Retinol acetate
Retinol acetate: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Retinol acetate
ATX code: A11CA01
Active ingredient: retinol (retinol)
Producer: Polisintez (Russia), Pharmaceutical Factory of St. Petersburg, JSC (Russia), Marbiopharm, JSC (Russia)
Description and photo update: 2019-13-08
Prices in pharmacies: from 13 rubles.
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Retinol acetate - vitamin A.
Release form and composition
Dosage forms of Retinol acetate:
- drops for oral administration and external use 3.44% and 8.6%: oily liquid from dark yellow to light yellow in color with a transparent structure, without rancid odor (10, 15, 30, 50 ml in glass vials of dark color or 10, 30 or 50 ml in vials with a dropper cap, in a cardboard box 1 bottle);
- solution for oral administration and external use oily 3.44% and 8.6%: transparent from dark yellow to light yellow oily liquid without rancid odor (10, 15, 30, 50 or 100 ml each in dark glass vials or 10 ml in a dropper bottle, in a cardboard box 1 bottle; 10 ml (3.4% solution) in a polymer bottle, in a cardboard box 1 bottle);
- capsules: yellow, spherical, without mechanical contamination and sagging; the contents of the capsules are an oily liquid from light yellow to dark yellow, there is no rancidity in the smell (10 pieces in a blister, in a cardboard box 1-3 or 5 packs; 25 or 50 pieces in dark glass jars, in a cardboard box 1 can).
1 ml of drops for oral administration and external use 3.44% and 8.6% contains:
- active substance: retinol acetate (including butylhydroxytoluene and peanut oil) 100,000 International Units (ME) and 250,000 ME, respectively;
- auxiliary components: butylhydroxyanisole, sunflower oil (refined deodorized sunflower oil).
1 ml of a solution for oral administration and external use of oil 3.44% and 8.6% contains:
- active substance: retinol acetate 100,000 IU (34.4 mg) and 250,000 IU, respectively;
- auxiliary components: frozen out refined deodorized sunflower oil, grade P.
1 capsule contains:
- active substance: retinol acetate solution for oral administration and external use oily 8.6% - 0.132 ml (33,000 ME);
- auxiliary components: refined deodorized sunflower oil;
- shell composition: glycerin (glycerol), methyl parahydroxybenzoate (nipagin), gelatin, quinoline yellow dye (E-104).
Pharmacological properties
Pharmacodynamics
Retinol acetate, vitamin A is an essential component for the normal functioning of the retina of the eye, which binds to the pigment opsin to form visual purpura rhodopsin, which provides visual adaptation in the dark. Vitamin A also participates in the processes of bone growth, embryonic development, regulation of division, differentiation of the epithelium (stimulates the reproduction of epithelial cells, rejuvenates the cell population, suppresses keratinization processes), and ensures normal reproductive function. Vitamin A is a cofactor in various biochemical processes.
Pharmacokinetics
Vitamin A is rapidly absorbed from the duodenum, jejunum and other organs of the gastrointestinal tract in the presence of bile acids, proteins, fats and pancreatic lipase. Normally, less than 5% binds to plasma proteins. With excessive consumption of food with vitamin A and overflow of the liver depot, the connection with lipoproteins can be up to 65%. Also, hyperlipoproteinemia may affect the increase in the amount of vitamin A associated with lipoproteins. Vitamin A, being released from the liver depot, forms a complex with retinol-binding protein, in the form of which it is in the blood. Small amounts cross the placenta and into breast milk. In the equivalent of a two-year need for an adult, it is deposited in the liver, in a small amount - in the kidneys and lungs. Mobilization from a depot requires zinc-containing substances.
Vitamin A is metabolized in the liver. It is excreted by the kidneys, and the non-absorbed part through the rectum.
Indications for use
The use of Retinol acetate is indicated for vitamin A deficiency, hypovitaminosis and as part of complex therapy:
- eye pathologies: hemeralopia, retinitis pigmentosa, xerophthalmia, eczematous lesions of the eyelids, keratomalacia with concomitant vitamin A deficiency;
- diseases and skin lesions: ulcers, ichthyosis, psoriasis, hyperkeratosis, tylotic (corn-like, horny) eczema, subacute and acute stages of eczema, neurodermatitis, burns, frostbite, erosion, cracks, wounds.
In addition, oily solution for oral and external use and Retinol acetate capsules are used as part of complex therapy:
- seborrheic dermatitis, skin tuberculosis;
- gastrointestinal diseases: peptic ulcer of the stomach and duodenum, erosive gastroduodenitis;
- colds and infectious and inflammatory (including chronic forms) diseases (including measles, dysentery, tracheitis, flu, bronchitis).
