Berlition 600
Berlition 600: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for the use of Berlition method and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Berlithion 600
ATX code: A16AX01
Active ingredient: Thioctic acid (Thioctic acid)
Producer: Jenahexal Pharma, EVER Pharma Jena GmbH, Haupt Pharma Wolfratshausen (Germany)
Description and photo update: 2018-22-10
Prices in pharmacies: from 794 rubles.
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Berlition 600 is an antioxidant and neurotrophic metabolic drug that regulates metabolism.
Release form and composition
Dosage form Berlition 600 - a concentrate for the preparation of a solution for infusion: a clear liquid, greenish-yellow [24 ml in glass ampoules (25 ml) of dark color with a break line (white marker) and green-yellow-green stripes, 5 pcs. in a plastic pallet, in a cardboard box 1 pallet].
1 ampoule contains:
- active substance: thioctic acid - 0.6 g;
- auxiliary components: ethylenediamine, water for injection.
Pharmacological properties
Pharmacodynamics
The active ingredient in Berlition 600 is α-lipoic (thioctic) acid, is a coenzyme of α-ketoacids decarboxylation reactions and an endogenous antioxidant of direct (binding free radicals) and indirect mechanisms of action. Promotes an increase in the content of glycogen in the liver, a decrease in the level of glucose concentration in blood plasma and insulin resistance. Participates in the regulation of metabolic processes of carbohydrates and lipids, stimulates cholesterol metabolism.
The antioxidant properties of thioctic acid make it possible to protect cells from damage by decay products, reduce (in diabetes mellitus) the formation of end products of progressive glycosylation of proteins in nerve cells, improve endoneural blood flow and microcirculation, and increase the physiological content of the antioxidant glutathione. By potentiating a decrease in the level of glucose in the blood plasma, in diabetes mellitus, it has an effect on the alternative metabolism of glucose, reducing the accumulation of pathological metabolites (polyols), thereby reducing the edema of the nervous tissue.
The participation of thioctic acid in fat metabolism allows an increase in the biosynthesis of phospholipids (including phosphoinositides), improving the disturbed structure of cell membranes. It restores energy metabolism and normalizes the conduction of nerve impulses. Neutralizes the toxic effects of alcohol metabolites, such as acetaldehyde and pyruvic acid, reduces the excessive formation of free oxygen radicals. By weakening the manifestations of polyneuropathy (paresthesia, burning sensation, numbness and pain of the extremities), it reduces endoneural hypoxia and ischemia.
The use of thioctic acid for therapy in the form of an ethylenediamine salt reduces the severity of possible side effects.
Pharmacokinetics
The maximum concentration of thioctic acid in the blood plasma 30 minutes after intravenous (IV) administration reaches about 0.02 mg / ml, the total concentration is about 0.005 mg / h / ml.
Berlition 600 undergoes presystemic elimination and is metabolized predominantly by the effect of the first pass through the liver. The formation of metabolites occurs as a result of side chain oxidation and conjugation. Vd (volume of distribution) - about 450 ml / kg. The total plasma clearance is 10-15 ml / min / kg. To a greater extent, 80–90% of the drug is excreted in the form of metabolites through the kidneys. The half-life is approximately 25 minutes.
Indications for use
- alcoholic polyneuropathy;
- diabetic polyneuropathy.
Contraindications
- age up to 18 years;
- period of pregnancy;
- breast-feeding;
- an indication of a history of hypersensitivity to the components of Berlition 600.
Instructions for the use of Berlition 600: method and dosage
The finished drug solution is intended for infusion administration.
Immediately before use, 1 ampoule of the concentrate is dissolved in 250 ml of 0.9% sodium chloride solution. The solution should be injected intravenously, the duration of the infusion should be at least 0.5 hour. Since the active substance is light-sensitive, the vial with the prepared solution must be wrapped in aluminum foil to protect it from light exposure.
Recommended daily dosage: 0.6 g or 1 ampoule, course of therapy 2-4 weeks. Further, for maintenance therapy, the oral form of thioctic acid should be used in a daily dose of 0.3-0.6 g.
The doctor determines the duration of the course or the need to repeat it individually.
