Doxycycline Solution Tablets
Doxycycline Solution Tablets: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Doxycycline Solution Tablets
ATX code: J01AA02
Active ingredient: doxycycline (Doxycycline)
Manufacturer: LLC "Ozon" (Russia)
Description and photo update: 2020-17-07
Prices in pharmacies: from 269 rubles.
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Doxycycline Solution Tablets is an antibiotic from the tetracyclines group with a broad spectrum of action.
Release form and composition
The drug is produced in the form of dispersible tablets, biconvex, oval, with a line, color from light or gray-yellow to brown-yellow with splashes (in blister strip packaging made of polyvinyl chloride film and lacquered aluminum foil, 6 or 10 pcs., In packs cardboard boxes together with instructions for use of the drug in 1-5 or 10 packs; in polypropylene or polyethylene terephthalate jars for medicines, sealed with polypropylene lids with a push-turn system or high / low pressure polyethylene lids with first opening control, 6, 10, 20, 30, 50 or 100 pcs., In a pack of cardboard 1 can and instructions for the use of Doxycycline Solution Tablets).
Composition of one dispersible tablet:
- active ingredient: doxycycline monohydrate - 104 mg (in terms of doxycycline - 100 mg);
- additional components: MCC (microcrystalline cellulose) - 96 mg; sodium saccharinate - 10 mg; magnesium stearate - 3.12 mg; milk sugar (lactose monohydrate) - 140.8 mg; low-substituted hyprolosis - 29.25 mg; hypromellose - 5.85 mg; colloidal silicon dioxide - 0.98 mg.
Pharmacological properties
Pharmacodynamics
Doxycycline is an antibiotic from the tetracyclines group with a wide spectrum of action. It has a bacteriostatic effect, helps to suppress protein synthesis in a microbial cell by interacting with the 30S ribosome subunit.
Doxycycline Solution Tablets is active against a variety of gram-negative and gram-positive bacteria: Klebsiella (Calymmatobacterium) granulomatis, Clostridium spp. (except for Clostridium difficile), Bartonella bacilliformis, Brucella spp., Campylobacter fetus, Typhus exanthematicus, Haemophilus influenzae, Ureaplasma urealyticum, Klebsiella spp., Streptococcus spp., Propionibacterium Vultococcus spp., Propionibacterium Variety acnes, Pasteurella multociri, Chlamydia spp., Enterobacter spp. (including E. aerogenes), Treponema spp., Actinomyces spp., Mycoplasma spp., Rickettsia spp., Shigella spp., Yersinia spp. (including Yersinia pestis), Bacillus anthracis, Neisseria meningitidis, Neisseria gonorrhoeae, Borrelia recurrentis, Staphylococcus spp., Fusobacterium fusiforme,some protozoa (Plasmodium falciparum, Entamoeba spp.).
Resistant to doxycycline: Enterococcus spp., Serratia spp., Acinetobacter spp., Providencia spp., Pseudomonas spp., Proteus spp.
It is important to take into account that some pathogens may have acquired resistance to doxycycline, which is most often cross-linked within the group (i.e., strains showing resistance to doxycycline will simultaneously be resistant to the entire group of tetracyclines).
