ACC Long
ACTS Long: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: ACC Long
ATX code: R05CB01
Active ingredient: Acetylcysteine (Acetylcysteine)
Manufacturer: Hexal AG (Germany)
Description and photo update: 19.10.2018
Prices in pharmacies: from 273 rubles.
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ACTS Long is a mucolytic drug.
Release form and composition
Dosage form ACTS Long - effervescent tablets: white, flat-cylindrical, round, on one side with a risk and a chamfer, have a blackberry smell, possibly a faint sulfur smell; the reconstituted solution is transparent, colorless with a blackberry smell and, possibly, a faint sulfur smell (6, 10 or 20 pcs. in polypropylene tubes, in a cardboard box 1 tube).
Composition of 1 tablet:
- active substance: acetylcysteine - 600 mg;
- auxiliary components: blackberry flavor "B" - 40 mg; anhydrous citric acid - 625 mg; sodium bicarbonate - 327 mg; mannitol - 72.8 mg; lactose - 70 mg; ascorbic acid - 75 mg; sodium citrate dihydrate - 0.45 mg; sodium saccharinate dihydrate - 5 mg; sodium carbonate - 104 mg; sodium cyclamate - 30.75 mg.
Pharmacological properties
Pharmacodynamics
ACTS Long is one of the mucolytic drugs. Acetylcysteine, a derivative of the amino acid cysteine, has a mucolytic effect, facilitating the discharge of phlegm, which is provided by a direct effect on its rheological properties. The effect of the substance is due to the ability to break the disulfide bonds of mucopolysaccharide chains, due to which the mucoproteins of sputum are depolymerized and its viscosity decreases. ACTS Long remains active with purulent sputum.
The drug has an antioxidant effect, based on the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidative radicals, thereby neutralizing them.
Acetylcysteine also promotes the synthesis of glutathione, which is an essential component of the body's chemical detoxification and antioxidant system. The antioxidant effect allows to increase the protection of cells against the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory process.
In the case of prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with cystic fibrosis and chronic bronchitis.
Pharmacokinetics
Acetylcysteine has high absorption. Oral bioavailability is 10%, which is due to the pronounced effect of the first passage through the liver. The time to reach the maximum plasma concentration in the blood is 1–3 hours.
Plasma protein binding is 50%. The substance crosses the placental barrier. There is no information on the ability of acetylcysteine to penetrate the BBB (blood-brain barrier) and be excreted in breast milk.
Acetylcysteine is rapidly metabolized in the liver and forms a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.
Acetylcysteine is excreted by the kidneys in the form of inactive metabolites (diacetylcysteine, inorganic sulfates). The half-life is approximately 1 hour.
With impaired hepatic function, the half-life is increased to 8 hours.
Indications for use
ACTS Long 600 mg is prescribed for the treatment of respiratory diseases that occur with the formation of viscous sputum difficult to separate, including the following diseases / conditions:
- obstructive bronchitis;
- bronchitis in acute and chronic course;
- pneumonia, lung abscess;
- laryngotracheitis, tracheitis;
- bronchial asthma, chronic obstructive pulmonary disease;
- bronchiectasis;
- cystic fibrosis;
- bronchiolitis;
- otitis media (inflammation of the middle ear);
- sinusitis in acute and chronic course.
Contraindications
Absolute:
- lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
- pulmonary hemorrhage, hemoptysis;
- peptic ulcer of the stomach and duodenum in the acute stage;
- pregnancy and lactation;
- age up to 14 years;
- individual intolerance to the components of the drug.
Relative (diseases / conditions in the presence of which the appointment of acetylcysteine requires caution):
- history of peptic ulcer and duodenal ulcer;
- histamine intolerance (prolonged use of the drug should be avoided, since acetylcysteine affects the metabolism of histamine, which can cause the appearance of signs of intolerance, manifested in the form of headache, vasomotor rhinitis and itching);
- bronchial asthma;
- varicose veins of the esophagus;
- obstructive bronchitis;
- adrenal gland disease;
- renal / hepatic impairment;
- arterial hypertension.
