Vicks Active Symptomax
Vicks Active Symptomax: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Vicks Active SymptoMax
ATX code: N02BE51
Active ingredient: paracetamol + phenylephrine (Paracetamolum + Phenylephrinum)
Manufacturer: WRAFTON Laboratories (UK)
Description and photo updated: 2018-11-07
Prices in pharmacies: from 324 rubles.
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Vicks Active Symptomax is a combined drug with anti-inflammatory, antipyretic and anti-congestive action, used for the symptomatic treatment of influenza and colds.
Release form and composition
The dosage form of the release of Viksa Active Symptomax is a powder for preparation of a solution for oral administration: fine-crystalline; lemon - light yellow, with a characteristic lemon scent, the prepared solution is yellow, with opalescence, with a characteristic lemon scent; black currant - light purple, with a characteristic smell of black currant, the prepared solution is red-purple, with a characteristic smell of black currant (5 g each in laminated sachets, 5 or 10 sachets in a cardboard box).
Active ingredients in 1 sachet (5 g) powder:
- phenylephrine hydrochloride - 12.2 mg;
- paracetamol - 1000 mg.
Auxiliary components (lemon / blackcurrant powder): ascorbic acid - 100/100 mg; sucrose - 1936/2351 mg; citric acid - 812/812 mg; sodium citrate - 501/501 mg; aspartame - 25/53 mg; acesulfame potassium - 65/51 mg; quinoline yellow dye - 1/0 mg; lemon flavoring F / 501.476 / AP0504 - 40/0 mg; lemon flavor F / 29088 - 30/0 mg; lemon flavor F / 28151 - 240/0 mg; lemon flavor F / 29089 - 240/0 mg; blackcurrant dye - 0/6 mg; blackcurrant flavor 1007348 - 0/60 mg; blackcurrant flavor S-133747 - 0/56 mg.
Pharmacological properties
Pharmacodynamics
Vicks Active Symptomax is one of the combined drugs; its action is due to the properties of its constituent components:
- paracetamol: has antipyretic and analgesic effects. These effects are due to inhibition of prostaglandin synthesis in the central nervous system;
- phenylephrine: is a postsynaptic agonist of alpha-adrenergic receptors with low cardioselective affinity for beta-adrenergic receptors; belongs to the number of decongestants; eliminates hyperemia and swelling of the nasal mucosa, constricts blood vessels.
Pharmacokinetics
Paracetamol
Completely and quickly absorbed from the small intestine. C max (maximum concentration of the substance) in the blood is reached 15–20 minutes after ingestion. Its systemic bioavailability is determined by presystemic metabolism and can fluctuate in the range of 70–90% (depending on the dose). It spreads rapidly into all body tissues.
The half-life is approximately 2 hours. It is metabolized in the liver, more than 80% of the substance is excreted in the form of sulfate compounds and glucuronides in the urine.
Phenylephrine
It is rapidly absorbed from the gastrointestinal tract. Time to reach C max - 1–2 hours.
At the "first pass" through the liver, the level of phenylephrine metabolism is quite high (approximately 60%), and therefore, when taken orally, its bioavailability decreases (approximately 40%).
The half-life is in the range of 2-3 hours. It is excreted in the form of sulfate compounds in the urine.
Indications for use
Vicks Active Symptomax powder is prescribed for the symptomatic treatment of influenza and colds, including:
- nasal congestion;
- sore throat;
- pains of various localization, including headache;
- increased body temperature.
Contraindications
Absolute:
- arterial hypertension;
- cardiac ischemia;
- severe impairment of renal function;
- impaired hepatic function;
- glaucoma;
- hyperplasia of the prostate;
- diabetes;
- hyperthyroidism;
- deficiency of sucrase / isomaltase, glucose-galactose malabsorption;
- intolerance to fructose;
- phenylketonuria (associated with aspartame, which is part of the drug);
- combined use with tricyclic antidepressants, monoamine oxidase inhibitors, beta-blockers or their use during the previous 14 days;
- pregnancy and the period of breastfeeding;
- age up to 18 years;
- individual intolerance to the components of the drug.
Long-term use of the drug is not recommended. Simultaneous use with other cough / paracetamol-containing drugs is not recommended. The drug should not be taken simultaneously with alcohol.
Relative (diseases / conditions in the presence of which the appointment of Viksa Active Symptomax requires caution):
- chronic obstructive pulmonary disease;
- bronchial asthma;
- deficiency of glucose-6-phosphate dehydrogenase;
- hyperoxaluria;
- blood diseases;
- congenital hyperbilirubinemia (Dubin-Johnson, Gilbert, Rotor syndromes).
Instructions for use of Viksa Active Symptomax: method and dosage
Powder Vicks Active Symptomax is taken orally.
Single dose - 1 sachet. First, you need to dissolve its contents with hot, but not boiling water with a volume of 250 ml. The solution is taken after it has cooled to an acceptable temperature.
If necessary, Vicks Active Symptomax can be taken every 4–6 hours, but no more than 4 times a day.
Recommended duration of admission (without medical advice):
- as an anesthetic - 5 days;
- as an antipyretic agent - 3 days.
If symptoms persist, a doctor's consultation is indicated.
