Ganaton
Ganaton: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Use in the elderly
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Ganaton
ATX code: A03FA
Active ingredient: itopride (itopride)
Manufacturer: ABBOTT JAPAN, Co. Ltd. (Japan)
Description and photo update: 2019-19-08
Prices in pharmacies: from 315 rubles.
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Ganaton is a stimulant for the release of acetylcholine, a drug that increases motility and tone of the gastrointestinal tract (GIT).
Release form and composition
Dosage form of Ganaton - coated tablets: white, round, engraved on one side "HC 803", on the other - dividing risk (7, 10 or 14 pcs. In a blister, in a cardboard box 1, 2, 3, 4 or 5 blisters).
1 tablet contains:
- active substance: itoprid hydrochloride - 50 mg;
- auxiliary components: hypromellose, corn starch, carmellose, lactose, titanium dioxide, anhydrous silicic acid, macrogol 6000, magnesium stearate, carnauba wax.
Pharmacological properties
Pharmacodynamics
The active substance of Ganaton is itopride hydrochloride, which enhances the motility of the gastrointestinal tract due to the inhibition of acetylcholinesterase and antagonism of D 2 -dopamine receptors. Activates the release of acetylcholine and leads to its destruction.
Also, the substance has an antiemetic effect (due to interaction with D 2 -receptors, which are located in the trigger zone), activates the propulsive motility of the stomach, causes a dose-dependent suppression of vomiting caused by apomorphine.
Due to the specific effect on the upper part of the gastrointestinal tract, transit through the stomach is accelerated and its emptying improves.
Itopride hydrochloride has no effect on serum gastrin levels.
Pharmacokinetics
The substance is absorbed in the gastrointestinal tract quickly and almost completely. Its relative bioavailability is 60%. This is mainly due to the metabolism on the first pass through the liver. Food has no effect on bioavailability.
With max (maximum plasma concentration) after taking 50 mg of itopride hydrochloride is achieved in 0.5-0.75 hours and is 0.28 μg / ml.
After repeated administration of itopride hydrochloride orally at a dose of 50-200 mg 3 times a day for 7 days, the pharmacokinetic parameters of the substance and its metabolites were linear, and the cumulation was minimal.
Plasma protein binding - 96% (mainly with albumin), binding to α 1 -acid glycoprotein - less than 15% of the total binding.
After oral administration of itopride, active tissue distribution occurs. V d (volume of distribution) is 6.1 l / kg. High concentrations of the substance are found in the liver, kidneys, small intestine, stomach and adrenal glands. Itopride passes into breast milk, penetrates into the brain and spinal cord in a minimal amount.
Active biotransformation of itopride occurs in the liver. Three metabolites have been identified, one of them exhibits insignificant activity, which has no pharmacological significance (about 2-3% of that of itopride). The primary metabolite is an N-oxide formed by oxidation of the quaternary amino-N-dimethyl group.
Metabolism occurs under the action of flavin-dependent monooxygenase (FMO3). Depending on the genetic polymorphism, the effectiveness and number of FMO isoenzymes may differ. Rarely, an autosomal recessive condition known as trimethylaminuria (fish odor syndrome) has developed. The half-life of itopride increases in patients with trimethylaminuria.
Itopride has no inhibitory or inducing effect on CYP2C19 and CYP2E1. Therapy with itopride does not affect the activity of uridine diphosphate glucuronisyltransferase or CYP.
Excretion of itopride hydrochloride and its metabolites occurs mainly in the urine. After a single dose of Ganaton in therapeutic doses, the renal excretion of itopride and its N-oxide in healthy people is 3.7 and 75.4%, respectively. The terminal half-life of itopride hydrochloride is approximately 6 hours.
Indications for use
According to the instructions, Ganaton is indicated for the treatment of gastrointestinal symptoms caused by delayed gastric motility and chronic gastritis (functional non-ulcer dyspepsia): rapid satiety, nausea and vomiting, a feeling of fullness in the stomach after eating, bloating, discomfort or pain in the epigastric region, heartburn, anorexia.
