Genferon Light
Genferon Light: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Genferone Light
ATX code: L03AB05
Active ingredient: Human recombinant interferon alpha-2b (Interferon alfa-2b)
Manufacturer: CJSC "BIOCAD", RF
Description and photo update: 2018-22-10
Prices in pharmacies: from 195 rubles.
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Genferon Light is a combined drug with antiviral, immunomodulatory and antioxidant effects.
Release form and composition
Dosage form of release of Genferon Light:
- vaginal and rectal suppositories: white with a yellowish tinge or white, cylindrical with a pointed end, on a longitudinal section they have a homogeneous structure, the presence of a funnel-shaped depression or an air rod is permissible (5 pcs. in blisters, in a cardboard box 1 or 2 packages);
- nasal drops: transparent, colorless or light yellow (in 10 ml vials with / without a spray nozzle, 1 vial in a cardboard box);
- dosed nasal spray: transparent, colorless or light yellow, has no visible mechanical impurities (in dark glass vials with a spray dispenser, 100 doses each, in a cardboard box 1 vial).
Active ingredients in 1 suppository:
- interferon alpha-2b - 125 thousand or 250 thousand ME;
- taurine - 5 mg.
Auxiliary components: solid fat, macrogol 1500, dextran 60,000, polysorbate 80, emulsifier T2, citric acid, sodium hydrocitrate, purified water - in an amount sufficient to obtain a suppository weighing 800 mg.
Active ingredients in 1 ml drops:
- interferon alpha-2b - 10 thousand IU;
- taurine - 0.8 mg.
Auxiliary components: disodium edetate dihydrate - 0.02 mg; glycerol - 7 mg; dextran 35-45 thousand - 2.4 mg; polysorbate-80 - 1 mg; sodium chloride - 0.8 mg; potassium chloride - 0.02 mg; sodium hydrogen phosphate - 0.115 mg; potassium dihydrogen phosphate - 0.02 mg; water for injection - up to 1 ml.
Active ingredients in 1 spray dose:
- interferon alpha-2b - 50 thousand IU;
- taurine - 1 mg.
Auxiliary components: glycerol - 7 mg; peppermint oil - 0.01 mg; disodium edetate dihydrate - 0.02 mg; dextran 40,000 - 2.4 mg; sodium hydrogen phosphate dodecahydrate - 0.115 mg; polysorbate 80 - 1 mg; sodium chloride - 0.8 mg; potassium chloride - 0.02 mg; methyl parahydroxybenzoate - 0.02 mg; potassium dihydrogen phosphate - 0.02 mg; water for injection - in sufficient quantity.
Pharmacological properties
Pharmacodynamics
Genferon Light is a combined drug, the action of which is due to the active substances that make up its composition. Has a systemic and local effect.
Human recombinant interferon alpha-2b, which is part of Genferon Light, is produced by a strain of the bacterium Escherichia coli, into which the human interferon alpha-2b gene is genetically engineered. It has the following effects:
- antiproliferative and immunomodulatory: manifests itself primarily as an increase in the cell-mediated responses of the immune system, which leads to an increase in the effectiveness of the immune response against intracellular parasites, viruses and cells that have undergone tumor transformation. This is due to the activation of CD8 + T-killers, NK cells, increased differentiation of B-lymphocytes and the production of antibodies by them, activation of phagocytosis and the monocyte-macrophage system, as well as an increase in the expression of molecules of the main histocompatibility complex type I, which increases the likelihood of recognition of infected cells by immune cells. systems;
- antiviral: mediated by the activation of a number of intracellular enzymes that inhibit viral replication;
- antibacterial: mediated by reactions of the immune system, which are enhanced by the influence of interferon.
The second active component, taurine, is a strong antioxidant, has an immunomodulatory and membrane stabilizing effect, helps to normalize metabolic processes and tissue regeneration, preserve the biological activity of interferon, thereby enhancing the therapeutic effect of Genferon Light. Taurine directly interacts with reactive oxygen species, the excessive accumulation of which leads to the appearance of pathological processes.
