Omez Insta
Omez Insta: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Omez Insta
ATX code: A02BC01
Active ingredient: omeprazole (Omeprazole)
Producer: Dr. Reddy's Laboratories Ltd (India)
Description and photo update: 2019-08-10
Prices in pharmacies: from 64 rubles.
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Omez Insta is an antiulcer drug, proton pump inhibitor.
Release form and composition
The drug is produced in the form of a powder for preparation of a suspension for oral administration: from almost white to white with a mint smell [5.885 g each in sachets made of a combined material (low density polyethylene / aluminum foil / low density polyethylene / glassine), in a cardboard box 5, 10, 20 or 30 sachets and instructions for the use of Omeza Insta].
Powder composition (content in 1 sachet):
- active substance: omeprazole - 20 mg;
- auxiliary components: sucrose - 2070 mg, xylitol - 2000 mg, sodium bicarbonate - 1680 mg, xanthan gum - 55 mg, sucralose - 30 mg, mint flavor - 30 mg.
Pharmacological properties
Pharmacodynamics
Omez Insta is an antiulcer drug that lowers the secretion of the stomach glands. Its active ingredient - omeprazole, being a specific inhibitor of the proton pump, reduces the production of hydrochloric acid. The mechanism of action of omeprazole is due to inhibition of the activity of hydrogen-potassium adenosine triphosphatase (H + / K + -ATPase) in parietal cells of the stomach and blocking the final stage of secretion of hydrochloric acid.
Omeprazole is a prodrug, its activation occurs only in the acidic environment of the secretory tubules of the parietal cells of the stomach.
The effect is dose-dependent and, regardless of the nature of the stimulating factor, provides effective inhibition of basal and stimulated acid secretion.
After taking Omeza Insta, heartburn is eliminated within half an hour, 50% of the maximum secretion of hydrochloric acid continues to be inhibited throughout the day.
A single dose per day provides effective and rapid suppression of both daytime and nocturnal gastric secretions. The maximum effect is achieved 96 hours after the start of application and disappears approximately 72–96 hours after the end of treatment. In case of duodenal ulcer disease, taking 20 mg of omeprazole maintains the acidity (pH) inside the stomach above 3 for 17 hours.
Pharmacokinetics
After oral administration, omeprazole is characterized by a high degree of absorption. The bioavailability of the drug is 30-40%, in patients with hepatic insufficiency - almost 100%. The maximum concentration in blood plasma (C max) is reached on average within 0.5 hours. Omeprazole is highly lipophilic, which allows it to easily penetrate into the parietal cells of the stomach. Simultaneous food intake does not affect the clinical effect of Omeza Insta.
Plasma protein binding (acid alpha 1 -glycoprotein and albumin) - 95%.
It is metabolized almost completely in the liver with the formation of six pharmacologically inactive metabolites (including hydroxyomeprazole, sulfone and sulfide derivatives). The enzyme system of cytochrome P 450 (CYP) is involved in metabolism. Biotransformation of omeprazole largely depends on the polymorphically expressed specific isoform CYP2C19 (S-mefenytoin hydroxylase), which is involved in the formation of hydroxyomeprazole, which is the main plasma metabolite. Omeprazole inhibits the CYP2C19 isoenzyme.
The half-life (T 1/2) is approximately 0.5-1 hours (it does not change during treatment), with hepatic insufficiency - 3 hours. The total plasma clearance is from 0.3 to 0.6 l / min.
Through the kidneys, 70–80% of the dose taken is excreted, with bile - 20–30%.
In chronic renal failure, excretion decreases in proportion to the decrease in creatinine clearance.
In elderly patients, there is an increase in bioavailability and a decrease in the excretion of omeprazole.
Indications for use
- peptic ulcer of the stomach and duodenum, including the prevention of relapse;
- non-erosive and erosive (reflux esophagitis) form of gastroesophageal reflux disease (GERD);
- heartburn and other symptoms associated with GERD;
- eradication of Helicobacter pylori in patients with gastric ulcer and duodenal ulcer - as part of combination therapy;
- hypersecretory conditions (stress ulcers of the gastrointestinal tract, Zollinger-Ellison syndrome, systemic mastocytosis, polyendocrine adenomatosis);
- non-steroidal gastropathy or gastropathy, the development of which is caused by the use of NSAIDs (non-steroidal anti-inflammatory drugs).
Contraindications
Absolute:
- fructose intolerance, glucose-galactose malabsorption syndrome, sucrase or isomaltase deficiency;
- concomitant therapy with atazanavir and / or nelfinavir;
- period of pregnancy;
- breast-feeding;
- childhood;
- hypersensitivity to the components of the drug.
