Metrogyl - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Metrogyl

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 22 rubles.

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Metrogyl is a drug with antiprotozoal, trichomonacid and antibacterial action.

Release form and composition

Metrogyl is available in the following dosage forms:

• Solution for intravenous administration: transparent, pale yellow or colorless (100 ml in polyethylene bottles, 1 bottle in a cardboard box; 20 ml in ampoules, 5 ampoules in a cardboard box or in thermal containers, 1 thermocontainer in a cardboard box);
• Film-coated tablets: biconvex, round, pink (200 mg) or orange (400 mg) in color (10 pcs. In blisters, 2 or 10 packs in a cardboard box);
• Vaginal gel: from colorless to light yellow, homogeneous (30 g in tubes, 1 tube in a cardboard box, complete with an applicator);
• Gel for external use: from colorless to yellow, homogeneous (30 g each in aluminum tubes, 1 tube each in a cardboard box);
• Suspension for oral administration (60 or 100 ml in vials, 1 vial in a cardboard box).

The composition of 1 ml of injection solution includes:

• Active ingredient: metronidazole - 5 mg;
• Auxiliary components: citric acid monohydrate, anhydrous sodium hydrogen phosphate, sodium chloride, water for injection.

The composition of 1 tablet includes:

• Active ingredient: metronidazole - 200 or 400 mg;
• Auxiliary components: magnesium stearate, colloidal silicon dioxide, corn starch, purified water; additionally: 200 mg tablets - hydrogenated castor oil and Opadry II pink dye 85G54815; 400 mg tablets - povidone and Opadry II orange 85G53070.

The composition of 100 mg vaginal gel includes:

• Active ingredient: metronidazole - 1 mg;
• Auxiliary components: propylene glycol, propyl hydroxybenzoate, sodium hydroxide, disodium edetate, carbomer-940, purified water.

The composition of 100 mg gel for external use includes:

• Active ingredient: metronidazole - 1 mg;
• Auxiliary components: carbomer 940, disodium edetate, propylene glycol, propyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium hydroxide, purified water.

The composition of 1 ml of suspension for oral administration contains the active ingredient: metronidazole - 40 mg.

Indications for use

Intravenous solution:

• Protozoal infections: trichomonas vaginitis, giardiasis, extraintestinal and intestinal amebiasis (amoebic liver abscess, amoebic dysentery), trichomoniasis, balantidiasis, trichomonas urethritis, cutaneous leishmaniasis;
• Infections caused by Bacteroides spp.: infections of the joints, bones, central nervous system (including meningitis), pneumonia, bacterial endocarditis, brain abscess, lung abscess, empyema;
• Infections caused by species of Bacteroides spp., Including group B. fragilis, Clostridium spp., Peptococcus spp., Peptostreptococcus spp.: infections of the abdominal cavity (including liver abscess, peritonitis), infections of the skin, soft tissues, pelvic organs (including endometritis, endomyometritis, abscess of the fallopian tubes and ovaries, infections of the vaginal vault after surgery);
• Infections caused by species of Bacteroides spp., Including the group B. fragilis, Clostridium spp.: sepsis;
• Pseudomembranous colitis, which developed due to the use of antibiotic drugs;
• Alcoholism;
• Gastritis or duodenal ulcer associated with Helicobacter pylori;
• Complications after operations, especially interventions in the near-rectal region, on the colon, gynecological operations, appendectomy (prevention).

Tablets:

• Protozoal infections, including amebiasis, amoebic dysentery, trichomoniasis, balantidiasis, giardiasis, urethritis, and trichomonas vaginitis;
• Respiratory tract infections, including necrotizing pneumonia, lung abscess;
• Anaerobic infections caused by Bac.fragilis and other bacteroids, fusobacteria, clostridia, eubacteria, anaerobic cocci;
• Gas gangrene;
• Septicemia;
• Tetanus;
• Osteomyelitis;
• Brain abscess, meningitis;
• The period after surgical interventions on the urinary tract and abdominal organs, including pelvic abscesses, peritonitis, intraperitoneal infections, appendicitis, cholecystitis, postoperative wound infections, liver abscess, postpartum sepsis (prevention and treatment of postoperative anaerobic infections).

