Chondroxide - Instructions For Use, Price, Reviews, Tablets, Ointment

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Chondroxide

Chondroxide: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Chondroxide

ATX code: M01AX25 (solution, tablets), M02AX10 (ointment, gel)

Active ingredient: chondroitin sodium sulfate (chondroitin sulfate sodium)

Manufacturer: Belmedpreparaty (Republic of Belarus), NIZHFARM (Russia)

Description and photo updated: 2018-26-11

Prices in pharmacies: from 289 rubles.

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Chondroxide - a stimulator of tissue regeneration: tablets and solution for intramuscular (i / m) administration - regulate metabolic processes in cartilage tissue; ointment and gel for external use - improve the regeneration of cartilage tissue, have an anti-inflammatory effect.

Release form and composition

Dosage forms of Chondroxide:

• tablets: from white with a yellow tint to white with a cream shade, inclusions are allowed, with a chamfer and a dividing line (10 pcs. in blisters, in a cardboard box of 3, 5, 6, 9 or 10 packages);
• solution for intramuscular injection: colorless or with a slight yellow tinge transparent liquid with the smell of benzyl alcohol (1 ml or 2 ml in glass ampoules, 5 ampoules in blisters, 1 or 2 packs in a cardboard box);
• ointment for external use 5%: light yellow mass with the smell of dimethyl sulfoxide (30 g or 50 g each in aluminum tubes, in a cardboard box 1 tube);
• gel for external use 5%: a translucent yellowish mass with a fruity odor (20 g, 25 g, 30 g, 35 g or 40 g each in aluminum tubes, in a cardboard box 1 tube).

1 tablet contains:

• active substance: chondroitin sodium sulfate - 250 mg;
• auxiliary components: crospovidone (Kollidone CL-M, Polyplasdone XL-10) calcium stearate monohydrate (1-water calcium stearate), Kollidone 30 (Povidone K30), magnesium hydroxycarbonate pentahydrate (basic water magnesium carbonate), microcrystalline cellulose.

1 ml of solution contains:

• active substance: chondroitin sodium sulfate - 100 mg;
• auxiliary components: benzyl alcohol, water for injection.

1000 mg ointment contains:

• active substance: chondroitin sodium sulfate - 50 mg;
• auxiliary components: petroleum jelly, dimexide (dimethyl sulfoxide), distilled monoglycerides, lanolin (wool wax, anhydrous lanolin), purified water.

1000 mg of gel contains:

• active substance: chondroitin sodium sulfate - 50 mg;
• auxiliary components: ethyl alcohol (ethanol), isopropanol (isopropyl alcohol, 2-propanol), dimexide (dimethyl sulfoxide), sodium disulfite (sodium metabisulfite), propylene glycol (1,2-propanediol), methyl parahydroxybenzoate (methylparaben, carbommer (nipagin),), propyl parahydroxybenzoate (propylparaben, nipazole), orange flavoring (food flavoring "Orange"), purified water.

Pharmacological properties

Pharmacodynamics

Chondroxide is a drug that stimulates regeneration and regulates metabolism in cartilage tissue. The action of the drug is due to the activity of chondroitin sulfate, a high molecular weight mucopolysaccharide involved in the construction of cartilage tissue. Being a natural substance, it helps to improve phosphorus-calcium metabolism in cartilage tissue and the synthesis of glycosaminoglycans. By reducing the activity of enzymes that cause the destruction of cartilage tissue, chondroitin sulfate inhibits the processes of degeneration and destruction of cartilage tissue, prevents the collapse of connective tissue. Influences metabolic processes in fibrous and hyaline cartilage.

As a result of stimulating the biosynthesis of proteoglycans, the processes of bone tissue repair are accelerated, the joint capsule and the cartilaginous surface of the joints are regenerated. The drug increases the production of intra-articular fluid. By slowing down bone resorption, it reduces calcium loss and accelerates bone regeneration. Structural similarity with heparin allows us to expect from the drug the ability to prevent the formation of fibrin thrombi in the synovial and subchondral microvasculature.

Chondroxide has chondrostimulating, regenerating and anti-inflammatory effects. The combined action of the drug slows down the progression of osteoarthritis and osteochondrosis, is manifested by a decrease in pain and increased mobility of the affected joints, and reduces their swelling.

Pharmacokinetics

Pills

After a single oral administration of an average therapeutic dose of Chondroxide, the maximum concentration (C _max) of chondroitin sodium sulfate in plasma is reached within 3-4 hours, in synovial fluid - within 4-5 hours, in articular cartilage - after 48 hours. The bioavailability of the drug is 13%.

The synovium does not prevent the drug from entering the joint cavity. The accumulation of chondroitin sodium sulfate occurs mainly in the cartilage tissue.

It is excreted through the kidneys within 24 hours.

Ointment and gel

Absorption of the active substance when applied externally is good. The penetration of chondroitin sulfate through the cell membranes into the tissues is facilitated by the presence of dimethyl sulfoxide in the preparation.

After applying chondroitin ointment or gel to the skin, sulphate quickly and selectively enters the joint, where its C _{max is} reached after 0.5 hours.

Removal of the drug from the cartilage tissue occurs in 2 phases. The fast withdrawal phase ends 1 hour after application. The retention period of chondroitin sulfate in the joint is 5 hours.

Indications for use

According to the instructions, Chondroxide is indicated for the prevention and treatment of degenerative-dystrophic diseases of the joints and spine: osteoarthritis, osteochondrosis of the spine.

Contraindications

The use of Chondroxide is contraindicated in case of hypersensitivity to the components of the drug.

