Cerucal
Instructions for use:
- 1. Pharmacological action
- 2. Indications for use
- 3. Contraindications
- 4. Side effects
- 5. Interaction with drugs
Prices in online pharmacies:
from 105 rub.
Buy
Cerucal is an antiemetic drug that blocks dopamine receptors, presented in two dosage forms:
- The tablets are round, flat, white, with beveled edges. 1 tablet contains 10.54 mg metoclopramide hydrochloride monohydrate (active substance) and auxiliary components (potato starch, lactose monohydrate, magnesium stearate, gelatin, precipitated silicon dioxide);
- Solution for intramuscular and intravenous administration. 1 ampoule of the drug contains 10 mg of metoclopramide hydrochloride - the active ingredient - and excipients: sodium chloride, sodium sulfite, disodium EDTA, water for injection.
Pharmacological action of Cerucal
According to the instructions for Cerucal, the drug has an antiemetic effect, normalizing the functioning of the digestive tract. Metoclopramide, the main active component of the drug, selectively blocks serotonin and dopamine receptors, preventing the passage of impulses along the receptors in the brain and reducing the sensitivity of nerve cells responsible for transmitting impulses from the duodenum to the vomiting center located in the medulla oblongata. Due to the effect of the drug on the work of the autonomic nervous system, Cerucal restores the motility of the upper gastrointestinal tract. Under the influence of Cerucal, the tone of the smooth muscles of the intestinal and stomach walls returns to normal, as a result of which the time for evacuation of the digested food into the duodenum decreases, and the peristalsis of the small intestine improves. In addition, Cerucal promotes normal bile flow, reducing the symptoms of gallbladder dyskinesia and preventing cholestatic jaundice. According to the instructions for Cerucal, the active substance of the drug has a direct effect on the sphincter of Oddi, reducing the manifestations of its spasm.
Despite the antiemetic effect of the drug, Cerucal, according to patients' reviews, is not able to exert a therapeutic effect on vomiting of a vestibular and psychogenic nature.
After oral administration, Cerucal is almost completely absorbed from the gastrointestinal tract, reaching a maximum concentration of metoclopramide in the blood within an hour. The main therapeutic effect of the drug lasts for 12 hours. Cerucal metabolism occurs in the liver. The drug is excreted in the urine: unchanged, and also in the form of metabolites.
After intramuscular or intravenous administration, the therapeutic effect of Cerucal reaches its maximum after 10-15 minutes and 1-3 minutes, respectively.
Indications for the use of Cerucal
Indications for Cerucal are conditions associated with impaired activity of the digestive tract, including: heartburn, irritable bowel syndrome, functional pyloric stenosis. The effectiveness of the drug also extends to nausea and vomiting of various origins (caused by taking medications, impaired liver and kidney function, migraine, craniocerebral trauma), gastric paresis, which developed due to diabetes mellitus. In addition, Cerucal is used as a means of reducing vomiting during diagnostic studies of the gastrointestinal tract (in particular, duodenal intubation).
Contraindications
The use of Cerucal is not recommended for:
- Pheochromocytoma;
- Intestinal obstruction;
- Bleeding from the gastrointestinal tract;
- Gastrointestinal perforation;
- The presence of a prolactin-dependent tumor;
- Epilepsy and convulsive seizures.
The drug is not prescribed in the presence of hypersensitivity to metoclopramide and sodium sulfite, especially to patients suffering from bronchial asthma and other allergic diseases. Cerucal is not intended for use by pregnant women in the first trimester of pregnancy, as well as children under 3 years of age. In the second and third trimesters of pregnancy, the use of the drug is possible only in case of vital indications. According to indications, Cerucal is taken with caution by patients with arterial hypertension, bronchial asthma, people suffering from liver dysfunctions, hypersensitivity to procainamide and procaine.
Side effects of Cerucal
According to reviews of Cerucal, the use of the drug can provoke the following side effects:
- From the side of the central nervous system: dizziness, tinnitus, headache, increased fatigue, fear, depression, anxiety;
- From the side of the cardiovascular system: tachycardia, agranulocytosis, changes in blood pressure;
- From the gastrointestinal tract: dry mouth, stool disturbance, change in taste;
- On the part of the endocrine system, unwanted symptoms can manifest itself as a change in the amount of estrogen, accompanied by menstrual irregularities and gynecomastia;
- Allergic reactions: urticaria, pruritus.
In case of an overdose of the drug, irritability, confusion, convulsions, hyperkinesis, bradycardia, extrapyramidal movement disorders, an increase or decrease in blood pressure are possible. According to reviews to Cerucal, the symptoms of mild poisoning disappear 24 hours after the drug is discontinued. For more severe disorders, symptomatic treatment is recommended.
In the course of treatment, patients are advised to give up alcohol and engage in potentially hazardous activities that require speed of psychomotor reactions and increased attention.
Interaction of Cerucal with drugs
Metoclopramide, when used simultaneously with other drugs, reduces the absorption of cimetidine and digoxin and accelerates the absorption of antibiotics, ethanol and paracetamol. The effectiveness of Cerucal when taken simultaneously with anticholinergics is reduced. The introduction of an injection solution of the drug promotes more rapid breakdown of vitamin B1 - thiamine.
This instruction to Cerucal is presented for informational purposes only. Consult a physician before using this medicine.
Cerucal: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Cerucal 10 mg tablets 50 pcs. RUB 105 Buy |
|
Cerucal tablets 10mg 50 pcs. 106 RUB Buy |
|
Cerucal 5 mg / ml solution for intravenous and intramuscular administration 2 ml 10 pcs. 203 r Buy |
|
Cerucal solution for intravenous and intramuscular injection. 5mg / ml 2ml 10 pcs. 227 r Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
