Lactoginal
Lactozhinal: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Lactoginal
ATX code: G01AX14
Active ingredient: Lyophilized culture of lactobacilli (Lactobacillus casei rhamnosus Doderleini)
Producer: Biose Industrie (France)
Description and photo update: 2020-04-06
Prices in pharmacies: from 816 rubles.
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Lactozhinal is an eubiotic preparation for intravaginal use, which helps to restore the natural microflora of the vagina and strengthen local immunity.
Release form and composition
Dosage form - vaginal capsules: gelatinous, translucent, size No. 0, the capsules contain a light yellow powder with a brownish tint (14 pcs. In colorless glass bottles, in a cardboard box 1 bottle and instructions for use of Lactozhinal).
Composition of 1 Lactozhinal vaginal capsule:
- active substance: lyophilized culture of lactobacilli Lactobacillus casei rhamnosus Doderleini, containing viable lactobacilli in an amount of at least 1 × 10 8 CFU (colony-forming units);
- additional components: magnesium stearate - 3.41 mg; lactose monohydrate - 5.59 mg; components of the protective drying medium (potato starch, lactose monohydrate, sodium glutamate, sodium thiosulfate);
- capsule shell: gelatin.
Auxiliary components of the protective environment for the protection of microbial cells during lyophilization (in% of the mass of the lyophilisate): potato starch ~ 41%; sodium thiosulfate ~ 26.8%; lactose monohydrate ~ 20.6%; monosodium glutamate ~ 4.5%.
Pharmacological properties
Pharmacodynamics
The active component of the drug Lactozhinal is a gram-positive rod-shaped anaerobic non-spore-forming bacteria of the species Lactobacillus casei (L. casei), which are representatives of the normal obligate microflora of the oral cavity, intestines, vulva and vagina of a person.
Along with such species of lactobacilli as L. acidophilus, L. cellobiosum, L. fermentum and others, L. casei are present in the natural microflora of the vulva and vagina of a woman. The Lactozhinal preparation contains the L. casei rhamnosus Doderleini strain, which exhibits antagonistic activity against a wide range of pathogenic and opportunistic microorganisms (including enteropathogenic Escherichia coli, Staphylococcus spp., Proteus spp.). It improves local metabolism, helping to restore natural local immunity. In the vagina, colonization with live rods of L. casei rhamnosus Doderleini creates a physiological environment.
After intravaginal administration, the gelatinous shell of the Lactozhinal capsule dissolves, releasing a lyophilized culture of live lactobacilli. As a result of in vitro studies, it was found that within a few hours L. casei rhamnosus Doderleini shift the acid-base balance towards higher acidity, lowering the pH. Due to this, the introduction of this strain of lactobacilli into the vagina helps to restore its natural microflora.
One of the important reasons for the development of vulvovaginal candidiasis in women is a deficiency of lactobacilli, physiological antagonists of yeast-like fungi of the genus Candida. L. casei rhamnosus Doderleini bacteria are involved in the secretion of antifungal agents and inhibit the growth and reproduction of Candida by competing for receptors in the vaginal epithelium, thereby inhibiting the attachment of yeast-like fungi to vaginal cells. In the course of clinical studies, the effectiveness of the use of Lactozhinal capsules after the end of antifungal therapy has been proven in order to restore normal vaginal microflora and prevent recurrence of vulvovaginal candidiasis.
In vitro resistance of L. casei subsp. rhamnosus LCR35 in co-cultivation with a number of antibiotics, including metronidazole and clindamycin. In studies both in vitro and in vivo, the phenomenon of potentiation of the effectiveness of antibacterial drugs by metabolites of the probiotic strain L. casei subsp. rhamnosus LCR35. That can enhance the clinical effect of antibiotic therapy for bacterial vaginosis, provided it is used simultaneously with Lactozhinal capsules.
As a result of a clinical study of the treatment of vaginal dysbiosis, the effectiveness of the drug Lactozhinal has been proven when it is used simultaneously with an antibacterial vaginal cream containing clindamycin (2%).
