Sulfacetamide

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Sulfacetamide: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Sulfacetamid

ATX code: A07AB

Active ingredient: N - [(4-aminophenyl) sulfonyl] acetamide {N - [(4-aminophenyl) sulfonyl] acetamide}

Manufacturer: JSC NPK "ESKOM" (Russia)

Description and photo update: 2020-16-01

Sulfacetamide is an antimicrobial drug for topical use in ophthalmology, it has a bacteriostatic effect.

Release form and composition

The drug is available in the form of eye drops 20%: a clear, colorless liquid, may have a yellow tint (5 or 10 ml in polyethylene or polypropylene dropper bottles, in a cardboard box 1 bottle and instructions for the use of Sulfacetamide; for hospitals - 50 bottles each in cardboard boxes).

1 ml of drops contains:

active substance: sodium sulfacetamide, in terms of 100% sulfacetamide - 200 mg;
auxiliary components: sodium thiosulfate pentahydrate, hydrochloric acid (1M solution), water for injection.

Pharmacological properties

Pharmacodynamics

Sulfacetamide is an antimicrobial drug with a bacteriostatic effect for topical use in ophthalmology. Its active substance is sulfacetamide, an intermediate product of the synthesis of streptocide, belongs to the pharmacological group of sulfonamides, and is a competitive antagonist of para-aminobenzoic acid. The mechanism of action of the drug is due to such properties of sulfonamides as the ability to inhibit dihydropteroate synthetase and disrupt the synthesis of tetrahydrofolic acid, which is involved in the formation of purines and pyrimidines.

Sulfacetamide is sensitive to gram-positive and gram-negative cocci, Shigella spp. (speciales), Chlamydia spp., Vibrio cholerae, Escherichia coli, Corynebacterium diphtheriae, Clostridium perfringens, Yersinia pestis, Toxoplasma gondii, Actinomyces israelii, Bacillus anthracis.

Pharmacokinetics

After application, the maximum concentration (C _max) of sulfacetamide is reached in the first 0.5 hours. In this case, C _max in the cornea is about 3 mg / ml, the moisture of the anterior chamber is ~ 0.5 mg / ml, the iris is ~ 0.1 mg / ml … In the tissues of the eyeball, the drug is stored for 3-4 hours at a concentration of less than 0.5 mg / ml.

With damage to the corneal epithelium, the penetrating activity of sulfonamides increases.

Indications for use

The use of eye drops Sulfacetamide is indicated in the complex therapy of the following diseases:

conjunctivitis;
purulent corneal ulcer;
blepharitis;
gonorrheal and chlamydial eye infections.

In addition, in newborns, drops are used for the prevention and treatment of blennorrhea.

Contraindications

It is contraindicated to use drops with established hypersensitivity to the components that make up their composition.

With caution, only on the recommendation of a doctor, the use of sulfonamides during pregnancy and lactation is allowed.

Sulfacetamide, instructions for use: method and dosage

Sulfacetamide eye drops are applied topically, by instillation into the conjunctival sac of each eye.

Recommended dosage:

conjunctivitis in adults and children: 1-2 drops every 2-3 hours for 7-10 days;
blepharitis in adults and children: 1-2 drops 6-8 times a day in the acute period of the disease, as the condition improves, the frequency of instillations decreases, and can be from 3 to 4 times a day. The drug should be used for 3-5 days;
purulent corneal ulcer (as part of complex therapy): 1-2 drops 5-6 times a day. The duration of the course of treatment is 5–7 days;
gonorrheal and chlamydial eye diseases (as part of complex therapy in adults): 1–2 drops 5–6 times a day for 28–42 days. With positive dynamics, a decrease in the frequency of procedures with an interval of 7 days is shown;
prevention of blenorrhea in newborns: immediately after birth - 2 drops in each conjunctival sac, then after 2 hours the procedure must be repeated.

Side effects

on the part of the organ of vision: burning, itching and / or pain in the eyes, transient blurred vision after instillation, lacrimation;
from the immune system: allergic reactions.

Overdose

Overdose symptoms have not been established.

special instructions

It should be borne in mind that hypersensitivity to Sulfacetamide can be observed in patients with established individual intolerance to thiazide diuretics, furosemide, sulfonylurea or carbonic anhydrase inhibitors. This category of patients is recommended to use the drug with caution.

Influence on the ability to drive vehicles and complex mechanisms

If, against the background of the use of the drug, a temporary violation of the clarity of vision occurs, then immediately after instillation, patients are not recommended to drive vehicles or engage in those activities that require clarity of visual perception.

Application during pregnancy and lactation

Sulfacetamide should be used during pregnancy or lactation only in cases where, in the opinion of the doctor, the expected clinical effect for the mother outweighs the potential risk to the fetus or child.

Pediatric use

Sulfacetamide in childhood should be used only according to indications and in doses recommended for treatment and prevention.

Drug interactions

It should be borne in mind that Sulfacetamide is pharmacologically incompatible with silver salts.

With simultaneous use with procaine or tetracaine, the bacteriostatic effect of drops is reduced.

Analogs

The analogues of Sulfacetamide are Albucid, Sulfacil sodium, Sulfacil sodium Vial, Sulfacil sodium-DIA, Sulfacil sodium-SOLOpharm.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 15 ° C in a dark place.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Sulfacetamide

There are currently no patient or professional reviews for Sulfacetamide. Perhaps this is due to the cancellation of the state registration of the drug in 2019 and its unavailability.

Price for Sulfacetamide in pharmacies

The price for Sulfacetamide has not been established due to the lack of the drug in the pharmacy network.

The cost of some pharmaceutically equivalent analogues:

Sulfacil sodium-SOLOpharm, eye drops 20%, in the package 1 bottle of 5 ml - 30 rubles;
Sulfacil sodium Renewal, eye drops 20%, in the package 2 bottles of 2 ml - 75 rubles;
Sulfacyl sodium, eye drops 20%, in the package 2 bottles of 1.5 ml - 60 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!