Diclofenac-Teva
Diclofenac-Teva: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Diclofenac-Teva
ATX code: M01AB05
Active ingredient: diclofenac (diclofenac)
Manufacturer: MERCKLE, GmbH (Germany)
Description and photo updated: 20.11.2018
Prices in pharmacies: from 120 rubles.
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Diclofenac-Teva is a non-steroidal anti-inflammatory drug for external use with an analgesic effect.
Release form and composition
The dosage form of the drug Diclofenac-Teva is a gel for external use 1%: colorless, transparent, with a specific odor (in an aluminum tube 40 or 100 g, in a cardboard box 1 tube).
100 g of gel contains:
- active substance: diclofenac sodium - 1 g;
- auxiliary components: diisopropyl adipate, lactic acid 90%, hyprolose, sodium disulfite, isopropanol, purified water.
Pharmacological properties
Pharmacodynamics
The active component of the gel, diclofenac sodium, belongs to the group of non-steroidal anti-inflammatory drugs. It has a pronounced analgesic and antipyretic effect. The mechanism of action of the substance is to block the enzyme cyclooxygenase and disrupt the biosynthesis of prostaglandins, which play an important role in the spread of pain, inflammation and fever.
Diclofenac reduces the severity of pain symptoms of rheumatic or traumatic origin, helps to eliminate edema associated with inflammatory processes, thereby increasing joint mobility and the activity of muscles and ligaments.
Pharmacokinetics
The degree of absorption of diclofenac sodium through the skin is influenced by the total dose of the applied drug and the degree of skin hydration. The amount of absorbed substance is in direct proportion to the area of the treated area. When measuring the concentration of diclofenac in blood plasma, synovial membrane and synovial fluid when applying the gel to the affected joint, it was determined that the maximum plasma content was about 100 times less than after oral administration of the same dose of diclofenac. 99.7% of the active substance binds to blood plasma proteins, of which 99.4% - with albumin. Diclofenac sodium is predominantly distributed and concentrated in the deep layers of tissues that are prone to inflammation. For example, the level of its content in joints is 20 times higher than in blood plasma.
In the process of metabolism, the glucuronization of the unchanged diclofenac molecule partially occurs, but a significant part of the substance undergoes single and multiple hydroxylation to form several phenolic metabolites, which are mostly converted into glucuronide conjugates. Two of these metabolites have pharmacological activity, but significantly less than diclofenac.
The final T 1/2 (half-life) of the active substance is 1–2 hours. T 1/2 of metabolites (including two biologically active metabolites) is in the range from 1 to 3 hours. Diclofenac and its metabolites are excreted mainly in the urine.
Indications for use
- joint pain (knee joints, finger joints and others) with osteoarthritis, rheumatoid arthritis;
- pain in the back in degenerative and inflammatory diseases of the spine (including sciatica, sciatica, lumbago, osteoarthritis);
- muscle pain (as a result of sprains, bruises, strains, injuries);
- swelling and inflammation of soft tissues and joints in rheumatic diseases (including tendovaginitis, wrist syndrome, lesions of periarticular tissues, bursitis) and due to trauma.
Contraindications
Absolute:
- a tendency to develop skin rashes, attacks of bronchial asthma or acute rhinitis when using acetylsalicylic acid or other non-steroidal anti-inflammatory drugs;
- III trimester of pregnancy, lactation period;
- age up to 12 years;
- ulcers, cracks and other violations of the integrity of the skin at the site of the intended application of the gel;
- increased individual sensitivity to diclofenac or any of the excipients of the drug.
Relative (the use of Diclofenac-Teva gel requires caution):
- erosive and ulcerative lesions of the gastrointestinal tract;
- severe renal and / or liver dysfunction;
- acute hepatic porphyrias;
- bleeding disorders (including hemophilia, bleeding tendency, prolonged bleeding time);
- bronchial asthma;
- chronic heart failure;
- I and II trimesters of pregnancy;
- elderly age.
Instructions for use of Diclofenac-Teva: method and dosage
Diclofenac-Teva gel is applied externally. Adults and children over 12 years of age are recommended to apply the drug to the skin surface 2 times a day (preferably in the morning and evening with an interval of 12 hours), gently rubbing it into the skin.
