Duzofarm
Duzofarm: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Dusopharm
ATX code: C04AX21
Active ingredient: Naftidrofuril (Naftidrofuryl)
Producer: ESCO PHARMA LLC (Russia)
Description and photo update: 2018-27-07
Prices in pharmacies: from 284 rubles.
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Duzopharm is a vasodilating agent.
Release form and composition
Dosage form - film-coated tablets: round, biconvex, orange (10 pcs. In blisters, in a carton box of 3, 6 or 9 blisters).
Composition of 1 tablet:
- active substance: naftidrofuryl oxalate - 50 mg;
- auxiliary components: sodium glycolate starch (type A), copovidone, microcrystalline cellulose, lactose monohydrate, wheat starch, magnesium stearate, colloidal silicon dioxide, crospovidone, talc;
- shell composition: methacrylic acid and ethyl acrylate copolymer, talc, titanium dioxide, macrogol 6000, dibutyl phthalate, sunset yellow dye E110.
Pharmacological properties
Pharmacodynamics
Naphtidrofuril oxalate is a substance that has a vasodilating effect and, as a result, improves cerebral and peripheral circulation.
The drug reduces peripheral vascular resistance and increases cardiac output. However, it does not significantly affect blood pressure and heart rate.
Naphtidrofuril has a vasodilating effect, which is the result of its selective action on 5HT2 receptors of the smooth muscle layer of blood vessels and platelets. Due to vasodilation, there is an improvement in microcirculation in the brain, retina and peripheral tissues.
Also, the drug has an M-anticholinergic effect. Under conditions of ischemia, it causes a decrease in anaerobic metabolism, as a result of which the lactate pyruvate coefficient decreases and the concentration of adenosine triphosphate increases, and the resistance of cells (including the brain) to hypoxia increases.
Duzopharm helps to normalize sleep, reduces episodes of headache and dizziness, improves cognitive function of the brain, as well as blood rheology by increasing the elastic properties of erythrocytes and inhibiting platelet aggregation.
Pharmacokinetics
After oral administration, naftidrofuril is almost completely absorbed from the gastrointestinal tract. Food has virtually no effect on its absorption.
After taking a single dose of 100 mg, the maximum plasma concentration is 0.175 mg / ml and is observed after 45-60 minutes. 24 hours after administration, the concentration in the brain tissues is 3 times higher than in the plasma.
The substance undergoes hepatic recirculation, which is why it is in the plasma for a longer time. The connection with blood proteins is about 80%. Penetrates the blood-brain barrier. There are no data on the penetration of naftidrofuril through the placenta and into breast milk.
The drug is metabolized mainly in the liver by hydrolysis, which is carried out by plasma esterases, with the formation of metabolites, the main studied of which are nafroic acid and diethylaminoethanol. The latter has a stimulating effect on the central nervous system.
It is excreted from the body mainly through the intestines, in small quantities - by the kidneys.
The half-life after taking a single dose of 100 mg is 1–2 hours, after a dose of 200 mg - 3.5 hours.
There are no data on changes in the rate of elimination of naftidrofuril in case of impaired renal or liver function.
Age has no effect on the pharmacokinetic parameters of the drug.
Indications for use
- peripheral circulatory disorders: leg pain at rest, calf muscle cramps, acrocyanosis, paresthesia, intermittent claudication syndrome, Raynaud's syndrome and disease;
- violation of cerebral circulation due to cerebral vascular insufficiency and atherosclerotic lesions of the cerebral vessels, especially in elderly patients;
- trophic disorders: diabetic retinopathy, long-term non-healing ulcers.
Contraindications
Absolute:
- tachyarrhythmias;
- arterial hypotension;
- acute stage of myocardial infarction;
- chronic heart failure stage II – III (III – IV in accordance with the functional classification of heart failure of the New York Heart Association NYHA);
- increased convulsive readiness;
- epilepsy;
- acute stage of hemorrhagic stroke;
- lactase deficiency, galactosemia, glucose-galactose malabsorption syndrome;
- age up to 18 years;
- individual intolerance to the drug.