Vaginal gel:

• Urogenital trichomoniasis;
• Bacterial vaginosis with different etiology (after confirmation by microbiological and clinical data).

Gel for external use:

• Acne rosacea, including post-steroidal;
• Seborrheic dermatitis, oily seborrhea;
• Acne vulgaris;
• Pressure sores, hard-to-heal wounds;
• Trophic ulcers of the lower extremities with varicose veins, diabetes mellitus;
• Hemorrhoids, fissures in the anus.

Suspension for oral administration:

• Amoebiasis;
• Giardiasis;
• Anaerobic bacterial infections;
• Amebic liver abscess.

Contraindications

Intravenous solution:

• Organic lesions of the central nervous system, including epilepsy;
• Diseases of the blood, including a history of them;
• Hepatic failure (with the appointment of large doses);
• I trimester of pregnancy and lactation;
• Hypersensitivity to the components of the drug, as well as to other derivatives of nitroimidazole.

In the II-III trimesters of pregnancy, the appointment of Metrogyl is possible only for health reasons.

The drug should be used with caution in case of renal failure.

Tablets:

• Organic lesions of the central nervous system, including epilepsy;
• Diseases of the blood, including a history of them;
• Hepatic failure (with the appointment of large doses);
• I trimester of pregnancy;
• Age under 12;
• Hypersensitivity to the components of the drug, as well as to other derivatives of nitroimidazole.

In the II-III trimesters of pregnancy, the appointment of Metrogyl is possible only for health reasons, during lactation, breastfeeding should be interrupted.

The drug should be used with caution in case of renal-hepatic insufficiency.

Vaginal gel:

• Leukopenia, including a history of it;
• Movement coordination disorders;
• Organic lesions of the central nervous system, including epilepsy;
• Liver failure;
• I trimester of pregnancy;
• Hypersensitivity to the components of the drug, as well as to other derivatives of nitroimidazole.

When using the drug in the form of a vaginal gel during lactation, breastfeeding should be interrupted.

Gel for external use:

A contraindication to the use of Metrogyl is hypersensitivity to the components of the drug.

The gel should be used with caution in the first trimester of pregnancy and lactating women.

Oral suspension:

• Organic lesions of the central nervous system;
• Diseases of the blood;
• I trimester of pregnancy;
• Hypersensitivity to drug components.

In the II-III trimesters of pregnancy, the appointment of Metrogyl is possible only for health reasons, when taking the drug during lactation, breastfeeding should be interrupted.

Method of administration and dosage

Solution for intravenous administration:

Intravenous administration of Metrogyl is indicated in cases of severe infections and the inability to take the drug inside.

For adults and children over 12 years old, Metrogyl is prescribed in an initial dose of 500-1000 mg intravenously (infusion duration - 30-40 minutes), then 500 mg is administered every 8 hours at a rate of 5 ml per minute. After the first 2-3 infusions, with good tolerance, they switch to jet administration. The duration of therapy is 7 days. If necessary, intravenous administration can be carried out for a longer period. The maximum daily dose is 4000 mg. In the future, the patient is transferred to supportive therapy, prescribing oral administration of the drug in a daily dose of 1200 mg (3 times a day, 400 mg).

For children under 12 years old, Metrogyl is prescribed according to the same scheme, using a single dose of 7.5 mg / kg.

In the treatment of purulent-septic diseases, 1 course of treatment is usually carried out.

For prophylactic purposes, adults and children from 12 years of age, Metrogyl is prescribed intravenously, 500-1000 mg, on the eve of the operation. On the day of surgery and the next day, the drug is administered every 8 hours, 500 mg. After 1-2 days, you should switch to supportive therapy inside.

The maximum daily dose for chronic renal failure and creatinine clearance of less than 30 ml per minute and / or liver failure should not exceed 1000 mg (with a frequency of application 2 times a day).

Tablets, suspension for oral administration:

Metrogyl tablets are taken orally, without chewing, preferably during or after a meal with milk.

As a rule, adults and children from 15 years of age are prescribed 200-400 mg 2-3 times a day.