Instructions for the use of ACTS Long: method and dosage
ACTS Long is taken orally, preferably after meals. The tablet must first be dissolved in 200 ml of water. The drug is recommended to be taken immediately after dissolution, as an exception, it can be stored for 2 hours. The intake of an additional volume of fluid leads to an increase in the mucolytic effect.
Unless otherwise prescribed by a doctor, ACC Long is taken 1 tablet per day.
For short-term colds, the duration of therapy is 5-7 days. With cystic fibrosis and chronic bronchitis, to achieve a preventive effect, the drug is taken for a longer time.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):
- respiratory system: rarely - shortness of breath, bronchospasm (mainly with bronchial hyperreactivity against the background of bronchial asthma);
- digestive system: infrequently - dyspepsia, nausea, diarrhea, vomiting, stomatitis, abdominal pain;
- sense organs: infrequently - tinnitus;
- allergic reactions: infrequently - lowering blood pressure, urticaria, pruritus, rash, exanthema, angioedema, tachycardia; very rarely - anaphylactic reactions up to anaphylactic shock, Lyell's syndrome, Stevens-Johnson syndrome;
- others: very rarely - a decrease in platelet aggregation, fever, headache, single reports of bleeding (associated with hypersensitivity reactions).
Overdose
The main symptoms are vomiting, diarrhea, stomach pains, nausea and heartburn.
Therapy: symptomatic.
special instructions
1 tablet corresponds to 0.001 XE (bread unit), which should be taken into account by patients with diabetes.
When dissolving the drug, it is recommended to use glassware and avoid contact with easily oxidizing substances, rubber, metals, oxygen.
In very rare cases, severe allergic reactions were observed during therapy, which requires the cancellation of ACC Long and seeking medical advice.
In bronchial asthma and obstructive bronchitis, the drug should be used with caution under the systemic control of bronchial patency.
You should not take the drug immediately before bedtime (later than 18.00).
Application during pregnancy and lactation
According to the instructions, ACC Long is contraindicated for use during pregnancy and lactation, due to the lack of data confirming the safety / effectiveness of therapy in this group of patients.
Pediatric use
For patients under 14 years of age, ACC Long is not prescribed.
With impaired renal function
In case of renal failure, the drug should be used with caution.
For violations of liver function
In liver failure, the drug should be used with caution.
Drug interactions
With the combined use of ACTS Long 600 mg with some drugs / substances, the following effects may develop:
- antibiotics for oral use (including tetracyclines, penicillins, cephalosporins), except for loracarbef and cefixime: a decrease in their antibacterial activity (it is recommended to observe an interval between their use of at least 2 hours);
- drugs with antitussive action: suppression of the cough reflex, which can lead to stagnation of sputum;
- vasodilating agents, nitroglycerin: enhancing their vasodilating effect.
Analogs
Analogs of ACC Long are: Fluimucil, Acestin, ESPA-NAC, Acetylcysteine, ACC, N-AC-ratiopharm and others.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 30 ° C in a tightly closed tube. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about ACC Long
According to reviews, ACC Long is an effective drug that significantly facilitates the discharge of viscous sputum. The development of adverse reactions is reported only in rare cases.
Price for ACC Long in pharmacies
The approximate price for ACC Long (10 or 20 pcs. In a package) is 260-360 or 435-480 rubles.
ACC Long: prices in online pharmacies
|
Drug name Price Pharmacy |
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ACTS Long 600 mg effervescent tablets 10 pcs. 273 r Buy |
|
Azz Long pills thorn. 600mg 10 pcs. 343 r Buy |
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ACTS Long 600 mg effervescent tablets 20 pcs. 480 RUB Buy |
|
Azz Long pills thorn. 600mg 20 pcs. 582 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
