Loratadin-Akrikhin
Loratadin-Akrikhin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews Loratadine-Akrikhin
- 18. Price in pharmacies
Latin name: Loratadine-Akrikhin
ATX code: R06AX13
Active ingredient: loratadine (loratadine)
Producer: JSC KhFK Akrikhin (Russia)
Description and photo update: 28.11.2018
Prices in pharmacies: from 63 rubles.
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Loratadin-Akrikhin is an anti-allergic agent, a blocker of histamine H 1 receptors.
Release form and composition
- tablets: flat-cylindrical, almost white or white, with a chamfer (7 or 10 pieces in a blister strip packaging, in a cardboard box 1 or 3 packs);
- syrup: a clear liquid from pale yellow to yellow in color with a slight fruity odor (100 ml in a dark glass bottle sealed with a polyethylene lid with first opening control; in a cardboard box 1 bottle with a measuring spoon or measuring cup).
Each pack also contains instructions for the use of Loratadin-Akrikhin.
Composition of 1 tablet:
- active substance: loratadine - 10 mg;
- additional components: calcium stearate, lactose monohydrate, sodium carboxymethyl starch, microcrystalline cellulose.
Composition of 100 ml syrup:
- active substance: loratadine - 100 mg;
- additional components: dye tropeolin O, propylene glycol, sucrose, benzoic acid, ethanol (rectified ethyl alcohol), citric acid, purified water, orange flavor.
Pharmacological properties
Pharmacodynamics
Loratadine is a blocker of H 1 -histamine receptors (long-term exposure). The substance inhibits the release of leukotriene C4 and histamine from mast cells, prevents the occurrence of allergic reactions and facilitates their course. The tool has antiallergic, antipruritic and antiexudative effects, reduces capillary permeability, eliminates smooth muscle spasms, and prevents tissue edema. The antiallergic effect of Loratadin-Akrikhin appears 30 minutes after administration, reaches a maximum after 8-12 hours and is observed for 24 hours. The drug has no effect on the central nervous system (since it does not pass through the blood-brain barrier) and is not addictive.
Pharmacokinetics
Loratadine is completely and rapidly absorbed in the gastrointestinal tract. The maximum concentration of the substance (C max) in the blood plasma is observed 1.3–2.5 hours after its administration. When using Loratadin-Akrikhin with meals, C max is reached 1 hour later.
The active component binds to plasma proteins by 97%. Its metabolic transformation, in which cytochrome CYP3A4 and, to a lesser extent, CYP2D6 isoenzymes take part, occurs in the liver with the formation of descarboethoxyloratadine, an active metabolite of loratadine. Stationary concentrations (C ss) of loratadine and its metabolite in the blood are observed on the 5th day of administration. The substance is excreted in urine and bile. The half-life (T ½) of loratadine is approximately 8.4 hours (3–20 hours), its active metabolite is approximately 28 hours (8.8–92 hours).
In elderly patients, the C max of the drug in the blood plasma increases by 50%, and T ½ of loratadine and its active metabolite averages 18.2 hours (6.7–37 hours) and 17.5 hours (11–38 hours), respectively.
In patients with alcoholic liver damage, C max and T ½ increase in proportion to the severity of the disease. In the presence of chronic renal failure and during hemodialysis, the pharmacokinetic parameters of the antihistamine practically do not change.
Indications for use
- allergic rhinitis (including seasonal and perennial), hay fever;
- urticaria (including chronic idiopathic);
- itchy dermatoses;
- allergic conjunctivitis;
- angioneurotic edema (Quincke's edema);
- allergic reactions to insect bites;
- pseudo-allergic reactions due to the release of histamine.
Contraindications
- lactation period;
- age up to 2 years (for syrup);
- body weight less than 30 kg (for tablets);
- glucose-galactose malabsorption, lactase deficiency, lactose intolerance (for tablets);
- hypersensitivity to any of the constituents of the drug.
With extreme caution, it is required to use Loratadin-Akrikhin during pregnancy and with liver failure.
Loratadin-Akrikhin, instructions for use: method and dosage
Both dosage forms of Loratadin-Akrikhin are used orally, once a day.
Children weighing more than 30 kg and adults are recommended to take the drug in a daily dose of 10 mg (1 tablet or 2 scoops of syrup).
Children from 2 to 12 years old with a body weight of less than 30 kg are prescribed Loratadin-Akrikhin syrup in a daily dose of 5 mg (1 measuring spoon).
In the presence of renal failure, the initial dose is 10 mg every other day.
In the presence of liver failure, the initial dose is 10 mg every other day or 5 mg (in the form of a syrup) per day.
