.5 hours after ingestion, after 6 hours it begins to decrease. After 1-2 days of regular intake, a constant concentration of the drug in the blood is established, according to reviews, Metformin begins to have a noticeable effect two weeks after the start of administration.

With the combined use of Metformin and insulin, medical supervision is necessary, with high doses of insulin - in a hospital.

Side effects

When used as directed, Metformin is generally well tolerated by patients, rarely causing side effects. If there are any, then, as a rule, they are associated either with an individual drug intolerance, or with interaction with other drugs, or with excess dosage.

According to reviews, Metformin most often causes disorders of the digestive system, manifested in the form of dyspepsia in one form or another, as one of the symptoms of lactic acidosis. Usually, such signs are observed at the beginning of the course of drug treatment, and after a period of adaptation they pass. According to the instructions, Metformin in this case must be used in a reduced dosage; in case of severe lactic acidosis, the drug is canceled.

With prolonged use, Metformin contributes to the disruption of the metabolism of vitamin B12 (cyanocobalamin), preventing its absorption in the intestine, which can cause symptoms of B12-deficiency anemia. This condition requires drug correction.

Contraindications to the use of Metformin

The following contraindications are indicated in the Metformin instructions:

  • Lactic acidosis, present or in history;
  • Precomatose state;
  • Hypersensitivity to any of the constituents of the drug;
  • Impaired renal function, as well as concomitant diseases that can cause such a violation;
  • Adrenal insufficiency;
  • Liver failure;
  • Diabetic foot;
  • All conditions that cause dehydration (vomiting, diarrhea) and hypoxia (shock, cardiopulmonary failure);
  • Alcoholism. It should be borne in mind that even a single combined use of Metformin and alcohol can cause severe metabolic disorders;
  • Infectious diseases in the acute period, accompanied by fever;
  • Chronic diseases in the stage of decompensation;
  • Extensive surgical interventions and postoperative rehabilitation;
  • Breast-feeding;

Pregnancy, like childhood, is no longer considered an absolute contraindication to taking the drug, since it is possible to prescribe Metformin for the treatment of gestational and juvenile diabetes, however, in these cases, therapy takes place strictly under medical supervision.

special instructions

With monotherapy with Metformin, there is no risk of developing hypoglycemia; in the complex therapy of diabetes, such a risk is not excluded, which must be warned about the patient. It is forbidden to take this drug and intravascular x-ray contrast agents containing iodine together. Any combined use of Metformin and another medicinal substance requires medical supervision. When carrying out a surgical intervention, drug therapy is canceled for 2-3 days of the postoperative period. Metformin's instruction prescribes adherence to a diet during the entire period of treatment, which allows avoiding sharp peaks and drops in blood glucose, which cause a deterioration in well-being.

Storage rules

The drug Metformin must be stored out of the reach of children, in a dry place at room temperature. Shelf life is three years.

Metformin: prices in online pharmacies

Drug name

Price

Pharmacy

Metformin 850 mg tablets 30 pcs.

RUB 85

Buy

Metformin 500 mg tablets 60 pcs.

RUB 87

Buy

Metformin Canon tablets 850mg 30 pcs

RUB 99

Buy

Metformin 500 mg film-coated tablets 60 pcs.

RUB 101

Buy

Metformin 500 mg film-coated tablets 60 pcs.

RUB 101

Buy

Metformin Canon tablets p.o. 1000mg 30 pcs. PharmVILAR

131 r

Buy

Metformin Zentiva 500 mg film-coated tablets 60 pcs.

132 RUB

Buy

Metformin 500 mg film-coated tablets 60 pcs.

132 RUB

Buy

Metformin 500 mg film-coated tablets 60 pcs.

141 r

Buy

Metformin Avexima tab. p / o captivity. 500 mg No. 60

142 RUB

Buy

Metformin 1000 mg film-coated tablets 60 pcs.

146 r

Buy

Metformin Canon tablets p.p. 500mg 60 pcs

158 RUB

Buy

Metformin 850 mg tablets 60 pcs.

158 RUB

Buy

Metformin Zentiva 850 mg film-coated tablets 60 pcs.

159 r

Buy

Metformin 850 mg film-coated tablets 60 pcs.

159 r

Buy

Metformin Avexima tab. p / o captivity. 850 mg. No. 60

166 r

Buy

Metformin tablets 850mg 60 pcs.

166 r

Buy

Metformin 850 mg film-coated tablets 60 pcs.

171 r

Buy

Metformin tablets p.o.p 850mg 60pcs

RUB 176

Buy

Metformin Canon tablets p.p. 850mg 60pcs

177 r

Buy

Metformin tab.p / o captive. 1000mg No. 60

183 r

Buy

Metformin 1000 mg film-coated tablets 60 pcs.

183 r

Buy

Metformin Sanofi 1000 mg film-coated tablets 60 pcs.

RUB 185

Buy

Metformin Prolong-Akrihin 750 mg film-coated tablets with prolonged release 30 pcs.

195 RUB

Buy

Metformin Prolong-Akrihin tablets p.p. with prolonged release. 750mg 30 pcs.

RUB 200

Buy

Metformin long 850 mg film-coated tablets of prolonged action 60 pcs.

203 r

Buy

Metformin Canon tablets p.p. 850mg 60 pcs

213 r

Buy

Metformin 1000 mg tablets 60 pcs.

RUB 218

Buy

Metformin long 500 mg film-coated tablets of prolonged action 30 pcs.

220 RUB

Buy

Metformin 850 mg film-coated tablets 60 pcs.

228 r

Buy

See all offers from pharmacies

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

Recommended: