Staphylococcal bacteriophage
Staphylococcal bacteriophage: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Bacteriophagum Staphylococcum
ATX code: J01XX
Active ingredient: Staphylococcal bacteriophage (Bacteriophagum staphylococcum)
Producer: Biopharma (Ukraine), NPO Microgen (Russia), Biomed (Russia)
Description and photo update: 2018-15-05
Prices in pharmacies: from 675 rubles.
Buy
Staphylococcal bacteriophage is a medical immunobiological drug for the treatment of diseases caused by staphylococci.
Release form and composition
Dosage form - solution for oral administration, local and external use: transparent yellow liquid of varying intensity (20 ml in vials, in a cardboard box of 4 or 8 bottles; 100 ml in bottles, in a cardboard box 1 bottle).
1 ml of solution contains:
- active substance: sterile filtrate of phagolysates of bacteria of the genus Staphylococcus - up to 1 ml;
- additional component: preservative-8-hydroxyquinoline sulfate or 8-hydroxyquinoline sulfate monohydrate.
Pharmacological properties
Staphylococcal bacteriophage is a drug that has a specific bactericidal effect against staphylococci - strains that are most significant in the etiology of the development of inflammatory and purulent diseases.
The drug causes specific lysis (dissolution) of bacteria of the genus Staphylococcus. Its mechanism of action is due to the ability of phage particles to attach to the membrane of sensitive bacteria, penetrate into cells and multiply at the expense of their resources, as a result of which these cells die, and mature phage particles come out, which can infect other sensitive bacterial cells.
The staphylococcal bacteriophage does not affect other bacteria, does not disturb the natural microflora.
Indications for use
Staphylococcal bacteriophage is intended for the treatment and prevention of pyoinflammatory and enteric diseases caused by Staphylococcus bacteria. In particular, it is applied in the following cases:
- generalized septic diseases;
- surgical infections: abscess, boils, carbuncles, panaritiums, hydradenitis, phlegmon, burns, wound suppuration, bursitis, paraproctitis, osteomyelitis, mastitis;
- intestinal dysbiosis;
- enteric infections (gastroenterocolitis, cholecystitis);
- diseases of the upper respiratory tract, respiratory tract and lungs: angina, laryngitis, pharyngitis, inflammation of the middle ear and sinuses, tracheitis, pleurisy, bronchitis, pneumonia;
- urogenital infections: colpitis, salpingo-oophoritis, endometritis, cystitis, urethritis, pyelonephritis;
- purulent-inflammatory diseases of newborns, including sepsis, gastroenterocolitis, pyoderma, omphalitis, conjunctivitis;
- other diseases caused by staphylococci.
For prophylactic purposes, the staphylococcal bacteriophage is also used to treat wounds (postoperative and freshly infected).
According to epidemic indications, it is prescribed for the prevention of nosocomial infections.
Contraindications
According to the instructions, Staphylococcal bacteriophage is contraindicated in case of hypersensitivity or intolerance to the components of the drug.
Instructions for use of staphylococcal bacteriophage: method and dosage
The solution is used orally, rectally, in the form of applications and irrigations, for introduction into the cavities and sinuses of the nose, in the cavity of the vagina and uterus, as well as in the drained cavity.
Before use, the bottle should be shaken and inspected for turbidity and sediment.
Recommended single doses for oral administration of Staphylococcal Bacteriophage, depending on age:
- 0-6 months - 5 ml;
- 6-12 months - 10 ml;
- 1-3 years - 15 ml;
- 3–8 years old - 15–20 ml;
- 8 years and older - 20-30 ml.
Recommended single doses for rectal administration of Staphylococcal Bacteriophage, depending on age:
- 0-6 months - 5-10 ml;
- 6-12 months - 10-20 ml;
- 1-3 years - 20-30 ml;
- 3–8 years old - 30–40 ml;
- 8 years and older - 40-50 ml.
With intestinal dysbiosis and enteral infections, the solution is taken orally 3 times a day, one hour before meals. It is also possible to use the following treatment regimen: 2 times a day ingestion and 1 time per day rectal administration of a single dose corresponding to age, in the form of an enema after bowel movement.
For the treatment of urethritis, cystitis and pyelonephritis, a bacteriophage is prescribed inside. If the cavity of the renal pelvis or bladder is drained, the drug is injected through the nephrostomy or cystostomy 1-2 times a day, 5-7 ml into the renal pelvis or 20-50 ml into the bladder.
In case of purulent-inflammatory diseases with localized lesions, the drug is prescribed both locally and internally: 2-3 times a day 1 hour before meals for 7-20 days (depending on the clinical situation).
