Phenazepam - Instructions For Use, Overdose, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Phenazepam

Instructions for use:

1. 1. Pharmacological action
2. 2. Dosage and instructions for use
3. 3. Indications for use
4. 4. Contraindications to use
5. 5. Special instructions
6. 6. Overdose
7. 7. Interaction with other drugs
8. 8. Pregnancy and lactation
9. 9. Side effects

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from 101 rub.

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pharmachologic effect

Phenazepam is a highly active tranquilizer, has anxiolytic, anticonvulsant, central muscle relaxant and sedative effect. The tranquilizing and anti-anxiety effect is stronger than the analogs of Phenazepam. Also, the drug has an anticonvulsant and hypnotic effect. The anxiolytic effect of the drug is expressed in reducing emotional stress, weakening fear, anxiety and anxiety.

According to the reviews received, Phenazepam has practically no effect on affective, hallucinatory and acute delusional disorders.

Dosage of Phenazepam and instructions for use

Intramuscularly and intravenously: for quick relief of psychomotor agitation, anxiety, fear, as well as in psychotic conditions and vegetative paroxysms - the initial dose is up to 1 mg, the average dose per day is 3-5 mg, the maximum is 7-9 mg.

Oral intake: for sleep disorders, from 250 to 500 mcg, 20-30 minutes before bedtime. When treating psychopathic, neurotic, psycho-like and neurosis-like states, the first dose is up to 1 mg, 2-3 times a day. The dosage can be increased after 2-4 days, if there is a positive effect, up to 4-6 mg per day. With pronounced fear, agitation, anxiety, pervadosis is 3 mg per day, with a rapid increase until a therapeutic effect is achieved. In the treatment of epilepsy 2-10 mg per day. In the treatment of diseases with muscle hypertonia, take 2-3 mg of the drug 1-2 times a day. The maximum dose is 10 mg / day.

In order to avoid the acquisition of dependence on Phenazepam, the instructions recommend that the course of therapy should not last more than two weeks. In exceptional cases, it is possible to increase the duration of the course up to 2 months. The reduction in dosage should be gradual.

Indications for Phenazepam's use

Phenazepam is indicated for neurotic, neurosis-like, psychopathic and psycho-like conditions. With reactive psychosis, senesto-hypochondriacal disorders, insomnia, alcoholism, substance abuse, status epilepticus, epileptic seizures.

Recommended as a remedy to overcome fear and emotional stress in extreme situations. For schizophrenia, with high sensitivity to antipsychotic medications.

For the treatment of muscle rigidity, hyperkinesis, athetosis, tics, autonomic lability.

Contraindications to the use of Phenazepam

• coma;
• myasthenia gravis;
• shock;
• severe depression;
• angle-closure glaucoma;
• poisoning with analgesics or acute alcohol poisoning;
• acute respiratory failure;
• I trimester of pregnancy;
• children under 18;
• during lactation;
• intolerance to benzodiazepines.

special instructions

Caution is required when using Phenazepam in patients with hepatic or renal insufficiency, people prone to substance abuse, with organic brain damage, and elderly patients.

Like analogs, Phenazepam can cause drug dependence with long-term therapy with large doses. During treatment with Phenazepam, the use of ethanol is strictly prohibited. There are no reviews on the treatment of persons under 18 years of age with Phenazepam, the effectiveness and safety of the drug has not been established. Phenazepam affects concentration, therefore, special care is required when driving vehicles for persons receiving treatment with Phenazepam.

Overdose with Phenazepam

Symptoms of an overdose with Phenazepam: decreased reflexes, drowsiness, tremor, nystagmus, prolonged dysarthria, shortness of breath or shortness of breath, bradycardia, coma, decreased blood pressure.

For the treatment of an overdose with Phenazepam, it is recommended to take activated charcoal, gastric lavage, and the introduction of flumazenil (in a hospital). Hemodialysis is ineffective.

Interaction of Phenazepam with other drugs

According to reviews, Phenazepam has a decrease in the effectiveness of levodopa in patients with Parkinson's disease. Phenazepam increases the toxicity of zidovudine.

A mutual enhancement of the effect was noted when combined with antipsychotic, antiepileptic and hypnotic drugs, as well as with central muscle relaxants, narcotic analgesics and ethanol.

When combined with antihypertensive drugs, it is possible to enhance their action. With the simultaneous administration of clozapine, respiratory depression is possible.

Pregnancy and lactation

The use of Phenazepam by pregnant women is permissible only for vital signs. The drug has a toxic effect on the fetus, increasing the risk of developing congenital defects, when used in the 1st trimester of pregnancy. The use of Phenazepam at a later date causes depression of the central nervous system in a newborn. Regular intake during pregnancy can develop addiction and withdrawal symptoms in the newborn.

The use of Phenazepam during childbirth, or immediately before them, can cause the appearance in a newborn: respiratory depression, hypothermia and hypotension.

Side effects of Phenazepam

From the side of the central and peripheral nervous system: in the first days of admission (especially in elderly patients) - a feeling of fatigue, confusion, drowsiness, dizziness, ataxia, decreased concentration, disorientation, delayed reactions; rarely - depression, euphoria, headache, tremor, impaired coordination, memory impairment, uncontrolled movements, asthenia, dysarthria, myasthenia gravis, epileptic seizures (in patients with epilepsy); extremely rarely - aggressive outbursts, fear, psychomotor agitation, suicidal tendencies, muscle spasms, hallucinations, irritability, agitation, insomnia, anxiety.

From the side of the circulatory system: leukopenia, agranulocytosis, neutropenia, thrombocytopenia, anemia.

From the digestive system: heartburn, vomiting, diarrhea or constipation.

Allergic reactions such as itching or skin rash are possible.

Other possible reactions: like its analogs, Phenazepam causes drug dependence, a decrease in blood pressure; rarely - visual impairment, tachycardia. With a sharp cancellation or dose reduction - the appearance of a withdrawal syndrome.

Phenazepam: prices in online pharmacies

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!