Poludan - Instructions For Use, Price, Analogues, Eye Drops, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Poludan

Latin name: Poludanum

ATX code: S01AD

Active ingredient: polyadenilic acid + polyuridilic acid

Producer: Veropharm, LLC (Russia), Lens-Farm, LLC (Russia)

Description and photo update: 2019-26-08

Poludan is an immunostimulating agent with a pronounced antiviral and immunomodulatory effect.

Release form and composition

Dosage forms of Poludan:

• Lyophilisate for preparation of solution for injection: white mass (100 units of action (U) in 1 ml ampoules or in 5 ml vials, in a cardboard box 10 ampoules or vials);
• Lyophilisate for the preparation of eye drops (in 5 ml vials, 100 units each, in a cardboard box 1 or 3 vials complete with 1 or 3 sterile dropper caps);
• Lyophilisate for the preparation of nasal drops (in 5 ml vials, 100 units each, in a cardboard box 1 or 3 vials complete with 1 or 3 sterile dropper caps);
• Nasal drops: colorless transparent liquid (5 ml in glass vials, in a cardboard box of 1, 3 or 100 vials complete with 1, 3 or 100 dropper caps).

The content of active substances of Poludan in 100 IU of lyophilisate / 1 ml of nasal drops:

• Potassium polyriboadenylate (potassium salt of polyriboadenylic acid) - 0.1 mg / 0.05 mg;
• Potassium polyriburidylate (potassium salt of polyriburidylic acid) - 0.107 mg / 0.0535 mg.

Auxiliary components in the composition of lyophilizates: sodium hydrogen phosphate (sodium phosphate 2-substituted), sodium chloride, potassium dihydrogen phosphate (potassium phosphate 1-substituted anhydrous).

Additionally, as part of nasal drops: disodium edetate (Trilon B), water for injection.

Pharmacological properties

Pharmacodynamics

Poludane is a biosynthetic polyribonucleotide complex of polyribouridylic and polyriboadenylic acids. Inductor of biosynthesis of endogenous interferon and other cytokines.

It has a pronounced immunomodulatory and antiviral activity. Promotes an increase in the activity of natural killer cells, which are initially reduced in patients with ophthalmic herpes, as well as other immunocompetent cells.

When injected, the production of endogenous interferon in blood serum and tear fluid is stimulated. It is determined 3 hours after drug administration. A high level of interferon (110 and 75 U / ml in blood and lacrimal fluid, respectively) is maintained with daily administration throughout the entire course of use. The next day after discontinuation of therapy, the substance is practically not detected (titer - not higher than 10 U / ml).

Indications for use

According to the instructions, Poludan is prescribed for adults and children for the treatment of viral pathologies.

Lyophilisate for preparation of solution for injection

Keratitis, keratoiridocyclitis (keratouveitis), stromal keratitis;

• Adenoviral and herpetic keratoconjunctivitis;
• Chorioretinitis;
• Iridocyclitis;
• Optic neuritis.

Lyophilisate for the preparation of eye drops

• Herpetic and adenoviral conjunctivitis;
• Keratitis;
• Superficial keratoconjunctivitis.

Lyophilisate for the preparation of nasal drops and nasal drops

• Acute respiratory viral infections;
• Flu.

Contraindications

You can not appoint Poludan to patients with hypersensitivity to its components.

In addition, contraindications for injecting the drug into the anterior chamber of the eye:

• Sinus infection;
• Tooth infection
• Conjunctivitis (if pathogenic microflora is present in the crop from the conjunctiva);
• Keratoiridocyclitis with ulceration of the anterior surface of the cornea.

Instructions for the use of Poludan: method and dosage

Lyophilisate for preparation of solution for injection

Poludan is intended for subconjunctival administration.

To prepare the solution, the contents of the vial or ampoule are dissolved in 1 ml of water for injection or 0.5% novocaine solution.

