Clotrimazole-Akrikhin - Instructions For The Use Of Ointments And Tablets, Price

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Clotrimazole-Akrikhin

Clotrimazole-Akrikhin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Clotrimazole-Akrikhin

ATX code: D01AC01

Active ingredient: Clotrimazole (Clotrimazole)

Producer: AKRIKHIN KhFK, JSC (Russia)

Description and photo update: 2018-25-10

Prices in pharmacies: from 35 rubles.

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Clotrimazole-Akrikhin is a broad-spectrum antifungal drug.

Release form and composition

Clotrimazole-Akrikhin is available in two dosage forms:

• vaginal tablets: almost white or white, biconvex, oval (in contoured cell packs, 6 pcs., 1 pack in a cardboard box);
• ointment for external use 1%: almost white or white, with a slight specific odor (in aluminum tubes, 20 g each, in a cardboard box 1 tube).

The composition of 1 vaginal tablet includes:

• active substance: clotrimazole - 0.1 g;
• auxiliary components: magnesium stearate, citric acid, microcrystalline cellulose, potato starch, lactose (milk sugar).

The composition of 1 g of ointment includes:

• active substance: clotrimazole - 0.01 g;
• auxiliary components: purified water - up to 1 g; distilled monoglycerides - 0.015 g; methylcellulose - 0.03 g; castor oil - 0.14 g; emulsion wax - 0.03 g; sodium benzoate - 0.06 g; succinic acid - 0.005 g; methyl parahydroxybenzoate (nipagin) - 0.002 g; propylene glycol - 0.125 g

Pharmacological properties

Pharmacodynamics

The actions of the drug Clotrimazole-Akrikhin, due to the active substance included in its composition (clotrimazole):

• has an antimycotic effect associated with a violation of the synthesis of ergosterol contained in the cell membranes of fungi, which changes the membrane permeability and serves the subsequent lysis of the cell;
• has a fungistatic effect when used in low concentrations and fungicidal when used in high doses, and not only in proliferating cells;
• increases the concentration of hydrogen peroxide to a toxic level (which also contributes to the destruction of fungal cells) through interaction with mitochondrial and peroxidase enzymes in fungicidal concentrations;
• is active against the causative agent of erythrasma, pityriasis versicolor (Malassezia furfur), mold and yeast-like fungi, dermatophytes;
• has antimicrobial activity against Trichomonas vaginalis, staphylococci and streptococci (gram-positive bacteria), bacteroids and gardnerella vaginalis (gram-negative bacteria).

Pharmacokinetics

Clotrimazole characteristics:

• absorption: intravaginal absorption is 3–10%; when applied externally, it is poorly absorbed into the skin and mucous membranes, practically does not have a systemic effect;
• distribution: for 48–72 hours, its low concentrations in the blood and high concentrations in the vaginal secretions remain; when used externally, it penetrates the keratin of the nails and accumulates in the stratum corneum of the epidermis; in the deep layers of the epidermis, its concentration is higher than the minimum inhibitory concentration for dermatophytes;
• metabolism: rapidly metabolized in the liver to inactive metabolites.

Indications for use

Vaginal pills

• genital superinfections caused by microorganisms sensitive to clotrimazole;
• genital infections caused by yeast-like fungi of the genus Candida and / or vaginal Trichomonas (trichomoniasis, vulvovaginal candidiasis);
• sanitation of the birth canal before childbirth.

Ointment for external use

• fungal paronychia, interdigital fungal erosion, candidiasis, microsporia, epidermophytosis, trichophytosis, dermatophytosis, dermatomycosis (caused by mold, yeast and other fungi, dermatophytes and pathogens sensitive to clotrimazole, fungal pathologies of the skin, including piles)
• mycoses complicated by secondary pyoderma (as part of complex treatment);
• pityriasis versicolor, erythrasma, versicolor versicolor.

Contraindications

• period of menstruation (for vaginal tablets);
• age under 2 years old (for ointment);
• I trimester of pregnancy;
• individual intolerance to the components contained in the preparation.

According to the instructions, Clotrimazole-Akrikhin is prescribed with caution in the following cases:

• vaginal tablets: breastfeeding period;
• ointment: II and III trimesters of pregnancy, lactation period.

Instructions for use of Clotrimazole-Akrikhin: method and dosage

Vaginal pills

Clotrimazole-Akrikhin tablets are administered intravaginally, as deep as possible into the vagina, in the supine position with legs slightly bent at the knees, in the evening.

Daily dose - 1 pc. The duration of therapy is 6 days, with a possible repetition of the course as prescribed by the doctor.

In order to sanitize the birth canal, 1 pc is injected once.

