Colbiocin - Instructions For Use, Price, Analogs, Eye Ointment

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Colbiocin - Instructions For Use, Price, Analogs, Eye Ointment
Colbiocin - Instructions For Use, Price, Analogs, Eye Ointment

Video: Colbiocin - Instructions For Use, Price, Analogs, Eye Ointment

Video: Colbiocin - Instructions For Use, Price, Analogs, Eye Ointment
Video: How To Use Eye Ointment | How To Apply Ointment To The Eyes | How To Administer An Eye Ointment 2023, March


Colbiocin: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  1. 10. Use in childhood
  2. 11. In case of impaired renal function
  3. 12. For violations of liver function
  4. 13. Drug interactions
  5. 14. Analogs
  6. 15. Terms and conditions of storage
  7. 16. Terms of dispensing from pharmacies
  8. 17. Reviews
  9. 18. Price in pharmacies

Latin name: Colbiocin

ATX code: S01AA20

Active ingredient: rolitetracycline / tetracycline (rolitetracyclinum / tetracycline), chloramphenicol (chloramphenicolum), sodium colistimethatum (colistimethatum natrium)

Manufacturer: S. I. F. I., S.p. A. (SIFI, SpA) (Italy)

Description and photo update: 2018-21-11

Prices in pharmacies: from 256 rubles.


Colbiocin eye ointment
Colbiocin eye ointment

Colbiocin is an antimicrobial combined preparation for topical use in ophthalmology.

Release form and composition

Colbiocin dosage forms:

  • powder for the preparation of eye drops: after dissolving in 5 ml of the supplied solvent, a transparent, colorless or light yellow solution is formed (120 mg each in a glass vial of dark color, in a cardboard box 1 bottle complete with a reservoir lid and dropper cap, wrapped in aluminum foil);
  • eye ointment: semi-solid mass, yellow (5 g each in aluminum tubes, in a cardboard box 1 tube).

1 ml of the finished solution contains:

  • active ingredients: rolitetracycline - 5 mg, sodium colistimethate - 180,000 IU (international units), chloramphenicol - 4 mg;
  • auxiliary component: sodium sulfite;
  • solvent: boric acid, sodium tetraborate, benzalkonium chloride, polysorbate 80, disodium edetate, purified water.

1 g of ointment contains:

  • active ingredients: tetracycline - 5 mg, sodium colistimethate - 180,000 IU, chloramphenicol - 10 mg;
  • auxiliary components: lanolin, vaseline oil, eye vaseline.

Pharmacological properties


Colbiocin is a combined preparation with antibacterial action for topical use in ophthalmology. Its therapeutic effect is due to the activity of the main components that make up:

  • tetracycline (rolitetracycline): a broad-spectrum antibiotic. Bacteriostatic activity of tetracycline against gram-negative bacteria Mycoplasma speciales (spp.), Chlamydia spp., Entamoeba histolytica and Rickettsia spp. associated with inhibition of bacterial protein synthesis at the RNA level (ribonucleic acid). Resistance of microorganisms to the drug develops slowly;
  • chloramphenicol: a broad-spectrum antibiotic. Shows activity against gram-positive and gram-negative bacteria, Mycoplasma spp., Chlamydia spp., Rickettsia spp., Inhibits the synthesis of proteins of sensitive microorganisms. Fungi, Pseudomonas aeruginosa, are resistant to chloramphenicol;
  • colistimethate sodium (antibiotic isolated from Bacillus polymixa var. colistinus): most gram-negative bacteria (including Haemophilus spp., Pseudomonas spp.) are susceptible to its bactericidal effect. Active against fungi. Colistimethate sodium is synergistic with broad-spectrum antibiotics and does not cause cross-resistance.

Indications for use

  • purulent, catarrhal or trachoma conjunctivitis;
  • dacryocystitis;
  • blepharitis;
  • septic ulcer of the cornea;
  • blepharoconjunctivitis;
  • bacterial keratitis.


  • age up to 8 years;
  • functional disorders of the kidneys and / or liver;
  • period of pregnancy;
  • breast-feeding;
  • individual intolerance to the components of Colbiocin.

Instructions for use of Colbiocin: method and dosage

Powder for making eye drops

To prepare eye drops, remove the cap from the bottle, install the reservoir and press its red cap into the bottle. After vigorous shaking until the powder in the vial is completely dissolved, the reservoir should be removed and a dropper (pipette) with a cap should be put on.

The prepared solution is instilled into the conjunctival sac by turning the bottle over and squeezing out the liquid drop by drop.

Recommended dosage: 1-2 drops 3-4 times a day.

Eye ointment

Colbiocin ointment is used by placing it in the lower conjunctival sac.

Recommended frequency of procedures: 3-4 times a day.

The doctor prescribes the dose, frequency and period of application of Colbiocin individually, taking into account the clinical indications and the patient's condition.

If a combination of Colbiocin ointment with eye drops is used for treatment, then the ointment can be used only in the evening before bedtime.

Side effects

  • local reactions: burning sensation, short-term conjunctival hyperemia;
  • allergic reactions: urticaria, bullous and maculopapular dermatitis, angioedema.

In addition, against the background of the use of eye drops, the development of severe systemic allergic reactions, including attacks of bronchial asthma, in patients with hypersensitivity to sodium sulfite is possible.


Symptoms of an overdose of Colbiocin have not been established.

special instructions

Colbiocin should be discontinued if, after several days of therapy, there is no significant improvement in the clinical condition.

If symptoms of allergic reactions appear, the use of the drug should be discontinued and a doctor should be consulted to prescribe appropriate antiallergic therapy.

It is recommended to use the drug under the supervision of an ophthalmologist for a short period of time, since with prolonged local use of chloramphenicol can contribute to the development of bone marrow hypoplasia.

Application during pregnancy and lactation

According to the instructions, Colbiocin is contraindicated during gestation and during breastfeeding.

Pediatric use

You can not prescribe the drug to children under the age of 8 years.

With impaired renal function

The appointment of Colbiocin is contraindicated in patients with renal insufficiency.

For violations of liver function

The appointment of Colbiocin is contraindicated in patients with hepatic insufficiency.

Drug interactions

The interaction of Colbiocin with simultaneous use with other drugs for topical use in ophthalmology has not been established.


The analogs of Colbiocin are Erythromycin, Gentamicin, Levomycetin, Tobrosopt, Tobrex, Nettacin, Azidrop, Tetracycline ointment.

Terms and conditions of storage

Keep out of the reach of children. Store at temperatures up to 25 ° C, after opening the bottle with the powder it must be stored in a refrigerator at a temperature of 2-8 ° C.

Shelf life: powder for the preparation of eye drops - 2 years, eye ointment - 3 years.

Store after opening: powder - no more than 15 days; ointment - 30 days.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Colbiocin

Reviews about Colbiocin are positive. Since the antibiotics that make up the drug are active against almost the entire spectrum of causative agents of eye infections, including chlamydia, mycoplasma and fungi, its use is most effective in the treatment of severe forms of chlamydial conjunctivitis, bacterial keratitis, keratouveitis with ulceration. Patients report that after long-term ineffective treatment of chlamydial conjunctivitis with other drugs, positive dynamics were immediately noted against the background of the use of the ointment, and within three weeks a complete recovery occurred.

Price for Colbiocin in pharmacies

The price of Colbiocin for a package containing 1 tube of ointment (5 g) can range from 484 rubles.

Colbiocin: prices in online pharmacies

Drug name



Colbiocin eye ointment 5 g 1 pc.

256 RUB


Colbiocin eye ointment 5g

335 RUB


Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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