Adisord
Adisord: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Adisord
ATX code: A07AX03
Active ingredient: nifuroxazide (Nifuroxazide)
Producer: CJSC Kanonfarma Production (Russia); LLC "NVTs Agrovetzashchita S.-P." (Russia)
Description and photo update: 2020-11-05
Prices in pharmacies: from 226 rubles.
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Adisord - antimicrobial agent, intestinal antiseptic; a drug used to treat diarrhea.
Release form and composition
Dosage forms of Adisord:
- capsules: gelatinous, hard; size No. 2, with a body and a dark yellow cap - for a dosage of 100 mg; size No. 0, with a yellow body and lid - for a dosage of 200 mg; the contents of the capsules are a mixture of powder and yellow granules with the possible inclusion of a yellow mass pressed into lumps, crumbling when lightly pressed (7, 10 or 15 pcs. in blister strip packaging made of lacquered aluminum printing foil and polyvinyl chloride film, in cartons of 2, 3 or 4 packages with instructions for use of the drug);
- suspension for oral administration: homogeneous, yellow, with a banana aroma (90 ml each in medical vials made of dark container glass, sealed with a screw-down plastic cap with first opening control, in a cardboard box 1 bottle, a measuring spoon and instructions for use of Adisord).
1 capsule contains:
- active ingredient: nifuroxazide - 100/200 mg;
- additional components: pregelatinized corn starch - 33/66 mg; magnesium stearate - 1/2 mg; calcium hydrogen phosphate dihydrate - 25/50 mg; mannitol - 20/40 mg; talc - 1/2 mg;
- body: gelatin - 37.3478 / 57.6681 mg; titanium dioxide - 0.3811 / 0.7867 mg; dyes: iron oxide yellow - 0.3811 / 0 mg; sunset yellow - 0 / 0.0026 mg; quinoline yellow - 0 / 0.5426 mg;
- cap: gelatin - 22.4322 / 36.1648 mg; titanium dioxide - 0.2289 / 0.4933 mg; dyes: iron oxide yellow - 0.2289 / 0 mg; sunset yellow - 0 / 0.0016 mg; quinoline yellow - 0 / 0.3403 mg.
5 ml of suspension contains:
- active ingredient: nifuroxazide - 200 mg;
- additional components: carbomer 971P - 9 mg; methyl parahydroxybenzoate - 5 mg; sucrose - 1000 mg; anhydrous citric acid - 0.75 mg; sodium hydroxide - 2 mg; ethanol 96% - 0.05 ml; banana flavor (Banana essence) - 0.6 mg; purified water - up to 5 ml.
Pharmacological properties
Pharmacodynamics
Nifuroxazide is an antimicrobial drug derived from nitrofuran. Presumably blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and other biochemical processes in the microbial cell. It helps to reduce the production of toxins by microorganisms, destroys the membrane of a microbial cell. Does not affect the balance of intestinal microflora.
Shows high activity against Yersinia spp., Shigella spp., Salmonella spp., Escherichia coli, Campylobacter jejuni, Vibrio cholerae, Clostridium perfringens, pathogenic Vibrio and Vibrions parahaemolyticus, Staphylococcus spp.
Low sensitivity to nifuroxazide is demonstrated by Proteus indologenes, Enterobacter cloacae, and Citrobacter spp.
Resistant to the antimicrobial action of nifuroxazide: Proteus mirabilis, Klebsiella spp., Pseudomonas spp., Providencia spp.
In acute bacterial diarrhea, nifuroxazide therapy helps to restore intestinal eubiosis. In the case of infection with enterotropic viruses, taking Adisord allows you to avoid the development of bacterial superinfection.
Pharmacokinetics
After oral administration, nifuroxazide is practically not absorbed from the digestive tract (99% of the dose taken remains in the intestine), and therefore it has its antibacterial effect exclusively in the intestinal lumen.
Excretion of the substance is carried out by the intestines: 20% - unchanged, the rest - in the form of chemically altered nifuroxazide.
Indications for use
Adisord is intended for the treatment of acute diarrhea of bacterial genesis in the absence of helminthic invasion, as well as proceeding without intoxication, increased body temperature and deterioration of the general condition.