Ointment for external use

Ointment Clotrimazole-Akrikhin is applied externally: it is applied in a thin layer on previously cleaned and dried affected skin areas. Frequency rate of application - 2-3 times a day.

A single dose of the drug when applied to the affected area the size of a palm - a column of ointment 5 mm long.

To obtain a therapeutic effect, it is important to apply the ointment regularly.

The duration of treatment is determined by the doctor on an individual basis, taking into account the severity and localization of the pathology.

In order to achieve complete recovery, it is recommended to continue using the drug for some time after the acute symptoms of inflammation disappear.

On average, Clotrimazole-Akrikhin is used for about 28 days.

With pityriasis versicolor, 7–21 days of therapy are usually sufficient for recovery, with erythrasma - 14–28 days.

In cases of fungal diseases of the skin of the legs, Clotrimazole-Akrikhin ointment is used for another 14 days after the relief of symptoms.

Side effects

Vaginal pills

During the period of using Clotrimazole-Akrikhin tablets, pain during intercourse, vaginal discharge, the development of intercurrent cystitis, frequent urination, gastralgia, headache, edema, burning or itching of the vaginal mucosa may occur, in the sexual partner - a burning sensation in the penis.

Ointment for external use

• allergic reactions: urticaria, itching;
• local reactions: blisters, erythematous rashes, paresthesias, peeling / irritation of the skin, edema, burning.

Overdose

Vaginal pills

The main symptoms: in case of accidental oral administration - liver dysfunction, gastralgia, vomiting, nausea, anorexia; rarely - allergic skin reactions, pollakiuria, hallucinations, drowsiness.

Therapy: there is no specific antidote. It is recommended to take activated carbon, symptomatic treatment (if necessary).

Ointment for external use

Since clotrimazole has a low systemic absorption when used externally, overdose is almost impossible.

special instructions

In liver failure, the functional state of the liver is periodically monitored.

Clotrimazole-Akrikhin is canceled when signs of hypersensitivity develop.

If the effect of therapy is absent for 28 days, it is recommended to clarify the diagnosis.

Vaginal pills

In order to prevent urogenital reinfection, simultaneous therapy of sexual partners is important.

In trichomoniasis, for more successful treatment, the drug is used in combination with other systemic agents (for example, oral metronidazole).

In cases of simultaneous candidal vulvitis, local treatment with a cream containing clotrimazole is additionally performed.

During pregnancy, vaginal tablets are administered without an applicator.

Ointment for external use

When applying the ointment, it is important to avoid contact with the eyes.

In children, Clotrimazole-Akrikhin should not be applied to large areas.

Application during pregnancy and lactation

The drug is contraindicated for use in the first trimester of pregnancy.

In the II and III trimesters of pregnancy, Clotrimazole-Akrikhin ointment for external use is used, observing precautions.

The drug is used with caution during lactation.

Pediatric use

Ointment Clotrimazole-Akrikhin is contraindicated in children under the age of 2 years.

Drug interactions

Vaginal pills

When administered vaginal clotrimazole reduces the activity of amphotericin B and other polyene antibacterial agents.

Clotrimazole activity can decrease nystatin.

Ointment for external use

The effectiveness of clotrimazole is reduced by natamycin, nystatin, amphotericin B.

Analogs

Analogs of Clotrimazole-Akrikhin are: Exifin, Terbinox, Antifungol, Mikozolon.

Terms and conditions of storage

Store in a place protected from light and moisture, vaginal tablets - at temperatures up to 25 ° C, ointment - up to 15 ° C. Keep out of the reach of children.

Shelf life:

• tablets - 3.5 years;
• ointment - 2 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Clotrimazole-Akrikhin

According to reviews, Clotrimazole-Akrikhin is an affordable and effective drug. Among the disadvantages are the development of skin reactions, the appearance of a burning sensation during therapy.

Price for Clotrimazole-Akrikhin in pharmacies

The approximate price for Clotrimazole-Akrikhin ointment for external use (20 g per package) is 97 rubles.

Clotrimazole-Akrikhin: prices in online pharmacies

Drug name Price Pharmacy

Clotrimazole-Akrikhin 100 mg vaginal tablets 6 pcs. 35 RUB Buy

Clotrimazole-Akrikhin tablets vaginal. 100mg 6 pcs. 41 rbl. Buy

Clotrimazole-Akrikhin 1% ointment for external use 20 g 1 pc. 89 RUB Buy

Clotrimazole-Akrikhin ointment 1% 20g 142 RUB Buy

Clotrimazole-Akrikhin 1% solution for external use 15 ml 1 pc. 246 r Buy

Clotrimazole-Akrikhin solution for outside. approx. 1% fl. 15ml 282 r Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!