Omez Insta should be taken with caution in patients with renal and / or hepatic insufficiency.
Omez Insta, instructions for use: method and dosage
The suspension prepared from Omez Insta powder is taken orally, 0.5 hours before meals, with a little water if necessary.
To prepare a suspension, the powder is thoroughly dissolved in 1-2 tablespoons of water immediately before taking.
Recommended dosage of Omeza Insta:
- heartburn: 20 mg (1 sachet of powder) once - usually this dose provides rapid relief of symptoms of heartburn;
- non-erosive form of GERD: 20 mg once a day for 28 days;
- erosive form of GERD (reflux esophagitis): 20 mg 2 times a day for 28–56 days. The duration of the course is individual, it depends on the severity of the disease;
- prevention of exacerbation of reflux esophagitis: 20 mg once a day. The duration of the course of maintenance therapy is determined by the doctor;
- exacerbation of gastric ulcer or duodenal ulcer (not associated with Helicobacter pylori): 20 mg once a day, in the morning, for 28-56 days;
- prevention of gastric ulcer or duodenal ulcer: 20 mg once a day, in the morning, for 28–56 days;
- non-steroidal gastropathy: treatment - 20 mg 2 times a day for 28-56 days; prevention in patients with risk factors for the development of NSAID gastropathy - 20 mg 1 time per day during the entire period of NSAID intake;
- hypersecretory states: 20 mg once a day, in the morning, for 28-56 days. For the treatment of Zollinger-Ellison syndrome, the dose should be selected individually, taking into account the clinical condition. The starting dose is usually 60 mg once a day. In most cases, the condition is adequately controlled in the dose range from 20 to 120 mg of the drug per day. When using a dose of more than 80 mg, it must be divided into 2 doses.
Combination therapy for the eradication of Helicobacter pylori in gastric ulcer and duodenal ulcer can last for 7-14 days and consist of the following combination of drugs:
- option 1: 20 mg omeprazole + 1000 mg amoxicillin + 500 mg clarithromycin - 2 times a day;
- option 2: 20 mg omeprazole + 500 mg clarithromycin + 500 mg metronidazole - 2 times a day;
- Option 3: 20 mg of omeprazole 2 times a day + 120 mg of bismuth 4 times a day + 500 mg of metronidazole 3 times a day + 500 mg of tetracycline 4 times a day.
In patients with renal insufficiency or in old age, there is no need to adjust the usual doses of Omeza Insta.
In patients with hepatic insufficiency, the therapeutic effect can be provided by taking Omez Insta in a daily dose of 20 mg.
Side effects
The disorders described below are classified according to the following frequency of occurrence: very common (≥ 1/10); often (from ≥ 1/100 to <1/10); infrequently (from ≥ 1/1000 to <1/100); rarely - (from ≥ 1/10 000 to <1/1000); very rare (<1/10 000, including isolated cases).
Taking Omeza Insta may be accompanied by the appearance of undesirable reactions:
- on the part of the hematopoietic organs: rarely - thrombocytopenia, leukopenia; very rarely - pancytopenia, agranulocytosis;
- from the senses: infrequently - vertigo; rarely - blurred vision;
- from the digestive system: often - abdominal pain, flatulence, diarrhea, constipation, nausea, vomiting; rarely - an increase in the activity of liver enzymes, a violation of taste; very rarely - stomatitis, dry mouth, candidiasis of the mucous membrane of the gastrointestinal tract, with a history of severe liver disease - hepatitis (including jaundice), liver failure, development of encephalopathy;
- from the musculoskeletal system: rarely - myalgia, arthralgia; very rarely - muscle weakness;
- on the part of the reproductive and reproductive system: very rarely - gynecomastia;
- from the urinary system: rarely - interstitial nephritis;
- from the immune system: rarely - hypersensitivity reactions (fever, angioedema, anaphylactic reactions up to anaphylactic shock);
- from the nervous system: often - headache; infrequently - drowsiness, dizziness, paresthesia;
- mental disorders: infrequently - insomnia; rarely - confusion, depression, agitation; very rarely - hallucinations, aggression;
- metabolic disorders: rarely - hyponatremia; very rarely - hypomagnesemia;
- dermatological reactions: infrequently - itching, rash, dermatitis, urticaria; rarely - photosensitivity, alopecia; very rarely - toxic epidermal necrolysis, Stevens-Johnson syndrome, exudative erythema multiforme;
- others: infrequently - peripheral edema, malaise; rarely - increased sweating, bronchospasm.