The dosage regimen is determined by the indications:

• Trichomoniasis: single dose - 200 mg, frequency of administration - 3 times a day, course duration - 7 days; additionally, women should use metronidazole in the form of vaginal ointments or suppositories. If necessary, it is possible to carry out a repeated course of therapy (with a break of 3-4 weeks, during which repeated control laboratory tests should be carried out) or to increase the dose to 750-1000 mg per day. You can also use another regimen for taking the drug - once 2000 mg to the patient and his sexual partner;
• Amebic liver abscess: adult daily dose - 1200-2400 mg (3 times a day, 400 or 800 mg), therapy should be carried out simultaneously with antibiotic drugs (most often tetracycline); children's daily dose - 30-35 mg / kg (in 3 divided doses); course duration - 5-10 days;
• Amoebiasis: adult daily dose - 1200 mg (3 times a day, 400 mg); children's daily dose - 30-40 mg / kg (in 3 divided doses); course duration - 7-10 days;
• Anaerobic bacterial infections: adult daily dose - 400-1200 mg (2-3 times a day, 200-400 mg); children's daily dose - 21 mg / kg (every 8 hours at 7 mg / kg); the duration of the course is 7-10 days.

Before carrying out surgical interventions on the large intestine and pelvic organs for the prevention of anaerobic infection, a single dose of Metrogyl is shown at a dose of 1000 mg, then - 3 times a day, 200 mg.

The daily dose of metronidazole in combination with amoxicillin (2250 mg per day) is 1500 mg (in 3 divided doses). With pronounced functional disorders of the kidneys and liver, daily doses should be reduced: metronidazole - up to 1000 mg, amoxicillin - up to 1500 mg (in 2 divided doses).

Vaginal gel:

Metrogyl is used intravaginally.

The recommended single dose is 1 full applicator (5000 mg), the frequency of application is 2 times a day (in the morning and in the evening).

The duration of therapy is 5 days.

Gel for external use:

Metrogyl should be applied in a thin layer 2 times a day (in the morning and in the evening) on previously cleansed affected skin areas.

The duration of therapy is 3-4 months, as a rule, improvement occurs 3 weeks after the start of therapy.

Side effects

Solution for intravenous administration, tablets:

• Digestive system: pseudomembranous colitis, dry mouth, vomiting, nausea, constipation, diarrhea, intestinal colic, lack of appetite, unpleasant metallic taste in the mouth, increased liver enzymes, cholestatic jaundice, hepatitis, stomatitis, glossitis, pancreatitis;
• Hematopoietic system: thrombocytopenia, leukopenia;
• Urogenital system: burning sensation in the urethra, dysuria, candidiasis (fungal flora of the vagina), red-brown staining of urine, polyuria, urinary incontinence;
• Nervous system: impaired coordination of movements, headache, hallucinations, ataxia, dizziness, epileptic seizures, impaired consciousness, increased excitability, sleep disturbances, depression, weakness, peripheral neuropathy;
• Allergic reactions: anaphylactic shock, nasal congestion, arthralgia, skin flushing, skin rash, itching, fever, urticaria;
• Local reactions (with intravenous administration): thrombophlebitis (pain, swelling or hyperemia at the injection site);
• Others: flattening of the T wave on the electrocardiogram, neutropenia.

Vaginal gel:

• Systemic reactions: dizziness, dry mouth, leukocytosis or leukopenia, headache, change in taste (including a metallic taste), loss of appetite, nausea, cramping abdominal pain, vomiting, diarrhea or constipation, dark urine staining;
• Local reactions: burning sensation or frequent urination, vulvitis; for a sexual partner - irritation or burning sensation of the penis; in women after the end of treatment - vaginal candidiasis;
• Allergic reactions: urticaria, skin rash.

Gel for external use:

The risk of systemic side effects when using Metrogyl topical gel is small. In rare cases, during therapy, there may be observed: allergic reactions (in the form of urticaria, skin rash), lacrimation (when applying the gel close to the eyes), peeling, hyperemia, slight burning sensation and dry skin.

special instructions

During the use of Metrogyl, alcohol should not be consumed, since this can lead to the development of a disulfiram-like reaction, manifested in the form of abdominal pain of a spastic nature, vomiting, nausea, headache, sudden flushes of blood to the face.