Side effects
Phenylephrine
- cardiovascular system: rarely - tachycardia, increased blood pressure;
- nervous system: rarely - nervousness, anxiety, tremor, confusion, insomnia, irritability, headache, irritability;
- digestive system: often - vomiting, anorexia, nausea;
- allergic reactions: rarely - allergic reactions, including skin rash, bronchospasm, anaphylaxis, urticaria.
Paracetamol
- urinary system: rarely - nephrotoxicity, urinary retention;
- central nervous system: rarely - dizziness;
- digestive system: rarely - hepatotoxic effect, vomiting, nausea, dryness of the oral mucosa;
- hematopoietic system: rarely - methemoglobinemia, aplastic anemia, increased blood pressure; very rarely - pathological changes in the blood, including thrombocytopenia, agranulocytosis, hemolytic anemia, neutropenia, leukopenia, pancytopenia;
- allergic reactions: rarely - urticaria, skin rash, anaphylaxis, angioedema, bronchospasm;
- others: rarely - increased intraocular pressure, paresis of accommodation, mydriasis.
Overdose
The main symptoms of a paracetamol overdose:
- more than 10 g: liver damage;
- more than 5 g: liver damage in the presence of risk factors (alcohol abuse, long-term therapy with primidone, carbamazepine, phenytoin, phenobarbital, rifampicin or other drugs that induce liver enzymes, cystic fibrosis, cachexia, starvation, glutathione deficiency, HIV infection).
Violations are manifested as pallor of the skin, vomiting, nausea, pain in the abdomen, anorexia. They can occur 12–48 hours after taking the drug. It is possible that only individual symptoms develop (for example, only vomiting or nausea), which may not reflect the real degree of risk of organ damage.
Symptoms of a severe overdose: coma, liver failure in combination with progressive encephalopathy, pancreatitis, arrhythmia, acute renal failure in combination with tubular necrosis (including in the absence of severe liver damage), death.
Symptoms of a phenylephrine overdose: irritability, headache, increased blood pressure.
In cases of an overdose of Viksa Active Symptomax, regardless of the presence / absence of primary symptoms, you should consult your doctor. In order to prevent serious consequences, measures should be taken, including the introduction of SH-group donors and precursors of the synthesis of glutathione - methionine (within 8-9 hours after an overdose) and acetylcysteine (within 8 hours). The need for additional measures is determined by the doctor individually based on the concentration of paracetamol in the blood, as well as the time that has passed after taking increased doses of the drug.
special instructions
It is recommended to refrain from taking anxiolytic and sleeping pills, as well as other medicines containing paracetamol during the period of therapy.
Vicks Active Symptomax distorts the results of laboratory tests to determine the concentration of uric acid and glucose in plasma.
Influence on the ability to drive vehicles and complex mechanisms
Patients who drive motor vehicles should consider the possibility of an individual reaction, including the risk of confusion and dizziness.
Application during pregnancy and lactation
According to the instructions, Vicks Active Symptomax is not prescribed during pregnancy and breastfeeding.
Pediatric use
Vicks Active Symptomax for patients under 18 years of age is prohibited.
With impaired renal function
Conducting therapy in the presence of severe renal dysfunction is contraindicated.
For violations of liver function
Therapy in the presence of impaired hepatic function is prohibited.
Drug interactions
Phenylephrine
- antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic drugs: development of urinary retention, dryness of the oral mucosa, constipation;
- glucocorticosteroids: an increase in the likelihood of glaucoma;
- halothane: increased risk of ventricular arrhythmias;
- tricyclic antidepressants: an increase in the adrenomimetic effect of phenylephrine.
Paracetamol
- ethanol, phenytoin, barbiturates, rifampicin, flumecinol, tricyclic antidepressants, phenylbutazone and other stimulants of microsomal oxidation in the liver: an increase in the production of hydroxylated active metabolites, which can cause severe intoxication;
- warfarin and other coumarin derivatives: enhancement of their anticoagulant effect (against the background of prolonged use of paracetamol);
- anticoagulants of indirect action: enhancing their action;
- metoclopramide, domperidone: increasing the rate of absorption of paracetamol;
- uricosuric drugs: decrease in their effectiveness;
- cholestyramine: reducing the rate of absorption of paracetamol;
- monoamine oxidase inhibitors, sedatives, ethanol: enhance their effects.
Analogs
Analogs of Viksa Active Symptomax are Caffetin KOLDmax, Lemsip Lemon, Lemsip Max.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Viksa Active Symptomax
According to reviews, Vicks Active Symptomax effectively eliminates the symptoms of colds and flu. It is noted that the drug acts quickly. Taking the solution at night makes it easier to fall asleep because it relieves aches, coughs, relieves headaches and relaxes muscles. Among the disadvantages indicate its high cost and the development of side effects, including lethargy and decreased concentration.
Price for Vicks Active Symptomax in pharmacies
The approximate price for Vicks Active Symptomax (5 or 10 sachets per pack) is 175–205 or 255–385 rubles.
Vicks Active Symptomax: prices in online pharmacies
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Drug name Price Pharmacy |
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Vicks Active Symptomax Plus powder for preparation of oral solution 5 g 10 pcs. 324 r Buy |
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Vicks Active Symptomax powder for solution for oral administration lemon (s) 5 g 5 pcs. 401 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
