Solvin
Solvin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Solvin
ATX code: R05CB02
Active ingredient: bromhexine (Bromhexine)
Manufacturer: Ipka Laboratories, Ltd. (Ipca Laboratories, Ltd.) (India)
Description and photo update: 2019-30-12
Solvin is a mucolytic and expectorant drug.
Release form and composition
Solvin's dosage forms:
- elixir: clear, pale orange liquid, with a pleasant mixed aroma of menthol and fruits (60 or 120 ml in an amber glass bottle, sealed with an aluminum screw cap and a plastic measuring cap; in a cardboard box 1 bottle);
- tablets: flat-cylindrical, round, from pale orange to orange, with the possible presence of inclusions of a lighter and darker color, with a notch and a chamfer on one side (10 pcs. in a blister of polyvinyl chloride and aluminum foil; in a cardboard box 10 blisters).
Each pack also contains instructions for using Solvin.
5 ml of elixir contains:
- active substance: bromhexine hydrochloride - 4 mg;
- additional components: benzoic acid, propylene glycol, sorbitol solution, citric acid, menthol, sodium saccharin, vanillin, pineapple essence, sunset dye, sweet orange essence, purified water.
1 tablet contains:
- active substance: bromhexine hydrochloride - 8 mg;
- additional components: corn starch, methyl parahydroxybenzoate, colloidal silicon dioxide, propyl parahydroxybenzoate, lactose, acacia gum, gelatin, magnesium stearate, talc, sunset yellow dye.
Pharmacological properties
Pharmacodynamics
Solvin's active substance has mucolytic (secretolytic) and expectorant effects. The mucolytic effect is provided by the process of depolymerization, followed by liquefaction of mucopolysaccharide and mucoprotein fibers. The effect of bromhexine is manifested 2–5 days after the start of the course. The agent activates the production of endogenous surfactant, which is responsible for maintaining the stability of alveolar cells during respiration.
Pharmacokinetics
After oral administration, the active substance is almost completely (up to 99%) absorbed from the gastrointestinal (GIT) within 30 minutes, the bioavailability is approximately 80%. The drug passes through the blood-brain barrier (BBB) and the placenta.
Biotransformation of bromhexine occurs in the liver by demethylation and oxidation, resulting in the formation of ambroxol. The half-life (T 1/2) is 15 hours, which is due to the slow process of reverse diffusion from tissues. The agent is excreted in the urine, and can accumulate during repeated use.
Indications for use
Solvin is recommended for use for the treatment of the following acute and chronic lung diseases, occurring with the formation of high-viscosity sputum: cystic fibrosis, bronchial asthma, tracheobronchitis, pneumonia, bronchiectasis, obstructive bronchitis, pneumoconiosis, pulmonary emphysema, tuberculosis.
Solvin is also prescribed for chest injuries.
Contraindications
Absolute:
- stomach ulcer;
- age up to 3 years (for tablets);
- pregnancy and lactation;
- glucose-galactose malabsorption, lactase deficiency, galactose intolerance (for tablets, since they contain lactose);
- hypersensitivity to any component of the mucolytic agent.
Relative (it is recommended to take Solvin with caution):
- history of gastric bleeding;
- lesions of the bronchi, accompanied by excessive accumulation of secretions;
- renal and / or hepatic impairment;
- weakened state.
Solvin, instructions for use: method and dosage
Elixir and Solvin tablets are taken orally. The effect of the drug does not depend on the time of the meal.
Recommended dosage regimen for tablets:
- children 3-5 years: 3 times / day, 2 mg (¼ pcs.);
- children 6-14 years old: 3-4 times / day, 4-8 mg (½ – 1 pc.);
- adults: 3-4 times / day, 8-16 mg (1-2 pcs.).
Children under 6 years of age should take Solvin Elixir.
Recommended single doses of the elixir:
- children under 2 years of age: 2.5 ml (½ teaspoon);
- children 2–6 years old: 2.5–5 ml (½ – 1 tsp);
- children 6-14 years old: 5-10 ml (1-2 tsp);
- adolescents over 14 years old and adults: 10-15 ml (2-3 tsp).
The course of treatment with Solvin can vary from 4 to 28 days.