Recommended dosage:

• Uncomplicated pathologies: 0.5 ml under the conjunctiva once a day or every other day, only 5-20 injections;
• Endothelial forms of herpetic keratoiridocyclitis: in the operating room, 0.3-0.6 ml is slowly injected into the anterior chamber of the eye once every 3 days, only 3-5 injections (the solution is prepared with water for injection);
• Herpetic lesion of the posterior parts of the eye (optic neuritis, chorioretinitis, uveitis): periocularly (retrobulbar, parabulbar) - 1 ml once every 2 days, 10-20 injections in total.

When treating children, Poludan is dissolved in water for injection and 0.25 ml is injected under the conjunctiva 1 time in 2 days, a total of 8-10 injections.

For the treatment of fresh rashes of herpes zoster on the skin of the face with herpetic keratitis, it is necessary to dissolve the contents of two vials of the drug in 10-20 ml of a 0.5% solution of novocaine and inject subcutaneously along the course of the rash, the procedure is carried out every other day, only 3-6 injections.

Lyophilisate for the preparation of eye drops

Ready-made eye drops Poludan are intended for instillation into the conjunctival sac of the eye.

To prepare the drug, add 2 ml of water for injection to the contents of the bottle and shake until the lyophilisate is completely dissolved.

Recommended dosage:

• Adults: at the beginning of treatment, 1-2 drops are instilled 6-8 times a day, then, with a decrease in the inflammatory process - 3-4 times a day;
• Children: at the beginning of treatment - 1-2 drops 3-4 times a day, then, with a decrease in the inflammatory process - 1-2 times a day.

The prepared solution can be stored in the refrigerator and used within 7 days.

In the absence of a therapeutic effect after 7 days of treatment, it is necessary to consult a doctor and consider prescribing the drug in the form of subconjunctival injections.

Lyophilisate for the preparation of nasal drops and nasal drops

A ready-made solution of lyophilisate and Poludan drops are applied topically in the form of nasal drops.

To prepare a solution from the lyophilisate, add boiled chilled water to the bottle (up to the mark indicated on the label) and shake.

It is recommended to start using each of the remedies no later than the first two days after the onset of symptoms of an exacerbation of the disease.

The recommended dosage of Poludan for adults: 2 drops in each nasal passage 5 times a day. Duration of treatment is 5 days.

Side effects

Allergic reactions are possible during the use of Poludan.

Subconjunctival administration of the drug causes an increase in superficial injection of the eye vessels, slight edema of the lower eyelid.

In the case of an injection into the anterior chamber of the eye, hemorrhages may appear at the injection site, a transient increase in intraocular pressure.

When using Poludan eye drops, it is possible to increase the conjunctival injection, the appearance of itching and individual follicles in the lower transitional fold, the sensation of a foreign body in the eye.

Overdose

There is no information.

special instructions

Injection administration of Poludan is prescribed in the absence of a clinical effect after 7 days of using eye drops.

Side effects after drug withdrawal disappear after 1-3 days.

Drug interactions

With simultaneous use with enzyme agents, the antiviral and immunomodulatory activity of Poludan decreases.

Combination therapy with drugs for the treatment of viral infections and antibiotics is indicated.

Analogs

Analogues of Poludan are Bonafton eye ointment 0.05%, Bonafton.

Terms and conditions of storage

Keep out of the reach of children.

Store in a dark, dry place at a temperature: lyophilisate for preparation of solution for injection - up to 4 ° C, lyophilisate for preparation of eye and nasal drops - up to 8 ° C, nasal drops - up to 30 ° C.

Shelf life: lyophilisate - 4 years, nasal drops - 2 years.

Terms of dispensing from pharmacies

Released:

• lyophilisate for preparation of solution for injection - by prescription;
• lyophilisate for the preparation of eye / nasal drops, nasal drops - without a prescription.

Reviews about Poludan

Most of the reviews about Poludan refer to the lyophilisate dosage form for the preparation of eye drops. Most often, it is noted that the drug is highly effective, does not cause irritation and pain.

The main disadvantage is considered to be inconvenient packaging, lack of water for injection in the set and a short shelf life after preparation. The cost is assessed as affordable, but indicates that the product is difficult to find in pharmacies.

Price for Poludan in pharmacies

The approximate price for Poludan (lyophilisate for the preparation of nasal drops 100 U, 1 bottle of 5 ml) is 430 rubles.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!