Neobutin Retard
Neobutin Retard: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Neobutine Retard
ATX code: A03AA05
Active ingredient: trimebutine (trimebutine)
Producer: JSC Pharmaceutical Enterprise Obolenskoye (Russia), Samil Pharm. Co., Ltd. (The Republic of Korea)
Description and photo update: 28.11.2018
Prices in pharmacies: from 316 rubles.
Buy
Neobutin Retard is an antispasmodic agent.
Release form and composition
Dosage form - tablets of prolonged action, film-coated: almost white or white, oblong with rounded ends, biconvex; the cross section shows an almost white or white core; from tablets manufactured by Samil Pharm. Co., Ltd. on one of the sides there is the “SR” mark applied by the embossing method (5 or 10 pcs. in blisters, in a cardboard box of 1, 2, 3, 4 or 6 packages and instructions for use of Neobutin Retard).
Composition of 1 tablet:
- active substance: trimebutine maleate - 300 mg;
- auxiliary components: povidone K30, tartaric acid, magnesium stearate, hypromellose, colloidal silicon dioxide, lactose monohydrate;
- shell composition: talc, hypromellose, silicon defoamer, white opadry M-1-7111 [hypromellose-2910, titanium dioxide, water, denatured ethanol (methylated alcohol)].
Pharmacological properties
Pharmacodynamics
Trimebutin acts on the enkephalinergic system of the intestine and regulates its peristalsis. By affecting peripheral δ-, μ- and κ-receptors (including receptors that are located directly on the smooth muscles of the entire gastrointestinal tract), the substance regulates motility without affecting the central nervous system.
Due to the properties of the active component, Neobutin Retard restores the normal physiological activity of the intestinal musculature in various diseases of the gastrointestinal tract associated with impaired motility.
Trimebutin also normalizes visceral sensitivity, thereby providing an analgesic effect in abdominal pain.
Pharmacokinetics
Once in the gastrointestinal tract, trimebutin is rapidly absorbed.
The volume of distribution of the substance is 88 liters. Only 5% of the drug binds to plasma proteins. In small amounts, trimebutin crosses the placental barrier.
The drug is metabolized in the liver. It is excreted mainly in the form of metabolites in the urine.
Indications for use
Neobutin Retard is intended to eliminate digestive disorders (pain, cramps, abdominal discomfort, flatulence, diarrhea or constipation, heartburn, belching, dyspepsia, nausea, vomiting) in diseases of the gastrointestinal tract and biliary tract, such as irritable bowel syndrome, cholelithiasis, dysfunction of the biliary tract, postcholecystectomy syndrome, non-erosive gastroesophageal reflux disease, dysfunction of the sphincter of Oddi.
The use of Neobutin Retard is also advisable for postoperative paralytic intestinal obstruction.
Contraindications
- lactose intolerance, glucose-galactose malabsorption, lactase deficiency;
- children under 12 years old;
- pregnancy;
- period of breastfeeding;
- individual intolerance to any component of the drug.
Neobutin Retard, instructions for use: method and dosage
Neobutin Retard tablets are taken orally, before meals.
The standard dosage for adults and children over 12 years old is 1 tablet (300 mg) 2 times a day. The maximum daily dose is 2 tablets (600 mg).
The recommended duration of treatment for acute irritable bowel syndrome is 4 weeks.
Side effects
- allergic reactions: skin manifestations of individual intolerance to the components of the drug;
- from the digestive system: unpleasant taste, dry mouth, pain in the epigastric region, constipation / diarrhea, nausea, dyspepsia;
- from the nervous system: anxiety, headache, fatigue, weakness, dizziness, feeling of heat or cold, drowsiness;
- others: urinary retention, painful enlargement of the mammary glands, menstrual irregularities.
Overdose
No cases of trimebutine overdose have been reported to date.
special instructions
Influence on the ability to drive vehicles and complex mechanisms
There is a risk of developing side effects from the central nervous system (for example, dizziness). In this regard, patients should be careful when performing activities that require coordination of movements and increased attention, including driving.
Application during pregnancy and lactation
Experimental studies did not reveal teratogenic and embryotoxic effects of trimebutin. However, there is no clinical experience of using the drug during pregnancy, therefore Neobutin Retard is contraindicated in women carrying a child.
There is no reliable data on the safety of using trimebutin during lactation, therefore it is recommended to stop breastfeeding during treatment.
Pediatric use
Neobutin Retard is not used to treat children under 12 years of age.
Drug interactions
Information not provided by the manufacturer.
Analogs
Analogues of Neobutin Retard are: Neobutin, Trimedat, Trimedat Valenta, etc.
Terms and conditions of storage
Store at temperatures up to 25 ° C, protected from light and out of reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Neobutin Retard
Reviews about Neobutin Retard are mostly positive: the drug effectively eliminates flatulence, cramps and abdominal pain, heartburn and other digestive disorders. Patients who have been prescribed a drug for irritable bowel syndrome leave good messages, only in this case the course of treatment should be long.
The price of Neobutin Retard in pharmacies
Depending on the pharmacy network, the price for Neobutin Retard (30 tablets per pack) can be 360–442 rubles.
Neobutin Retard: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Neobutin Retard 300 mg film-coated tablets of prolonged action 20 pcs. 316 RUB Buy |
|
Neobutin retard tablets p.p. prolonged action 300mg 20 pcs. 410 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
