Encetron-SOLOfarm - Instructions For Use, Price, Reviews, Analogues

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Encetron-SOLOfarm - Instructions For Use, Price, Reviews, Analogues
Encetron-SOLOfarm - Instructions For Use, Price, Reviews, Analogues

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Encetron-SOLOpharm

Latin name: Encetron-SOLOpharm

ATX code: N06BX06

Active ingredient: citicoline (Citicoline)

Manufacturer: LLC "Grotex" (Russia)

Description and photo update: 2020-18-04

Prices in pharmacies: from 537 rubles.

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Oral solution Encetron-SOLOpharm
Oral solution Encetron-SOLOpharm

Encetron-SOLOpharm is a nootropic drug.

Release form and composition

Dosage forms of Encetron-SOLOpharm:

  • oral solution: clear liquid, colorless or with a yellow-brown or yellow tint (5 or 10 ml in polyethylene ampoules, in a cardboard box of 3, 5, 6 or 10 ampoules);
  • solution for intravenous (intravenous) and intramuscular (intramuscular) administration: clear liquid, colorless or with a yellow, brown or yellow-brown tint (4 ml each in polyethylene ampoules equipped with a twisting cap for needleless intake of solution, in a cardboard box 3, 5 or 10 ampoules; 4 ml each in glass ampoules without color, in blister packs or cardboard forms with cells: 3 ampoules - in a cardboard box 1 package or a form complete with an ampoule scarifier, or without it, 5 ampoules each - in a cardboard box 1–2 packs or forms, complete with an ampoule scarifier, or without it).

Each pack also contains instructions for the use of Encetron-SOLOpharm.

1 ml of oral solution contains:

  • active substance: citicoline sodium - 104.5 mg, which corresponds to 100 mg of citicoline;
  • auxiliary components: liquid non-crystallizing sorbitol, anhydrous glycerol, sodium citrate dihydrate, anhydrous citric acid, water for injection.

1 ml of solution for intravenous and intramuscular administration contains:

  • active substance: citicoline sodium - 130.63 or 261.26 mg, which in terms of citicoline corresponds to 125 or 250 mg, respectively;
  • auxiliary components: 1 M sodium hydroxide solution or 1 M hydrochloric acid solution, water for injection.

Pharmacological properties

Pharmacodynamics

Encetron-SOLOpharm is a nootropic drug. Its active substance, citicoline, is a natural endogenous compound, an intermediate metabolite in the synthesis of one of the main structural components of the cell membrane, phosphatidylcholine.

The wide spectrum of action of the drug is due to such properties of citicoline as restoration of damaged cell membranes, inhibition of the action of phospholipases, prevention of the formation of excess free radicals, prevention of cell death due to the effect on the mechanisms of apoptosis.

In the acute period of stroke, it improves cholinergic transmission, reduces the amount of damage to the brain tissue.

The use of Encetron-SOLOpharm in traumatic brain injury (TBI) reduces the duration of post-traumatic coma, helps to reduce the severity of neurological symptoms and reduce the duration of the recovery period.

In chronic hypoxia of the brain, taking citicoline contributes to the effective treatment of such cognitive disorders as lack of initiative, memory impairment, difficulties arising from self-care and performing daily activities. In patients, the manifestation of amnesia decreases, the level of attention and consciousness increases markedly.

Encetron-SOLOpharm is effective for sensitive and motor neurological disorders of degenerative and vascular etiology.

Pharmacokinetics

Citicoline is well absorbed when taken orally, intravenously and intramuscularly. Its bioavailability after oral administration is comparable to that after intravenous administration.

It is largely distributed in the structures of the brain, embedded in cellular, cytoplasmic and mitochondrial membranes. Takes part in the construction of the phospholipid fraction.

