Truxal
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 346 rub.
Buy
Truxal is a thioxanthene derivative; neuroleptic with antipsychotic, pronounced sedative and moderate antidepressant effects.
Release form and composition
Dosage form - film-coated tablets: biconvex, round (tablets 5, 15 and 25 mg) or oval (tablets 50 mg), dark brown (50 and 100 pcs. In plastic containers with a screw cap and first opening control, 1 container in a carton box).
Active ingredient: chlorprothixene hydrochloride, its content in 1 tablet is 5, 15, 25 or 50 mg.
Additional components: glycerol 85%, croscarmellose sodium, copovidone, lactose monohydrate, magnesium stearate, talc, microcrystalline cellulose, corn starch.
Shell composition: Opadry OY-S-9478 brown, consisting of macrogol 400, hypromellose, titanium dioxide (E 171), red iron oxide (E 172) and black iron oxide (E 172).
Indications for use
- neuroses, depressions, psychosomatic disorders accompanied by sleep disturbances, insomnia, tension, anxiety and anxiety;
- schizophrenia and other psychoses, proceeding with anxiety, agitation and psychomotor agitation;
- epilepsy and mental retardation, combined with mental disorders such as agitation, agitation, mood lability, behavioral disturbances;
- pain syndrome (in combination with analgesics);
- withdrawal symptoms in alcoholism and drug addiction;
- behavioral and sleep disorders in children;
- behavioral and sleep disorders, confusion, irritability, agitation, anxiety, hyperactivity in the elderly.
Contraindications
- uncorrected hypokalemia or hypomagnesemia;
- congenital long QT interval syndrome, acquired prolonged QT interval (more than 450 msec in men and 470 msec in women);
- impaired absorption of glucose and galactose;
- depression of consciousness of any origin (including caused by the intake of barbiturates, opiates or alcohol);
- vascular collapse;
- coma;
- presence in the status or history of clinically significant cardiovascular diseases, such as bradycardia (less than 50 beats / minute), cardiac hypertrophy, decompensated heart failure, recent myocardial infarction, arrhythmias requiring the use of class IA and III antiarrhythmics, ventricular arrhythmias, polymorphic pirouette ventricular tachycardia (Torsade de Pointes);
- hereditary galactose intolerance, lactase deficiency;
- simultaneous use of drugs that lengthen the QT interval;
- hypersensitivity to any component of the drug.
Carefully:
- severe pseudoparalytic myasthenia gravis;
- seizure disorders;
- a family history of lengthening of the QT interval;
- mental retardation;
- organic diseases of the brain;
- benign prostatic hypertrophy;
- severe hepatic and renal impairment;
- presence in the status of cardiovascular diseases;
- intraocular hypertension (in patients with a local anatomical predisposition - a narrow angle of the anterior chamber);
- the presence of risk factors for the development of stroke;
- alcohol or opiate abuse;
- During pregnancy and breastfeeding.
Method of administration and dosage
Truxal should be taken orally with water.
Doses are set by the doctor individually for each patient, depending on his condition. Treatment is usually started with small doses, which are increased until the desired effect is achieved as quickly as possible, depending on the therapeutic response.
Average doses used:
- manic states, schizophrenia and other psychoses: the initial dose is 50-100 mg per day, then it is gradually increased to the optimal effective level, usually 300 mg per day. In some cases, it is possible to increase the daily dose to 1200 mg. The daily maintenance dose may be 100-200 mg. The daily dose should be divided into 2-3 doses, while the smaller part should be taken during the day, the greater part - in the evening;
- psychosomatic disorders, depressive states and neuroses: in a daily dose of up to 75 mg in 2-3 doses, the maximum dose is 150 mg per day;
- withdrawal symptoms for alcoholism and drug addiction: 500 mg per day in 2-3 doses for, as a rule, 7 days. After the withdrawal symptoms disappear, the dose is gradually reduced. The maintenance daily dose to stabilize the condition and reduce the risk of another binge is 25–75 mg;
- epilepsy and mental retardation, combined with mental disorders: 50 mg in 2-3 doses, if necessary, the daily dose is increased to 75-100 mg;
- behavioral disorders in the elderly: 25–75 mg per day;
- chronic pain: in a daily dose of 75-300 mg (if necessary, Truxal is used in combination with analgesics);
- insomnia: 25 mg 1 hour before bedtime;
- behavioral disorders in children: in a daily dose of 0.5–2 mg / kg.
The duration of treatment is determined individually. Chlorprothixene does not cause drug dependence or addiction, so it can be used for a long time.
For patients with impaired renal and liver function, the drug is prescribed in a lower dose. During treatment, it is recommended to monitor the concentration of chlorprothixene in the blood serum.
Side effects
Most side effects are dose-dependent. The frequency and severity of their development are most pronounced at the beginning of treatment and decrease as therapy continues.
The classification of side effects is presented in accordance with the following gradation of the frequency of their development: very often - ≥1 / 10, often - from ≥ 1/100 to 1/1000 to <1/100, rarely - from ≥ 1/10 000 to <1 / 1000, very rarely - <1/10 000, the frequency is unknown - on the basis of existing data it is not possible to estimate the frequency of development.