Side effects
Rarely, with prolonged drug therapy, the following undesirable effects may occur:
- nervous system: headache, dizziness;
- allergic reactions: skin rash, rhinitis, angioedema;
- digestive system: dyspepsia, nausea, vomiting, exacerbation of gastric ulcer, increased activity of hepatic transaminases.
With the development of similar or other disorders not listed above, you should consult your doctor.
Overdose
Symptoms of an overdose of bromhexine may include dyspeptic symptoms, vomiting, diarrhea, and nausea.
Treatment (in the first 1-2 hours after administration) is gastric lavage, induction of vomiting.
special instructions
During the period of treatment with Solvin, it is necessary to consume a sufficient amount of liquid to ensure an increase in the mucolytic effect of bromhexine.
Influence on the ability to drive vehicles and complex mechanisms
There is no data on the adverse effect of Solvin on the ability to drive and maintain complex mechanisms.
Application during pregnancy and lactation
During pregnancy and lactation, the use of Solvin is contraindicated.
Pediatric use
Children under 3 years old are contraindicated to take Solvin tablets. For pediatric patients under 6 years of age, it is recommended to use the drug in the form of an elixir.
Therapy with the drug in children should be combined with vibration massage of the chest or postural (positional) drainage to facilitate the evacuation of secretions from the bronchi.
With impaired renal function
In the presence of chronic renal failure (CRF), the elimination of bromhexine metabolites is impaired. Patients with renal insufficiency should take Solvin with caution.
For violations of liver function
Patients with hepatic dysfunction are advised to use Solvin with caution.
Drug interactions
When using bromhexine with other drugs / substances, the following pharmacological interactions are possible:
- other drugs prescribed for the treatment of bronchopulmonary diseases: the combined use of these funds with Solvin is allowed;
- medicines containing codeine: evacuation of diluted sputum from the bronchi worsens, this combination is not recommended;
- phenylbutazone, butadione, salicylates (non-steroidal anti-inflammatory drugs): the risk of irritation of the gastric mucosa is aggravated;
- cephalexin, erythromycin, oxytetracycline and other antibiotics: the penetration of these substances into the lung tissue improves;
- alkaline solutions: the combined use of these funds with bromhexine is not allowed.
In case of taking any medications before starting treatment with Solvin, you should consult a specialist.
Analogs
Solvin's analogs are Bromhexine, Bromhexine Grindeks, Bromhexine Nycomed, Bromhexine MS, Bromhexine Medisorb, Bromhexine-UBF, Bromhexine 8 Berlin-Chemi, Bromhexine-Akrikhin, etc.
Terms and conditions of storage
Store out of the reach of children, protected from moisture and light, at a temperature below 25 ° C.
The shelf life of the elixir is 3 years, of the tablets - 4 years.
Terms of dispensing from pharmacies
Available without a prescription
Reviews about Solvin
Since there are currently no patient reviews on Solvin on specialized Internet resources, the opinion of specialists about the drug is interesting. For example, Dr. Komarovsky writes in his book that the active component of the drug, bromhexine, is one of the five chemical compounds of mucolytic action. And the choice of a particular mucolytic, as well as the duration of its use, and the dose are individual. They must be determined by a doctor, in accordance with the patient's age, diagnosis, severity of the disease and taking into account other important criteria.
It is advisable to use mucolytics for thick, viscous sputum. But they are practically useless for wet coughs and mild forms of acute respiratory viral infections with upper respiratory tract damage. Moreover, most often these drugs aggravate the patient's condition, since they can provoke an increase in coughing. Mucolytics are also unable to exert their therapeutic effect, that is, to improve the rheology of sputum, if the rheology of the blood is not improved, and this requires additional therapy with drugs of a different pharmacological property.
The effectiveness of mucolytic agents is expressed insignificantly and for a short time, if the factors provoking the drying out of mucous membranes and mucus are not eliminated, and the optimal temperature and humidity in the room are not provided.
It should also be remembered that bromhexine is not related to alternative medicine, or to medicinal herbs and traditional medicine.
Solvin price in pharmacies
There is no reliable information about the price of Solvin, since at the moment it is not sold in pharmacies. The cost of its analogue, Bromhexine, in the form of tablets (8 mg), can be 20-60 rubles. for 50 pcs., in the form of a syrup (4 mg / 5 ml) per bottle, with a volume of 100 ml - 70-130 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
