Choline alfoscerate
Choline alfoscerate: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Choline alfoscerate
ATX code: N07AX02
Active ingredient: choline alfoscerate (choline alfoscerate)
Producer: SINTEZ OJSC (Russia), DEKO Company LLC (Russia), ATOLL LLC (Russia), PharmIntellekt LLC (Russia), Borisov Medicines Plant OJSC (Republic of Belarus)
Description and photo update: 2018-21-11
Prices in pharmacies: from 163 rubles.
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Choline alfoscerate is a nootropic agent.
Release form and composition
Dosage form - solution for intravenous and intramuscular administration: clear, colorless or slightly yellowish liquid [4 ml in ampoules: 3 or 5 ampoules in blisters, in a cardboard box 1 or 2 packs; 5 ampoules in cardboard forms (trays) with cells for ampoules, in a cardboard box 1 or 2 trays; 10 ampoules in blisters, in a cardboard box 1 package].
Composition of 1 ml solution:
- active substance: choline alfoscerate polyhydrate (in terms of choline alfoscerate) - 250 mg;
- auxiliary component: water for injection.
Pharmacological properties
Pharmacodynamics
Choline alfoscerate is a precursor of phosphatidylcholine and a carrier of choline. It has the potential to correct and prevent biochemical damage, which is of particular importance among the pathogenetic factors of the psychoorganic involutional syndrome, namely, to reduce cholinergic transmission and change the damaged phospholipid composition of the membranes of nerve cells.
The chemical formula of choline alfoscerate contains 40.5% choline. It has the property of metabolic protection and provides the release of choline in the tissues of the brain.
The drug is involved in the synthesis of phosphatidylcholine and acetylcholine in neuronal membranes, enhances metabolic processes and improves blood flow in the central nervous system, activates the reticular formation. Increases the linear velocity of blood flow on the side of the traumatic brain injury. Normalizes the spatio-temporal characteristics of the spontaneous bioelectric activity of the brain. Promotes regression of neurological symptoms, restores consciousness.
The drug has a positive effect on cognitive and memory functions, indicators of behavior and emotional state, which can be reduced due to involutional pathology of the brain.
Choline alfoscerate stimulates dose-dependent release of acetylcholine under physiological conditions. Participates in the synthesis of membrane phospholipid (phosphatidylcholine), thereby improving receptor function, plasticity of neuronal membranes and synaptic transmission.
It has no mutagenic and teratogenic effects, does not adversely affect the reproductive cycle.
Pharmacokinetics
In studies on different types of animals (dogs, rats, monkeys), it was found that the pharmacokinetic characteristics of the radioactive labeled drug are similar.
Choline alfoscerate is rapidly and completely absorbed from the gastrointestinal tract. It rapidly accumulates and is distributed in various tissues and organs, including the brain, where the concentration is higher than that of tritiated choline. Easily penetrates the blood-brain barrier.
The drug is excreted mainly by the lungs (85%) in the form of carbon dioxide, as well as by the kidneys and through the intestines (15%).
Indications for use
- psychoorganic syndrome against the background of degenerative and involutional processes in the brain;
- senile pseudomelancholia;
- violation of behavior and affective sphere in old age: decreased interest, increased irritability, emotional lability;
- consequences of cerebrovascular insufficiency, primary and secondary cognitive impairments in the elderly: memory impairment, disorientation, confusion, decreased concentration, initiative and motivation;
- traumatic brain injury with a predominantly stem level of the lesion (acute period);
- multi-infarction dementia.
Contraindications
- acute stage of hemorrhagic stroke;
- age up to 18 years;
- During pregnancy and breastfeeding;
- hypersensitivity to any component of the drug or drugs with a similar chemical structure.
Instructions for the use of Choline alfoscerate: method and dosage
Choline alfoscerate is administered slowly intramuscularly or intravenously.
The recommended daily dose is 1000 mg.
For intravenous use, the contents of one ampoule are diluted in 50 ml of 0.9% sodium chloride solution. The drug is administered at a rate of 60–80 drops per minute.
Therapy is usually given within 10 days. If necessary, the doctor can increase the dose and / or prolong the treatment, if this is justified by the clinical picture and the characteristics of the course of the disease, taking into account the patient's age and the tolerability of the drug.
After stabilization of the patient's condition, the patient is switched to oral dosage forms of choline.
Side effects
- from the nervous system: drowsiness or insomnia, headache, dizziness, anxiety, aggressiveness, nervousness;
- from the digestive system: pharyngitis, dryness of the oral mucosa, diarrhea or constipation;
- on the part of the skin: skin rashes, urticaria;
- others: pain at the injection site, increased urination.
Overdose
In case of overdose, the severity of dose-dependent side effects may increase.
Treatment is symptomatic. The effectiveness of dialysis has not been established.
special instructions
During therapy, nausea is possible, but it can be a consequence of dopaminergic activation.
Influence on the ability to drive vehicles and complex mechanisms
During the period of treatment, care should be taken when driving vehicles and performing work requiring increased attention, speed of mental and motor reactions.
Application during pregnancy and lactation
According to the instructions, Choline alfoscerate is contraindicated in pregnant and breastfeeding women.
Pediatric use
The drug is not used to treat patients under the age of 18.
Drug interactions
The interaction of Choline alfoscerate with other drugs that would be of clinical importance have not been established.
Analogs
Choline alfoscerat analogs are Gleatser, Gliatilin, Delecit, Cholytilin, Cerepro, Nookholin Rompharm, Cereton.
Terms and conditions of storage
Keep out of reach of children, protected from light at temperatures up to 25 ° C. Avoid freezing.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Choline alfoscerate
According to reviews, Choline alfoscerate is an effective nootropic agent that is often used in severe cases. The drug is well tolerated and rarely causes side effects, but the full course of treatment is relatively expensive.
The price of Choline alfoscerate in pharmacies
The price of Choline alfoscerate varies from 215 to 680 rubles. depending on the number of ampoules in the package, the manufacturer of the drug and the pharmacy network where it is sold.
Choline alfoscerate: prices in online pharmacies
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Drug name Price Pharmacy |
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Choline alfoscerate solution for intravenous and intramuscular injection. 250mg / ml amp. 4ml 3 pcs. 163 r Buy |
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Choline alfoscerate 250 mg / ml solution for intravenous and intramuscular administration 4 ml 3 pcs. 224 r Buy |
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Choline alfoscerate 250 mg / ml solution for intravenous and intramuscular administration 4 ml 5 pcs. 247 r Buy |
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Choline alfoscerat solution for inf. and in / m entered. 250 mg / ml 4 ml No. 5 461 r Buy |
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Choline alfoscerate solution for infusion and intramuscular injection. 250mg / ml 4ml 10 pcs. 553 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