- from the nervous system: very often - dizziness, drowsiness; often - headache, dystonia; infrequently - parkinsonism, akathisia, tardive dyskinesia, convulsions; very rarely - neuroleptic malignant syndrome (muscle rigidity, hyperthermia, impaired consciousness, increased sweating, tachycardia, labile blood pressure);
- on the part of the psyche: often - agitation, insomnia, decreased libido, nervousness;
- from the respiratory system: rarely - shortness of breath;
- from the endocrine system: rarely - hyperprolactinemia;
- from the digestive system: very often - increased salivation, dry mouth; often - nausea, dyspepsia, constipation; infrequently - diarrhea, vomiting;
- from the urinary system: infrequently - painful urination, urinary retention;
- on the part of the hematopoietic organs: rarely - leukopenia, neutropenia, thrombocytopenia, agranulocytosis;
- on the part of the cardiovascular system: often - a feeling of palpitations, tachycardia; infrequently - hot flashes, hypotension; rarely - lengthening the QT interval on the electrocardiogram; very rarely - venous thromboembolism, ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation, pirouette ventricular tachycardia, sudden death);
- from the immune system: rarely - anaphylactic reactions and hypersensitivity reactions;
- metabolic disorders and eating disorders: often - increased appetite, weight gain; infrequently - decreased appetite and weight loss; rarely - impaired glucose tolerance, hyperglycemia;
- on the part of the reproductive system: infrequently - erectile dysfunction, ejaculation disorders; rarely - amenorrhea, galactorrhea, gynecomastia;
- on the part of the visual organs: often - visual impairment and accommodation; infrequently - movement of the eyeballs;
- from the musculoskeletal system: often - myalgia; infrequently - muscle rigidity;
- from the hepatobiliary system: infrequently - changes in laboratory parameters of liver function; very rarely - jaundice;
- on the part of the skin and subcutaneous tissue: often - hyperhidrosis; infrequently - itching, dermatitis, skin rash, photosensitivity;
- others: often - fatigue, asthenia.
In case of abrupt withdrawal of Truxal, withdrawal syndrome may develop: anxiety, increased sweating, insomnia, agitation, paresthesia, dizziness, nervousness, nausea, diarrhea, anorexia, vomiting, myalgia, rhinorrhea, tremor, additional sensation of warmth and cold.
Overdose symptoms: drowsiness, hyperthermia or hypothermia, extrapyramidal symptoms, convulsions, renal failure, coma, shock, polymorphic pirouette ventricular tachycardia, ventricular arrhythmia, prolongation of the QT interval, cardiac arrest.
In newborns whose mothers took the drug in the last months of pregnancy or during childbirth, signs of intoxication may occur: excessive excitability, tremors, lethargy. A low Apgar score is also possible.
special instructions
Truxal is not used to treat behavioral disorders in older people with dementia.
Patients receiving antipsychotics are often at risk of developing venous thromboembolism, therefore, prior to the appointment of Truxal and periodically during treatment, it is necessary to assess the presence of risk factors for the development of this disease and, if necessary, take precautions.
Electrocardiography (ECG) should be performed before starting therapy. You should not prescribe the drug if the QT interval in men is more than 450 msec, in women - more than 470 msec.
If the QT interval increases during the use of Truxal, the dose should be reduced. If the indicator exceeds the above limits, the drug is canceled.
The need for an ECG during treatment is assessed by the doctor based on the patient's condition.
When carrying out long-term therapy, especially in high doses, the patient's condition should be carefully monitored in order to make a decision to reduce the maintenance dose.
Patients with diabetes mellitus during the period of use of the drug may need to adjust the dose of insulin.
During treatment, one should refrain from engaging in potentially hazardous activities that require quick psychophysical reactions and increased attention, including driving.
Drug interactions
- antipsychotics and lithium preparations: the risk of neurotoxicity increases;
- ethanol, barbiturates and other drugs that depress the central nervous system: their effect is enhanced;
- disulfiram: it is possible to reduce or eliminate its action;
- tricyclic antidepressants: mutual inhibition of metabolism is noted;
- drugs that cause electrolyte disturbances (thiazide and similar diuretics), drugs that can increase the concentration of chlorprothixene in the blood plasma: it is possible to prolong the QT interval and the occurrence of life-threatening arrhythmias (such combinations should be used with great caution);
- levodopa, adrenergic drugs: their effectiveness decreases;
- anticholinergics: their effect is enhanced;
- metoclopramide, piperazine: the risk of developing extrapyramidal disorders increases;
- guanethidine and similar agents: their effect is weakened;
- antihypertensive drugs: it is possible to increase or decrease their action.
An increase in the QT interval, characteristic of antipsychotics, can be enhanced with the simultaneous use of drugs that significantly prolong the QT interval (cisapride, lithium), quinolone antibiotics (gatifloxacin, moxifloxacin), antiarrhythmic drugs of IA and III classes (dofetilide, sotalol, quinidine, amiodarone), some antihistamines (for example, astemizole, terfenadine), some macrolide antibiotics (for example, erythromycin), some antipsychotics (for example, thioridazine). Such combinations should be avoided.
Analogs
Chlorprothixene is an analogue of Truxal.
Terms and conditions of storage
Keep out of the reach of children at a temperature not exceeding 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Truksal: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Truxal 50 mg film-coated tablets 50 pcs. 346 r Buy |
|
Truxal 25 mg film-coated tablets 100 pcs. 391 r Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