Ways of using Staphylococcal Bacteriophage, depending on the nature of the focus of infection:
- in the form of tamponing, lotions and irrigation in a volume of up to 200 ml (depending on the size of the affected area). In osteomyelitis, after surgical treatment, the solution is poured into the wound in an amount of 10–20 ml. In case of an abscess after removal of purulent exudate, the drug is administered by puncture in a volume less than the amount of the removed contents;
- in the form of instillation, rinsing, rinsing, introduction of moistened turundas. In case of purulent-inflammatory diseases of the upper respiratory tract, the drug is administered 2-10 ml 1-3 times a day. Turundas soaked in solution are injected for 1 hour;
- introduction into cavities (articular, pleural and other organic cavities) in a volume of up to 100 ml. In the future, a capillary drainage is left, through which the bacteriophage is introduced for several more days;
- introduction into the cavity of the vagina and uterus. In case of purulent-inflammatory diseases, the drug is administered at 5-10 ml 1 time per day, with colpitis - it is used in the form of tampons 2 times a day for 2 hours or 10 ml in the form of irrigation.
In cases where chemical antiseptics were used to treat wounds prior to the appointment of a bacteriophage, the wounds must be thoroughly washed with a sterile 0.9% sodium chloride solution.
Application of bacteriophage in children under 6 months
For enterocolitis and sepsis in newborns, including premature infants, Staphylococcal bacteriophage is used in the form of high enemas (through a catheter or a gas tube), 5-10 ml 2-3 times a day. If the child does not vomit or regurgitate, the bacteriophage can be given orally by mixing with breast milk. A combination of oral and rectal administration is possible. The duration of therapy is from 5 to 15 days. In the case of a recurrent course of the disease, repeated courses are carried out.
For the prevention of enterocolitis and sepsis in cases of intrauterine infection or the presence of a risk of nosocomial infection, the drug is used in the form of enemas 2 times a day for a course of 5-7 days.
For infected wounds, pyoderma and omphalitis Staphylococcal bacteriophage is used in the form of applications: a gauze napkin moistened with a solution is applied to the affected skin area or umbilical wound 2 times a day.
Side effects
The drug does not cause side effects.
Overdose
Overdose cases were not noted.
special instructions
An important condition for effective phage therapy is to determine the sensitivity of the causative agent of the disease to the bacteriophage and prescribe the drug as early as possible after the appearance of purulent-inflammatory signs.
In severe manifestations of infection, Staphylococcal bacteriophage is used as part of complex therapy.
The preparation contains a nutrient medium in which bacteria from the environment can develop, causing the solution to become cloudy. In this regard, the following rules of use and storage must be observed:
- wash your hands thoroughly;
- treat the cap with an alcohol-containing agent;
- do not put the cork on the table or other objects with the inner surface;
- do not leave the bottle open;
- after the first opening of the bottle, store the drug only in the refrigerator.
After opening the bottle, subject to the listed rules and in the absence of turbidity, the drug can be used throughout the shelf life.
Extraction of the required amount of solution from the vial should be carried out with a sterile syringe by piercing the stopper.
It is forbidden to use Staphylococcal Bacteriophage if the expiration date of the drug has expired, the solution becomes cloudy, the labeling or the integrity of the vial is broken.
Influence on the ability to drive vehicles and complex mechanisms
Not installed.
Application during pregnancy and lactation
Staphylococcal bacteriophage can be used as directed by a doctor during pregnancy and lactation in the presence of infections caused by phage-sensitive strains of staphylococci.
Pediatric use
There are no age restrictions for the use of the drug.
Drug interactions
Can be used in combination with other drugs, including antibiotics.
Analogs
There is no information about analogs of Staphylococcal Bacteriophage.
Terms and conditions of storage
Store and transport in accordance with Sanitary and Epidemiological Rules 3.3.2.1248-03 in a dark place with a temperature of 2–8 ° С. Transportation is allowed under temperature conditions of 9–25 ° С, but not more than 1 month. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Staphylococcal Bacteriophage
Reviews of Staphylococcal Bacteriophage are predominantly positive. Patients confirm the high efficiency of the drug in the fight against diseases caused by staphylococci, and consider it a worthy and safer alternative to antibiotics.
However, there are also separate reviews, which indicate that the bacteriophage was ineffective and even caused side effects (diarrhea, fever), although the instructions indicate a very good tolerance of the drug and the absence of unwanted reactions.
The disadvantages of almost all patients include the high cost of staphylococcal bacteriophage and its unpleasant taste, as well as the inconvenience of storage (in the refrigerator) and use (the need to draw up the solution with a sterile syringe to maintain asepsis).
Price for Staphylococcal Bacteriophage in pharmacies
The prices for Staphylococcal Bacteriophage are 630–795 rubles for a package of 4 vials of 20 ml each, 710–1165 rubles for 1 bottle of 100 ml.
Staphylococcal bacteriophage: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Bacteriophage staphylococcal solution for internal and external use 20 ml 4 pcs. RUB 675 Buy |
|
Bacteriophage staphylococcal liquid solution for topical use and oral administration 100 ml 1 pc. 734 RUB Buy |
|
Bacteriophage staphylococcal solution 20ml 4 pcs. 801 RUB Buy |
|
Bacteriophage staphylococcal liquid. solution 100ml 908 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