Indications for use
The drug Lactozhinal is used to restore the normal microflora of the vagina in the following diseases / conditions:
- bacterial vaginosis: from the first day of antibiotic therapy or immediately after the completion of their course use;
- planned gynecological operations: in the process of preoperative preparation;
- preparation for childbirth in pregnant women with a high risk of developing bacterial vaginosis.
Lactozhinal is also recommended to be used for the prevention of recurrence of vulvovaginal candidiasis (including exacerbations of recurrent vulvovaginal candidiasis) after local and / or systemic treatment with antifungal drugs.
Contraindications
- thrush (vulvovaginal candidiasis);
- age up to 18 years;
- individual intolerance to the components of the drug.
Laktozhinal, instructions for use: method and dosage
Lactoginal is used intravaginally. Before administration, the capsule must be moistened in a small amount of water, which will accelerate its dissolution.
Recommended dosage regimen:
- bacterial vaginosis therapy (to restore normal vaginal microflora): Method I (after completion of therapy with antibacterial drugs) - 1 capsule in the morning and evening, course duration - 1 week or 1 capsule daily, course duration - 2 weeks; Method II (from the first day of therapy with antibacterial drugs) - 1 capsule daily, course duration - 2 weeks;
- preparation for planned gynecological operations, prenatal preparation of pregnant women with a high risk of developing bacterial vaginosis: as part of complex treatment, 1 capsule in the morning and evening, course duration - 1 week or 1 capsule daily, course duration - 2 weeks; correction of the dosage regimen is possible depending on the severity of the clinical effect of the drug;
- prevention of relapses of vulvovaginal candidiasis (including exacerbations of recurrent vulvovaginal candidiasis) after local and / or systemic treatment with antifungal drugs: 1 capsule before bedtime, the duration of the course is determined by a specialist; treatment should not last more than 3 weeks; on an individual basis, the doctor may decide on the need for re-therapy.
It is necessary to seek the advice of a doctor if there is no improvement in the condition after treatment, aggravation or the appearance of new symptoms of the disease.
The drug is required to be used in the recommended doses, according to the indications and method of use indicated in the instructions.
Side effects
The use of Lactozhinal capsules can cause hypersensitivity reactions such as redness in the genital area, itching and burning, as well as increased mucus secretion from the vagina.
With the development of the above side effects, their aggravation or the appearance of any other reactions not prescribed in the instructions, you need to consult a doctor.
Overdose
Overdose cases have not been reported.
special instructions
The capsule dissolves after injection, leaving no odor or stains on the laundry.
Influence on the ability to drive vehicles and complex mechanisms
Lactozhinal does not affect the patient's ability to concentrate and the speed of her psychomotor reactions, which are necessary to perform potentially hazardous activities, including driving vehicles and complex mechanisms.
Application during pregnancy and lactation
Lactozhinal capsules are allowed to be used at any stage of pregnancy and during breastfeeding.
Pediatric use
Lactozhinal vaginal capsules are not prescribed for girls under 18 years old.
Drug interactions
No clinically significant interactions have been reported.
Combined use with drugs with immunomodulatory, antiviral and antibacterial action is possible.
Combined use with spermicidal agents is not recommended.
When using the above drugs or other drugs (including over-the-counter), before using Lactozhinal capsules, you must consult a doctor.
Analogs
Lactozhinal's analogues are: Lactonorm, Atsilakt, Lactobacterin, VAGIFLOR.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Laktozhinal
According to reviews, Laktozhinal, when used with contraindications, is an effective drug. However, many indicate the development of side reactions, manifested as burning, itching and increased discharge. Most of those who left reviews about the drug also note its high cost.
Price for Lactoginal in pharmacies
The approximate price for Lactozhinal vaginal capsules, 100 million CFU, per pack containing 14 pcs. Is 850-870 rubles.
Lactozhinal: prices in online pharmacies
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Drug name Price Pharmacy |
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Lactozhinal 100 million CFU vaginal capsules 14 pcs. RUB 816 Buy |
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Lactozhinal capsules vaginal. 14 pcs. 842 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
