Vasar
Vasar: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Vasar
ATX code: C09CA03
Active ingredient: valsartan (valsartan)
Manufacturer: Actavis Group (Bulgaria)
Description and photo update: 2019-17-09
Vasar is a drug used for arterial hypertension.
Release form and composition
The drug is produced in the form of coated tablets: Vazar 40 and Vazar 160 - yellow, Vazar 80 - pink (10 pcs. In blisters, in a cardboard box 3 or 9 packs and instructions for using Vazar).
Composition of 1 tablet:
- active substance: valsartan - 40, 80 or 160 mg;
- auxiliary components: talc, magnesium stearate, lactose monohydrate, croscarmellose sodium, microcrystalline cellulose, povidone, colloidal silicon dioxide.
Pharmacological properties
Pharmacodynamics
The active ingredient of Vasar tablets is valsartan, an angiotensin II receptor antagonist, which is an active hormone of the renin-angiotensin-aldosterone system and is formed by the action of the angiotensin-converting enzyme (ACE) from angiotensin. It has a direct and indirect effect on blood pressure, having a pressor effect and reducing sodium excretion from the body. Valsartan selectively affects the receptors responsible for the action of angiotensin II.
Vasar affects cardiovascular regulation, does not block or bind other ion channels or hormonal receptors. The antihypertensive effect of valsartan develops within 2 hours, the maximum decrease in blood pressure (BP) is observed within 4-6 hours after a single dose of the drug and persists throughout the day.
With the course of taking the drug, the maximum decrease in blood pressure is achieved within 2-4 weeks and is further maintained throughout the entire course of therapy. If an additional decrease in blood pressure is required, hydrochlorothiazide is added to valsartan.
With repeated administration of valsartan, a slight cumulation of the substance is noted. Cancellation of Vasar is not accompanied by the development of withdrawal syndrome.
Pharmacokinetics
Once in the gastrointestinal tract, valsartan is rapidly absorbed. Its absolute bioavailability is 23%. The connection with plasma proteins is 94–97%.
The drug is excreted from the body unchanged through the intestines (83%) and kidneys (13%).
Indications for use
- Arterial hypertension;
- Diseases of the cardiovascular system, accompanied by symptoms of chronic heart failure.
Contraindications
- Renal dysfunction and bile outflow;
- Cirrhosis of the liver;
- Severe functional disorders of the liver;
- Pregnancy and lactation;
- Hypersensitivity to components.
Vasar is contraindicated in patients on hemodialysis.
Vasar tablets should be taken with caution in patients with renal artery stenosis, subject to the simultaneous administration of potassium and potassium-sparing diuretics, at the initial stage of treatment of CHF (chronic heart failure), while prescribing angiotensin-converting enzyme (ACE) inhibitors, in the postinfarction period.
Vasar, instructions for use: method and dosage
With arterial hypertension, the drug is taken once a day. The average therapeutic dose of Vasar is 160 mg, if necessary, it can be doubled. The simultaneous use of other antihypertensive drugs is possible.
In chronic heart failure, the initial dose of the drug is 40 mg 2 times a day. If necessary, the dose can be gradually increased to 160 mg 2 times a day.
After suffering myocardial infarction, the initial dose is 20 mg 2 times a day. It is gradually increased to 160 mg 2 times a day.
Side effects
When using Vazar, it is possible to develop such side effects as:
- Accession of infections of the paranasal sinuses and upper respiratory tract (pharyngitis, sinusitis);
- Orthostatic hypotension.
In some cases, during therapy, there are: heart failure, hypotension, diarrhea, abdominal pain, cough, back pain, arthritis, myalgia, asthenia, headache, conjunctivitis.
Development of neurological disorders in the form of insomnia, depression, syncope, neuralgia is possible. Hyperkalemia and thrombocytopenia may occur, leading to epistaxis and bleeding at other sites.
It is extremely rare during treatment to develop: angioedema, acute renal failure and other functional disorders of the kidneys, gastroenteritis.
Overdose
In case of an overdose, arterial hypotension may develop, which is accompanied by dizziness. The patient should take a horizontal position. Saline solutions are administered as a treatment. Dialysis is ineffective because valsartan binds significantly to plasma proteins.
special instructions
Caution is required when using tablets in patients with renal artery stenosis in the case of simultaneous administration of potassium-sparing diuretics and potassium preparations.
The use of large doses of diuretics can cause symptomatic hypotension (with reduced blood volume and sodium levels).
At the initial stage of treatment of chronic heart failure, in the postinfarction period and with the simultaneous administration of ACE inhibitors, careful use of Vasar and medical supervision are required.
For liver diseases, the maximum allowable dose of Vasar is 80 mg.
Application during pregnancy and lactation
The use of Vasar is contraindicated during pregnancy and lactation.
Pediatric use
The degree of efficacy and safety of valsartan use in childhood and adolescence has not been studied.
With impaired renal function
In case of impaired renal function, Vasar is not prescribed. Also, the appointment of the drug is contraindicated in patients on hemodialysis.
In case of renal artery stenosis, the simultaneous administration of the drug along with potassium preparations and potassium-sparing diuretics requires caution.
For violations of liver function
In severe violations of hepatic function, cirrhosis of the liver, Vasar is contraindicated. For liver diseases, the daily dose should not exceed 80 mg.
Drug interactions
With the simultaneous use of Vasar with potassium-sparing diuretics, potassium preparations, drugs that increase the level of potassium, you need to be careful and measure the concentration of potassium in the blood.
In the case of joint use with cimetidine, indomethacin, atenolol, furosemide, warfarin, digoxin, hydrochlorothiazide, glibenclamide and amlodipine, used to treat hypertension, no interaction is observed.
When prescribing other antihypertensive drugs, it is possible to increase the antihypertensive effect of Vasar.
The simultaneous use of nonsteroidal anti-inflammatory drugs with valsartan leads to a decrease in the hypotensive effect, impaired renal function (it is temporary and reversible). In some cases, patients with impaired renal function and elderly patients may develop acute renal failure.
Analogs
Vazar's analogs are: Valz, Valsakor, Valaar, Diovan, Lozap, Lorista, Mikardis, Nortivan, Cardosal, Kandesar, Tareg, Teveten.
Terms and conditions of storage
Store in a dark, dry place out of reach of children at temperatures up to 25 ° C.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Vasar
According to reviews, Vasar is a high-quality effective antihypertensive drug that is well tolerated and does not cause side effects. Its disadvantages include a fairly high cost.
The price of Vazar in pharmacies
At the moment, the drug is not available in pharmacies, so the price of Vazar is unknown. The cost of an analogue of Valza is: tablets (28 pcs. In a package) 40 mg - 223-352 rubles, 80 mg - 287-400 rubles, 160 mg - 315-478 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