Also, Retinol acetate capsules are taken in the treatment of liver cirrhosis, and drops are prescribed as part of the complex therapy of atopic dermatitis.
Contraindications
- acute inflammatory skin diseases;
- cholelithiasis;
- hypervitaminosis A;
- chronic pancreatitis;
- period of pregnancy;
- age up to 7 years;
- individual intolerance to the components of the drug.
With caution, only after consulting the attending physician, Retinol acetate can be used for liver cirrhosis, alcoholism, viral hepatitis, renal failure, in old age.
In addition, care should be taken when prescribing the solution and capsules to patients with heart failure of II and III degrees, with nephritis.
Instructions for the use of Retinol acetate: method and dosage
The use of Retinol acetate is carried out only under the supervision of a physician.
Drops for oral and external use 3.44% and 8.6%
Drops are taken orally after meals, after 10-15 minutes.
Recommended dosage of Retinol acetate:
- mild to moderate vitamin deficiency: adults - 11.35 mg (33,000 IU), which corresponds to 0.33 ml drops with a concentration of 3.44% (13 drops from an eye pipette or 10 drops from a dropper cap) or 0.13 ml 8.6% of the drug (5 drops from an eye dropper or 4 drops from a dropper cap) per day;
- eye diseases: adults - 17.2-34.4 mg (50,000-100,000 ME), which corresponds to 0.5-1 ml drops with a concentration of 3.44% (20-40 drops from an eye pipette or 14-28 - from a dropper cap) or 0.2-0.4 ml with a concentration of 8.6% (8-16 drops from an eye pipette or 6-8 - from a dropper cap) per day; children (taking into account age) - 0.34-1.72 mg each (1000-5000 ME), which corresponds to 0.01-0.05 ml of 3.44% drug (1-2 drops from an eye pipette or 1 drop from dropper caps) or 0.004-0.02 ml of the drug with a concentration of 8.6% (1 drop from an eye pipette or from a dropper cap) per day;
- skin pathologies: adults - 17.2-34.4 mg (50,000-100,000 IU), which corresponds to 0.5-1 ml of 3.44% of the drug (20-40 drops from an eye pipette or 14-28 - from dropper caps) or 0.2-0.4 ml drops of 8.6% (8-16 drops from an eye pipette or 6-8 drops from a dropper cap) per day; children - 1.72-6.88 mg (5000-20,000 ME), which corresponds to 0.05-0.2 ml drops of 3.44% (2-8 drops from an eye pipette or 2-6 drops - from the lid -drops) or 0.02-0.08 ml of the drug with a concentration of 8.6% (1-4 drops from an eye pipette or 1-2 drops from a dropper cap) per day.
The doctor determines the duration of treatment individually.
When treating ulcers, burns and frostbite, it is simultaneously recommended to treat skin lesions with an oil solution of Retinol acetate. For this, the preparation is applied to the previously cleaned surface of the lesion 5-6 times a day and covered with gauze. Frequency rate of lubrication frequency as epithelization and scarring is reduced to 1 time per day.
Solution for oral administration and external use oil 3.44% and 8.6%
Retinol acetate solution is taken orally, 10-15 minutes after meals (early in the morning or late in the evening).
Recommended dosage:
- mild and moderate severity of vitamin deficiency: adults - up to 33,000 ME, children over 7 years old - 5,000 ME per day;
- eye diseases: adults - 50,000-100,000 ME per day with simultaneous intake of 20 mg of riboflavin;
- skin pathologies: adults - 50,000-100,000 ME, children - 5,000-20,000 ME per day. In the treatment of burns, frostbite and ulcers, in addition to oral administration, local applications with the drug are prescribed, which are applied to the cleaned affected areas 5-6 times a day during the acute period of the condition, then, as the healing progresses, the frequency of procedures is reduced.
A single dose should not exceed 50,000 ME for adults, 5,000 ME for children, and a daily dose of 100,000 ME and 20,000 ME, respectively.
Capsules
Retinol acetate capsules are taken orally after meals late in the evening or early in the morning.
Recommended dosage:
- avitaminosis of mild and moderate severity: 1 pc. (33,000 IU) per day;
- eye pathologies: adults - 3 pcs. (100,000 IU) per day in combination with 20 mg of riboflavin;
- skin diseases: adults - 3 pcs. (100,000 ME) per day.
The maximum daily intake for adults is 100,000 IU.
Side effects
Against the background of Retinol acetate therapy, hypervitaminosis A, allergic reactions may develop, with prolonged use, the risk of intoxication increases.
