Flagil
Instructions for use:
- 1. Indications for use
- 2. Contraindications for use
- 3. Method of application, dosage
- 4. Side effects
- 5. Special instructions
- 6. Interaction with other drugs
- 7. Application during pregnancy
- 8. Reviews
- 9. Analogs
Prices in online pharmacies:
from 92 rub.
Buy
Flagil is a drug with antiprotozoal and antibacterial effect, intended for local use in gynecological practice. The preparation contains the active ingredient - metronidazole. The mechanism of action of Flagil lies in its ability to cause biochemical reduction of the 5-nitro group of metronidazole due to intracellular transport proteins of cells of protozoa and anaerobic microorganisms. As a result, the synthesis of amino acids by the cell of the microorganism or protozoa is inhibited, and, as a consequence, their death.
Flagil has a broad spectrum of antiprotozoal and antibacterial action. Possesses high activity against Trichomonas vaginalis, Entamoeba histolytica, Lamblia intestinalis, Giardia intestinalis, as well as obligate anaerobic microorganisms (Bacteroides spp., B.distasonis, B.ovatus, B.fragilis, B.vulgatus, B.thetaiotaomicron)., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Sensitive strains of Eubacterium.
20% of the taken drug enters the systemic circulation, the plasma concentration is 12% of a single dose taken. The half-life is 8-12 hours. It binds to plasma proteins in an amount of about 20%.
Indications for use of Flagil
According to the instructions for Flagil, the drug is indicated for:
- local therapy of Trichomonas and nonspecific vaginitis;
- prevention of the development of anaerobic infections in the case of surgical intervention in the abdominal cavity and small pelvis.
Contraindications to the use of Flagil
The instructions for Flagil indicate the following contraindications for use:
- hypersensitivity to imidazoles;
- organic damage to the central nervous system, including epilepsy;
- blood diseases (including a history);
- violations of coordination of movements;
- pregnancy, lactation;
- liver failure.
Method of application, dosage
Flagil is intended for intravaginal use. Available in suppositories. Used in adults only.
According to the instructions for Flagil, the dosage for Trichomonas vaginitis is 1 suppository per day. The average duration of the course of therapy is 10 days. Must be combined with oral metronidazole.
The dosage for nonspecific vaginitis is 1 suppository twice a day. The course lasts a week. Oral metronidazole can also be used if necessary. Be sure to parallel treatment of a sexual partner, regardless of whether he has symptoms.
Therapy with Flagil and analogues should not last more than 10 days, and the courses should be repeated more than 3 times a year.
Flagil's side effects
When taking Flagil, the following side effects were recorded:
- from the gastrointestinal tract: metallic taste in the mouth, nausea, dry mouth, glossitis, loss of appetite, stomatitis, anorexia, pancreatitis, diarrhea, vomiting, epigastric pain;
- from the side of the NA: dizziness, headache, impaired coordination of movements, irritability, confusion, increased excitability, depression, convulsions, insomnia, peripheral neuropathy, hallucinations;
- allergic reactions: skin flushing, urticaria, fever, allergic rhinitis;
- on the part of the urinary system: cystitis, polyuria, dysuria, candidiasis, urinary incontinence, brown urine;
- local reactions: burning sensation in the genital area, vulvitis;
- others: neutropenia, leukopenia, flattening of the T wave on the electrocardiogram.
Side effects are often the reason for negative reviews about Flagil. To prevent them, you should use the drug only after a medical consultation and study the instructions for Flagil in detail.
special instructions
When taking Flagil, alcohol is contraindicated, since it is possible to develop effects similar to those of disulfiram (vomiting, fever, tachycardia).
If it is necessary to take Flagil for a long time, hematological parameters should be monitored. With the development of leukopenia, the question of the further use of this drug depends on the risk of an infectious process.
During the treatment of Trichomonas vaginitis, one should refrain from sexual intercourse. During menstruation, treatment with Flagil should not be stopped.
If neurological symptoms appear, treatment with this drug should be discontinued.
Metronidazole, which is part of Flagil, has the ability to immobilize treponemas, which can lead to a false positive Nelson's reaction.
Interaction of Flagil with other drugs
Flagyl causes ethanol intolerance.
The simultaneous use of Flagil with disulfiram can cause neurological symptoms.
The drug enhances the effect of indirect anticoagulants, increases the plasma concentration of lithium, cyclosporine, bisulfan.
Concomitant use of phenobarbital and phenytoin can accelerate the elimination of Flagil.
The combination of Flagil with non-depolarizing muscle relaxants, in particular, vecuronium bromide, is not recommended.
Flagil use during pregnancy
The use of Flagil is contraindicated during pregnancy and lactation.
Reviews
The drug has high anti-trichomonas and antibacterial efficacy, proven in a number of clinical studies, therefore, most of the reviews about Flagil from doctors are positive. Subject to the recommendations and dosage regimen, the drug is well tolerated.
Flagil's analogs
The following analogs of Flagil are found: Batsimex, Deflamon, Metrovagin, Klion, Metrogin, Metroxan, Metron, Metrolacer, Metronidazole, Metronidal, Orvagin, Metroseptol, Rosamet, Rozex, Cyptrogil, Tricho-PIN, Trichopol, Trichobrol, Efloran.
Flagil: prices in online pharmacies
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Drug name Price Pharmacy |
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Flagil 250 mg film-coated tablets 20 pcs. 92 RUB Buy |
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Flagil tablets p.o. 250mg 20 pcs. RUB 101 Buy |
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Flagil (suppositories) 500 mg, vaginal suppositories 10 pcs. RUB 817 Buy |
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Flagil vaginal suppositories. 500mg 10 pcs. 841 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