Contraindications
- gastrointestinal bleeding;
- perforation or mechanical obstruction of the gastrointestinal tract;
- age under 16;
- the period of pregnancy and breastfeeding;
- individual intolerance to the components of the drug.
With caution, Ganaton should be prescribed with concomitant therapy with other drugs, in elderly patients, in patients in whom the appearance of cholinergic side reactions may negatively affect the course of the underlying disease.
Instructions for the use of Ganaton: method and dosage
Ganaton tablets are taken orally before meals.
The dose of the drug is prescribed taking into account the clinical indications and the patient's age.
Recommended dosage: 1 pc. 3 times a day. The duration of treatment is no more than 2 months.
The daily dose of Ganaton should not exceed 150 mg (3 tablets).
Side effects
- from the digestive system: abdominal pain, nausea, diarrhea, constipation, increased salivation, jaundice;
- on the part of the blood and lymphatic system: thrombocytopenia, leukopenia;
- endocrine disorders: gynecomastia, increased prolactin content;
- from the nervous system: headache, dizziness, tremor;
- allergic reactions: itching, rash, skin flushing, anaphylaxis;
- laboratory parameters: an increase in the level of bilirubin concentration, the activity of gamma-glutamyl transpeptidase, aspartate aminotransferase (ACT), alanine aminotransferase (ALT), alkaline phosphatase.
Overdose
There is no evidence of an overdose.
In case of an overdose, gastric lavage is indicated, symptomatic treatment is performed.
special instructions
In elderly patients, the use of the drug may cause a decrease in liver and / or kidney function.
Against the background of the use of Ganaton, acetylcholine enhances its effect, increasing the risk of developing cholinergic side reactions.
Since the action of the drug can cause dizziness, care should be taken when driving vehicles and mechanisms.
Application during pregnancy and lactation
Ganaton is not prescribed during pregnancy / lactation.
Pediatric use
Ganaton therapy is contraindicated in patients under 16 years of age.
Use in the elderly
Ganaton therapy for elderly patients is prescribed with caution.
Drug interactions
Itopride metabolism occurs under the action of flavin monooxygenase.
With the simultaneous use of Ganaton:
- warfarin, diazepam, diclofenac sodium, ticlopidine hydrochloride, nifedipine, nicardipine hydrochloride do not cause changes in protein binding;
- oral medicinal products with a low therapeutic index, or an enteric coating, or sustained release of the active substance may interfere with their absorption;
- ranitidine, cimetidine, teprenone, cetraxate (antiulcer drugs) do not affect the effect of the drug;
- anticholinergics can reduce the therapeutic effect of itopride.
Analogs
Analogues of Ganaton are: tablets - Zirid, Itomed, Primer.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture and light.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ganaton
According to reviews, Ganaton is rated as an effective drug. Helps with heartburn and gastritis pain, nausea, vomiting, bloating. Has good tolerance. The tablets are small so they are easy to swallow. Among the shortcomings indicate a high cost.
Price for Ganaton in pharmacies
The approximate price for Ganaton (10, 40 or 70 tablets) is 271–395, 570–795 or 883–1007 rubles.
Ganaton: prices in online pharmacies
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Drug name Price Pharmacy |
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Ganaton 50 mg film-coated tablets 10 pcs. RUB 315 Buy |
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Ganaton tablets p.p. 50mg 10 pcs. 351 r Buy |
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Ganaton 50 mg film-coated tablets 40 pcs. 582 r Buy |
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Ganaton tablets p.p. 50mg 40 Pcs. RUB 676 Buy |
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Ganaton 50 mg film-coated tablets 70 pcs. 802 RUB Buy |
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Ganaton tablets p.p. 50mg 70 Pcs. RUB 936 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
