Andriol
Andriol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Pregnancy and lactation
- 10. Application with alcohol
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Andriol
ATX code: G03BA03
Active ingredient: Testosterone (Testosterone)
Manufacturer: Catalent France Beineim, SA, France
Description and photo update: 2019-06-08
Andriol is a drug that compensates for the deficiency of testosterone, an endogenous hormone that is necessary for the normal development of male genital organs and secondary sexual characteristics.
Release form and composition
Dosage form - capsules with a dosage of 40 mg.
The main active ingredient is testosterone undecanoate.
Excipients: medium chain triglycerides, propylene glycol monolaurate, lecithin, glycerol, castor oil, gelatin, dye.
Pharmacodynamics and pharmacokinetics
The use of Andriol in men with hypogonadism, with an individual dose selection, normalizes the total concentration of testosterone in the blood serum and increases the level of bioavailable testosterone. During therapy, the content of dihydrotestosterone and estradiol in the blood serum rises, and the level of globulin, which binds sex hormones, follicle-stimulating hormone and luteinizing hormone, decreases.
The active component of the drug - testosterone undecanoate - causes a lesser severity of symptoms of testosterone deficiency in both boys and adult men with hypogonadism. Its use leads to an increase in bone mineral density and lean body mass, and also improves sexual function, in particular potency and libido.
Depending on the dose of testosterone undecanoate, a decrease in the concentration of low-density lipoproteins, high-density lipoproteins and triglycerides, an increase in hemoglobin and hematocrit, clinically insignificant changes in the content of liver enzymes and prostate specific antigen are observed. Treatment can cause an increase in the size of the prostate, but there are no side effects from the prostate. Patients with hypogonadism and diabetes have increased insulin sensitivity and decreased blood glucose levels.
The use of Andriol in boys with delayed growth and puberty accelerates the growth and development of secondary sexual characteristics.
In women with removed ovaries who were treated with estrogens only, taking the drug causes an increase in libido, an increase in bone mineral density and a decrease in body fat mass. In transsexuals (who have turned from women to men), therapy enhances masculinization.
After oral administration, most of the testosterone undecanoate is absorbed along with the lipophilic solvent in the small intestine. Substances enter the lymphatic system, partially avoiding the primary passage through the liver. To improve absorption, the capsules are taken simultaneously with meals. The bioavailability of the active ingredient is approximately 7%.
When testosterone passes through the lymphatic system, undecanoate is hydrolyzed to testosterone. A single dose of the drug in a dose of 80-160 mg causes a clinically significant increase in the total concentration of testosterone in plasma. Its maximum level of approximately 40 nmol / L is reached 4–5 hours after ingestion. The increased testosterone content in the blood plasma persists for at least 8 hours. Testosterone undecanoate and testosterone bind almost 97% non-specifically to SHBG and blood proteins.
In tissues and plasma, the active substance Andriol is hydrolyzed to the natural male androgen - testosterone, which is further metabolized to estradiol and dihydrotestosterone.
Testosterone and its metabolites are excreted mainly in the urine in the form of conjugates (androsterone and etiocholanolone).
Indications for use
Andriol is prescribed as hormone replacement therapy for diseases and conditions caused by a lack of testosterone:
- Endocrine impotence;
- Eunuchoidism;
- Post-castration syndrome;
- Hypopituitarism;
- Infertility associated with impaired spermatogenesis;
- Menopause in men (decreased libido, deterioration in general health);
- Masculinization in transsexuals;
- Osteoporosis caused by androgen deficiency.
Contraindications
The use of the drug is contraindicated in case of suspicion of breast or prostate carcinoma, as well as in case of hypersensitivity to the components.
The drug is prescribed with caution for latent or severe heart failure, migraine, hypertension, impaired renal function, epilepsy, benign prostatic hypertrophy.
Instructions for the use of Andriol: method and dosage
The initial dose is 120-160 mg / day for 2-3 weeks. For maintenance therapy, the drug is taken at 40-120 mg / day. The daily dose is divided into two doses.
The drug should be taken with food, without chewing, drinking plenty of fluids.
Side effects
In prepubertal boys, testosterone undecanoate can cause premature epiphyseal closure, accelerated puberty, penile enlargement and erection frequency.
In men, the drug can cause priapism (painful and prolonged erection, often not associated with sexual arousal), oligospermia, and a decrease in ejaculate volume.
In addition, the drug promotes sodium and water retention in the body.
Overdose
Testosterone is not acutely toxic. An overdose of the drug can provoke gastrointestinal disorders due to the content of castor oil in it. In this case, the stomach is washed and symptomatic treatment is prescribed.
special instructions
If androgen-dependent side effects develop, treatment should be discontinued. You can resume taking capsules only after the disappearance of undesirable phenomena, while the dosage should be reduced.
Pregnancy and lactation
Since Andriol is not intended for use by women, pregnant and lactating mothers should not use the drug. Its appointment during pregnancy can cause fetal virilization.
Application with alcohol
During treatment, the use of alcoholic beverages is not recommended, since such a combination may affect the effectiveness of the drug.
Drug interactions
While taking some other drugs, the following effects may occur:
- inducers of microsomal oxidation enzymes: a decrease in the concentration of testosterone in the body (an adjustment of the dose of testosterone undecanoate is necessary);
- inhibitors of microsomal oxidation enzymes: an increase in the concentration of testosterone in the body (an adjustment of the dose of testosterone undecanoate is necessary);
- adrenocorticotropic hormones, glucocorticosteroids: increased edema formation;
- insulin and other hypoglycemic drugs: an increase in glucose tolerance and a decrease in the need for insulin or other hypoglycemic drugs in patients with diabetes mellitus (special monitoring is recommended before, during and after treatment with Andriol);
- coumarin-type anticoagulants: increasing the effect of the latter while taking high doses of testosterone undecanoate (prothrombin time should be carefully monitored and, if necessary, the dose of anticoagulant should be reduced).
According to the instructions, Andriol is able to reduce the content of thyroxine-binding globulin, as a result of which the level of total T4 in serum decreases and the binding of T3 and T4 increases. At the same time, the level of free thyroid hormones does not change, and there are no clinical symptoms of thyroid dysfunction.
Analogs
Analogues of Andriol are the following drugs: Nebido, Testosterone propionate, Androgel.
Storage conditions and periods
Store in a place protected from sunlight at a temperature of 8-30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Andriol
According to reviews, Andriol works well when used in bodybuilding to strengthen muscles and increase their volume. Patients confirm the effectiveness of this expensive drug in the treatment of conditions caused by low testosterone levels, as well as as a prophylactic agent. However, it is noted that Andriol should be taken only after consulting a specialist, confirming the insufficient production of this steroid and identifying the causes of the violation. In some cases, weakness, drowsiness and other side effects associated with changes in hormonal levels in the body are observed.
The price of Andriol in pharmacies
The price for a package of Andriol 40 mg, containing 30 capsules, averages 1100-1200 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
