Fervex for children
Fervex for children: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Fervex for children
ATX code: N02BE51
Active ingredient: paracetamol + pheniramine + ascorbic acid (Paracetamol + Pheniramine + Ascorbic acid)
Manufacturer: Bristol-Myers Squibb (Bristol-Myers Squibb) (France)
Description and photo update: 2020-10-03
Prices in pharmacies: from 183 rubles.
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Fervex for children is a drug for the symptomatic treatment of acute respiratory infections (acute respiratory infections) and influenza.
Release form and composition
Fervex for children is produced in the form of a powder for the preparation of a solution for oral administration, which is a homogeneous substance of light yellow color with darker yellow blotches (for a powder with a banana flavor) or light pink with white and dark pink blotches (for a powder with raspberry flavor).
The drug is packed in sachets of 3 g, 8 sachets in a cardboard box and instructions for the use of Fervex for children.
Composition for 1 sachet:
- active substances: paracetamol - 0.28 g; pheniramine maleate - 0.01 g; ascorbic acid - 0.1 g;
- auxiliary components for powder with banana flavor: sucrose, riboflavin sodium phosphate, magnesium citrate, aspartame, banana-caramel flavoring [maltodextrin, acacia gum or gum arabic (E414), sorbitol (E420), aromatic components (butyl butyryllactate, vanillin, geranyl isoamyl acetate, isoamyl alerianate, ethyl butyrate, citral, ethyl vanillin];
- auxiliary components for powder with raspberry flavor: potassium acesulfame, mannitol, povidone K30, citric acid, magnesium citrate, raspberry flavor [maltodextrin, modified corn starch (E1450), permastabil 505528 RI, dye sunny sunset yellow (E110), dye red E129), brilliant blue dye (E133), raspberry 054428 A (acetic acid, isoamyl acetate, ethyl acetate, benzyl alcohol, vanillin, triacetin, p-hydroxybenzyl acetone), sodium chloride and / or sulfate].
Pharmacological properties
Pharmacodynamics
Fervex for children is a combined drug that contains paracetamol, ascorbic acid and pheniramine maleate.
Paracetamol is a non-steroidal anti-inflammatory drug. It acts on the centers of thermoregulation and pain by blocking cyclooxygenases (mainly in the central nervous system). It has antipyretic and analgesic effects. Anti-inflammatory properties are poorly expressed.
Ascorbic acid regulates oxidation and reduction processes. It reduces the permeability of blood vessels and increases the overall resistance of the body.
Pheniramine maleate is a blocker of H1-histamine receptors. It narrows the vessels in the nasal cavity, eliminates hyperemia and swelling of the nasal mucosa, nasopharynx and sinuses.
Pharmacokinetics
Paracetamol is completely and quickly absorbed. In 30-60 minutes after taking the drug, the maximum concentration is observed in the blood plasma. Rapid tissue distribution. Paracetamol concentrations in plasma, blood and saliva are comparable. Plasma proteins bind no more than 10-25%. Passes through the blood-brain barrier. Paracetamol metabolism occurs in the liver. About 80% conjugates with sulfates and glucuronic acid to form inactive metabolites; approximately 17% is hydroxylated to form 8 pharmacologically active metabolites, which then enter into conjugation reactions with glutathione, resulting in the formation of inactive metabolites. In the case of a lack of glutathione, these metabolites are able to block the enzyme systems of liver cells and cause their death. The half-life is 1-4 hours. No more than 5% of paracetamol is excreted unchanged. The main part is excreted by the kidneys in the form of metabolites (mainly conjugates).
Ascorbic acid is well absorbed in the gastrointestinal tract. The time to reach the maximum plasma concentration is 4 hours. The main metabolism occurs in the liver. It is excreted in the form of metabolites and unchanged through the intestines, kidneys and sweat.
Pheniramine maleate is also well absorbed in the digestive tract. The half-life is 1-1.5 hours. It is excreted mainly by the kidneys.
Indications for use
Fervex for children is used in children and adolescents aged 6-15 years for short-term therapy of diseases that are accompanied by a runny nose and fever (for colds, as well as rhinitis and rhinopharyngitis of allergic and infectious-inflammatory origin).
Contraindications
Absolute:
- severe kidney and / or liver dysfunction;
- blood diseases;
- phenylketonuria;
- lack of glucose-6-phosphate dehydrogenase;
- fructose intolerance, sucrase / isomaltase deficiency, glucose-galactose malabsorption syndrome;
- children under 6 years of age;
- the period of pregnancy (first and third trimesters);
- period of breastfeeding;
- hypersensitivity to the main or auxiliary ingredients of the drug.
Relative (Fervex for children is used with caution):
- mild to moderate renal and / or liver dysfunction;
- diabetes;
- benign hyperbilirubinemia;
- period of pregnancy (second trimester).
Fervex for children, instructions for use: method and dosage
Fervex powder for children is taken orally. Before use, the contents of one sachet are dissolved in 200 ml of warm water.
Recommended doses:
- children aged 6-10 years - 1 sachet twice a day;
- children aged 10-12 years - 1 sachet three times a day;
- adolescents aged 12-15 years - 1 sachet four times a day.