Relative: prostatic hyperplasia, angle-closure glaucoma.
Instructions for use of Duzofarm: method and dosage
Duzopharm tablets are indicated for oral use: they must be swallowed whole with plenty of water (at least 1 glass).
For disorders of cerebral circulation, the recommended daily dose is 300-600 mg in 3 divided doses.
For peripheral circulatory disorders, 200 mg is prescribed 2-3 times a day.
Long-term treatment. The duration is determined individually, depending on the individual clinical situation.
No dose adjustment is required for hepatic or renal impairment.
Side effects
When taken in a daily dose of up to 600 mg, Duzopharm is generally well tolerated.
Possible side effects:
- headache, sleep disturbances, dizziness;
- decreased appetite, diarrhea, pain in the epigastric region, ulcers of the gastric mucosa, intestinal colic, nausea, vomiting, a reversible increase in the activity of liver enzymes;
- allergic reactions.
Overdose
In case of an overdose, it is possible to increase the severity of side effects, the appearance of anxiety, the development of bradycardia and ventricular arrhythmias, and a decrease in blood pressure.
There is no specific antidote. Overdose treatment methods include gastric lavage, intake of activated charcoal and laxatives, and symptomatic therapy.
special instructions
At the beginning of treatment, patients should be closely monitored to control the reactions of individual drug tolerance. It is also necessary to monitor blood pressure in patients with a tendency to hypotension.
Patients with celiac disease (gluten enteropathy) should take into account that the drug contains wheat starch.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Duzofarm does not adversely affect psychophysical reactions and the ability to drive vehicles.
Application during pregnancy and lactation
Duzopharm does not have a teratogenic effect, however, special studies on the safety of its use in pregnant women have not been conducted. In this regard, the drug can be prescribed only in cases where the expected benefit outweighs the potential risks.
It is not recommended to use the drug during breastfeeding.
Pediatric use
Due to the lack of data on the safety and effectiveness of Duzofarm tablets are not used to treat patients under the age of 18 years.
Drug interactions
Naphtidrofuril enhances the antihypertensive effect of antihypertensive drugs. If necessary, their simultaneous use should be monitored more often blood pressure, especially at the beginning of treatment.
Analogs
An analogue of Duzofarm is Enelbin 100 retard.
Terms and conditions of storage
Keep out of the reach of children, protected from light, in a dry place at temperatures up to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Duzofarm
Reviews about Duzofarm are mostly positive. Patients report a significant improvement in their condition. With diabetic retinopathy, swelling and pain are reduced. Stroke patients write that the drug helps to restore lost functions, improves memory and sleep, eliminates dizziness and headaches. Patients note the convenience of taking pills - without reference to meals.
However, there are also neutral reviews, in which patients confirm the effectiveness of Duzofarm, but complain about the development of side effects, more often in the form of nausea and decreased appetite.
Price for Duzopharm in pharmacies
The price for Duzopharm, depending on the number of tablets in the package:
- No. 30 - from 380 to 500 rubles;
- No. 60 - from 635 to 850 rubles;
- No. 90 - from 835 to 1040 rubles.
Duzopharm: prices in online pharmacies
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Drug name Price Pharmacy |
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Duzopharm 50 mg film-coated tablets 60 pcs. 284 r Buy |
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Duzopharm 50 mg film-coated tablets 30 pcs. 365 RUB Buy |
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Duzopharm tablets p.p. 50mg 30 Pcs. 449 r Buy |
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Duzopharm tablets p.p. 50mg 60 Pcs. 717 RUB Buy |
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Duzopharm 50 mg film-coated tablets 90 pcs. RUB 781 Buy |
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Duzopharm tablets p.p. 50mg 90 Pcs. 805 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
