Troxerutin Vramed
Troxerutin Vramed: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Troxerutin Vramed
ATX code: C05CA04
Active ingredient: troxerutin (Troxerutin)
Producer: JSC "Sopharma" (AD Sopharma) (Bulgaria)
Description and photo update: 2020-25-02
Prices in pharmacies: from 37 rubles.
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Troxerutin Vramed is an angioprotective agent used for disorders of venous circulation.
Release form and composition
Dosage forms:
- capsules: hard gelatin No. 1, yellow; content - a pressed mass that takes the form of a capsule, or granules from light yellow to dark yellow (in a cardboard box, instructions for the use of Troxerutin Vramed and 5 blisters containing 10 capsules each);
- gel for external use: a uniform yellow consistency (in a cardboard box there is a medical instruction for the preparation and 1 aluminum tube containing 40 g of gel).
Composition of 1 capsule:
- active substance: troxerutin - 300 mg;
- auxiliary components: magnesium stearate, colloidal silicon dioxide, macrogol 6000, milk sugar (lactose monohydrate);
- capsule shell: titanium dioxide, gelatin, quinoline yellow (E104) and sunset yellow (E110) dyes.
Composition of 1 g of gel:
- active substance: troxerutin - 20 mg;
- auxiliary substances: benzalkonium chloride, disodium edetate, sodium hydroxide, carbomer 940, purified water.
Pharmacological properties
Pharmacodynamics
The active ingredient of the drug, troxerutin, is a flavonoid (a derivative of rutin). Shows P-vitamin activity. Reduces capillary permeability and fragility. It has anti-inflammatory, anti-edematous, angioprotective and venotonic effects.
The pharmacological property of troxerutin is due to the ability of its bioflavonoids to participate in redox processes and suppress hyaluronidase. By inhibiting hyaluronidase, the drug stabilizes the hyaluronic acid of the cell membranes and reduces their permeability.
Troxerutin has antioxidant properties, thereby preventing the oxidation of lipids, ascorbic acid and adrenaline. Also, the drug reduces fragility and reduces capillary permeability. When exposed to negative factors, it prevents damage to the basement membrane of endothelial cells.
Troxerutin prevents platelets from adhering to the vascular wall, reducing the likelihood of developing exudative inflammation. As a result of drug treatment, trophism in the tissues improves, swelling decreases, and the feeling of heaviness in the legs disappears.
Pharmacokinetics
When taken internally and externally, troxerutin is well absorbed.
From the gel, the active substance penetrates into the blood vessels of the subcutaneous tissue.
After oral administration, the maximum plasma concentration (C max) is reached within 2-8 hours. The second peak C max is observed approximately 3 hours after taking the capsule. It is excreted from the body: about 70% - with bile, the rest - with urine.
When applied topically, troxerutin does not have a systemic effect, since it practically does not penetrate into the general bloodstream.
Indications for use
For both dosage forms:
- phlebeurysm;
- chronic venous insufficiency;
- superficial thrombophlebitis;
- post-traumatic edema of soft tissues, hematomas;
- post-thrombotic syndrome.
Additional indications for different dosage forms of Troxerutin Vramed:
- capsules: varicose dermatitis, varicose ulcers, hemorrhoids (to relieve symptoms), complex therapy for diabetic retinopathy;
- gel for external use: periphlebitis, phlebothrombosis.
Contraindications
Absolute contraindications for taking Troxerutin Vramed in capsule form:
- galactose intolerance, glucose-galactose malabsorption syndrome, lactase deficiency;
- exacerbation of chronic gastritis, gastric ulcer and duodenal ulcer;
- I trimester of pregnancy;
- age up to 18 years;
- hypersensitivity to any component of Troxerutin Vramed.
Conditions / diseases in which taking capsules is required with extreme caution:
- II and III trimesters of pregnancy;
- lactation period;
- renal failure (if long-term treatment is necessary).