Pharmacokinetics
Pharmacokinetic parameters of doxycycline:
- absorption: doxycycline is absorbed quickly and almost completely (about 100%). Food intake has little effect on the absorption of the drug. The maximum concentration (C max) of doxycycline in blood plasma is observed 2 hours after taking Doxycycline Solution Tablets at a dose of 200 mg and is 2.6–3 μg / ml; in a day, this indicator decreases to 1.5 μg / ml. After taking 200 mg of doxycycline on the first day of treatment and 100 mg per day on the following days, its C max fluctuates within 1.5-3 μg / ml;
- distribution: the connection with plasma proteins at the level of 80–90%; good penetration into tissues and organs is noted, poor penetration into the cerebrospinal fluid (from 10 to 20% of the concentration in blood plasma), but with inflammation of the spinal membrane, the concentration of doxycycline in the cerebrospinal fluid increases. The volume of distribution (V d) is equal to 1.58 l / kg. 30-45 minutes after oral administration, doxycycline in therapeutic concentrations is found in the spleen, lungs, kidneys, liver, eye tissues, prostate gland, teeth, bones, bile, exudate of the frontal and maxillary sinuses, synovial exudate, in ascitic and pleural fluids, in sulcus fluids. In the absence of violations in the liver, the content of doxycycline in bile is 5-10 times higher than its content in plasma. From 5 to 27% of the concentration of the substance in the blood plasma is found in saliva. Doxycycline accumulates in dentin and bone tissue; penetrates the placental barrier, in small quantities is secreted into breast milk;
- metabolism: doxycycline is metabolized in negligible amounts;
- excretion: after a single oral administration, the half-life (T 1/2) varies from 16 to 18 hours, after repeated doses - from 22 to 23 hours. The kidneys are excreted ~ 40% of the taken dose of the drug, intestines in the form of inactive forms (chelates) - from 20 to 40%.
Pharmacokinetics in special clinical situations:
- patients with renal dysfunction: T 1/2 of doxycycline in patients of this category does not change, since there is an increase in its excretion by the intestine. Peritoneal dialysis and hemodialysis have no effect on C max of doxycycline;
- elderly patients: there are no data on the effect of age on the pharmacokinetics of doxycycline.
Indications for use
Doxycycline Solution Tablets are used in the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to doxycycline:
- infections of ENT organs: tonsillitis, sinusitis, otitis media, etc.;
- respiratory tract infections: pleural empyema, community-acquired pneumonia, lobar pneumonia, bronchopneumonia, tracheitis, pharyngitis, lung abscess, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, etc.;
- infections of the biliary tract and gastrointestinal tract (gastrointestinal tract): travelers' diarrhea, amoebic and bacillary dysentery, cholecystitis, cholera, cholangitis, gastroenterocolitis, yersiniosis;
- infections of the skin and soft tissues: severe acne - as part of a combination therapy; wound infections after a bite of animals, etc.;
- infections of the genitourinary system: salpingo-oophoritis, endocervicitis, endometritis - as a tool in combination therapy; acute orchiepididymitis, cystitis, urethrocystitis, urogenital mycoplasmosis, pyelonephritis, urethritis, bacterial prostatitis; sexually transmitted infections - lymphogranuloma venereum, inguinal granuloma, syphilis in patients with penicillin intolerance, urogenital chlamydia, uncomplicated gonorrhea (as an alternative therapy);
- infectious eye diseases: trachoma - as a remedy in combination therapy;
- other diseases: subacute septic endocarditis, sepsis, peritonitis; whooping cough, osteomyelitis, brucellosis; bartonellosis, leptospirosis, granulocytic ehrlichiosis, ornithosis, psittacosis, anthrax (including the pulmonary form); malaria, plague, typhoid fever (including tick-borne recurrent and typhus), chlamydia of various localization (including proctitis and prostatitis), yaws, actinomycosis, legionellosis, tularemia, rickettsiosis, Lyme disease, Q fever, Rocky Mountain spotted fever.
In addition, Doxycycline Solution Tablets are prescribed for the prevention of postoperative purulent complications; for Plasmodium falciparum malaria, when traveling for less than 4 months (short-term travel) in an area where strains resistant to pyrimethamine sulfadoxine and / or chloroquine are common.
Contraindications
- severe renal and / or liver dysfunction;
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
- porphyria;
- children under 8 years old;
- gestation period;
- lactation period (breastfeeding);
- hypersensitivity to the active substance of the drug - doxycycline, other tetracyclines or auxiliary components in the composition of Doxycycline Solution Tablets.
