Siflox
Siflox: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Sifloks
ATX code: J01MA02
Active ingredient: ciprofloxacin (ciprofloxacin)
Producer: Ejzachibashi Ilyach Sanayi (Turkey)
Description and photo updated: 2018-23-11
Siflox is a broad spectrum antibacterial agent.
Release form and composition
Dosage form of Siflox - coated tablets (10 pcs. In a blister, 1 blister in a cardboard box).
The drug contains the active substance ciprofloxacin (in the form of monohydrate hydrochloride), in 1 tablet - 250 or 500 mg.
Auxiliary components: microcrystalline cellulose, corn starch, colloidal silicon dioxide, magnesium stearate, crospovidone; film casing - Opadry White OY S 28842.
Pharmacological properties
Pharmacodynamics
Ciprofloxacin is a broad-spectrum antimicrobial agent. Refers to the group of fluoroquinolones. Possesses bactericidal properties. The mechanism of action is due to the ability to suppress DNA gyrase and inhibit the synthesis of bacterial DNA.
Shows high activity against most gram-negative bacteria, including Haemophilus influenzae, Neisseria meningitidis, Shigella spp., Escherichia coli, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Salmonella spp.
Effective against Staphylococcus spp. (including methicillin-resistant strains and strains producing and not producing penicillinase), some strains of Enterococcus spp., Mycoplasma spp., Mycobacterium spp., Legionella spp., Campylobacter spp., Chlamydia spp., as well as bacteria producing beta-lactamases …
Microorganisms Clostridium difficile, Ureaplasma urealyticum and Nocardia asteroides are resistant to the action of ciprofloxacin.
The effect of the drug against Treponema pallidum has not been sufficiently studied.
Pharmacokinetics
After oral administration, ciprofloxacin is rapidly absorbed from the gastrointestinal tract. Simultaneous food intake has a slight effect on absorption. Bioavailability is approximately 70%.
When taken on an empty stomach, the maximum serum concentration is reached within 30-180 minutes. Depending on the dose taken, the maximum concentration is:
- 250 mg - 0.76 mg / ml;
- 500 mg - 1.6 mg / ml;
- 750 mg - 2.5 mg / ml;
- 1000 mg - 3.4 mg / ml.
It binds to plasma proteins by 20-40%. Distributed in tissues and body fluids. Reaches high concentrations in bile. Penetrates into the cerebrospinal fluid: with non-inflamed meninges, the concentration of ciprofloxacin reaches 10%, with inflamed meninges - up to 37%.
Excreted in urine and bile.
Indications for use
According to the instructions, Siflox is used to treat infectious and inflammatory diseases caused by microorganisms sensitive to its active substance, including diseases of the respiratory tract and ENT organs, infections of the gastrointestinal tract, biliary tract, pelvic organs, genital organs (including gonorrhea), skin and soft tissues, bones and joints, eye infections, wound infections, postoperative septicemia.
Also Siflox is prescribed for the treatment and prevention of infections in patients with reduced immunity.
Contraindications
- childhood;
- pregnancy and lactation;
- hypersensitivity to the components of Siflox or other drugs of the quinolone series.
With caution, Siflox should be used in the elderly, with disorders of cerebral circulation, atherosclerosis of the cerebral vessels, convulsive syndrome of unclear etiology, epilepsy.
Siflox instructions for use: method and dosage
Siflox tablets are taken orally.
The optimal dose is determined individually.
Average effective doses depending on indications:
- urinary tract infections: uncomplicated - 250 mg 2 times a day, severe - 500 mg 2 times a day;
- severe respiratory tract infections, osteomyelitis: 750 mg 2 times a day;
- other infections: 500 mg 2 times a day.
Duration of treatment:
- urinary tract and kidney infections - 7-10 days;
- streptococcal infections - at least 10 days.
Usually it is recommended to continue taking Siflox for 72 hours after clinical and microbiological recovery.
In acute gonorrhea, the drug is taken once in a dose of 250 mg.
For patients with severe renal impairment (creatinine clearance <20 mg / min), the usual dose is reduced by 2 times.
Side effects
- from the digestive system: abdominal pain, nausea, diarrhea, vomiting, pseudomembranous colitis, increased bilirubin, alkaline phosphatase, hepatic transaminase activity, lactate dehydrogenase;
- from the urinary system: polyuria, dysuria, hematuria, albuminuria, crystalluria, transient increase in serum creatinine, glomerulonephritis;
- on the part of the hematopoietic system: changes in the number of platelets, leukopenia, eosinophilia, neutropenia;
- from the central nervous system: fatigue, headache, visual disturbances, dizziness, hallucinations, sleep disorders, nightmares, fainting;
- on the part of the cardiovascular system: arterial hypotension, cardiac arrhythmias, tachycardia;
- allergic reactions: urticaria, pruritus, angioedema, arthralgia, Stevens-Johnson syndrome;
- others: candidiasis, vasculitis.
Overdose
No information available.
special instructions
In order to avoid the development of crystalluria during the treatment period, you should ensure a sufficient intake of fluid in the body.
In case of persistent diarrhea, therapy should be discontinued.
Ethanol increases the likelihood of side effects, so you should avoid drinking alcohol during treatment.
Influence on the ability to drive vehicles and complex mechanisms
Ciprofloxacin can slow down the rate of reactions, therefore, during the entire period of taking Siflox, it is recommended to refrain from performing potentially hazardous activities, including driving a car and operating complex mechanisms.
Application during pregnancy and lactation
Siflox is contraindicated to prescribe during pregnancy and lactation. In the latter case, if the use of the drug is clinically justified, breastfeeding should be discontinued.
Pediatric use
Siflox is not used in pediatrics.
With impaired renal function
If kidney function is impaired, caution is required. With creatinine clearance <20 mg / min, the dose of the drug is halved.
Use in the elderly
Elderly patients should be treated with the drug under close medical supervision.
Drug interactions
Didanosine reduces the absorption of ciprofloxacin (due to the formation of complexones of ciprofloxacin with magnesium and aluminum buffers contained in didanosine).
The absorption of ciprofloxacin can be slowed down by antacids and agents containing iron, zinc, magnesium or aluminum ions. A minimum of 4-hour intervals should be observed between taking these drugs.
Siflox can increase the concentration of theophylline in blood plasma and increase its half-life, resulting in the development of toxic effects.
When used simultaneously with warfarin, ciprofloxacin increases the risk of bleeding.
Ethanol increases the likelihood of side effects.
Analogs
Siflox analogs are Ciprolet, Tseprova, Quintor, Tsiprinol, Tsiprinol SR, Ificipro, Basigen, Cifran, Ciprobid, Ciprolacer, Cifloxinal, Vero-Ciprofloxacin, Ciprofloxacin, Ciprofloxacin-Promed, Ciprodifrox, Tsiproxid FPO, Ciprofloxacin Ecocifol, Ciprofloxabol, Tsiprobay, Ciprofloxacin-Teva, Tsifran OD, etc.
Terms and conditions of storage
Shelf life is 4 years.
Keep out of reach of children at temperatures up to 30 ° C.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Siflox
There are practically no reviews of Siflox on specialized medical sites. On drugs that also contain ciprofloxacin as an active substance, the reviews are mostly positive: they are effective for infectious diseases caused by sensitive microorganisms. The disadvantages include the development of side effects and the lack of effect with influenza.
Price for Siflox in pharmacies
The price of Siflox is currently unknown, since the state registration of this drug has expired. The approximate cost of an analogue of Ciprofloxacin: 16–21 rubles. for 10 tablets of 250 mg, 30-40 rubles. for 10 tablets of 500 mg.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
