Akineton
Akineton: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Use in the elderly
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Akineton
ATX code: N04AA02
Active ingredient: biperiden (biperiden)
Producer: Laboratorio Pharmaceutico SIT (Italy), EBEWE Pharma (Austria), Sirton Pharmaceuticals SpA (Italy)
Description and photo updated: 28.08.
Prices in pharmacies: from 217 rubles.
Buy
Akineton is a synthetic drug used for Parkinson's syndrome, as well as for extrapyramidal symptoms caused by neuroleptics.
Release form and composition
- Tablets: flat-cylindrical, almost white, with chamfers, on one side there is a cross-shaped risk (10 or 20 pieces in blisters, to a cardboard box of 2, 5 or 10 blisters);
- Solution: transparent, colorless (1 ml in ampoules, in a cardboard box 5 ampoules).
Each pack also contains instructions for the use of Akineton.
The tablets contain 2 mg of biperidene hydrochloride. Auxiliary substances are microcrystalline cellulose, corn and potato starch, calcium hydrogen phosphate dihydrate, lactose monohydrate, copovidone, magnesium stearate, purified water, talc.
1 ml of the drug solution contains 5 mg of biperiden lactate. Excipients - sodium lactate and water for injection.
Pharmacological properties
Pharmacodynamics
Akineton is a centrally acting anticholinergic drug that reduces the activity of cholinergic neurons in the striatum (refer to the structural components of the extrapyramidal system). The peripheral anticholinergic effect of biperiden is less pronounced.
Biperiden reduces rigidity and tremors. Leads to psychomotor agitation, autonomic disorders.
Pharmacokinetics
After taking biperiden inside C max (maximum concentration of the substance) is 1.01-6.53 ng / ml, the time to reach it is from 30 to 120 minutes. C ss (equilibrium concentration) after oral administration of 2 mg of the drug 2 times a day is reached in 15.7–40.7 hours. Bioavailability after a single dose is approximately 33 ± 5%.
Plasma protein binding of biperiden after oral and parenteral administration ranges from 91 to 94%. Plasma clearance - 11.6 ± 0.8 ml / min / kg.
Biperiden is excreted in breast milk.
The substance is completely metabolized. Its main metabolites are piperidine and bicycloheptane.
Excretion is carried out with feces and urine in the form of metabolites and occurs in two phases. T 1/2 (half-life) of the first phase - 1.5 hours, the second - 24 hours.
In elderly patients, the T 1/2 value can increase up to 38 hours.
Indications for use
Akineton is used for:
- Parkinson's syndrome in adults;
- Poisoning with nicotine or phosphorus-containing organic substances in adults;
- Extrapyramidal symptoms caused by antipsychotics or drugs similar in action in children and adults.
Contraindications
The drug is contraindicated in:
- Stenosis and obstruction of the gastrointestinal tract;
- Closed-angle glaucoma;
- Megacolone;
- Increased individual sensitivity to any component of the drug.
Akineton tablets are not prescribed for children under the age of 3 years.
The drug is used with caution during pregnancy, especially in the first trimester. If it is necessary to use Akineton during lactation, it is recommended to stop feeding, since the active substance of the drug is excreted in breast milk.
The drug should be taken with caution in old age, as well as with:
- Delayed urination;
- Hyperplasia of the prostate gland;
- Heart rhythm disorders;
- Predisposition to epileptic seizures.
Akineton, instructions for use: method and dosage
In severe cases of Parkinson's syndrome in adult patients, the drug is administered slowly intravenously or intramuscularly in 2-4 ml doses, divided into several doses. When using Akineton tablets, they usually start with small doses - 1 mg up to 2 times a day. Depending on the side effects and the therapeutic effect, the dose can be gradually increased by 2 mg daily. The maximum dose of the drug is 16 mg. It can be divided into 4 steps.
For movement disorders that are caused by the drugs taken, a single use of Akineton is prescribed:
- Children under 1 year old - intravenously 0.2 ml;
- Children 1-6 years old - 0.4 ml;
- Children over 10 years old - 0.6 ml;
- For adults, the drug is prescribed intramuscularly or intravenously, 0.5-1 ml, the maximum dose is 2-4 ml.
If necessary, a repeated dose can be administered in half an hour. If during the administration, the development of side effects is observed, the use of the solution must be discontinued.