Side effects
- from the immune system: very rarely - allergic reactions (itching, skin rash, hives); in isolated cases - anaphylactic shock;
- from the nervous system: very rarely - diplopia, impairment or change in taste, convulsions;
- from the side of metabolism: very rarely - lowering the level of glucose in the blood plasma; possibly dizziness, headache, sweating, visual impairment (symptoms of a hypoglycemic state);
- on the part of the hematopoietic system: very rarely - purpura (hemorrhagic rash), thrombocytopathy, thrombophlebitis;
- local reactions: very rarely - burning sensation at the injection site;
- other reactions: against the background of a high rate of intravenous injection - a transient increase in intracranial pressure, difficulty breathing.
Overdose
Symptoms of a thioctic acid overdose are: headache, nausea, vomiting. For severe cases of intoxication, including with the accidental administration of more than 80 mg of the drug per 1 kg of body weight, the appearance of generalized seizures, psychomotor agitation, and clouding of consciousness is characteristic. In addition, the development of severe violations of acid-base balance, hypoglycemia (up to the development of coma), lactic acidosis, acute necrosis of skeletal muscles, hemolysis, deseminated intravascular coagulation syndrome, multiple organ failure, suppression of bone marrow activity is possible.
Treatment: due to the lack of a specific antidote, emergency symptomatic therapy is indicated in a hospital setting. Application of appropriate measures to eliminate symptoms of poisoning, including methods of modern intensive care for the treatment of cases that threaten the patient's life.
The use of hemodialysis, hemoperfusion, or thioctic acid excretion filtration methods are ineffective.
special instructions
Patients with diabetes mellitus need to ensure regular monitoring of the level of glucose concentration in blood plasma, especially at the beginning of the use of the drug. If necessary, the dose of oral hypoglycemic agent or insulin should be reduced to prevent the development of hypoglycemia.
Since ethanol reduces the clinical effect of Berlition 600, during the period of treatment and in the intervals between courses, you should not drink alcohol and take ethanol-containing drugs.
Against the background of intravenous administration of the drug, hypersensitivity reactions may develop, if the patient develops itching, malaise and other symptoms of drug intolerance, immediate termination of the infusion is required.
Dissolve the Berlition 600 concentrate only in 0.9% sodium chloride solution. It is allowed to store the prepared solution for about 6 hours, provided it is protected from light.
Influence on the ability to drive vehicles and complex mechanisms
It is recommended to exercise caution when performing potentially hazardous activities and driving vehicles. The effect of Berlition 600 on the concentration of attention and the speed of the patient's psychomotor reactions has not been studied, but possible side reactions such as dizziness or visual impairment can affect these indicators.
Application during pregnancy and lactation
The use of the drug during gestation and lactation is contraindicated, due to the lack of sufficient clinical experience in the treatment of this category of patients.
Pediatric use
According to the instructions, Berlition 600 cannot be prescribed for the treatment of children and adolescents under the age of 18, since the safety of the drug and its effectiveness have not been established.
Drug interactions
With simultaneous use with Berlition 600:
- insulin, oral hypoglycemic agents for oral administration: enhance their clinical effect;
- ethanol: significantly reduces the therapeutic effect of thioctic acid;
- iron preparations: promote the formation of chelate complexes, therefore it is recommended to avoid such combinations;
- cisplatin: thioctic acid reduces its effectiveness.
Since when thioctic acid is combined with sugar molecules, poorly soluble complex compounds are formed, Berlition 600 cannot be mixed with the following solutions: Ringer, glucose, fructose, dextrose or with solutions that react with disulfide and SH-groups.
Analogs
Berlition 600 analogues are: Apilak Grindeks, Aloe Extract, Actovegin, Gastricumel, Bioglobin-U, Zaveska, Dalargin, Kuvan, Methyldronate, Lipin, Plazmol, Spirulina, Erbisol, Orfadin, Solcoseryl.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C (do not freeze), protected from light.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Berlition 600 reviews
Reviews of 600 doctors about Berlition testify to the high efficiency and good tolerance of the drug. Patients call the drug high-quality and effective, but they are dissatisfied with its high cost.
Price for Berlition 600 in pharmacies
The price for Berlition 600 is approximately 895 rubles.
Berlition 600: prices in online pharmacies
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Drug name Price Pharmacy |
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Berlition 600 25 mg / ml concentrate for preparation of solution for infusion 24 ml 5 pcs. 794 r Buy |
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Berlition 600 end for prig solution for inf. 25mg / ml 24ml 5 pcs. RUB 817 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