Contraindications
Absolute:
- isomaltase / sucrase deficiency, glucose-galactose malabsorption syndrome (for suspension);
- fructose intolerance (for suspension);
- neonatal period (up to 1 month) and prematurity (for suspension);
- children under 3 years old (for capsules);
- pregnancy;
- established sensitivity to nitrofuran derivatives, to the active substance of the drug, nifuroxazide, or one or more auxiliary components that make up its composition.
Relative contraindications for Adisord suspension (the agent is used with precautions):
- diseases of the brain;
- traumatic brain injury (TBI);
- alcoholism;
- liver disease;
- lactation period;
- children's age from 1 month.
Adisord, instructions for use: method and dosage
Capsules
Adisord capsules are taken orally, swallowed whole and washed down with a little water.
Recommended dosage:
- children aged 3 to 6 years: 1 capsule (dosage 200 mg) or 2 capsules (dosage 100 mg) 3 times a day; daily dose - 600 mg;
- children from 6 years old and adult patients: 1 capsule (dosage 200 mg) or 2 capsules (dosage 100 mg) 4 times a day; the daily dose is 800 mg.
The duration of therapy is 5-7 days. In the absence of signs of improvement in the condition within three days of taking the drug, it is necessary to urgently seek the advice of a specialist.
Oral suspension
Suspension Adisord is intended for oral administration. Shake well before taking the suspension. The drug is recommended to be used according to the method of application specified in this manual and strictly in recommended doses. For this purpose, the supplied 5 ml dosing spoon with 2.5 ml graduation is used.
Recommended dosage of Adisord:
- children aged 1 to 6 months: 2.5 ml (100 mg of nifuroxazide) 2-3 times a day, observing 12- and 8-hour intervals between doses, respectively;
- children aged 6 months to 3 years: 2.5 ml 3 times a day, observing an 8-hour interval between doses;
- children aged 3 to 6 years: 5 ml (200 mg of nifuroxazide) 3 times a day, observing an 8-hour interval between doses;
- children aged 6 to 18 years: 5 ml 3-4 times a day, observing the 8- and 6-hour intervals between doses, respectively;
- adult patients: 5 ml 4 times a day with a 6-hour interval between doses.
The duration of therapy is 5-7 days. In the absence of signs of improvement in the condition within three days of taking Adisord, it is necessary to urgently seek advice from a specialist.
Side effects
When receiving Adisord, the following are possible:
- disorders of the immune system: allergic reactions - urticaria, skin rash, shortness of breath, Quincke's edema, anaphylactic shock;
- general disorders: increased diarrhea, abdominal pain, nausea, granulocytopenia.
The aggravation of any of the above adverse events or the appearance of new ones that are not noted in this instruction should be reported to the attending physician.
Overdose
There have been no reports of an overdose of nifuroxazide, and the symptoms of this condition have not been described.
In case of taking an excessive dose of Adisord, gastric lavage is recommended, in the future - symptomatic treatment.
special instructions
Before starting therapy with Adisord, it is recommended to seek the advice of a specialist.
Treatment of diarrhea with nifuroxazide requires rehydration therapy. The volume of the injected fluid and the method of its administration (orally or parenterally) should correspond to the patient's age, clinical condition, and the severity of diarrhea. In children under 3 years of age, diarrhea is treated under medical supervision.
In case of bacterial diarrhea with signs of systemic damage (the presence of symptoms of infection or intoxication, an increase in body temperature, a deterioration in the general condition), it is necessary to consult a doctor to decide on the appointment of antimicrobial drugs of systemic action.
Drinking alcohol while taking nifuroxazide is prohibited.
If, against the background of treatment with the drug, symptoms of an allergic reaction appear (including rash, itching, shortness of breath), its use should be stopped immediately.
Due to the content of methyl parahydroxybenzoate in the suspension of Adisord, allergic reactions (possibly delayed) may develop during its use.
5 ml of suspension contains 1000 mg of sucrose (0.0833 XE). According to this, in 2.5 ml of suspension (single dose), the sucrose content is 0.04165 XE (bread units).
