Anavenol
Anavenol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Reviews
- 16. Price in pharmacies
Latin name: Anavenol
ATX code: C05CA51
Active ingredient: Dihydroergocristine mesilate (Dihydroergocristine mesilate), Esculin trihydrate (Esculina trihydras), Rutoside (Rutoside rutoside trihydrate)
Manufacturer: Leciva (Czech Republic)
Description and photo updated: 2018-26-07
Anavenol is a combined drug with a capillaroprotective and venotonic effect.
Release form and composition
It is produced in the form of green coated tablets (20 pieces in a blister, 3 blisters in a cardboard box).
1 tablet contains: dihydroergocristine - 0.5 mg, esculin - 1.5 mg, rutoside - 30 mg.
Excipients: corn starch, lactose monohydrate, povidone 25, stearic acid, sodium carboxymethyl starch.
Pharmacodynamics and pharmacokinetics
The drug improves microcirculation, reduces the permeability of the vascular walls and has a venotonic effect.
Dihydroergocristine, which is part of Anavenol, is a semi-synthetic derivative of ergot alkaloids. It has an alpha-adrenergic blocking effect, increases the tone of the veins and dilates the arterioles, thereby improving peripheral circulation.
Esculin and rutoside, which are also part of the drug, have antiexudative and vasoprotective effects.
Dihydroergocristine is absorbed in the gastrointestinal tract by about 25%, about 68% is bound to plasma proteins. The half-life of dihydroergocristine is approximately 14 hours. The substance is excreted through the intestines. Dihydroergocristine is excreted in milk, and is also able to penetrate the placental barrier.
Esculin and rutoside are rapidly absorbed after oral administration. Esculin undergoes a "first pass" effect through the liver. It binds 90% to plasma proteins, and is excreted mainly through the intestines and a little by the kidneys. The excretion of rutoside is carried out mainly through the intestines.
Indications for use
The drug is indicated as part of complex therapy for:
- Prevaricose syndrome;
- Chronic venous circulatory insufficiency;
- Post-thrombotic syndrome;
- Thrombophlebitis;
- Trophic ulcers of the leg;
- Post-traumatic circulation disorders.
Contraindications
The use is contraindicated:
- With bleeding;
- With increased sensitivity to the components of the drug;
- Children under 15 years old.
The drug should be taken with caution: in patients with severe renal and hepatic impairment, bradycardia, heart failure, arterial hypotension.
Instructions for the use of Anavenol: method and dosage
The drug should be taken after meals, inside, without chewing, with a small amount of liquid. During the first week, 2 tablets 3 times a day, then 1 tablet 3 times a day.
Side effects
- Allergic manifestations (rash, urticaria, itching);
- Swelling of the nasal mucosa;
- Increased fatigue;
- Diarrhea;
- Dizziness and headache;
- Nausea and vomiting;
- Menorrhagia;
- Metrorrhagia.
Overdose
In case of an overdose, side effects may increase (headache, vomiting, nausea, weakness, dizziness, loose stools, swelling of the nasal mucosa, tremor).
Dihydroergocristine in high doses can cause a delayed spasm of blood vessels with subsequent organ ischemia.
If there are signs of an overdose, Anavenol should be discontinued, the stomach should be rinsed and immediately seek medical attention.
If necessary, symptomatic therapy is performed.
special instructions
According to the instructions, Anavenol has an effect on psychomotor reactions and concentration. For the period of taking the drug, you should refrain from driving vehicles and controlling complex mechanisms.
Application during pregnancy and lactation
The experience of using the drug during pregnancy is limited. Anavenol is not recommended for pregnant women in the first trimester. The use of the drug in the second and third trimesters of pregnancy is possible only after assessing the ratio of the benefits of treatment to the mother and the risk to the fetus.
The drug should not be used during breastfeeding.
Pediatric use
The drug is contraindicated in children and adolescents under 15 years of age.
With impaired renal function
In case of severe renal dysfunction, the drug is used with caution.
For violations of liver function
In patients with severe hepatic impairment, the drug is used with caution.
Analogs
There is no information about analogues of Anavenol. To prescribe a drug with a similar therapeutic effect, it is recommended to consult a doctor.
Terms and conditions of storage
Store in a dry, dark place at a temperature of 10-25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Reviews about Anavenol
Reviews about Anavenol are mostly positive. The drug is effective both for the treatment and prevention of varicose veins. It relieves swelling well and eliminates pain, improves vascular microcirculation. Patients and pharmacists say that the drug is well tolerated and side effects are rare.
Its cost, in comparison with some analogues, is low.
The price of Anavenol in pharmacies
The price of Anavenol No. 60 in pharmacies ranges from 126 to 263 rubles. The average price in different cities may differ. The cost of the drug is the lowest in Moscow pharmacies.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