Between the receptions of Fervex for children, an interval of at least 4 hours must be maintained. The maximum duration of therapy is 3 days.
Side effects
Fervex for children in the recommended doses is well tolerated.
Sometimes the following side reactions may occur: vomiting, nausea, dry mouth, constipation, abdominal pain, leukopenia, anemia, thrombocytopenia, agranulocytosis, urinary disorders, drowsiness, accommodation spasm, pruritus, rash, angioedema, urticaria.
With long-term treatment in high doses, it is possible to develop toxic effects on the kidneys and liver, as well as aplastic anemia, hemolytic anemia, pancytopenia and methemoglobinemia.
Overdose
In acute poisoning with paracetamol, the patient develops nausea and vomiting, pains occur in the epigastric region, pallor of the skin integuments is observed, sweating and drowsiness increase.
1-2 days after intoxication, the first signs of liver damage are noted. In especially severe cases, hepatonecrosis, liver failure, encephalopathy and coma develop.
At the first symptoms of an overdose, taking Fervex for children should be discontinued and urgently consult a doctor. The patient is washed stomach, given enterosorbents, and also prescribed methionine and intravenous administration of acetylcysteine (antidote).
special instructions
Fervex for children should not be used in conjunction with other paracetamol-containing drugs.
If treatment continues for more than one week, it is necessary to monitor liver function and monitor the picture of peripheral blood.
One sachet of the drug contains 2.4 g of sucrose, which should be taken into account when prescribing the drug for children with diabetes mellitus or on a low sugar diet.
When determining the content of uric acid and glucose in blood plasma, unreliable results are possible, since paracetamol distorts these data.
If there is no therapeutic effect (pain syndrome persists for more than 5 days, and body temperature for more than 3 days), you should consult your doctor.
Influence on the ability to drive vehicles and complex mechanisms
During treatment, it is advisable to refrain from driving vehicles and working with other complex and potentially dangerous mechanisms, since Fervex for children can cause disruption of accommodation and drowsiness.
Application during pregnancy and lactation
Fervex for children is contraindicated in the first and third trimesters of pregnancy, as well as during breastfeeding. In the second trimester, the drug is used with caution.
Pediatric use
The drug should not be prescribed to children under 6 years of age.
With impaired renal function
The drug is contraindicated in patients with severe renal impairment. With mild to moderate renal failure, Fervex for children is used with caution.
For violations of liver function
In severely impaired liver function, the use of Fervex powder for children is contraindicated. In patients with Gilbert's syndrome, as well as with mild to moderate liver failure, the drug is prescribed with caution.
Drug interactions
Due to the content of pheniramine maleate in the composition of Fervex for children, it enhances the effect of sedatives, and in the case of the simultaneous administration of antipsychotic drugs (phenothiazine derivatives), it increases the risk of adverse reactions (dry mouth, urinary retention, constipation).
When used together with other drugs with anticholinergic action (antipsychotics of the phenothiazine series, atropine-like antispasmodics, antihistamines, anticholinergic antiparkinsonian drugs, antidepressants of the imipramine group, disopyramide), it is possible to increase the central atropine-like effects.
Tricyclic antidepressants, phenylbutazone, barbiturates, ethanol, anticonvulsants, rifampicin and flumecinol significantly increase the risk of drug hepatotoxicity.
Salicylates increase the likelihood of nephrotoxic effects.
When used simultaneously with chloramphenicol, its toxicity increases.
Paracetamol enhances the therapeutic effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.
Metoclopramide increases the absorption of paracetamol, and myelotoxic drugs increase its hematotoxicity.
Analogs
Fervex analogs for children are ORVIS Flu, DesGrippin, Gripand HotActive Max, Rinzasip for children, AntiFlu, Antigrippin-Express, Febricet, Fastorik, Fervex, etc.
Terms and conditions of storage
Store in a place protected from moisture at a temperature of + 15 … + 25 ° С. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Fervex for children
According to reviews, Fervex for children copes well with the first signs of a cold and does not allow them to get sick more. The drug reduces fever and relieves the main symptoms of the common cold. The solution is easy and quick to prepare, it has a pleasant banana or raspberry flavor, so children drink it with pleasure.
Parents of children taking Fervex for children indicate that in the midst of an illness, it does not always help. In addition, the solution can irritate the stomach lining and cause other side effects. Age restrictions are also considered disadvantages, since the drug is allowed only from the age of 6.
Price for Fervex for children in pharmacies
The price of Fervex for children in powder form for oral administration 280 mg + 10 mg + 100 mg with raspberry flavor (8 sachets per pack) is 230–250 rubles, with banana flavor (8 sachets per pack) - 280–320 rub.
Fervex for children: prices in online pharmacies
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Drug name Price Pharmacy |
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Fervex for children 280 mg + 10 mg + 100 mg powder for preparation of oral solution banana 3 g 8 pcs. 183 r Buy |
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Fervex for children 280 mg + 10 mg + 100 mg powder for preparation of oral solution raspberry 3 g 8 pcs. 225 RUB Buy |
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Fervex for children powder for prig solution for internal approx. raspberry 8 pcs. 295 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