Side effects
During treatment with the drug, adverse reactions were recorded approximately with the same frequency as when using placebo. During the period of therapy, the following side effects were observed in adults: drowsiness, fatigue, headache, dry mouth, nausea, liver dysfunction, gastritis, alopecia, anaphylaxis, allergic reactions (rash), tachycardia.
In children, while taking Loratadin-Akrikhin, disorders such as sedation, increased nervous excitability, and headache were noted.
Overdose
Loratadine overdose symptoms may include headache, drowsiness, tachycardia. In this condition, gastric lavage and the intake of activated carbon are prescribed. The drug is not excreted from the body by hemodialysis.
special instructions
No data.
Influence on the ability to drive vehicles and complex mechanisms
Patients driving motor vehicles or other complex and potentially dangerous equipment while on loratadine therapy need to be careful.
Application during pregnancy and lactation
During pregnancy, taking Loratadine-Akrikhin is possible only if the expected benefit to the mother outweighs the potential threat to fetal health.
If it is necessary to use the drug during lactation, breastfeeding should be stopped during treatment (since loratadine passes into breast milk).
Pediatric use
Tablets are not prescribed for children weighing less than 30 kg, Loratadin-Akrikhin syrup is contraindicated in children under 2 years of age.
With impaired renal function
Patients with renal insufficiency are recommended to take Loratadin-Akrikhin in an initial dose of 10 mg every other day.
For violations of liver function
With existing functional disorders of the liver, the initial dose of Loratadin-Akrikhin should be 10 mg (1 tablet or 2 scoops of syrup), taken every other day, or 5 mg (1 scoop of syrup) per day.
Drug interactions
- ethanol - there is no increase in its effect on the central nervous system;
- ketoconazole, erythromycin and other CYP3A4 inhibitors; cimetidine and other inhibitors of CYP2D6 and CYP3A4 - the concentration of loratadine in the blood plasma increases, while there are no clinical manifestations and no effect on the ECG parameters (electrocardiography);
- tricyclic antidepressants, barbiturates, phenytoin, phenylbutazone, rifampicin (inducers of microsomal oxidation) - the effectiveness of loratadine decreases.
Analogs
Loratadin-Akrikhin analogs are: Claridol, Alerpriv, Clarisens, Clarifer, Claritin, Klarnedin, Loratavel, Lomilan, LoraGEXAL, Loratadin, Erolin.
Terms and conditions of storage
Store in a place protected from moisture, out of reach of children, at a temperature of 12-15 ° C - for syrup, and not higher than 25 ° C - for tablets.
The shelf life of the syrup is 4 years, of the tablets - 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Loratadin-Akrikhin
Reviews of Loratadin-Akrikhin are overwhelmingly positive. The antihistamine, according to many patients, has proven itself well in the treatment of allergic rhinitis, hay fever, itchy dermatoses, urticaria, and allergic conjunctivitis in adults and children. Loratadin-Akrikhin effectively relieves allergy symptoms, however, a positive result when taking pills, according to patients, is observed only on the second day of treatment. The advantages of the product include its availability, convenient dosing regimen and the fact that it is not addictive. Some patients do not like the too sweet, specific taste of the syrup.
Sometimes there are complaints about the insufficient or temporary effect of the remedy, since according to reviews, after taking it, the allergy is not completely cured, but only its symptoms are eliminated. Also, in isolated cases, they indicate severe drowsiness that occurs during drug therapy.
The price of Loratadin-Akrikhin in pharmacies
The price for Loratadin-Akrikhin is approximately:
- tablets (10 mg): 50-75 rubles. for 7 pcs., 60-80 rubles. - for 10 pcs., 160-190 rubles. - for 30 pcs. packaged;
- syrup (5 mg / 5 ml): 160-180 rubles. per bottle of 100 ml.
Loratadin-Akrikhin: prices in online pharmacies
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Drug name Price Pharmacy |
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Loratadin-Akrikhin 10 mg tablets 7 pcs. RUB 63 Buy |
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Loratadin-Akrikhin 10 mg tablets 10 pcs. RUB 66 Buy |
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Loratadin-Akrikhin tablets 10mg 10 pcs. RUB 98 Buy |
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Loratadin-Akrikhin 5 mg / 5 ml syrup 100 ml 1 pc. RUB 98 Buy |
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Loratadin-Akrikhin 10mg tablets 7 pcs. 118 RUB Buy |
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Loratadin-Akrikhin 10 mg tablets 30 pcs. 157 r Buy |
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Loratadin-Akrikhin syrup 5mg / 5ml fl. 100ml 170 RUB Buy |
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Loratadin-Akrikhin tablets 10mg 30 pcs. 205 RUB Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
