Grippol Plus - Instructions, Use For Children, Reviews Of The Vaccine, Price

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Grippol plus

Grippol plus: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Grippol Plus

ATX code: J07BB02

Active ingredient: vaccine influenza virus inactivated + azoximer bromide for the prevention of influenza

Producer: Nearmedic Plus LLC (Russia), Oxygen Plus LLC (Russia), JV Novofarma Plus LLC (Uzbekistan)

Description and photo update: 2018-04-07

Grippol plus is a trivalent inactivated polymer-subunit influenza vaccine.

Release form and composition

Dosage form of Grippol plus - suspension for intramuscular (i / m) and subcutaneous administration: colorless or yellowish, slightly opalescent liquid (0.5 ml in a disposable syringe or ampoule / vial; 1, 5 or 10 syringes, or 5 ampoules / vials in a blister; in a cardboard box: 1 or 2 blister packs, 5 or 10 ampoules / vials without blister packaging).

Composition for 0.5 ml of suspension:

• active substances: antigen of the influenza virus type A (H ₁ N ₁) with a hemagglutinin content - 5 μg; antigen of influenza virus type A (H ₃ N ₂) with a hemagglutinin content - 5 μg; antigen of the influenza virus type B with a hemagglutinin content - 5 μg; polyoxidonium - 500 mcg;
• auxiliary components: phosphate-saline buffer solution.

The drug contains strains of influenza virus antigens - in accordance with the recommendations of the World Health Organization (WHO) for the current epidemic season.

Pharmacological properties

Pharmacodynamics

Grippol plus is a flu vaccine containing an immunostimulant, due to which the dosage of antibodies in its composition is reduced.

Under the influence of the drug, within 7-12 days after the injection, persistent immunity to influenza A and B develops, which persists later throughout the year. In 75–95% of patients after vaccination, protective antibody titers were found in the blood.

Polyoxidonium has an immunomodulatory and detoxifying effect. Its action is due to the activation of phagocytes and T-killers, which are an important component of cellular immunity. In addition, polyoxidonium increases the resistance of cell membranes to the effects of various drugs, thereby reducing their toxicity.

Grippol plus does not contain preservatives.

Indications for use

Grippol plus is indicated as a specific prophylaxis against influenza in children over 6 months of age and in adults.

Vaccination is especially indicated for the following groups:

1. Patients at high risk of complications in case of influenza: children of preschool and school age; patients with anemia, a tendency to allergic reactions, bronchial asthma, chronic kidney disease, a tendency to frequent acute respiratory viral infections (ARVI) and colds, chronic diseases of the central nervous system (CNS), diseases of the bronchopulmonary or cardiovascular system, diabetes mellitus, metabolic pathologies; HIV-infected and patients with congenital / acquired immunodeficiency; elderly patients over 60 years old.
2. Persons who often communicate with people by the nature of their professional activities: medical workers, social workers, educational institutions, trade, transport, police, military personnel, etc.

Contraindications

• ARVI (including mild);
• acute intestinal diseases;
• acute febrile conditions;
• exacerbation of a chronic disease;
• history of allergic reactions to influenza vaccine;
• an allergic reaction to chicken protein or vaccine components.

In case of diseases and their exacerbation, vaccination is allowed after recovery or during a period of remission.

Instructions for the use of Grippol plus: method and dosage

Vaccination is recommended to be carried out annually in the autumn-winter period, or during a period of increased morbidity.

The suspension is injected deeply subcutaneously, or intramuscularly into the deltoid muscle (in the upper third of the outer surface of the shoulder). Grippol plus for children under 3 years old is recommended to be injected into the anterolateral surface of the thigh in / m.

Recommended dosage:

• children 6 months - 3 years old, as well as older ones, if they have not previously had the flu and have not been vaccinated: 0.25 ml, twice, with an interval of 3-4 weeks;
• children over 3 years old and adults: 0.5 ml once;
• patients with immunodeficiency, as well as patients receiving immunosuppressive therapy: 0.5 ml, twice, with an interval of 3-4 weeks.

The vaccine should be kept to room temperature before use. The syringe is thoroughly shaken, then, removing the protective cap from the needle, remove air from the syringe, holding it with the needle up. If necessary, inject 0.25 ml of the drug, remove the excess vaccine by pushing the plunger up to the mark on the syringe body or label.

The vaccination procedure should be carried out in compliance with the rules of asepsis and antiseptics. After opening the vial or ampoule, the vaccine cannot be stored.

It is forbidden to inject Grippol plus intravenously. The office where the vaccination is carried out must have anti-shock therapy. The patient must be monitored for 30 minutes after vaccination.

Side effects

Grippol plus is a highly purified vaccine and is well tolerated if the vaccination rules are followed. However, the following reactions are possible, which usually go away on their own within 1-2 days after vaccination:

• soreness, induration, swelling and redness at the injection site;
• weakness, malaise, low-grade fever;
• runny nose, sore throat, fever above subfebrile.

In rare cases, possible: neuralgia, paresthesia, neurological disorders, myalgia, allergic reactions, including immediate type.

Patients are advised to consult a doctor in case of aggravation of the described or other side effects.

Overdose

There is no evidence of an overdose of the Grippol plus vaccine.

special instructions

Immediately before vaccination, the patient must be examined by a medical specialist, with mandatory thermometry, in case of temperature rise above 37 ° C, vaccination is not carried out.

If the labeling or the integrity of the package is violated, as well as if the color or transparency of the suspension changes, the expiration date and storage conditions are violated, the use of the drug is not permissible.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Grippol plus does not affect the ability to drive vehicles and other complex mechanisms that require the speed of psychomotor reactions.

Application during pregnancy and lactation

In preclinical studies, no embryotoxic and teratogenic effects of the drug were detected. Vaccination of pregnant women is carried out only by the decision of the doctor, after a careful assessment of the benefit / risk ratio. The safest vaccination is in the II and III trimesters.

During lactation, the Grippol plus vaccine is approved for use.

Pediatric use

For children, Grippol plus is used from 6 months of age.

Drug interactions

The combined use of Grippol plus with the rabies vaccine, as well as with the BCG and BCG-M tuberculosis vaccines, is not allowed.

When used together with other vaccines, the contraindications of each should be taken into account, while the drugs should be injected into different parts of the body with different syringes.

The use of Grippol plus is allowed against the background of basic therapy of the underlying disease. In patients receiving immunosuppressive therapy, the effect of vaccination may be reduced.

Analogs

An analogue of Grippol plus is MonoGrippol et al.

Terms and conditions of storage

Store away from light, at temperatures between 2 and 8 ° C. Keep out of the reach of children. Do not freeze.

Transportation in light-tight containers is allowed at temperatures from 2 to 8 ° C, as well as at temperatures not exceeding 25 ° C, no longer than 6 hours.

Shelf life is 1 year.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Grippol plus

Reviews about Grippol plus on the network are controversial, some users note the good tolerance of the vaccine, the development of persistent immunity to SARS and influenza, while other patients report the presence of strong side reactions and no effect. Episodes of serious illness on the first day after vaccination are described.

Price for Grippol plus in pharmacies

The estimated price for Grippol plus is 235 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!