Citicoline is metabolized with intravenous and intramuscular administration in the liver, when taken orally - in the intestine and liver, with the formation of choline and cytidine. There is a significant increase in the level of choline concentration in the blood plasma. Upon reaching the brain, the choline fractions are rapidly incorporated into structural phospholipids and cytidine fractions (cytidine nucleotides and nucleic acids).

Only 15% of the administered dose of citicoline is excreted from the body: with exhaled air - about 12%, through the kidneys - less than 3%. In the elimination of the drug, two phases are distinguished. The first phase of excretion with urine lasts about 36 hours, in this phase the rate of excretion decreases rapidly, the second phase - with a slower rate of excretion. The rate of excretion of citicoline with exhaled air in the first phase, on average, during the first 15 hours after administration, decreases rapidly, in the second phase - much more slowly.

Indications for use

  • acute (as part of complex therapy) and recovery period of ischemic stroke;
  • acute (as part of complex therapy) and recovery period of TBI;
  • the recovery period of hemorrhagic stroke;
  • cognitive and behavioral disorders due to degenerative and vascular diseases of the brain.

Contraindications

Absolute:

  • severe vagotonia (high tone of the parasympathetic autonomic nervous system);
  • breast-feeding;
  • age up to 18 years;
  • hypersensitivity to the components of the drug.

With caution and only in cases of extreme necessity, it is allowed to use Encetron-SOLOfarm during pregnancy.

Encetron-SOLOfarm, instructions for use: method and dosage

Oral solution

The solution is taken orally during or after meals, including by mixing it with 100-120 ml of water.

Recommended dosage:

  • acute period of ischemic stroke or TBI: 1000 mg (10 ml) 2 times a day at regular intervals. The duration of the course of treatment is at least 42 days;
  • recovery period for TBI, ischemic and hemorrhagic strokes, cognitive and behavioral disorders in patients with degenerative and vascular diseases of the brain: 500–2000 mg (5–20 ml) per day. The dosage and duration of therapy are determined individually, taking into account the severity of the symptoms of the disease.

Elderly patients do not need Encetron-SOLOpharm dose adjustment.

Solution for i / v and i / m administration

The solution is used by intramuscular or slow (within 3-5 minutes) intravenous injection, as well as intravenous infusion (injection rate 40-60 drops per minute).

Encetron-SOLOpharm is compatible with all types of intravenous dextrose solutions or isotonic solutions.

After opening the ampoule, the solution should be used immediately!

Polymer ampoules are equipped with a twisting cap, which allows the intake of the solution into the syringe without a needle. Before the procedure, after shaking the contents of the ampoule, it is lightly squeezed by hand and rotated with a rotating movement and the protective valve is separated. Having inserted a syringe into the resulting hole, the ampoule is turned over and a slow intake of the solution is made. Then put the needle on the syringe.

It is preferred to use the intravenous route of administration. With intramuscular injection, injections should not be allowed in the same place.

Recommended dosage of Encetron-SOLOpharm:

  • acute period of ischemic stroke and TBI: 1000 mg 2 times a day at regular intervals. Treatment should be started immediately after diagnosis, the duration of treatment is at least 42 days. Patients with normal swallowing function after 3-5 days can be transferred to the oral form of the drug;
  • cognitive and behavioral disorders in degenerative and vascular diseases of the brain, the recovery period of ischemic and hemorrhagic strokes, the recovery period of TBI: 500-2000 mg per day. The doctor sets the dose and treatment period individually, taking into account the patient's condition.

If intracranial bleeding is suspected, the dose of the drug should not exceed 1000 mg per day. The drug should be injected intravenously (infusion rate - 30 drops per minute).

When Encetron-SOLOfarm is prescribed to elderly patients, there is no need to adjust the dose.

Side effects

Possible adverse events that occur during therapy with Encetron-SOLOpharm:

  • from the nervous system: numbness in paralyzed limbs, insomnia, dizziness, headache, stimulation of the parasympathetic nervous system, tremor;
  • on the part of the cardiovascular system: short-term violation of blood pressure;
  • from the digestive system: decreased appetite, nausea, diarrhea, vomiting, changes in the activity of liver enzymes;
  • mental disorders: agitation, hallucinations;
  • allergic reactions: itching, rash, anaphylactic shock;
  • others: a feeling of heat, shortness of breath, swelling.