Pharmacokinetics
Suppositories
- rectal administration: high bioavailability (more than 80%) of interferon. Thanks to this, a local and pronounced systemic immunomodulatory effect is achieved;
- intravaginal application: a pronounced local antiviral, antibacterial and antiproliferative effect is provided due to the high concentration of the substance in the focus of infection and its fixation on the cells of the mucous membrane. The systemic effect is insignificant, due to the low absorption capacity of the vaginal mucosa.
The maximum serum concentration of interferon in the blood is reached 5 hours after drug administration. The main route of elimination of α-interferon is renal catabolism.
The half-life is 12 hours, which necessitates the use of Genferon Light 2 times a day.
Drops, spray
Genferon Light, when applied intranasally, creates a high concentration of interferon in the focus of infection, produces a pronounced local immunostimulating and antiviral effect.
Systemic absorption is negligible; interferon, when administered intranasally in a small amount, is determined in the blood and lung tissue. Biotransformation in the body occurs mainly in the kidneys with a half-life of 5.1 hours.
A small amount of the drug, when it enters the systemic circulation, has a systemic immunomodulatory effect.
Indications for use
Suppositories
- ARVI (acute respiratory viral infections) and other infectious diseases of bacterial and viral genesis in children (as part of combined treatment);
- infectious and inflammatory diseases of the urogenital tract in women, including pregnant women, and children (against the background of specific therapy under medical supervision).
Drops and spray
Genferon Light is prescribed for influenza and ARVI to children aged 29 days to 14 years (drops), as well as children aged 14 years and older (spray) for treatment and prevention.
Contraindications
Absolute:
- I trimester of pregnancy (suppositories);
- age up to 28 days (drops) or up to 14 years (spray);
- individual intolerance to the components of the drug.
Relative (the appointment of Genferon Light requires caution in cases of the following diseases / conditions):
- exacerbation of autoimmune and allergic diseases (suppositories);
- nosebleeds (spray).
Instructions for the use of Genferon Light: method and dosage
Suppositories
The route of administration is vaginal and rectal. The regimen of drug use is determined by age and a specific clinical situation.
For children under 7 years of age, Genferon Light is prescribed with a content of 125 thousand IU of interferon alpha-2b; children from 7 years old, adults, including women at 13-40th week of pregnancy - 250 thousand IU.
The drug is used 2 times a day at intervals of 12 hours.
Recommended treatment regimen:
- acute respiratory viral infections and other acute diseases of a viral nature in children: rectally 1 suppository 2 times a day simultaneously with the main treatment for 5 days, in the absence or insufficiency of the effect, it is recommended to consult a doctor; if there is evidence, a repetition of the course is possible after 5 days;
- chronic infectious and inflammatory diseases of viral etiology in children over 7 years old: rectally 1 suppository 2 times a day simultaneously with the main treatment for 10 days; in the future, for 1–3 months, 1 suppository is prescribed every other day at night;
- acute infectious and inflammatory diseases of the urogenital tract in children: rectally 1 suppository 2 times a day for a course of 10 days simultaneously with specific therapy;
- infectious and inflammatory diseases of the urogenital tract in women: rectally or vaginally (depending on the nature of the disease), 1 suppository 2 times a day for a course of 10 days simultaneously with specific therapy; for protracted forms of the disease, the drug is used for 1-3 months every other day (3 times a week), 1 suppository per day;
- infectious and inflammatory diseases of the urogenital tract in pregnant women: vaginally 1 suppository 2 times a day for 10 days simultaneously with specific therapy.
Drops
When the first signs of the disease appear, the drug should be instilled into the nose (in each nasal passage) for 5 days.
The recommended dosage regimen of Genferon Light for children:
- from 29 days to 1 year: 5 times a day, 1 drop in each nasal passage (single dose - 1 thousand ME, daily - 5 thousand ME);
- from 1 year to 3 years: 3-4 times a day, 2 drops (single dose - 2 thousand ME, daily - 6-8 thousand ME);
- from 3 to 14 years: 4-5 times a day, 2 drops (single dose - 2 thousand ME, daily - 8-10 thousand ME).
