Cetrin
Instructions for use:
- 1. Pharmacological action and pharmacokinetics
- 2. Indications
- 3. Contraindications
- 4. Pregnancy and lactation
- 5. Side effects
- 6. Overdose
- 7. Dosage and instructions for use
- 8. Special instructions
- 9. Interaction
- 10. Storage conditions
Prices in online pharmacies:
from 135 rubles.
Buy
International name - Cetirizine
Pharmacological action and pharmacokinetics of Tsetrin
Cetrin - is a histamine antagonist that blocks H1 - histamine receptors. The active ingredient is cetirizine. Cetrin is indicated as a prophylactic agent against allergic reactions, as well as to facilitate their course. It has an antipruritic and antiexudative effect. Influences early allergic reactions. At the stage of the onset of an allergic reaction, the drug limits the release of inflammatory mediators. Tsetrin prevents tissue edema, relieves spasms of smooth muscles, reduces capillary permeability. Eliminates skin reactions to specific allergens. Does not have antiserotonin and anticholinergic effects. Subject to therapeutic doses, it practically does not have a sedative effect. After a single dose of the drug, the onset of the effect, in about half of the patients,observed after 20 minutes, after 1 hour in 95% of patients. The effect of the drug lasts more than 24 hours. With therapeutic treatment, tolerance to the antihistamine effect of the drug does not develop. After the end of treatment, the effect of the drug lasts up to 3 days.
Cetrin is well absorbed in the gastrointestinal tract. Taking the drug with food does not affect absorption. The maximum concentration of cetirizine in the blood occurs 1 hour after taking the drug and is equal to 0.3 μg / ml. To a small extent, the drug is metabolized in the liver. The half-life is approximately 10 hours, in elderly patients up to 12 hours, in children about 6 hours. The drug is excreted mainly in the urine.
Indications
The use of Tsetrin is recommended for:
- perennial and seasonal rhinitis and conjunctivitis of allergic origin;
- hives, including chronic urticaria;
- hay fever;
- allergic dermatitis;
- itchy skin;
- angioedema;
- atopic bronchial asthma (in combination therapy).
Contraindications Cetrin
- hypersensitivity to cetirizine;
- pregnancy;
- lactation.
Caution should be exercised when using Tsetrin in persons with chronic renal failure, as well as in elderly patients and children. No feedback was received on the treatment of children under one year old with Cetrin.
Pregnancy and lactation
Like its analogues, Tsetrin is not recommended for use by pregnant women and breastfeeding.
Side effects
Side effects of Cetrin can be expressed in the form of drowsiness, dry mouth, less often in the form of headache, dizziness, migraine, gastrointestinal disorders, allergic reactions.
Cetrin overdose
Overdose symptoms can occur with a single dose of 50 mg. An overdose is manifested by dry mouth, drowsiness, urinary retention, constipation, anxiety, irritability. It is treated by gastric lavage, symptomatic treatment. There is no antidote. The effectiveness of hemodialysis has not been confirmed.
Dosage of Tsetrin and instructions for use
Cetrin is taken orally, in the form of a tablet, washed down with water, in the form of drops it dissolves in water.
Dosage for children over 6 years of age and adults - 1 time per day 10 mg of the drug, or 2 times a day 5 mg. For children 2-6 years old, half the adult dose. Children from one to two years, 2 times a day, 2.5 mg (5 drops). Patients with reduced renal function 5 mg once a day. In severe forms of chronic renal failure, Cetrin is indicated at 5 mg once every 48 hours.
special instructions
According to the reviews received, Cetrin, in doses over 10 mg per day, can have an effect on reducing the speed of reaction. In this regard, the instruction of Tsetrin is recommended to be especially careful during the period of therapy, for persons driving a car. Within the recommended doses, the drug does not enhance the effect of ethanol. However, it is not recommended to use ethanol during the period of therapy with Cetrin analogues.
Interaction Tsetrin
There was no significant pharmacokinetic interaction of Cetrin with cimetidine, pseudoephedrine, azithromycin, glipizide, ketoconazole, diazepam, erythromycin.
Simultaneous use with theophylline leads to a decrease in the clearance of cetirizine, without changing the kinetics of theophylline.
Storage conditions
Cetrin is stored in a dry, dark place out of the reach of children. The drug should be stored at room temperature, not exceeding 25 ° C.
Cetrin: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Cetrin 10 mg film-coated tablets 20 pcs. 135 RUB Buy |
|
Cetrin tablets p.p. 10mg 20 pcs. 139 RUB Buy |
|
Cetrin 10 mg film-coated tablets 30 pcs. 194 r Buy |
|
Cetrin tablets p.p. 10mg 30 pcs. 241 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
