Drastop
Drastop: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Drastop
ATX code: M01AX25
Active ingredient: Chondroitin sulfate (Chondroitin sulfate)
Manufacturer: CO Rompharm Company SRL (Romania)
Description and photo update: 18.10.2018
Prices in pharmacies: from 690 rubles.
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Drastop is a drug that stimulates tissue repair.
Release form and composition
The drug is produced in the form of a solution for intramuscular administration of 100 mg / ml: transparent, has a yellowish color (2 ml in an ampoule made of transparent colorless glass with a white break ring, 5 ampoules in a blister strip, 1 or 2 packages in a cardboard box together with instructions for use).
1 ml of solution contains:
- active substance: chondroitin sodium sulfate - 100 mg;
- auxiliary substances: benzyl alcohol - 12 mg, sodium hydroxide solution 1% or 0.1 M hydrochloric acid solution - up to pH 6.5–6.8, water for injection - up to 1 ml.
Pharmacological properties
Pharmacodynamics
The drug has a regenerating, chondrostimulating, anti-inflammatory and analgesic effect. Strengthens metabolic processes in fibrous and hyaline cartilage, subchondral bone, has chondroprotective properties. Chondroitin sulfate takes part in the construction of the basic substance of bone and cartilage tissue, inhibits enzymes that destroy articular cartilage, and stimulates the production of proteoglycans by chondrocytes. It slows down bone resorption and also reduces calcium loss. Increases the rate of bone tissue repair processes, suppresses the secretion of prostaglandins and leukotrienes, reduces the release of inflammatory mediators and pain factors into the synovial fluid, reduces the rate of progression of osteochondrosis, as well as osteoporosis. Chondroitin sulfate prevents connective tissue collapse,normalizes the production of joint fluid, and also helps to restore the cartilaginous surfaces of the joints and the joint capsule.
In cases where degenerative diseases of the joints are treated, accompanied by secondary synovitis, the effect of the treatment is visible already after 2-3 weeks from the beginning of the use of chondroitin sulfate.
While taking the drug, as well as for a long time after the end of therapy, there is a decrease in pain and an increase in the mobility of the affected joints.
The drug has a structural similarity to heparin, due to which it can prevent the formation of fibrin thrombi in the subchondral microvasculature.
Pharmacokinetics
The active substance of the drug is rapidly absorbed after intramuscular administration. After 30 minutes, it is found in the blood in high concentrations, after an hour, the maximum concentration of chondroitin sodium sulfate is reached in the plasma, after which it gradually decreases within 2 days.
The drug easily penetrates through the synovium into the joint cavity. It accumulates mainly in the cartilage that forms the joints. Chondroitin sulfate is found in synovial fluid 15 minutes after intramuscular injection, then it penetrates into the articular cartilage, where its maximum concentration is reached 48 hours after injection.
Indications for use
Diseases of the joints and spine of a degenerative nature, such as:
- intervertebral osteochondrosis and osteoarthritis;
- osteoarthritis of the peripheral joints.
Contraindications
- thrombophlebitis;
- tendency to bleeding, bleeding;
- hypersensitivity to any component of the drug;
- pregnancy and lactation;
- childhood.
Instructions for the use of Drastop: method and dosage
At the beginning of therapy, Drastop is prescribed 1 ml intramuscularly, every other day. Starting from the fourth injection, subject to good tolerance, the dose is increased to 2 ml. The course of treatment is 25-30 injections (Drastop injections). A repeated course of treatment is carried out as needed, but not earlier than 6 months later.
Side effects
- pain and hemorrhage at the injection site;
- allergic reactions (pruritus, urticaria, erythema, dermatitis);
- dyspepsia;
- angioedema.
Overdose
Overdose is unlikely and has not been reported.
special instructions
The course of the drug, at which a stable clinical effect is achieved, is at least 25 injections. After the end of the course, the effect lasts for several months. Repeated courses are used to prevent exacerbation of the disease.
If allergic reactions or hemorrhages occur during drug therapy, treatment must be interrupted.
Influence on the ability to drive vehicles and complex mechanisms
The drug does not affect the ability to drive vehicles and engage in potentially hazardous activities.
Application during pregnancy and lactation
According to the instructions, Drastop is contraindicated for use during pregnancy.
If necessary, drug treatment during lactation should stop breastfeeding due to the lack of data on the safety of use in this group of patients.
Pediatric use
Drastop injections should not be given to children due to the fact that there is no data on the safety of the drug in patients of this age group.
Drug interactions
With the combined use of indirect anticoagulants, fibrinolytics and antiplatelet agents, careful monitoring of blood clotting indicators is required (due to the possible increase in their action).
Analogs
Drastop's analogs are: Artogistan, Artra Chondroitin, Artravir-Inkampharm, Artradol, Artrafik, Mucosat, Chondrogard, Chondroitin-AKOS, Chondroitin sulfate, Chondroxide, Chondroxide Forte, Chondrolon.
Terms and conditions of storage
The drug is valid for 3 years from the date of issue.
Keep out of the reach of children, at a temperature not exceeding 25 ° C.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Drastop
There are no reviews about Drastop.
Price for Drastop in pharmacies
The price for Drastop in pharmacies is on average 1050 rubles (10 ampoules per pack).
Drastop: prices in online pharmacies
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Drug name Price Pharmacy |
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Drastop 100 mg / ml solution for intramuscular injection 2 ml 10 pcs. RUB 690 Buy |
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Drastop solution for intramuscular injection 100mg / ml, 2ml amp. 10 pieces. 934 RUB Buy |
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Drastop advance tablets p.o.p 1640mg 30pcs 1042 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