Doxycycline Solution Tablets, instructions for use: method and dosage
Dispersible tablets Doxycycline Solution Tablets are intended for oral administration. They can be dissolved in a small amount of water (about 20 ml) to obtain a suspension, swallowed whole or divided into parts, or chewed with water. The preferred time to take the drug is with meals. Taking the tablets is recommended while sitting or standing, which can reduce the likelihood of developing an esophageal ulcer or esophagitis. Doxycycline Solution Tablets should not be taken immediately before bedtime.
The duration of treatment is usually 5-10 days. In the case of an infection caused by Streptococcus pyogenes, the duration of therapy should not be less than 10 days.
Recommended dosage regimen:
- adults and children over 8 years old with a body weight of more than 50 kg: 200 mg for 1-2 doses on the first day of treatment, then 100 mg of doxycycline daily. If the infectious disease is severe, Doxycycline Solution Tablets are taken in a dose of 200 mg daily throughout the course of treatment;
- children aged 8 to 12 years with a body weight of less than 50 kg: the average daily dose is 4 mg / kg on the first day, then - 2 mg / kg per day (for 1-2 doses). If the infectious disease is severe, the drug is taken at a dose of 4 mg / kg daily throughout the course of treatment.
Dosing features of Doxycycline Solution Tablets for certain diseases:
- uncomplicated gonorrhea (with the exception of anorectal infections in men): adults - 100 mg 2 times a day until complete cure (on average, the antibiotic is continued for 1 week), or 600 mg of doxycycline is taken within one day - 300 mg in 2 reception (second reception 1 hour after the first);
- uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealyticum: 100 mg 2 times a day for 1 week;
- syphilis: primary - 100 mg 2 times a day for 2 weeks, secondary - 100 mg 2 times a day for 4 weeks;
- acne: 100 mg once a day for 6-12 weeks;
- leptospirosis: treatment - 100 mg 2 times a day for 1 week; for prophylactic purposes - 200 mg 1 time in 7 days during the entire stay in a disadvantaged area and 200 mg - at the end of the trip;
- malaria (for prophylactic purposes): 100 mg once a day two days before the trip, then daily during the trip and for 4 weeks after returning; the dose for children over 8 years old is 2 mg / kg once a day;
- diarrhea of travelers (for preventive purposes): 200 mg on the first day of the trip in 1-2 doses, then 100 mg once a day during the entire stay in the region (but not more than 21 days);
- medical abortion (for the prevention of infections): 100 mg of doxycycline 1 hour before and 200 mg after the intervention.
The maximum daily dose of Doxycycline Solution Tablets for adults should not exceed 300 mg per day; for severe gonococcal infections, 600 mg per day for 5 days.
The maximum daily dose for children is: at the age of 8 years with a body weight of more than 50 kg - up to 200 mg, at the age of 8 to 12 years with a body weight of less than 50 kg - 4 mg / kg daily throughout the course of therapy.
Patients with hepatic and / or renal insufficiency (with creatinine clearance less than 60 ml / min) Doxycycline Solution Tablets are prescribed in reduced daily doses, since due to the presence of these pathologies, there is a gradual accumulation of doxycycline in the body, which increases the risk of hepatotoxic action …
Side effects
- central nervous system: vestibular disorders (instability or dizziness), benign increase in intracranial pressure (tinnitus, headache, optic nerve edema, tremor, vomiting, anorexia), double vision, blurred vision, hallucinations, scotoma;
- digestive tract: nausea, vomiting, anorexia, esophageal ulcer, esophagitis, anal itching, diarrhea, dysphagia, staining of the tongue in a dark color. With prolonged use of Doxycycline Solution Tablets, due to the suppression of the growth of vitamin B-producing bacteria in the normal intestinal microflora, a deficiency of B vitamins is possible;
- hematopoietic system: decreased prothrombin activity, neutropenia, thrombocytopenia, eosinophilia, hemolytic anemia;
- heart and blood vessels: tachycardia, decreased blood pressure, pericarditis;
