Xanthinol nicotinate
Xanthinol nicotinate: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Xantinol nicotinate
ATX code: C04AD02
Active ingredient: xanthinol nicotinate (xantinol nicotinate)
Producer: JSC "Usolye-Sibirskiy KhFZ", Irbitskiy Khimfarmzavod, JSC "Avexima", Dalkhimpharm, Moskhimpharmpreparaty them. N. A. Semashko, Ellara LLC, Uralbiopharm OJSC, Novosibkhimfarm OJSC, Russia
Description and photo update: 2019-13-08
Prices in pharmacies: from 63 rubles.
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Xanthinol nicotinate is a vasodilating agent that improves microcirculation.
Release form and composition
Dosage forms:
- Tablets (10 pcs. In a non-cell contour packaging, in a cardboard box 2 packs; 10 pcs. In a blister strip, in a cardboard box 3 or 6 packs; 120 pcs. In a polymer container, in a cardboard box 1 container);
- Solution for intravenous (i / v) and intramuscular (i / m) administration (10 ml or 2 ml in ampoules, 10 ampoules in a cardboard box; 10 ml or 2 ml in ampoules, in a blister strip of 10 or 5 ampoules, in a cardboard box 1 or 2 packages).
The active substance is xanthinol nicotinate:
- 1 tablet - 150 mg;
- 1 ml of solution - 150 mg.
Auxiliary component of the solution: water for injection.
Pharmacological properties
Xanthinol nicotinate combines the characteristics of nicotinic acid and drugs of the theophylline group: it improves collateral circulation, promotes the expansion of peripheral vessels and has an antiplatelet effect. The substance blocks phosphodiesterase and adenosine receptors, which leads to an increase in the concentration of cyclic adenosine monophosphate (cAMP) in the cell and substrate stimulation of the synthesis of nicotinamide adenine dinucleotide phosphate (NADO) and nicotinamide adenine dinucleotide (NAD).
The drug normalizes nutrition, oxygenation and tissue microcirculation. With prolonged use, it has an anti-sclerotic effect, inhibits platelet aggregation, activates fibrinolysis processes, lowers blood viscosity, increases lipoprotein lipase activity, and reduces cholesterol and atherogenic lipids in the body.
Xanthinol nicotinate reduces the total peripheral vascular resistance and enhances myocardial contractions, which provides a more intense cerebral circulation and an increase in the minute volume of blood circulation, and also makes the consequences of cerebral hypoxia less pronounced.
Pharmacodynamics
The pharmacodynamics of xanthinol nicotinate is currently not well understood.
Pharmacokinetics
There is no information on the pharmacokinetics of the drug.
Indications for use
- Cerebral circulation disorders;
- Obliterating endarteritis and / or thromboangiitis (Buerger's disease), obliterating atherosclerosis of the vessels of the extremities;
- Raynaud's disease;
- Diabetic angiopathy;
- Vascular embolism and thrombosis, post-thrombophlebitic syndrome;
- Meniere's syndrome;
- Pressure ulcers, hard healing wounds, trophic ulcers of the legs;
- Atherosclerosis of the coronary vessels and / or cerebral vessels;
- Hypertriglyceridemia;
- Hypercholesterolemia;
- Fetal asphyxia - intrauterine and postpartum;
- Dermatoses in violation of the trophism of vascular etiology;
- Scleroderma, including Buschke's scleredema.
Contraindications
- Severe renal failure;
- Acute myocardial infarction;
- Acute heart failure
- Arterial hypotension;
- Chronic heart failure in the stage of decompensation;
- Mitral stenosis;
- Acute bleeding;
- Exacerbation of gastric ulcer and duodenal ulcer;
- Glaucoma;
- The period of pregnancy and breastfeeding;
- Hypersensitivity to xanthinol nicotinate.
With caution, the drug should be taken simultaneously with antihypertensive drugs and with labile blood pressure (BP).
Instructions for the use of Xanthinol nicotinate: method and dosage
- Tablets: should be taken orally, after meals. The recommended dosage is 150-600 mg 3 times a day;
- Solution: prescribed for intramuscular and intravenous drip. The recommended dosage for the treatment of acute disorders of the blood supply to tissues is i / m, 300 mg 1-3 times a day. Depending on the clinical indications, the dose can be gradually increased to 600-900 mg 2-3 times a day. The treatment period is 2-3 weeks. For patients with acute disorders of cerebral and peripheral circulation, the drug is injected intravenously at a dose of 1500 mg. For infusion, the drug should be diluted in 200 ml of 0.9% sodium chloride solution or 200-500 ml of 5% glucose solution, the resulting solution is injected at a rate of 40-50 drops per minute for 1.5-4 hours. If necessary, repetition of the infusion is possible up to 4 times a day. The course of treatment is 5-10 days. With pronounced disorders of the blood supply to the tissues, the simultaneous use of xanthinol nicotinate by mouth 300 mg 3 times a day is indicated.
Side effects
According to the instructions, Xanthinol nicotinate can cause side effects:
- Cardiovascular system: possibly - a decrease in blood pressure, redness of the skin, a feeling of warmth (transient);
- Digestive system: rarely - diarrhea, nausea, anorexia, gastralgia; possibly - an increase in the level of hepatic enzymes and alkaline phosphatase against the background of long-term therapy in high doses;
- Others: dizziness, weakness; possibly - a change in glucose tolerance, an increase in serum uric acid concentration (with prolonged treatment with high doses).
Overdose
Xanthinol nicotinate has low toxicity. Symptoms of acute overdose are abdominal pain, vomiting, dizziness, general weakness, arterial hypotension, tachycardia. If they occur, you must consult a doctor who will prescribe symptomatic therapy.
special instructions
During the period of use of the drug, patients are advised to take special care when driving vehicles and mechanisms, as well as performing potentially hazardous activities.
Drug interactions
Simultaneous intake of Xanthinol nicotinate can dramatically enhance the effect of strophanthin, beta and alpha blockers, ganglion blockers, ergot alkaloids, sympatholytics.
Analogs
Analogs of Xanthinol nicotinate are: Xanthinol nicotinate-NS., Xanthinol nicotinate-UBF, Xatinate.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperature: tablets - room temperature, solution - up to 25 ° C, protected from light.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Xanthinol nicotinate
According to reviews, Xanthinol nicotinate is effective when used according to indications. Some patients mention adverse reactions such as intense blood flow to the head, and also talk about changes in the smell and taste of ethanol-containing drinks.
Price for Xanthinol nicotinate in pharmacies
The price of Xanthinol nicotinate in the form of tablets is approximately 96–189 rubles, depending on the manufacturer (the package includes 60 tablets). The solution for intravenous and intramuscular administration can be purchased for 55–195 rubles (the package includes 10 ampoules of 2 ml each).
Xanthinol nicotinate: prices in online pharmacies
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Drug name Price Pharmacy |
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Xanthinol nicotinate 150 mg tablets 60 pcs. RUB 63 Buy |
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Xanthinol nicotinate 15% solution for intravenous and intramuscular injection 2 ml 10 pcs. 123 r Buy |
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Xanthinol nicotinate 150 mg tablets 60 pcs. 134 r Buy |
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Xanthinol nicotinate 15% solution for intramuscular injection 2 ml 10 pcs. 241 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