The daily dose of sucrose when taking 2.5 ml of the suspension 2 times a day is 0.0833 XE and 0.125 XE when taking the same dose 3 times a day.
The daily dose of sucrose when taking 5 ml of suspension 3 times a day is equal to 0.25 XE and 0.333 XE when taking the same dose 4 times a day.
The content of 96% ethanol in the Adisord suspension is 1%. The minimum single dose of the drug (2.5 ml of suspension, which corresponds to the intake of 100 mg of nifuroxazide) contains 0.02 g of ethanol (in terms of absolute alcohol), in the maximum daily dose (5 ml of suspension 4 times a day, which corresponds to the intake 800 mg of nifuroxazide) - 0.16 g of ethanol (in terms of absolute alcohol).
Influence on the ability to drive vehicles and complex mechanisms
Adisord does not affect the ability to drive vehicles and complex mechanisms, as well as the ability to engage in other potentially hazardous activities.
Application during pregnancy and lactation
During preclinical studies, risks to the fetus during drug therapy were not identified, however, controlled studies on the safe use of nifuroxazide in pregnant women have not been conducted. For this reason, Adisord is not recommended as a precautionary measure during pregnancy.
During the period of breastfeeding, short-term therapy with nifuroxazide is allowed, provided that the intended benefits to the mother exceed the potential risks to the child. Before use, you should consult your doctor.
Pediatric use
Adisord capsules are contraindicated in children under 3 years of age.
Suspension Adisord should not be administered to premature babies and infants less than 1 month old.
With impaired renal function
For patients with impaired renal function, there are no special recommendations for the use of Adisord.
For violations of liver function
For liver diseases, Adisord in the form of a suspension for oral administration is taken with caution.
Use in the elderly
Elderly patients do not need dose adjustment.
Drug interactions
It is not recommended to take Adisord together with ethanol and other drugs that cause the development of disulfiram-like reactions (nausea, vomiting, weakness, tachycardia, abdominal pain, headache, blurred vision, convulsions).
You should also avoid the simultaneous administration of nifuroxazide with drugs that inhibit the function of the central nervous system.
When using any medications, including over-the-counter drugs, you should consult a specialist before using Adisord.
Analogs
Adisord's analogs are KontrDiar, Mirofuril, Nifural, Nifuroxazid, Nifuroxazide Alkaloid, Nifuroxazide-VERTEX, Stopdiar, Ekofuril, Elufor, Enterofuril, Ersefuril, etc.
Terms and conditions of storage
Keep out of the reach of children. Store in the manufacturer's packaging in compliance with the temperature regime - no more than 25 ° С; capsules - in a dry, dark place.
Shelf life: capsules - 2 years, oral suspension - 3 years. It is prohibited to use the drug after the expiration date indicated on the package.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Adisord
On the Internet, reviews about Adisord are mostly positive. The drug is characterized as effective, fast-acting, capable of relieving pain and not disturbing the beneficial microflora of the digestive tract. In addition, users find the cost of the drug, OTC dispensing, and a small list of adverse reactions to be attractive. An additional advantage of Adisord in the form of a suspension is the possibility of its use for the treatment of children aged 1 month and older. Parents note that children love the sweet banana flavor of the slurry and its bright yellow color.
The only drawback, according to some patients, is the frequent lack of Adisord on sale. Users also warn that a bright yellow suspension can leave stubborn stains, and therefore, care must be taken when taking and storing it.
The price of Adisord in pharmacies
Price for Adisord, 200 mg capsules, per pack of 20 pcs. in pharmacy chains is from 190 to 389 rubles. The cost of the drug in the form of a suspension for oral administration for 1 bottle of 90 ml varies in the range of 264-330 rubles.
Adisord: prices in online pharmacies
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Drug name Price Pharmacy |
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Adisord 200 mg capsule 20 pcs. 226 r Buy |
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Adisord capsules 200mg 20 pcs. 259 r Buy |
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Adisord suspension for internal approx. 200 mg / 5ml 90ml 263 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
