Mezapam - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Mezapam

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Mesapam is a drug with anxiolytic and sedative effects.

Release form and composition

Mesapam is produced in the form of tablets (in blisters of 10 pcs., 5 packages in a cardboard box; in dark glass jars of 50 pcs., 1 can in a cardboard box).

The composition of 1 tablet includes:

• Active ingredient: medazepam - 10 mg;
• Auxiliary components: potato starch - 20 mg, lactose monohydrate (milk sugar) - 69 mg, calcium stearate (calcium stearic acid) - 1 mg.

Indications for use

• Disorders of a psychosomatic and psycho-vegetative nature, including vegetative-vascular dystonia, functional disorders of the gastrointestinal tract and cardiovascular system, sleep disorders, climacteric syndrome, migraine (to prevent attacks);
• Psychopathies, neuroses, psychopathic and neurosis-like states, accompanied by irritability, increased excitability, decreased mood, emotional lability, tension, anxiety, fear;
• "School" neuroses, excessive excitability and mental lability in children;
• Alcohol withdrawal syndrome (with uncomplicated course);
• Delayed neurotic disorders developing in the structure of drug addiction and alcoholism remission (simultaneously with other drugs).

Contraindications

• Drug and alcohol addiction;
• Sleep apnea;
• Severe myasthenia gravis;
• Closed-angle glaucoma;
• Diseases of the kidneys and liver (in acute course);
• Renal and / or hepatic impairment (in severe cases);
• First trimester of pregnancy and lactation;
• Hypersensitivity to the components of the drug, as well as to other benzodiazepines.

In the II-III trimesters of pregnancy, the use of Mezapam is possible in cases where the benefits of therapy are higher than the expected harm to the health of the fetus (it is necessary to avoid the use of the drug in high doses or for a long time).

Method of administration and dosage

Mesapam is taken orally, preferably before meals.

The initial adult dose is 5 mg 2-3 times a day, the daily dose is gradually increased to 30 mg (if necessary, up to 40 mg). On an outpatient basis, 5 mg is usually prescribed in the morning and at noon, in the evening - 10 mg. The average single dose is 10-20 mg, the daily dose is 30-40 mg. The maximum daily dose on an outpatient basis is 40 mg, in a hospital - 60-70 mg. The duration of therapy is up to 60 days. It is possible to repeat the course with a break of at least 21 days.

Elderly patients and adolescents are prescribed Mezapam in a daily dose of 10-20 mg.

A single / daily dose for children is determined by age:

• 1-2 years: 1 / 2-3 mg;
• 3-6 years: 1-2 / 3-6 mg;
• 7-10 years old: 4-8 / 6-24 mg;
• Over 10 years old: 6-10 / 20-60 mg.

With alcoholism, 30 mg per day is usually prescribed for 7-14 days.

Side effects

• Cardiovascular system and blood (hemostasis, hematopoiesis): lowering blood pressure, bradycardia, tachycardia;
• Nervous system and sensory organs: drowsiness, dizziness, headache (usually occurs as the first reaction to the intake, after lowering the dose it usually goes away), lethargy, weakness, chest pain, depressed mood, confusion, fatigue (in including in patients with a history of depressive diseases), double blurred vision, stunnedness, anterograde amnesia, paresis of accommodation, dysarthria, twitching of the eyeball, ataxia (in elderly and debilitated patients), paradoxical reactions (in the form of increased aggressiveness, sleep disturbances, convulsions of various muscle groups; strong excitement, feelings of fear, suicidal thoughts - more often in elderly patients and children);
• Gastrointestinal tract: epigastric pain, dry mouth, vomiting, nausea, jaundice, constipation, dyspeptic symptoms, increased activity of hepatic transaminases;
• Respiratory system: laryngospasm, oppression of the respiratory center (with brain damage or airway obstruction), shortness of breath, alveolar hypoventilation (in patients with chronic obstructive pulmonary disease when taken in high doses);
• Others: chest pain, myasthenia gravis, urinary retention, skin-allergic reactions (itching, redness, rash, exanthema), dysmenorrhea, decreased libido; with prolonged use - the development of dependence (mental and physical), addiction, withdrawal syndrome.

special instructions

Patients taking long-term beta-blockers, antihypertensive drugs of central action, hypoglycemic drugs, oral contraceptives, cardiac glycosides and anticoagulants Mezapam should be prescribed with caution (it is impossible to accurately predict the nature of the interaction of these drugs with medazepam).

Therapy should be interrupted in cases of increased aggressiveness, excitement, fear, thoughts of suicide, hallucinations, muscle cramps.

With daily intake of Mezapam for several weeks, there may be a risk of developing mental and physical dependence (this violation can be observed both when taking high doses of the drug, and when using it in usual therapeutic doses), and therefore the continuation of therapy is possible only for health reasons and only after carefully balancing the benefits of the drug with the risk of dependence on it. The risk of developing drug dependence increases in patients who previously abused ethanol or drugs, as well as when using large doses, increasing the duration of therapy.

Long-term use of Mezapam by pregnant women can cause the development of withdrawal syndrome in the newborn. Taking high doses of the drug immediately before or during childbirth can cause a decrease in blood pressure, respiratory depression, difficulty in sucking ("flaccid baby syndrome") and hypothermia in the newborn.

In cases where the next dose of Mezapam is missed, it must be taken immediately, as soon as it was noticed, but you cannot double a single dose.

The use of alcoholic beverages during the period of therapy is unacceptable.

During the treatment and prevention of withdrawal symptoms, Mezapam should be canceled gradually.

During the aftereffect period, severe states of arousal may occur.

It should be borne in mind that tension or anxiety associated with everyday stress are usually not indications for the appointment of anxiolytics.

For drivers of vehicles and patients whose profession is associated with increased concentration of attention, Mezapam must be taken with caution (in the first days of therapy, it is recommended to completely abandon driving vehicles and performing work that requires quick mental and physical reactions).

Drug interactions

With the simultaneous use of Mezapam with some drugs, the following effects may develop:

• Drugs that depress the central nervous system (including sleeping pills, narcotic analgesics, antipsychotics, drugs for anesthesia, antihistamines with a sedative component), muscle relaxants, alcohol and ethanol-containing drugs: enhancing their action;
• Alcohol: development of a paradoxical reaction;
• Levodopa: oppression of its action;
• Theophylline (low doses): reduced sedative effect of medazepam;
• Oral contraceptives containing estrogen, cimetidine, disulfiram, omeprazole: strengthening and prolonging the action of medazepam;
• Nicotine: accelerates the elimination of medazepam from the body.

Analogs

Analogs of Mezapam are: Rudotel, Nobretem.

Terms and conditions of storage

Keep out of reach of children at temperatures up to 30 ° C.

The shelf life is 5 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!