Spray
According to the instructions, Genferon Light is applied intranasally by aerosol administration of 1 dose (1 short press on the dispenser corresponds to 1 dose). It is necessary to start using the drug at the first signs of the disease.
Recommended dosage regimen: 3 times a day, 1 dose. A single dose is 50 thousand IU of interferon alpha, the daily dose is not more than 500 thousand IU. Duration of use - 5 days.
For prophylactic purposes (in case of hypothermia or contact with a patient with acute respiratory viral infections) Genferon Light is prescribed for a course of 5-7 days, 1 dose 2 times a day. If necessary, the course can be repeated.
Side effects
Suppositories
As a rule, Genferon Light is well tolerated.
In very rare cases, allergic reactions develop. These disorders are usually reversible and disappear within 72 hours after drug withdrawal. Continuation of therapy is possible only after a medical consultation.
No serious or life-threatening adverse reactions have been reported.
Drops
During the period of use of the drug, the development of local allergic reactions (in the form of a burning sensation, itching) can be observed. These disorders are usually reversible and disappear within 72 hours after drug withdrawal. Continuation of therapy is possible only after a medical consultation.
Spray
The development of side effects when using the drug was not observed.
Overdose
Overdose cases have not been registered.
If the daily dose of suppositories is accidentally exceeded, it is necessary to suspend the administration of Genferon Light for 24 hours, after which the therapy can be resumed according to the standard scheme.
special instructions
After instillation of Genferon Light, it is recommended to massage the wings of the nose with your fingers for several minutes, which contributes to the even distribution of the drug in the nasal cavity.
Application during pregnancy and lactation
The first trimester of pregnancy is a contraindication to the use of suppositories.
Pediatric use
In the form of drops, Genferon Light is not prescribed for children under the age of 28 days, in the form of a spray - up to 14 years.
Drug interactions
Genferon Light is most effective as a component of complex therapy. When combined with antibacterial, antiviral and fungicidal drugs, a mutual enhancement of the action is observed.
The simultaneous use of Genferon Light drops with intranasal vasoconstrictor drugs is not recommended, since this can lead to additional dryness of the nasal mucosa.
Analogs
The analogues of Genferon Light are Grippferon, Nazoferon, Viferon Feron, Ruferon, Laferobion, Virogel, Laferon Farmbiotek, Alfarekin.
Terms and conditions of storage
Store in a place protected from light and moisture at a temperature of 2-8 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Drops after opening the package can be used for 7 weeks at a storage temperature of 2-8 ° C.
Terms of dispensing from pharmacies
Released:
- suppositories 125 thousand IU - without a prescription;
- suppositories 250 thousand IU, drops, spray - prescription.
Reviews about Genferon Light
According to reviews, Genferon Light is an effective drug. There are many positive responses to the spray formulation. They indicate the convenience of use and its therapeutic effect for the treatment and prevention of ARVI.
Regarding Genferon Light in the form of candles, it is noted that the drug is not always effective and can lead to the development of side effects. Also among the disadvantages are the high cost, the need to store the drug in the refrigerator and the fact that candles stain laundry and, in the absence of high body temperature, slowly dissolve.
The price of Genferon Light in pharmacies
The approximate price for Genferon Light is:
- suppositories (10 pieces in a package of 125 or 250 thousand IU): 255–330 or 340–420 rubles;
- spray (1 bottle): 320-420 rubles.
Genferon Light: prices in online pharmacies
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Drug name Price Pharmacy |
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Genferon Light 125000 IU + 5 mg vaginal and rectal suppositories 10 pcs. 195 RUB Buy |
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Genferon Light 250,000 IU + 5 mg vaginal and rectal suppositories 10 pcs. 236 r Buy |
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Genferon Light 10000 IU + 0.8 mg / ml nasal drops 10 ml 1 pc. 303 RUB Buy |
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Genferon Light gave drops. 10,000 IU / ml + 0.8mg / ml vial + nozzle-drip. 10ml 347 r Buy |
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Genferon Light spray 50,000 IU + 1 mg / dose 100 doses nasal spray dosed 1 pc. 446 r Buy |
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Genferon Light vaginal suppositories. and rectal. 250000ME + 5mg 10 pcs. 475 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