In addition, there are additional contraindications for certain dosage forms.

Pills

• period of pregnancy;
• lactation;
• childhood.

With caution, Chondroxide tablets should be prescribed to patients with a tendency to bleeding, with bleeding.

Solution

• thrombophlebitis;
• tendency to bleeding, bleeding;
• age up to 18 years;
• period of pregnancy;
• breast-feeding.

Ointment and gel

Do not apply Chondroxide ointment and gel to areas of the body with impaired skin integrity.

Care should be taken to apply ointment and gel during pregnancy and lactation, in childhood.

Instructions for the use of Chondroxide: method and dosage

Pills

Chondroxide tablets are taken orally with plenty of water.

Recommended dosage: 2 pcs. (500 mg) 2 times a day for 180 days.

90–150 days after the withdrawal of the pills can be repeated, the duration of the repeated course is determined by the doctor individually, taking into account the clinical indications of the patient.

Solution

Chondroxide solution is intended for intramuscular administration.

Recommended dosage: initial dose - 100 mg 1 time in 2 days. With good tolerance, after three injections, the initial dose is increased to 200 mg. The course of treatment is 25–35 injections.

After 180 days, therapy can be repeated.

Ointment and gel

Chondroxide ointment or gel is intended for external use. They are applied to the areas of the body over the lesion and rubbed until completely absorbed, the gel - with the help of light patting movements.

The recommended frequency of procedures is 2-3 times a day. The duration of the course of treatment is 14–21 days, the use of the gel can be extended to 60–90 days.

The course of treatment is repeated as needed.

Side effects

Against the background of the use of Chondroxide, it is possible to develop allergic reactions in the form of itching, rash, erythema, urticaria, dermatitis, edema.

In addition, when using the solution, bleeding at the injection site may become an undesirable phenomenon, and taking pills in rare cases causes a disturbance from the gastrointestinal tract in the form of diarrhea, nausea and vomiting.

Overdose

Symptoms of an overdose of Chondroxide tablets: in rare cases - diarrhea, nausea, vomiting; possibly - hemorrhagic rashes against the background of prolonged oral administration in a dose of more than 12 tablets (3 g of chondroitin sodium sulfate) per day.

Treatment: the appointment of symptomatic therapy.

Cases of overdose when using a solution, ointment or gel have not been established.

special instructions

With parenteral or oral administration of Chondroxide in patients on simultaneous therapy with indirect anticoagulants, fibrinolytics or antiplatelet agents, regular monitoring of blood coagulation parameters is required.

Do not allow the ointment or gel to get on open wounds and mucous membranes of the body.

If the gel gets on clothes, it is easily washed off with water and does not leave stains.

Influence on the ability to drive vehicles and complex mechanisms

Chondroxide does not affect the patient's ability to drive vehicles and complex mechanisms.

Application during pregnancy and lactation

The use of tablets and solution is contraindicated during gestation and breastfeeding.

It is recommended to use ointment and gel with caution during pregnancy and lactation.

Pediatric use

There is no information on the safety and efficacy of Chondroxide for the treatment of children under the age of 18, therefore it is contraindicated to use tablets and solution in this category of patients.

Apply ointment and gel with caution, only as directed by a doctor.

Drug interactions

The use of Chondroxide in the form of tablets and solution can increase the effect of antiplatelet agents, indirect anticoagulants, fibrinolytics.

Analogs

Analogs of Chondroxide are: solutions - Artogistan, Mukosat, Drastop, Artravir-Inkampharm, Hondrogard; lyophilisate - Artradol, Chondroitin sulfate, Chondrolone; capsules - ARTPA Chondroitin, Artradol, Structum; ointment - Artrafik, Mucosat, Chondroitin-AKOS; cream - Teraflex Hondrocrem Forte; gel - Chondroitin.

Terms and conditions of storage

Keep out of the reach of children.

Store: ointment - at a temperature of 2–20 ° C in a dark place, gel - at a temperature of up to 25 ° C, tablets - at a temperature of up to 25 ° C in a place protected from moisture and light, solution - at a temperature of up to 20 ° C in a dark place.

Shelf life: ointment - 3 years, gel, tablets, solution - 2 years.

Terms of dispensing from pharmacies

Released: ointment and gel - without a prescription, tablets and solution - with a prescription.

Reviews about Chondroxide

Reviews of Chondroxide are mostly positive. Patients indicate the effectiveness of tablets and forms of the drug for external use in the treatment of osteoarthritis and osteochondrosis of the spine. They note the analgesic, decongestant, anti-inflammatory effect and good tolerance of the funds.

Price for Chondroxide in pharmacies

The price of Chondroxide for a package containing 1 tube of gel weighing 30 g can range from 346 rubles, weighing 40 g - from 399 rubles, 1 tube of ointment weighing 30 g - from 341 rubles, 60 tablets - from 591 rubles, 10 ampoules 2 ml - from 1197 rubles.

Chondroxide: prices in online pharmacies

Drug name Price Pharmacy

Chondroxide ointment 5% ointment for external use 30 g 1 pc. 289 r Buy

Reviews Chondroxide ointment 289 r Buy

Chondroxide 5% gel for external use 30 g 1 pc. 296 r Buy

Chondroxide ointment 5% 30g 304 RUB Buy

Chondroxide 5% gel for external use 40 g 1 pc. 362 r Buy

Chondroxide gel 5% 30g 388 r Buy

Chondroxide 250 mg tablets 60 pcs. RUB 500 Buy

Chondroxide Maximum 8% cream for external use 50 g 1 pc. RUB 545 Buy

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Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!