Gel for external use Troxerutin Vramed is contraindicated for children and adolescents under the age of 18, as well as for patients with established hypersensitivity to any component of the drug.
Troxerutin Vramed, instructions for use: method and dosage
Capsules
Troxerutin Vramed in capsule form should be taken orally with meals.
Adults are prescribed 1 capsule 2-3 times a day.
The duration of treatment is determined by the moment the symptoms disappear completely.
In the next 3-4 weeks, maintenance therapy is carried out - 1 capsule 1 time per day.
Gel for external use
Troxerutin Vramed in the form of a gel should be applied 2 times a day (morning and evening) to the affected areas and rubbed gently with light massaging movements.
If necessary, occlusive dressings can be applied from above. Also, the gel can be used in the form of compresses.
Side effects
Troxerutin Vramed capsules are generally well tolerated, in rare cases they cause the following undesirable reactions:
- on the part of the skin: itching, erythema;
- from the digestive system: flatulence, stomach pain, diarrhea, nausea, vomiting, erosive and ulcerative lesions of the gastrointestinal tract;
- from the nervous system: headache.
Patients also generally tolerate gel Troxerutin Vramed well. With long-term treatment, there is a possibility of skin redness and itching.
Overdose
There are no reports of overdose cases of Troxerutin Vramed when taken orally and externally.
special instructions
The drug is not effective for edema caused by diseases of the heart, kidneys and liver.
The composition of the capsules contains a food additive E110, which can cause allergic reactions.
The gel for external use has a pH corresponding to human skin, therefore it does not cause irritation and hypersensitivity. The drug is water-based, therefore, does not violate the physiological properties of the skin: permeability, acid-base balance, passage through the pores.
Influence on the ability to drive vehicles and complex mechanisms
Troxerutin Vramed capsules and gel for external use do not adversely affect the speed of reactions and a person's ability to concentrate.
Application during pregnancy and lactation
Troxerutin Vramed capsules are not recommended for use in the first trimester of pregnancy. In the II-III trimesters and during lactation, the drug should be used with caution, after a careful assessment of the balance of benefits and possible risks.
Gel Troxerutin Vramed does not adversely affect the course of pregnancy, the development of the fetus and the child, therefore, it is allowed for use during pregnancy and lactation.
Pediatric use
Both dosage forms of the drug are contraindicated in children and adolescents under the age of 18.
With impaired renal function
Troxerutin Vramed capsules should be used with caution in patients with renal insufficiency if long-term treatment is required.
For violations of liver function
There are no restrictions on the appointment of all forms of Troxerutin Vramed for patients with functional liver disorders.
Drug interactions
There is no evidence of a negative interaction of troxerutin with other drugs.
Analogs
Analogues of Troxerutin Vramed are Angiorus, Vasoket, Venarus, Venatabs, Detravenol, Detralex, Diosmin, Stimulven, Troxevasin, Troxerutin, Flebaven, Phlebopress, Phlebodia 600.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Troxerutin Vramed
Reviews about Troxerutin Vramed are predominantly positive: the drug effectively eliminates heaviness in the legs, bruises and edema. Both capsules and gel are well tolerated, do not cause adverse reactions. They are freely available from many pharmacy chains. The cost of the drug is most often called affordable.
Price for Troxerutin Vramed in pharmacies
Approximate prices for Troxerutin Vramed depending on the form of release:
- 300 mg capsules per pack of 50 - 290 rubles;
- gel for external use 2% for 1 tube weighing 40 g - 67 rubles.
Troxerutin Vramed: prices in online pharmacies
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Drug name Price Pharmacy |
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Troxerutin Vramed 2% gel for external use 40 g 1 pc. RUB 37 Buy |
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Troxerutin Vramed gel 2% 40g RUB 69 Buy |
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Troxerutin Vramed 300 mg capsules 50 pcs. 266 r Buy |
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Troxerutin Vramed capsules 300mg 50 pcs. RUB 300 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
