Betahistine
Betagistin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Betahistine
ATX code: N07CA01
Active ingredient: betahistine (betahistine)
Manufacturer: PRANAPHARM LLC (Russia)
Description and photo update: 2019-19-08
Prices in pharmacies: from 37 rubles.
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Betahistine is a histamine drug that improves labyrinth microcirculation. It is used for pathologies of the vestibular apparatus.
Release form and composition
Dosage form - tablets: flat-cylindrical, almost white or white; 8 mg tablets - with a chamfer, 16 and 24 mg tablets - with a line and a chamfer (5, 7, 10, 14 and 20 pcs. in blisters, in a cardboard box 1, 2, 3, 4, 5, 6 or 10 packs; 20 and 30 pcs. In polymer bottles or cans, in a cardboard box 1 can or 1 bottle).
Active ingredient: betahistine dihydrochloride, in 1 tablet - 8, 16 or 24 mg.
Auxiliary components: citric acid, magnesium stearate, lactose (milk sugar), colloidal silicon dioxide (aerosil), microcrystalline cellulose, starch 1500 (pregelatinized starch), sodium lauryl sulfate, talc.
Pharmacological properties
Pharmacodynamics
The mechanism of action of betahistine is only partially known. There are several possible hypotheses that have been confirmed in the course of preclinical and clinical studies.
Betahistine is a partial agonist of H 1 -histamines and an antagonist of H 3 -histamine receptors of the vestibular nuclei of the central nervous system, slightly active against H 2 -receptors. Increases the exchange and release of histamine by blocking presynaptic H 3 receptors and decreasing the number of H 3 receptors.
In the course of preclinical studies, it has been shown that betahistine increases blood flow in the vascular stria of the inner ear, relaxing the capillary sphincters of the vessels of the inner ear, and also stimulates blood circulation in the human brain.
In animals, after unilateral vestibular neurectomy, betahistine helps restore vestibular function, facilitating and accelerating central vestibular compensation due to antagonism with H 3 -histamine receptors.
In humans, the recovery time after vestibular neurectomy is also reduced.
Betahistine provides a dose-dependent decrease in the generation of action potentials in the neurons of the medial and lateral vestibular nuclei.
The pharmacodynamic properties of betahistine revealed in animals provide its positive therapeutic effect for the vestibular system.
The effectiveness of the drug has been demonstrated during the treatment of patients with Meniere's syndrome and vestibular dizziness, which was manifested by a decrease in the frequency and severity of dizziness.
Pharmacokinetics
When taken orally, the drug is rapidly and almost completely absorbed from the gastrointestinal tract. After absorption, betahistine is almost completely metabolized to the metabolite of 2-pyridylacetic acid (does not have pharmacological activity), found in urine and blood plasma. Since the concentration of unchanged betahistine in plasma is very low, pharmacokinetic analyzes are based on measuring the content of the metabolite of 2-pyridylacetic acid. When taken on an empty stomach, the maximum concentration of betahistine in the blood is higher than when taken together with food, however, the total absorption in both cases is the same, which indicates a slowdown in the absorption of the drug when eating.
Less than 5% of betahistine binds to blood plasma proteins.
The time to reach the maximum concentration of 2-pyridylacetic acid in urine or blood plasma is about 60 minutes. The half-life is about 210 minutes.
Excretion of 2-peridylacetic acid is carried out in the urine. When taking from 8 to 48 mg of the drug, approximately 85% of the initial dose is found in the urine. Excretion of betahistine by the kidneys or through the intestine is negligible.
When the drug is taken orally at a dose of 8–48 mg, the rate of its elimination remains constant, which indicates the linearity of the pharmacokinetics of the active substance and suggests that the involved metabolic pathway remains unsaturated.
Indications for use
- vestibular dizziness of various origins (treatment and prevention);
- Meniere's disease and syndrome;
- syndromes accompanied by dizziness, headache, tinnitus, progressive hearing loss, nausea and vomiting.
Contraindications
- age up to 18 years;
- pregnancy and lactation;
- hypersensitivity to the individual components of the drug.
According to the instructions, Betagistine should be used with caution in the following cases:
- bronchial asthma;
- pheochromocytoma;
- peptic ulcer and 12 duodenal ulcer, including a history.
Instructions for the use of Betagistin: method and dosage
The drug should be taken orally with meals.
Recommended adult dose:
- 8 mg tablets: 1-2 pcs. 3 times a day;
- tablets 16 mg: ½ ‒ 1 pc. 3 times a day;
- tablets 24 mg: 1 pc. 2 times a day.