For movement disorders, Akineton can also be used in tablets taken during or after meals. The duration of treatment depends on the course of the disease. The dose for adults is 1-4 mg up to 4 times a day, for children 3-15 years old - 1-2 mg up to 3 times a day.
When discontinuing the drug, the dose taken should be reduced gradually.
In cases of poisoning with an organic phosphorus mixture, the dose is prescribed depending on the degree of poisoning, while Akineton is used until the symptoms disappear.
In case of nicotine poisoning, the drug is prescribed as an additional therapy intramuscularly, 1-2 ml.
Side effects
The use of Akineton in some cases can cause:
- Drowsiness;
- Dizziness;
- Ataxia;
- Weakness;
- Anxiety;
- Increased fatigue;
- Dyskinesia;
- Confusion of consciousness;
- Nervousness;
- Euphoria
- Memory impairment;
- Delirious disorders;
- Insomnia;
- Muscle cramps;
- Impaired speech.
In some cases, hallucinations may occur. With increased excitement of the nervous system, the dose of the drug should be reduced.
Also, the use of Akineton can provoke:
- Digestive system disorders - constipation, enlarged salivary glands, dry mouth, nausea, epigastric discomfort. To reduce the development of such undesirable effects, the drug is recommended to be taken after meals;
- Tachycardia, bradycardia, and decreased blood pressure;
- Violations of the organ of vision - angle-closure glaucoma, paresis of accommodation, mydriasis;
- Allergic reactions, decreased sweating, difficulty urinating;
- Drug dependence.
Side effects are most often observed in the early stages of treatment, as well as when the dose is increased too quickly.
In case of an overdose with Akineton, the following symptoms may occur:
- Redness of the skin;
- Hyperthermia;
- Atony of the bladder and intestines;
- Delirium;
- Dilated pupils slowly reacting to light - mydriasis;
- Confusion of consciousness;
- Collapse;
- Dry mucous membranes;
- Cardiopalmus.
Overdose
The main symptoms: mydriasis (dilated, slowly reacting pupils to light), redness of the skin, dry mucous membranes, palpitations, intestinal and bladder atony, hyperthermia (especially in children), collapse, agitation, delirium, confusion.
Therapy: symptomatic. The antidote is acetylcholinesterase inhibitors and especially physostigmine, if necessary, bladder catheterization is prescribed.
special instructions
In the case of a long course of treatment with Akineton, a regular check of intraocular pressure is necessary.
Influence on the ability to drive vehicles and complex mechanisms
The drug can reduce the speed of reactions, contributing to a deterioration in the ability to drive vehicles.
Application during pregnancy and lactation
- pregnancy, especially the first trimester: Akineton should be used under medical supervision after assessing the ratio of the expected benefit with the possible risk; the experience of using the drug in this group of patients is limited;
- lactation period: therapy is contraindicated.
Pediatric use
For patients under 3 years of age, the drug in the form of tablets is not prescribed.
The experience of using Akineton in children with drug-induced dystonia is limited to short courses.
Use in the elderly
Elderly patients, especially in the presence of organic cerebral symptoms, Akineton is prescribed with caution.
Drug interactions
The simultaneous use of Akineton with other anticholinergic psychotropic drugs, as well as with antiparkinsonian, antihistamines and antiepileptic drugs can enhance peripheral and central side effects.
You also need to be careful when combining the drug with Levodopa, Pethidine, Quinidine and some other drugs.
Analogs
The analogs of Akineton include the following drugs: Mendilex, Biperiden, Biperiden hydrochloride.
Terms and conditions of storage
Store in a dry place out of the reach of children, at a temperature not exceeding 25 ° C.
The shelf life of solution for injection and tablets is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Akineton
According to reviews, Akineton is an effective drug. Indicate that the therapeutic effect develops in a short time. Doctors and patients note that the drug is well tolerated.
Price for Akineton in pharmacies
The approximate price for Akineton is: tablets (100 pcs.) - 530 rubles, injection solution (5 ampoules of 1 ml) - 850 rubles.
Akineton: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Akineton 5 mg / ml solution for intravenous and intramuscular administration 1 ml 5 pcs. 217 r Buy |
|
Akineton 2 mg tablets 100 pcs. 229 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
