Table of contents:
- Release form and composition
- Pharmacological properties
- Indications for use
- Metrovagin, instructions for use: method and dosage
- Side effects
- special instructions
- Application during pregnancy and lactation
- Pediatric use
- With impaired renal function
- For violations of liver function
- Use in the elderly
- Drug interactions
- Terms and conditions of storage
- Terms of dispensing from pharmacies
- Reviews about Metrovagin
- The price of Metrovagin in pharmacies
Video: Metrovagin - Instructions For Using Candles, Reviews, Price, Analogues
2023 Author: Rachel Wainwright | [email protected]. Last modified: 2023-06-01 00:39
Metrovagin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Metrovagin
ATX code: G01AF01
Active ingredient: metronidazole (Metronidazole)
Manufacturer: JSC "Altayvitaminy" (Russia)
Description and photo update: 2020-18-08
Metrovagin is a drug with antimicrobial and antiprotozoal action.
Release form and composition
The dosage form of the drug is vaginal suppositories: torpedo-shaped, from white to yellowish-white (in a cardboard box, instructions for the use of Metrovagin and 2 blister packs of 5 suppositories each).
Composition of 1 suppository:
- active substance: metronidazole - 500 mg;
- auxiliary component: solid fat.
Metronidazole is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties.
The mechanism of action of the drug consists in the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of protozoa and anaerobic microorganisms. Subsequently, the reduced 5-nitro group of metronidazole, inhibiting the synthesis of nucleic acids, interacts with the DNA of the cells of pathogenic bacteria, due to which they die.
Metrovagin is active against the following microorganisms:
- microaerophiles: Helicobacter pillory, Gardnerella vaginalis;
- gram-negative anaerobes: Fusobacterium spp., Bacteroides spp. (including B. ovatus, B. distasonis, B. thetaiotaomicron, B. fragilis, B. vulgatus);
- gram-positive anaerobic cocci: Peptostreptococcus spp., Peptococcus niger;
- protozoa: Lamblia intestinalis, Entamoeba histolytica, Trichomonas vaginalis, Balantidium coli;
- gram-positive anaerobic spore-forming rods: Clostridium spp., Eubacterium spp.
The MIC (minimum inhibitory concentration) of these strains ranges from 0.125 to 6.25 μg / ml.
With intravaginal use of Metrovagin suppositories, approximately 56% of metronidazole undergoes systemic absorption.
The bioavailability of the drug is 20%. No more than 20% binds to plasma proteins.
Metronidazole penetrates into most body tissues, into breast milk, through the blood-brain barrier and the placenta.
The drug undergoes biotransformation in the body in three ways: glucuronidation, oxidation and hydroxylation. The main metabolite is 2-oxymetronidazole. Its activity is approximately 30% of that of metronidazole.
The half-life is 6-11 hours. From 40 to 70% is excreted through the kidneys, with about 20% unchanged.
Indications for use
Metrovagin is used to treat Trichomonas and nonspecific vaginitis in women.
- active blood diseases;
- leukopenia (including a history);
- hepatic impairment (in the case of prescribing the drug in high doses);
- organic lesions of the central nervous system (including epilepsy);
- violation of coordination of movements;
- I trimester of pregnancy;
- lactation period;
- hypersensitivity to any component of the drug or other nitroimidazole derivatives.
With caution, Metrovagin should be used in the II – III trimesters of pregnancy, as well as in patients with a history of leukopenia.
Metrovagin, instructions for use: method and dosage
Suppositories Metrovagin are used intravaginally. The suppository should be inserted deep into the vagina, having previously freed it from the packaging (use scissors to cut the film along the contour of the suppository).
Recommended dosage regimen:
- Trichomonas vaginitis: 1 suppository 1 time per day. The course of treatment is 10 days;
- nonspecific vaginitis: 1 suppository 2 times a day. The duration of therapy is 7 days.
- local reactions: burning, itching, irritation and pain in the vagina, vaginal discharge (odorless or faint, mucous, white, thick), frequent urination; vaginal candidiasis (may develop after discontinuation of Metrovagin);
- allergic reactions: skin rashes, itching of the skin, urticaria;
- from the digestive system: dry mouth, metallic taste in the mouth, change in taste, cramping pain in the abdominal cavity, decreased appetite, diarrhea / constipation, nausea, vomiting;
- on the part of the hematopoietic organs: a decrease or increase in the number of leukocytes in the blood compared with the norm;
- from the central nervous system: headache, dizziness;
- others: in rare cases, urine staining red-brown, irritation or burning sensation of the partner's penis.
In case of an overdose of the drug, ataxia may develop, the appearance of nausea and vomiting.
There is no specific antidote for metronidazole. Treatment is symptomatic and supportive.
The duration of drug treatment should not exceed 10 days. You cannot conduct more than 3 courses per year.
With the simultaneous administration of oral metronidazole, especially in the case of a repeated course of treatment, it is necessary to monitor the peripheral blood picture due to the risk of leukopenia.
During the treatment with Metrovagin of Trichomonas vaginitis, women should refrain from sexual intercourse. In addition, concomitant treatment of the sexual partner with a drug containing metronidazole (in oral dosage form) is recommended.
During treatment with the drug, one should refrain from drinking alcohol because of the risk of developing a disulfiram-like reaction, manifested by abdominal pain, nausea, vomiting, headache, and a sharp flush of blood to the face.
Influence on the ability to drive vehicles and complex mechanisms
Due to the risk of dizziness during treatment, caution should be exercised by vehicle drivers and persons whose activities are associated with increased attention or speed of reactions.
Application during pregnancy and lactation
In the first trimester of pregnancy, Metrovagin is contraindicated. In the II and III trimesters, the drug can be used only if there are absolute indications and under the strict supervision of a physician.
Metronidazole passes into breast milk, therefore it is contraindicated during lactation. If the appointment of the drug is clinically justified, breastfeeding should be temporarily discontinued. It can be resumed 24–48 hours after Metrovagin is discontinued.
Vaginal suppositories Metrovagin are not recommended for the treatment of children.
With impaired renal function
There is no information on the need to adjust the dose of the drug for patients with impaired renal function.
For violations of liver function
Metrovagin, especially in high doses, should be used with caution in liver failure.
Use in the elderly
No information is available regarding recommendations for elderly patients.
Barbiturates can reduce the effectiveness of Metrovagin, as they accelerate the inactivation of metronidazole in the liver.
Cimetidine inhibits the metabolism of the drug, which increases the concentration of metronidazole in the blood serum, increasing the risk of side effects.
The drug increases the concentration of lithium in the blood plasma. Enhances the effect of warfarin and other indirect anticoagulants, as a result of which an increase in prothrombin time is possible.
Metronidazole can be combined with antibiotics and sulfonamides.
Metrovagin is not recommended to be used simultaneously with non-depolarizing muscle relaxants (for example, vecuronium).
The drug should not be administered in conjunction with disulfiram, it can cause depression of consciousness and the development of mental disorders.
Similar to disulfiram, metronidazole in combination with alcohol causes intolerance to ethanol.
Analogs of Metrovagin are Metrogyl, Ornidazole, Ornisid, Osarbon, Trichopol, Flagil, etc.
Terms and conditions of storage
Store out of the reach of children, protected from light, at temperatures up to 20 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Metrovagin
There are currently no reviews of Metrovagin from women who have used it. Therefore, there is no way to assess its effectiveness and tolerability from the point of view of patients.
The price of Metrovagin in pharmacies
The average price for Metrovagin in the form of vaginal suppositories is 210 rubles. per pack of 10
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!