- kidneys: aggravation of azotemia in patients with impaired renal function, an increase in the concentration of residual urea nitrogen due to the antianabolic effect of Doxycycline Solution Tablets. Patients who consume products that contain citric acid may experience symptoms similar to Fanconi's syndrome while taking doxycycline, namely: hypokalemia, glucosuria, renal tubular acidosis, albuminuria and hypophosphatemia;
- hepatobiliary system: cholestasis, liver damage, in some cases associated with pancreatitis (with prolonged use by patients with impaired renal / liver function);
- thyroid gland: reversible staining of thyroid tissue in a dark brown color is possible in patients who receive antibiotics from the tetracycline group for a long time. In most cases, this effect does not affect the function of the thyroid gland;
- skin integuments: Shenlein-Henoch purpura, erythematous and maculopapular rash, urticaria, photoonycholysis, photosensitivity, exfoliative dermatitis, anaphylactic reactions, angioedema;
- musculoskeletal system: myalgia, arthralgia;
- bones and teeth: therapy with doxycycline helps to slow down osteogenesis, in children there is a violation of the normal development of teeth (hypoplasia of the enamel develops, the color of the teeth changes irreversibly);
- allergic reactions: Stevens-Johnson syndrome, exacerbation of systemic lupus erythematosus, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS syndrome), a syndrome similar to serum sickness;
- others: pseudomembranous colitis, vaginitis, candidiasis, anogenital candidiasis, glossitis, stomatitis, staphylococcal enterocolitis.
Overdose
Symptoms of an overdose of Doxycycline Solution Tablets: increased dose-dependent side reactions caused by liver damage (increased prothrombin time, increased transaminase activity, azotemia, jaundice, fever, vomiting).
Treatment: after taking a large dose of doxycycline, the patient should immediately rinse the stomach and drink plenty of fluids; if necessary, artificially induce vomiting. Shows the intake of activated carbon and osmotic laxatives. Peritoneal dialysis and hemodialysis are not recommended due to their low efficiency.
special instructions
When taking doxycycline, hypersensitivity and cross-resistance with other drugs of the tetracycline series may develop.
Due to therapy with tetracyclines, an increase in prothrombin time is possible, therefore, the use of such drugs by patients with coagulopathies must be accompanied by careful medical supervision.
The concentration of residual nitrogen of urea in the blood may increase due to the anti-anabolic effect of tetracyclines. This usually does not have a significant effect on the patient, provided the kidneys are functioning normally. However, with impaired renal function, an increase in azotemia is possible. In patients of this category, the use of tetracyclines requires medical supervision.
In patients using Doxycycline Solution Tablets for a long time, you should periodically monitor the function of the kidneys and liver, laboratory blood counts.
During treatment and within 4–5 days after it, it is necessary to limit insolation due to the possible development of photodermatitis.
While taking Doxycycline Solution Tablets or 2–3 weeks after completion of therapy, diarrhea caused by Clostridium difficile may develop. If it is mild, it is enough to cancel the treatment and prescribe ion exchange resins (colestipol, colestyramine), in severe cases it is necessary to compensate for the loss of fluid, protein and electrolytes, prescribe metronidazole, vancomycin. Medicines that inhibit intestinal peristalsis are prohibited.
Long-term therapy with doxycycline can lead to the development of dysbiosis and, as a consequence, the appearance of hypovitaminosis (especially B vitamins).
To avoid the occurrence of dyspeptic phenomena, Doxycycline Solution Tablets dispersible tablets are recommended to be taken with meals.
In order to prevent the development of esophageal ulcers and esophagitis, Doxycycline Solution Tablets should be taken with plenty of water and should not be taken immediately before bedtime.
Influence on the ability to drive vehicles and complex mechanisms
There are no data on the effect of doxycycline on a person's ability to drive vehicles and complex mechanisms.
If a patient develops dizziness while taking Doxycycline Solution Tablets, blurred vision or double vision is present, driving vehicles or using complex and potentially dangerous mechanisms is not recommended.