The required amount of gel depends on the area of the painful area. A single dose is 2–4 g (by volume it roughly corresponds to the size of a cherry or a walnut, respectively), which is sufficient for application to an area of 400–800 cm 2. The duration of therapy is determined by the indications and the observed effect. In the case of post-traumatic inflammation and rheumatic diseases of soft tissues, it is not recommended to use Diclofenac-Teva without the recommendation of a specialist for more than two weeks. If, after 1 week of using the drug, the therapeutic effect is insufficient or worsening of the condition is observed, you should consult a doctor.
After applying the gel, you should thoroughly wash your hands (if the skin of your hands is not the treatment area).
Side effects
The incidence of adverse reactions is assessed on a special scale: often - more than 1%, but less than 10%; rarely - more than 0.01%, but less than 0.1%; extremely rare - less than 0.01%, including individual messages.
Possible side effects of Diclofenac-Teva on the part of systems and organs:
- immune system: extremely rarely - generalized skin rash, allergic reactions (including hypersensitivity, urticaria, angioedema);
- skin: often - dermatitis, including contact dermatitis (with symptoms of eczema, itching, swelling of the treated area, rash, papules, vesicles, peeling), erythema; rarely, bullous dermatitis; extremely rarely - photosensitization reactions, pustular rashes (with infectious and parasitic diseases);
- respiratory system and organs of the chest and mediastinum: extremely rare - bronchospastic reactions, attacks of suffocation.
Overdose
Since Diclofenac-Teva has a low systemic absorption, overdose is unlikely. In case of unintentional ingestion of the drug, systemic side reactions may develop. Treatment for accidental ingestion consists of gastric lavage, induction of vomiting, intake of activated charcoal, and symptomatic therapy. Forced diuresis and dialysis are ineffective due to the intense binding of diclofenac to blood plasma proteins.
special instructions
It is necessary to avoid getting Diclofenac-Teva gel on open wounds; it should be applied only to intact skin.
A bandage can be applied to the treated area, but occlusive airtight dressings are not recommended.
Do not allow the drug to come into contact with mucous membranes, eyes and mouth.
If skin rash appears after applying the gel, the use of Diclofenac-Teva should be discontinued.
Application during pregnancy and lactation
Since there is no data on the safety of using diclofenac in pregnant women, the drug should be used in the first and second trimesters of pregnancy only as directed by a doctor and when the expected benefit to the mother is higher than the potential risk to the fetus. In the third trimester of pregnancy, Diclofenac-Teva is contraindicated due to a possible decrease in uterine tone and premature closure of the fetal ductus arteriosus.
Since there is no information on the penetration of diclofenac into breast milk, it is not recommended to use the drug during breastfeeding. If it is absolutely necessary to use Diclofenac-Teva during lactation, do not apply it to the mammary glands, to the damaged surface of the skin, and also to use it for a long time.
Pediatric use
According to the instructions, Diclofenac-Teva is contraindicated in children under 12 years of age.
With impaired renal function
Patients with severe renal impairment should use the drug with caution.
For violations of liver function
In severe liver dysfunctions, as well as in acute hepatic porphyrias, the use of Diclofenac-Teva gel requires caution.
Use in the elderly
Elderly patients should be careful when using the drug.
Drug interactions
Diclofenac, when used simultaneously, can lead to an increase in the action of drugs that can cause photosensitization. No clinically significant interaction of diclofenac with other drugs was observed.
Analogs
Diclofenac-Teva analogues are: Voltaren Emulgel, Diklak, Diklak Lipogel, Diklovit, Diclogen, Dicloran, Diclofenac, Ortofen and others.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life - 4 years, after opening the tube - 1 year.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Diclofenac-Teva
In reviews of Diclofenac-Teva, users write that the gel quickly and reliably relieves pain in sciatica, joint and muscle pain. Due to its effective action, as well as its low cost and ease of use, the drug is present in many a home medicine cabinet.
The price of Diclofenac-Teva in pharmacies
The price for Diclofenac-Teva for a 40 g tube is approximately 150-200 rubles.
Diclofenac-Teva: prices in online pharmacies
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Drug name Price Pharmacy |
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Diclofenac-Teva 1% gel for external use 40 g 1 pc. 120 RUB Buy |
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Diclofenac-Teva 1% gel for external use 100 g 1 pc. 256 RUB Buy |
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Diclofenac-Teva gel for outside. approx. 1% tube 100g 301 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
