Cefotaxime

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Instructions for use:

1. Composition and form of release
2. Pharmacological action
3. Indications for use
4. Contraindications
5. Method of administration and dosage regimen
6. Side effects
7. Application during pregnancy and breastfeeding
8. Drug interactions

Prices in online pharmacies:

from 17 rubles.

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Cefotaxime is a 3rd generation cephalosporin.

Composition and form of release of Cefotaxime

The drug is produced in the form of a white or slightly yellowish powder for the preparation of a solution for injection, in vials. One bottle contains the active ingredient - Cefotaxime sodium salt 0.5 or 1 g.

pharmachologic effect

According to the instructions, Cefotaxime is a third generation cephalosporin antibiotic. The use of Cefotaxime has a bactericidal effect on the body by inhibiting the synthesis of the bacterial cell wall.

The drug is active against the following gram-negative bacteria: Proteus mirabilis, Escherichia coli, Providencia spp., Citrobacter spp., Serratia spp., Klebsiella spp., As well as some strains of Haemophilus influenzae, Pseudomonas spp.

Less active against Neisseria gonorrhoeae, Streptococcus spp., Bacteroides spp., Staphylococcus spp., Neisseria meningitidis.

According to reviews, Cefotaxime is resistant to most β-lactamases.

Indications for use

According to the instructions, Cefotaxime is prescribed for the treatment of infectious and inflammatory diseases that are severe and caused by microorganisms sensitive to this drug, namely:

• sepsis;

• peritonitis;

• infectious diseases of the pelvic organs;

• abdominal infections;

• infections of joints and bones;

• infectious diseases of soft tissues and skin;

• urinary tract infections;

• infectious diseases of the lower respiratory tract;

• gonorrhea;

• Lyme disease;

• infected burns and wounds.

Also, an indication for Cefotaxime is the prevention of infections after operations.

Contraindications

According to the instructions, Cefotaxime is contraindicated in case of hypersensitivity to cephalosporins.

The drug should be administered with caution in case of impaired renal function, a history of colitis, as well as newborns.

Dosing and Administration of Cefotaxime

According to indications, Cefotaxime is used for intramuscular or intravenous injections.

Children and adults weighing more than 50 kg are prescribed 1-2 g every 4-12 hours. With a body weight of less than 50 kg, the dosage is 50-180 mg per kg of body weight per day, divided by 2-6 times.

The maximum dosage for children weighing less than 50 kg is 180 mg per kg of body weight per day, for adults - 12 g per day.

Side effects

According to reviews, Cefotaxime causes the following adverse reactions:

• Hematopoietic system: thrombocytopenia, leukopenia, hemolytic anemia, neutropenia (only with prolonged use of Cefotaxime in high dosages).

• Digestive system: diarrhea, nausea, vomiting, hepatitis, cholestatic jaundice, pseudomembranous colitis, transient increase in the activity of hepatic transaminases.

• Blood coagulation system: hypoprothrombinemia.

• Allergies: eosinophilia, skin rash and itching. According to reviews, Cefotaxime can, in rare cases, cause Quincke's edema.

• Urinary system: interstitial nephritis.

• Local adverse reactions: with intravenous administration - phlebitis, with intramuscular administration - pain at the injection site.

In addition, according to reviews, Cefotaxime can cause candidiasis due to the chemotherapeutic effect of the drug.

Use of Cefotaxime during pregnancy and breastfeeding

It is not recommended to take the drug in the first trimester of pregnancy. In the second and third trimester, as well as during breastfeeding, it is recommended to take the drug only on strict indications for Cefotaxime.

It should be borne in mind that when administered intravenously in a dosage of 1 g, the maximum concentration of the active substance in breast milk after a few hours reaches 0.32 ± 0.09 μg / ml, which can adversely affect the oropharyngeal flora of the child.

Drug interactions

The drug suppresses the intestinal flora and interferes with the synthesis of vitamin K; therefore, it is not recommended to take it simultaneously with drugs that reduce platelet aggregation, as there is an increased risk of bleeding.

It is also not recommended to use the drug in conjunction with anticoagulants, since it is possible to increase the anticoagulant effect.

Simultaneous use of Cefotaxime with:

• aminoglycosides, loop diuretics and polymyxin B cause the risk of kidney damage;

• drugs that reduce calcium secretion, increases the concentration of cefotaxime in blood plasma;

• Probenecid slows down the elimination of cefotaxime due to a decrease in calcium secretion.

Cefotaxime: prices in online pharmacies

Drug name

Price

Pharmacy

Cefotaxime 1 g powder for the preparation of a solution for intravenous and intramuscular administration 10 ml 1 pc.

RUB 17

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