Application during pregnancy and lactation
Doxycycline crosses the blood-placental barrier. Tetracyclines have a negative effect on the fetus (slow down osteogenesis) and on the formation of tooth enamel (cause hypoplasia, irreversibly change the color of tooth enamel). For this reason, as well as in view of the increased risk of liver damage in the mother, tetracycline drugs are not prescribed for pregnant women. The exception is when Doxycycline Solution Tablets is the only remedy for the treatment / prevention of particularly dangerous and severe infections (for example, inhalation exposure to Bacillus anthracis, Rocky Mountain spotted fever, etc.). Before prescribing doxycycline for women of childbearing age, pregnancy must be excluded.
Doxycycline passes into breast milk. Since it, like other tetracyclines, has an adverse effect, its use during breastfeeding is contraindicated. If there is an urgent need to prescribe tetracyclines to a nursing mother, breastfeeding is stopped.
Pediatric use
In pediatrics, Doxycycline Solution Tablets are not used to treat children under 8 years of age.
With impaired renal function
Severe renal dysfunction is an absolute contraindication to the use of Doxycycline Solution Tablets.
For patients with renal failure (with creatinine clearance less than 60 ml / min), the drug is prescribed in reduced daily doses in order to avoid the gradual accumulation of doxycycline in the body and reduce the risk of hepatotoxic action.
For violations of liver function
Severe violations of hepatic function are an absolute contraindication to the use of the drug.
For patients with hepatic insufficiency, Doxycycline Solution Tablets are prescribed in reduced daily doses in order to avoid the gradual accumulation of doxycycline in the body and to reduce the risk of hepatotoxic action.
Use in the elderly
Elderly patients use Doxycycline Solution Tablets according to the dosing regimen indicated in the instructions. There are no special recommendations for taking dispersible tablets for patients of this age category.
Drug interactions
- bactericidal antibiotics that disrupt the synthesis of the cell wall (cephalosporins, penicillins): when taken simultaneously with doxycycline, their effectiveness decreases;
- antacids containing magnesium, calcium, aluminum, iron preparations, magnesium-containing laxatives, sodium bicarbonate: when combined with these agents, the absorption of doxycycline decreases, and therefore a 3-hour interval should be maintained between taking these drugs;
- indirect anticoagulants: doxycycline suppresses the intestinal microflora, thereby reducing the prothrombin index; dose adjustment of indirect anticoagulants is required;
- barbiturates, ethanol, carbamazepine, rifampicin, phenytoin and other stimulants of microsomal oxidation: accelerate the metabolism of doxycycline, reducing its concentration in blood plasma;
- hormonal contraceptives containing estrogen: while taking doxycycline, the reliability of contraception decreases, and the frequency of acyclic bleeding increases;
- retinol: combined with doxycycline may cause an increase in intracranial pressure.
Analogs
Analogs of Doxycycline Solution Tablets are Vidoccin, Doxycycline, Xedocin, Doxycycline Express, Doxycycline Velpharm, Doxycycline-Ferein, Unidox Solutab, etc.
Terms and conditions of storage
Store in a place inaccessible to children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
The use of the drug after the expiration date indicated on the package is prohibited by the manufacturer.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Doxycycline Solution Tablets
Patients leave positive reviews about Doxycycline Solution Tablets. The drug has established itself as an effective remedy in the treatment of thrush, acne (including severe; used as part of combination therapy), many other diseases of infectious etiology. Another advantage of the drug, users consider its affordable cost.
Some patients do not like the taste of Doxycycline Solution Tablets and the presence of an impressive list of side effects. More often than others, disorders of the digestive system developed, and therefore antibiotic therapy is recommended to be accompanied by the intake of probiotics to relieve adverse events from the gastrointestinal tract.
The price of Doxycycline Solution Tablets in pharmacies
The price of Doxycycline Solution Tablets, dispersible tablets, 100 mg, is 253–267 rubles. per package containing 10 pcs.
Doxycycline Solution Tablets: prices in online pharmacies
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Drug name Price Pharmacy |
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Doxycycline solution tablets dispersible tablets 100mg 10pcs 269 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