The simultaneous use of Metrogyl with amoxicillin is not recommended for patients under the age of 18.

The possibility of continuing treatment for leukopenia is determined by the risk of developing an infectious process.

During long-term therapy, it is desirable to monitor peripheral blood parameters.

If ataxia, dizziness and any other deterioration in neurological status appear, therapy should be discontinued.

The use of Metrogyl can immobilize treponemas and lead to a false positive Nelson's test.

During the therapy of Trichomonas vaginitis in women and Trichomonas urethritis in men, one should refrain from sexual activity and carry out simultaneous treatment of sexual partners. Treatment should not be interrupted during menstruation. At the end of the course, you need to conduct control tests for three successive cycles before and after menstruation.

After the end of the treatment of giardiasis, if symptoms persist after 3-4 weeks, it is necessary to conduct 3 fecal analyzes with interruptions of several days (in some successfully treated patients, lactose intolerance caused by invasion can persist for a long time, resembling the symptoms of giardiasis).

Avoid contact with the eyes of the vaginal and external gel. In case of accidental contact, they must be washed immediately with plenty of water.

Drug interactions

When Metrogyl is used together (inside, intravenously) with some drugs, the following effects may occur:

• Indirect anticoagulants: increasing their action (leads to an increase in the time of prothrombin formation);
• Ethanol: the development of its intolerance;
• Medicines that stimulate enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin): acceleration of the elimination of metronidazole (may lead to a decrease in its concentration in plasma);
• Sulfonamides: strengthening the antimicrobial action of Metrogyl;
• Cimetidine: inhibition of metronidazole metabolism (may lead to an increase in its concentration in the blood serum and the risk of side effects);
• Lithium preparations (high doses): an increase in the concentration of lithium in the blood plasma with the development of signs of intoxication.

The simultaneous use of Metrogyl with depolarizing muscle relaxants (vecuronium bromide) is not recommended.

When using Metrogil topically (external and vaginal gel), the interaction with other drugs is negligible, however, during therapy, care must be taken when prescribing it with warfarin and other indirect anticoagulants.

Metrogil injection solution should not be mixed with other drugs.

Analogs

Analogs of Metrogyl are: Deflamon, Batsimex, Klion, Metrovagin, Metrolacer, Metron, Metronidazole, Metronidazole Nycomed, Metroseptol, Orvagil, Trichobrol, Trichopolum, Cyptrogil, Rozex, Efloran.

Terms and conditions of storage

Store in a dark place, out of reach of children.

Shelf life:

• Injection solution, gel for external use - 3 years at temperatures up to 30 ° C;
• Film-coated tablets - 5 years at temperatures up to 30 ° C;
• Vaginal gel - 2 years at temperatures up to 25 ° C;
• Oral suspension - 3 years at room temperature.

Terms of dispensing from pharmacies

The tablets and solution are available with a prescription, and the gel is available without a prescription.

Metrogyl: prices in online pharmacies

Drug name Price Pharmacy

Metrogyl (for infusion) 5 mg / ml solution for intravenous administration 100 ml 1 pc. 22 RUB Buy

Metrogyl (vaginal gel) 1% vaginal gel 30 g 1 pc. RUB 97 Buy

Metrogyl Plus vaginal gel with applicator 50 g 1 pc. 129 RUB Buy

Metrogyl gel vaginal. 10mg / g 30g 157 r Buy

Metrogyl (gel) 1% gel for external use 30 g 1 pc. 171 r Buy

Reviews Metrogyl (gel) 171 r Buy

Metrogyl gel for outside. approx. 1% 30g 182 r Buy

Metrogyl Denta dental gel 20 g 1 pc. 192 RUB Buy

Reviews Metrogyl Denta 192 RUB Buy

Metrogyl Plus vaginal gel with 10 applicators 50 g 1 pc. 198 RUB Buy

Metrogyl plus vaginal gel 50g tube No. 1 246 r Buy

Metrogyl Denta dental gel for gums 20g 1pc 293 r Buy

Metrogyl plus gel vag. 10mg / g 50g (+10 applicators) 301 RUB Buy

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!