Any side effects should be reported to your doctor.

Overdose

Symptoms of citicoline overdose have not been established.

In case of accidental administration of a high dose of Encetron-SOLOpharm, symptomatic treatment is recommended.

special instructions

Influence on the ability to drive vehicles and complex mechanisms

During the entire period of treatment with Encetron-SOLOpharm, patients are advised to be careful when driving vehicles, complex mechanisms and performing other potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Application during pregnancy and lactation

The use of Encetron-SOLOpharm during breastfeeding is contraindicated.

If necessary, the appointment of the drug during lactation should stop breastfeeding.

With caution and only on condition that the expected therapeutic effect for the mother outweighs the potential threat to the fetus, Encetron-SOLOpharm may be prescribed during pregnancy.

Pediatric use

Due to the fact that there are no sufficient clinical data on the safety and efficacy of the drug in the treatment of children, the use of Encetron-SOLOpharm in patients under the age of 18 is contraindicated.

Use in the elderly

When Encetron-SOLOfarm is prescribed to elderly patients, there is no need to adjust the dose.

Drug interactions

It should be borne in mind that Encetron-SOLOpharm enhances the effects of levodopa.

Do not use citicoline while treating with meclofenoxate.

Analogs

Encetron-SOLOpharm analogs are Cerakson, Quinel, Lekuver, Neipilept, Neuropol, Neurocholine, Noocil, Proneiro, Recognan, Ronocyte, Ceralin-Lekpharm, Ceresil Canon, Citicoline, etc.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 30 ° C, solution for intravenous and intramuscular administration - in a dark place.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Encetron-SOLOpharm

The few reviews about Encetron-SOLOpharm are positive.

Price for Encetron-SOLOpharm in pharmacies

The price for Encetron-SOLOpharm per package can be:

  • oral solution: in ampoules of 5 ml - from 192 rubles. for 3 ampoules, from 321 rubles. for 5 ampoules, from 385 rubles. for 6 ampoules, from 642 rubles. for 10 ampoules; in ampoules of 10 ml - from 385 rubles. for 3 ampoules, from 642 rubles. for 5 ampoules, from 770 rubles. for 6 ampoules, from 1283 rubles. for 10 ampoules;
  • solution for intravenous and intramuscular administration: 250 mg / ml - from 450 rubles. for 3 ampoules, from 750 rubles. for 5 ampoules, from 1497 rubles. for 10 ampoules; 125 mg / ml - from 260 rubles. for 3 ampoules, from 432 rubles. for 5 ampoules, from 865 rubles. for 10 ampoules.

Encetron-SOLOpharm: prices in online pharmacies

Drug name

Price

Pharmacy

Encetron-SOLOpharm solution for intravenous and intramuscular injection. 125mg / ml 4ml amp. 5 pieces.

RUB 537

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Encetron-Solofarm 125 mg / ml solution for intravenous and intramuscular administration 4 ml 5 pcs.

RUB 537

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Encetron-Solofarm 100 mg / ml oral solution 10 ml 5 pcs.

RUB 625

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Encetron-SOLOpharm solution for internal administration 100 mg / ml 10ml 5pcs

RUB 780

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Encetron-SOLOpharm solution for intravenous and intramuscular injection. 250mg / ml 4ml amp. 5 pieces.

RUB 910

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Encetron-Solofarm 250 mg / ml solution for intravenous and intramuscular administration 4 ml 5 pcs.

RUB 910

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Encetron-Solofarm 100 mg / ml oral solution 10 ml 10 pcs.

1537 RUB

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Encetron-SOLOpharm solution for internal approx. 100mg / ml 10ml 10 pcs.

1544 RUB

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Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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