Hypervitaminosis A symptoms:
- adults: drowsiness, headache, lethargy, nausea, vomiting, facial flushing, gait disturbance, pain in the bones of the lower extremities;
- children: skin rashes, fever, vomiting, drowsiness, sweating.
Overdose
In acute overdose in adults after 6 hours, the following symptoms of hypervitaminosis A develop: lethargy, drowsiness, dizziness, double vision, nausea, vomiting, severe headache, irritability, diarrhea, bleeding gums, dryness and ulceration of the oral mucosa, peeling lips, skin (especially palms), increased intracranial pressure, confusion.
Symptoms of chronic intoxication: bone pain, loss of appetite, dryness of the oral mucosa, cracks and dry skin, vomiting, gastralgia, increased fatigue, hyperthermia, asthenia, severe abdominal pain, headaches, pollakiuria, nocturia, polyuria, photosensitivity, irritability, the appearance of yellow-orange spots on the palms, soles, in the areas of the nasolabial triangle, hair loss, convulsions, hepatotoxic phenomena, oligomenorrhea, portal hypertension, intraocular hypertension, hemolytic anemia, the appearance of changes on the radiographs of bones.
Acute hypervitaminosis in children is characterized by excitement, anxiety, insomnia during the first day, drowsiness, signs of suffocation, vomiting, fever up to 39 ºC, protrusion of the large fontanel.
Treatment: drug withdrawal and symptomatic therapy.
special instructions
Retinol acetate should not be used in combination with other multivitamin preparations containing vitamin A in order to prevent hypervitaminosis.
For adults, the daily requirement of retinol is 0.9 mg, for children - 0.4-1 mg.
For breastfeeding women and children living in the Far North, it is recommended to increase the dose by 50%.
The use of the drug in the recommended doses does not affect the patient's ability to drive vehicles and mechanisms.
Application during pregnancy and lactation
According to the instructions, Retinol acetate is contraindicated for treatment during pregnancy.
Pediatric use
Retinol acetate is contraindicated for the treatment of patients under the age of 7 years. When treating children over 7 years old, the drug should be used with caution.
With impaired renal function
In case of renal failure, the drug should be used with caution.
For violations of liver function
With cirrhosis of the liver, Retinol acetate should be used with caution.
Use in the elderly
When treating elderly patients, the drug should be used with caution.
Drug interactions
It is not recommended to prescribe vitamin A preparations during long-term therapy with tetracyclines, since this combination can cause intracranial hypertension.
With the simultaneous use of Retinol acetate:
- oral contraceptives - increase the concentration of vitamin A in blood plasma;
- glucocorticosteroids, salicylates - reduce the risk of unwanted effects;
- colestipol, cholestyramine, neomycin, mineral oils - reduce the absorption of the drug (it may be necessary to increase the dose of retinol acetate);
- isotretinoin - increases the risk of developing a toxic effect;
- calcium preparations - reduce their therapeutic effect, causing the risk of hypercalcemia;
- vitamin E - causes a decrease in the deposition in the liver and the use of vitamin A, the toxicity of the drug and its absorption, taking high doses of vitamin E can reduce the reserves of vitamin A in the body.
Analogs
Retinol Acetate analogues are: Retinol Palmitate, Retinol Acetate solution in oil, Retinol, Vitamin A.
Terms and conditions of storage
Keep out of the reach of children.
Store at a temperature: drops and solution - up to 10 ° C, capsules - up to 25 ° C, protected from light, protect capsules from moisture.
Shelf life: drops - 3 years; solution and capsules - 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews of Retinol acetate
Reviews of Retinol acetate indicate the high effectiveness of this tool. Users note that taking vitamin A can quickly improve the condition of the hair and get rid of acne.
Retinol acetate price in pharmacies
The approximate price of Retinol acetate is: oil solution 3.44% 50 ml - 85 rubles, oil solution 8.6% 50 ml - 102 rubles, 10 capsules 33,000 IU - 8 rubles, 30 capsules 33,000 IU - 33 rub.
Retinol acetate: prices in online pharmacies
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Drug name Price Pharmacy |
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Retinol acetate (Vitamin A) 33000 IU capsules 10 pcs. RUB 13 Buy |
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Retinol acetate 33000 IU capsules 30 pcs. RUB 20 Buy |
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Retinol acetate 3.44% solution for oral administration and external use (oil) 10 ml 1 pc. RUB 29 Buy |
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Retinol acetate 3.44% solution for oral and external use (oil) 50 ml 1 pc. RUB 75 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