The treatment is long, the doctor determines the duration for each patient individually. Improvement in the condition is usually noted already at the beginning of regular use of the drug and can increase over several months.
Side effects
- from the digestive system: nausea, abdominal pain, dyspepsia, bloating;
- hypersensitivity reactions: rash, itching, urticaria, angioedema, anaphylactic reactions.
Overdose
Symptoms: abdominal pain, nausea, drowsiness (when taking up to 640 mg of the drug), cardiopulmonary complications, convulsions (when taking more than 640 mg of betahistine, or in combination with other drugs).
Treatment: symptomatic.
special instructions
Betahistine does not have a sedative effect, does not affect the speed of reactions and the ability to concentrate.
Application during pregnancy and lactation
It is forbidden to use the drug during pregnancy and lactation, as there is insufficient data to assess its effect. During therapy, breastfeeding must be discontinued.
Pediatric use
It is forbidden to use Betahistine for the treatment of patients under the age of 18 years.
With impaired renal function
No dose adjustment is required in patients with renal impairment.
For violations of liver function
No dose adjustment is required when treating patients with hepatic impairment.
Use in the elderly
When treating elderly patients, dose adjustment is not required.
Drug interactions
Cases of incompatibility or interaction of betahistine with other drugs are unknown.
Analogs
Analogues of Betagistin are: Betaver, Vertran, Betacsentrin, Betaserk, Vestibo, Microzer, Vestikap, Tagista.
Terms and conditions of storage
Keep out of the reach of children, dry, protected from light at temperatures up to 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Betagistin
Reviews about Betahistin are mixed. Some women report that the drug has helped them cope with severe headaches and dizziness attacks during menopause. Other users report that taking Betahistine does not provide a stable effect (the drug has to be taken constantly) and does not always relieve headaches and dizziness.
The price of Betagistin in pharmacies
The approximate price for Betagistin is: 30 tablets of 8 mg - 45-80 rubles, 30 tablets of 16 mg - 95-156 rubles, 30 tablets of 24 mg - 65-104 rubles, 20 tablets of 24 mg - 130– 164 rubles., 60 tablets of 24 mg - 325-415 rubles.
Betagistin: prices in online pharmacies
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Drug name Price Pharmacy |
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Betahistine 8 mg tablets 30 pcs. RUB 37 Buy |
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Betahistine Canon 8 mg tablets 30 pcs. RUB 45 Buy |
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Betahistine 8 mg tablets 30 pcs. RUB 54 Buy |
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Betahistine 24 mg tablets 30 pcs. RUB 54 Buy |
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Betahistine 16 mg tablets 30 pcs. RUB 64 Buy |
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Betahistine 24 mg tablets 30 pcs. RUB 65 Buy |
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Betahistine 24 mg tablets 20 pcs. 74 RUB Buy |
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Betahistine 16 mg tablets 30 pcs. RUB 78 Buy |
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Betahistine 24 mg tablets 20 pcs. RUB 78 Buy |
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Betahistine Canon 24 mg tablets 20 pcs. 79 RUB Buy |
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Betahistine Canon 16 mg tablets 30 pcs. 83 rbl. Buy |
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Betahistine Canon 8mg tablets 30 pcs. RUB 86 Buy |
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Betahistine Canon 24 mg tablets 30 pcs. RUB 86 Buy |
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Betahistine 8 mg tablets 30 pcs. RUB 90 Buy |
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Betahistine 24 mg tablets 20 pcs. RUB 99 Buy |
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Betahistine tablets 24mg 20 pcs. Pranapharm 102 RUB Buy |
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Betahistine Canon 24mg tablets 30 pcs. RUB 105 Buy |
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Betahistine tablets 24mg 30 pcs. Pranapharm 106 RUB Buy |
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Betahistine Canon tablets 16mg 30 pcs. 106 RUB Buy |
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Betahistine tablets 16mg 30 pcs. 124 RUB Buy |
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Betahistine tablets 24mg 30 pcs. 135 RUB Buy |
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Betahistine Canon 24mg tablets 20 pcs. 141 r Buy |
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Betahistine 16 mg tablets 30 pcs. 148 RUB Buy |
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Betahistine 24 mg tablets 60 pcs. 149 r Buy |
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Betahistine 24 mg tablets 20 pcs. 163 r Buy |
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Betahistine 24 mg tablets 60 pcs. 170 RUB Buy |
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Betahistine Canon 24 mg tablets 60 pcs. 171 r Buy |
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Betahistine 8 mg tablets 30 pcs. 173 r Buy |
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Betahistine tablets 8mg 30 pcs. 177 r Buy |
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Betahistine 24 mg tablets 20 pcs. 177 r Buy |
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Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