Overdose
Symptoms of an Omeza Insta overdose are dry mouth, nausea, vomiting, flatulence, headache, drowsiness, lethargy, dizziness, confusion, arrhythmia, tachycardia, blurred vision.
As therapeutic measures to relieve the symptoms of an overdose, immediate gastric lavage and the intake of activated carbon are used. In the future, symptomatic treatment is prescribed. The use of hemodialysis is ineffective.
special instructions
The appointment of Omeza Insta should be performed (especially for patients with stomach ulcers) only after excluding the patient with a malignant process. This is due to the fact that the use of the drug can mask the symptoms and delay the establishment of a reliable diagnosis.
The resulting side reactions are usually reversible.
With concomitant therapy with other drugs, one should take into account the possible decrease or increase in their absorption due to the intake of omeprazole.
Influence on the ability to drive vehicles and complex mechanisms
During the period of drug treatment, patients should be advised to be careful when driving or working with complex mechanisms because of the existing risk of dizziness or drowsiness.
Application during pregnancy and lactation
The use of Omeza Insta during pregnancy and lactation is contraindicated.
Pediatric use
The appointment of Omeza Insta for the treatment of patients under the age of 18 is contraindicated.
With impaired renal function
It is recommended to use Omez Insta with caution in case of renal failure.
No dose adjustment is required for patients in this category.
For violations of liver function
It is recommended to use Omez Insta with caution in liver failure.
The therapeutic effect in this category of patients can be provided by taking the drug in a daily dose of 20 mg.
Use in the elderly
For elderly patients, dose adjustment of Omez Insta powder is not required.
Drug interactions
- atazanavir, nelfinavir and other antiretroviral drugs: Omez Insta can affect the absorption of antiretroviral drugs and lower their serum concentration, so this combination should be avoided;
- ketoconazole, itraconazole: the absorption of these drugs decreases;
- digoxin: against the background of the use of omeprazole at a dose of 20 mg once a day, the bioavailability (10%) and absorption of digoxin increase;
- saquinavir: there is an increase in the serum concentration of saquinavir;
- drugs metabolized with the participation of the isoenzyme CYP2C19, including vitamin K antagonists, cilostazol, diazepam, warfarin, phenytoin: the metabolism of these drugs may decrease;
- phenytoin: there is a risk of an increase in the concentration of phenytoin in plasma, therefore, if it is necessary to use it together with omeprazole, it is recommended to control the level of phenytoin in plasma in order to reduce its dose in a timely manner;
- warfarin and other vitamin K antagonists: control of the international normalized ratio (INR) is required in patients on concomitant therapy with these drugs, in order to reduce their dose if necessary;
- cilostazol: taking omeprazole in a daily dose of 40 mg leads to an average increase of 18% C max and 26% AUC (area under the concentration-time curve) of cilostazol;
- cyclosporine, lidocaine, estradiol, erythromycin, quinidine, budesonide: Omez Insta does not affect the metabolism of these agents;
- tacrolimus: there is a risk of increased serum tacrolimus levels;
- clarithromycin, voriconazole (inhibitors of the isoenzyme CYP2C19, CYP3A4): it is possible to slow down the metabolism of omeprazole and increase its concentration in blood plasma, which does not require dose adjustment;
- rifampicin and preparations of St. John's wort (inducers of the isoenzyme CYP2C19, CYP3A4): it is possible to accelerate the metabolism of omeprazole and lower its level in blood plasma.
Analogs
Omez Insta analogs are Omez, Omeprazole, Omeprazole Zentiva, Omeprazole Stada, Omeprazole-OBL, Omeprazole-Akrikhin, Omeprazole-Richter, Omeprazol-C3, Omeprazol-Teva, Omal, OmeVel, Omizakol, Los Omitoks, 20, Promez, Romesek, Ulkozol, Ultop, Helicid, Tsisagast, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture and light.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Omez Insta
Reviews about Omez Insta are positive. Pointing to the effectiveness of the drug, patients emphasize its rapid action in heartburn, relief of severe pain syndrome in case of stomach and duodenal ulcers, gastritis or other gastroenterological pathologies.
Price for Omez Insta in pharmacies
The approximate price for Omez Insta for a package containing 5 sachets may be 69–85 rubles.
Omez Insta: prices in online pharmacies
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Drug name Price Pharmacy |
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Omez Insta 20 mg powder for suspension for oral administration 5.885 g 5 pcs. RUB 64 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
